Hypercholesterolemic Myocardium Is Vulnerable to Ischemia-Reperfusion Injury and Refractory to Sevoflurane-Induced Protection

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Xu, Yong ^a   Ma, Lei Lei ^a   Zhou, Chen ^a   Zhang, Fei Jiang ^a   Kong, Fei Juan ^b   Wang, Wen Na ^a   Qian, Ling Bo ^c   Wang, Can Can ^c   Liu, Xian Bao ^a   Yan, Min ^a   Wang, Jian An ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SEVOFLURANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLOGICAL MONITORING; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RATE; HYPERCHOLESTEROLEMIA; ISCHEMIC POSTCONDITIONING; MALE; NONHUMAN; PROTEIN TARGETING; RAT; REPERFUSION INJURY;

ANESTHETICS, INHALATION; ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CORONARY ARTERY DISEASE; DIET; GLYCOGEN SYNTHASE KINASE 3; HEART VENTRICLES; HEMODYNAMICS; HYPERCHOLESTEROLEMIA; ISCHEMIC POSTCONDITIONING; MALE; METHYL ETHERS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCULAR DYSTROPHIES, LIMB-GIRDLE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS;

EID: 84885027145     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076652     Document Type: Article

References (30)

1. Ferdinandy P, Schulz R, Baxter GF, (2007) Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 59: 418-458. doi:10.1124/pr.107.06002. PubMed: 18048761.
2. Pagel PS, (2008) Postconditioning by volatile anesthetics: salvaging ischemic myocardium at reperfusion by activation of prosurvival signaling. J Cardiothorac Vasc Anesth 22: 753-765. doi:10.1053/j.jvca.2008.03.005. PubMed: 18922439.
3. Lecour S, (2009) Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway? J Mol Cell Cardiol 47: 32-40. doi:10.1016/j.yjmcc.2009.03.019. PubMed: 19344728.
4. Juhaszova M, Zorov DB, Yaniv Y, Nuss HB, Wang S, et al. (2009) Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res 104: 1240-1252. doi:10.1161/CIRCRESAHA.109.197996. PubMed: 19498210.
5. Zhang Y, Lv F, Jin L, Peng W, Song R, et al. (2011) MG53 participates in ischaemic postconditioning through the RISK signalling pathway. Cardiovasc Res 91: 108-115. doi:10.1093/cvr/cvr029. PubMed: 21285295.
6. Corti R, Fuster V, Badimon JJ, Hutter R, Fayad ZA, (2001) New understanding of atherosclerosis (clinically and experimentally) with evolving MRI technology in vivo. Ann N Y Acad Sci 947: 181-195. PubMed: 11795266.
7. Ballantyne CM, Olsson AG, Cook TJ, Mercuri MF, Pedersen TR, et al. (2001) Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S. Circulation 104: 3046-3051. doi:10.1161/hc5001.100624. PubMed: 11748098.
8. Osipov RM, Bianchi C, Feng J, Clements RT, Liu Y, et al. (2009) Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion. Circulation 120: S22-S30. doi:10.1161/CIRCULATIONAHA.108.842724. PubMed: 19752371.
9. Sack MN, Murphy E, (2011) The role of comorbidities in cardioprotection. J Cardiovasc Pharmacol Ther 16: 267-272. doi:10.1177/1074248411408313. PubMed: 21821527.
10. Drenger B, Ostrovsky IA, Barak M, Nechemia-Arbely Y, Ziv E, et al. (2011) Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition. Anesthesiology 114: 1364-1372. doi:10.1097/ALN.0b013e31820efafd. PubMed: 21368653.
11. Zhao HX, Wang XL, Wang YH, Wu Y, Li XY, et al. (2010) Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1alpha. Basic Res Cardiol 105: 109-118. doi:10.1016/j.amjcard.2010.01.310. PubMed: 19597757.
12. Gross ER, Hsu AK, Gross GJ, (2004) Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res 94: 960-966. doi:10.1161/01.RES.0000122392.33172.09. PubMed: 14976126.
13. Ballantyne CM, Houri J, Notarbartolo A, Melani L, Lipka LJ, et al. (2003) Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial. Circulation 107: 2409-2415. doi:10.1161/01.CIR.0000068312.21969.C8. PubMed: 12719279.
14. Iliodromitis EK, Zoga A, Vrettou A, Andreadou I, Paraskevaidis IA, et al. (2006) The effectiveness of postconditioning and preconditioning on infarct size in hypercholesterolemic and normal anesthetized rabbits. Atherosclerosis 188: 356-362. doi:10.1016/j.atherosclerosis.2005.11.023. PubMed: 16376892.
15. Zhang SZ, Wang NF, Xu J, Gao Q, Lin GH, et al. (2006) Kappa-opioid receptors mediate cardioprotection by remote preconditioning. Anesthesiology 105: 550-556. doi:10.1097/00000542-200609000-00019. PubMed: 16931988.
16. Yu CK, Li YH, Wong GT, Wong TM, Irwin MG, (2007) Remifentanil preconditioning confers delayed cardioprotection in the rat. Br J Anaesth 99: 632-638. doi:10.1093/bja/aem261. PubMed: 17872933.
17. Mykytenko J, Kerendi F, Reeves JG, Kin H, Zatta AJ, et al. (2007) Long-term inhibition of myocardial infarction by postconditioning during reperfusion. Basic Res Cardiol 102: 90-100. doi:10.1007/s00395-006-0625-0. PubMed: 17003965.
18. Zheng Z, Yang M, Zhang F, Yu J, Wang J, et al. (2011) Gender-related difference of sevoflurane postconditioning in isolated rat hearts: focus on phosphatidylinositol-3-kinase/Akt signaling. J Surg Res 170: e3-e9. doi:10.1016/S0022-4804(11)00696-2. PubMed: 21704330.
19. Zhao H, Wang Y, Wu Y, Li X, Yang G, et al. (2009) Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1alpha upregulation. Acta Biochim Biophys Sin (Shanghai) 41: 745-753. doi:10.1093/abbs/gmp063.
20. Penumathsa SV, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, et al. (2007) Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat. J Mol Cell Cardiol 42: 508-516. doi:10.1016/j.yjmcc.2006.10.018. PubMed: 17188708.
21. Roach PD, Balasubramaniam S, Hirata F, Abbey M, Szanto A, et al. (1993) The low-density lipoprotein receptor and cholesterol synthesis are affected differently by dietary cholesterol in the rat. Biochim Biophys Acta 1170: 165-172. doi:10.1016/0005-2760(93)90067-J. PubMed: 8399341.
22. Horton JD, Cuthbert JA, Spady DK, (1995) Regulation of hepatic 7 alpha-hydroxylase expression and response to dietary cholesterol in the rat and hamster. J Biol Chem 270: 5381-5387. doi:10.1074/jbc.270.10.5381. PubMed: 7890651.
23. Kupai K, Csonka C, Fekete V, Odendaal L, van Rooyen J, et al. (2009) Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite. Am J Physiol Heart Circ Physiol 297: H1729-H1735. doi:10.1152/ajpheart.00484.2009. PubMed: 19734363.
24. Görbe A, Varga ZV, Kupai K, Bencsik P, Kocsis GF, et al. (2011) Cholesterol diet leads to attenuation of ischemic preconditioning-induced cardiac protection: the role of connexin 43. Am J Physiol Heart Circ Physiol 300: H1907-H1913. doi:10.1152/ajpheart.01242.2010. PubMed: 21398600.
25. Wang TD, Chen WJ, Su SS, Lo SC, Lin WW, et al. (2002) Increased cardiomyocyte apoptosis following ischemia and reperfusion in diet-induced hypercholesterolemia: relation to Bcl-2 and Bax proteins and caspase-3 activity. Lipids 37: 385-394. doi:10.1007/s1145-002-0906-2. PubMed: 12030319.
26. Okamura T, Miura T, Takemura G, Fujiwara H, Iwamoto H, et al. (2000) Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart. Cardiovasc Res 45: 642-650. doi:10.1016/S0008-6363(99)00271-0. PubMed: 10728385.
27. Gustafsson AB, Gottlieb RA, (2007) Bcl-2 family members and apoptosis, taken to heart. Am J Physiol Cell Physiol 292: C45-C51. PubMed: 16943242.
28. Wang X, Xie W, Zhang Y, Lin P, Han L, et al. (2010) Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res 107: 76-83. doi:10.1161/CIRCRESAHA.109.215822. PubMed: 20466981.
29. Cao CM, Zhang Y, Weisleder N, Ferrante C, Wang X, et al. (2010) MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation. 121: 2565-2574. doi:10.1161/CIRCULATIONAHA.110.954628. PubMed: 20516375.
30. Iliodromitis EK, Andreadou I, Prokovas E, Zoga A, Farmakis D, et al. (2010) Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation. Basic Res Cardiol 105: 193-203. doi:10.1007/s00395-009-0078-3. PubMed: 20066537.