Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: Potential application to cartilage regenerative medicine

Stem Cells

Volumn 30, Issue 3, 2012, Pages 471-480

  Merceron, Christophe ^a,b   Portron, Sophie ^a,b   Vignes Colombeix, Caroline ^a,b   Rederstorff, Emilie ^a,b,c   Masson, Martial ^a,b   Lesoeur, Julie ^a,b,d   Sourice, Sophie ^a,b   Sinquin, Corinne ^c   Colliec Jouault, Sylvia ^c   Weiss, Pierre ^a,b   Vinatier, Claire ^a,b,d   Guicheux, Jérôme ^a,b  

^a Universite de Nantes   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c IFREMER   (France)

^d GRAFTYS SAS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; COLLAGEN; GAG PROTEIN; GLYCOSAMINOGLYCAN; GROWTH FACTOR; GY 785DR; GY 785DRS; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYSACCHARIDE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADIPOSE TISSUE CELL; ARTICLE; BINDING AFFINITY; CARTILAGE; CELL CULTURE; CELL DIFFERENTIATION; CELL REGENERATION; CHONDROGENESIS; CONTROLLED STUDY; DATA ANALYSIS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOLOGY; MEDICAL RECORD; MESENCHYMAL STEM CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SULFATION; SURFACE PLASMON RESONANCE; TISSUE ENGINEERING; UPREGULATION;

ADIPOSE TISSUE, WHITE; ANTIGENS, DIFFERENTIATION; CARTILAGE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHONDROGENESIS; HUMANS; INSULIN; MESENCHYMAL STEM CELLS; POLYSACCHARIDES; REGENERATION; REGENERATIVE MEDICINE; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84857475667     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1686     Document Type: Article

References (37)

1. Archer CW, Francis-West P. The chondrocyte. Int J Biochem Cell Biol 2003;35:401-404. (Pubitemid 36140061)
2. Aigner T, Stove J. Collagens-Major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair. Adv Drug Deliv Rev 2003;55: 1569-1593. (Pubitemid 37412594)
3. Hunziker EB. Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2002;10:432-463. (Pubitemid 34679298)
4. Vinatier C, Mrugala D, Jorgensen C et al. Cartilage engineering: A crucial combination of cells, biomaterials and biofactors. Trends Biotechnol 2009;27:307-314.
5. Friedenstein AJ, Piatetzky S II, Petrakova KV. Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol 1966;16: 381-390.
6. Vinatier C, Bouffi C, Merceron C et al. Cartilage tissue engineering: Towards a biomaterial-assisted mesenchymal stem cell therapy. Curr Stem Cell Res Ther 2009;4(4):318-329.
7. Dominici M, Le Blanc K, Mueller I et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-317. (Pubitemid 44269669)
8. Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell 1991;64:867-869. (Pubitemid 121001173)
9. Gandhi NS, Mancera RL. The structure of glycosaminoglycans and their interactions with proteins. Chem Biol Drug Des 2008;72:455-482.
10. Ramirez F, Rifkin DB. Cell signaling events: A view from the matrix. Matrix Biol 2003;22:101-107. (Pubitemid 36627468)
11. Rougeaux H, Pichon R, Kervarec N et al. Novel bacterial exopolysaccharides from deep-sea hydrothermal vents. Carbohydr Polym 1996; 31:237-242. (Pubitemid 126371435)
12. Guezennec J. Deep-sea hydrothermal vents: A new source of innovative bacterial exopolysaccharides of biotechnological interest? J Ind Microbiol Biotechnol 2002;29:204-208. (Pubitemid 35229937)
13. Colliec Jouault S, Chevolot L, Helley D et al. Characterization, chemical modifications and in vitro anticoagulant properties of an exopolysaccharide produced by Alteromonas infernus. Biochim Biophys Acta 2001;1528:141-151. (Pubitemid 33001275)
14. Matou S, Colliec-Jouault S, Galy-Fauroux I et al. Effect of an oversulfated exopolysaccharide on angiogenesis induced by fibroblast growth factor-2 or vascular endothelial growth factor in vitro. Biochem Pharmacol 2005;69:751-759. (Pubitemid 40248618)
15. Raguenes GH, Peres A, Ruimy R et al. Alteromonas infernus sp. nov., a new polysaccharide-producing bacterium isolated from a deep-sea hydrothermal vent. J Appl Microbiol 1997;82:422-430. (Pubitemid 27229699)
16. Guezennec J, Pignet P, Lijour Y et al. Sulfation and depolymerization of a bacterial exopolysaccharide of hydrothermal origin. Carbohydr Polym 1998;37:19-24. (Pubitemid 128425424)
17. Estes BT, Diekman BO, Gimble JM et al. Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc 2010;5:1294-1311.
18. Merceron C, Vinatier C, Portron S et al. Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells. Am J Physiol Cell Physiol 2010;298:355-364.
19. Merceron C, Masson M, Portron S et al. Chondrogenic potential of differentially cultured human adipose-derived stem cells after transplantation with a cellulose hydrogel. Cell Transplant 2011 (in press).
20. Vinatier C, Magne D, Weiss P et al. A silanized hydroxypropyl methylcellulose hydrogel for the three-dimensional culture of chondrocytes. Biomaterials 2005;26:6643-6651. (Pubitemid 41024932)
21. Julien M, Khoshniat S, Lacreusette A et al. Phosphate-dependent regulation of MGP in osteoblasts: Role of ERK1/2 and Fra-1. J Bone Miner Res 2009;24:1856-1868.
22. Awad HA, Halvorsen YD, Gimble JM et al. Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells. Tissue Eng 2003;9:1301-1312. (Pubitemid 37467678)
23. Puetzer JL, Petitte JN, Loboa EG. Comparative review of growth factors for induction of three-dimensional in vitro chondrogenesis in human mesenchymal stem cells isolated from bone marrow and adipose tissue. Tissue Eng Part B Rev 2010;16:435-444.
24. Malafaya PB, Oliveira JT, Reis RL. The effect of insulin-loaded chitosan particle-aggregated scaffolds in chondrogenic differentiation. Tissue Eng Part A 2010;16:735-747.
25. Wang CY, Chen LL, Kuo PY et al. Apoptosis in chondrogenesis of human mesenchymal stem cells: Effect of serum and medium supplements. Apoptosis 2010;15:439-449.
26. Massague J, Chen YG. Controlling TGF-beta signaling. Genes Dev 2000;14:627-644.
27. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-584. (Pubitemid 37280136)
28. Arita NA, Pelaez D, Cheung HS. Activation of the Extracellular signal-regulated kinases 1 and 2 (ERK1/2) is needed for the TGFbeta-induced chondrogenic and osteogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun 2011; 405(4):564-569.
29. Lai CF, Feng X, Nishimura R et al. Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling. J Biol Chem 2000;275:36400-36406.
30. Zuk PA, Zhu M, Ashjian P et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-4295. (Pubitemid 35471185)
31. Rapraeger AC. Syndecan-regulated receptor signaling. J Cell Biol 2000;149:995-998.
32. Penc SF, Pomahac B, Winkler T et al. Dermatan sulfate released after injury is a potent promoter of fibroblast growth factor-2 function. J Biol Chem 1998;273:28116-28121. (Pubitemid 28496107)
33. Park JS, Woo DG, Yang HN et al. Heparin-bound transforming growth factor-beta3 enhances neocartilage formation by rabbit mesenchymal stem cells. Transplantation 2008;85:589-596.
34. San Antonio JD, Winston BM, Tuan RS. Regulation of chondrogenesis by heparan sulfate and structurally related glycosaminoglycans. Dev Biol 1987;123:17-24.
35. Hadler-Olsen E, Fadnes B, Sylte I et al. Regulation of matrix metalloproteinase activity in health and disease. FEBS J 2011;278:28-45.
36. Vlodavsky I, Abboud-Jarrous G, Elkin M et al. The impact of heparanese and heparin on cancer metastasis and angiogenesis. Pathophysiol Haemost Thromb 2006;35:116-127.
37. Jackson RL, Busch SJ, Cardin AD. Glycosaminoglycans: Molecular properties, protein interactions, and role in physiological processes. Physiol Rev 1991;71:481-539.