Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination

Cell Death and Disease

Volumn 4, Issue 9, 2013, Pages

  Takahashi, C ^a,b   Muramatsu, R ^a,b   Fujimura, H ^c   Mochizuki, H ^a,b   Yamashita, T ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TONEYAMA NATIONAL HOSPITAL   (Japan)

Author keywords

Lysophosphatidylcholine; Multiple sclerosis; Protein kinase A

Indexed keywords

CICAPROST; CYCLIC AMP DEPENDENT PROTEIN KINASE; ILOPROST; LYSOPHOSPHATIDYLCHOLINE; PROSTACYCLIN; PROSTACYCLIN SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DEMYELINATION; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; PRIORITY JOURNAL; REMYELINIZATION; SPINAL CORD;

AGING; ANIMALS; CELL MOVEMENT; CYCLIC AMP; DEMYELINATING DISEASES; EPOPROSTENOL; HUMANS; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; MYELIN SHEATH; OLIGODENDROGLIA; PROTEIN KINASES; RECEPTORS, EPOPROSTENOL; SIGNAL TRANSDUCTION; SPINAL CORD; STEM CELLS;

EID: 84885003682     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.335     Document Type: Article

References (44)

1. Smith KJ, Blakemore WF, McDonald WI. The restoration of conduction by central remyelination. Brain 1981; 104: 383-404
2. Nave KA. Myelination and the trophic support of long axons. Nat Rev Neurosci 2010; 11: 275-283
3. Achiron A, Barak Y. Multiple sclerosis-from probable to definite diagnosis: A 7-year prospective study. Arch Neurol 2000; 57: 974-979
4. Prineas JW, Connell F. Remyelination in multiple sclerosis. Ann Neurol 1979; 5: 22-31
5. Prineas JW, Barnard RO, Kwon EE, Sharer LR, Cho ES. Multiple sclerosis: Remyelination of nascent lesions. Ann Neurol 1993; 33: 137-151
6. Irvine KA, Blakemore WF. Remyelination protects axons from demyelination-Associated axon degeneration. Brain 2008; 131: 1464-1477
7. Franklin RJ. Why does remyelination fail in multiple sclerosis? Nat Rev Neurosci 2002; 3: 705-714
8. Dawson MRL, Polito A, Levine JM, Reynolds R. NG2-expressing glial progenitor cells: An abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 2003; 24: 476-488
9. Young KM, Psachoulia K, Tripathi RB, Dunn SJ, Cossell L, Attwell D et al. Oligodendrocyte dynamics in the healthy adult CNS: Evidence for myelin remodeling. Neuron 2013; 77: 873-885
10. Franklin RJM, Ffrench-Constant C. Remyelination in the CNS: From biology to therapy. Nat Rev Neurosci 2008; 9: 839-855
11. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases. Brain 1999; 122: 2279-2295
12. Schölkens BA, Bartmann W, Beck G, Lerch U, Konz E, Weithmann U. Vasodilation and inhibition of platelet aggregation by prostacyclins with modified omega-side chain. Prostaglandins Med 1979; 3: 7-22
13. Vane JR, Botting RM. Pharmacodynamic profile of prostacyclin. Am J Cardiol 1995; 75: 3A-10A.
14. Oida H, Namba T, Sugimoto Y, Ushikubi F, Ohishi H, Ichikawa A et al. In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs. Br J Pharmacol 1995; 116: 2828-2837
15. Siegle I, Klein T, Zou MH, Fritz P, Kö mhoff M. Distribution and cellular localization of prostacyclin synthase in human brain. J Histochem Cytochem 2000; 48: 631-641
16. Cazevieille C, Muller A, Bonne C. Prostacyclin (PGI2) protects rat cortical neurons in culture against hypoxia/reoxygenation and glutamate-induced injury. Neurosci Lett 1993; 160: 106-108
17. Fang YC, Wu JS, Chen JJ, Cheung WM, Tseng PH, Tam KB et al. Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 2006; 26: 491-501
18. Muramatsu R, Takahashi C, Miyake S, Fujimura H, Mochizuki H, Yamashita T. Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin. Nat Med 2012; 18: 1658-1664
19. Howe AK. Regulation of actin-based cell migration by cAMP/PKA. Biochim Biophys Acta 2004; 1692: 159-174
20. Hall SM. The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord. J Cell Sci 1972; 10: 535-546
21. Jeffery ND, Blakemore WF. Remyelination of mouse spinal cord axons demyelinated by local injection of lysolecithin. J Neurocytol 1995; 24: 775-781
22. Murray PD, McGavern DB, Sathornsumetee S, Rodriguez M. Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis. Brain 2001; 124: 1403-1416
23. Jeffery ND, Blakemore WF. Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. Brain 1997; 120: 27-37
24. D'Amelio P, Cristofaro MA, D'Amico L, Veneziano L, Roato I, Sassi F et al. Iloprost modulates the immune response in systemic sclerosis. BMC Immunol 2010; 11: 62
25. Jung S, Donhauser T, Toyka KV, Propentofylline Hartung H. and Iloprost suppress the production of TNF-A by macrophages but fail to ameliorate experimental autoimmune encephalomyelitis in Lewis rats. J Autoimmun 1997; 10: 519-529
26. Boswell MG, Zhou W, Newcomb DC, Peebles RS Jr. PGI2 as a regulator of CD4 subset differentiation and function. Prostaglandins Other Lipid Mediat 2011; 96: 21-26
27. Dore-Duffy P, Donaldson JO, Koff T, Longo M, Perry W. Prostaglandin release in multiple sclerosis: Correlation with disease activity. Neurology 1986; 36: 1587-1590
28. Mirshafiey A, Jadidi-Niaragh F. Prostaglandins in pathogenesis and treatment of multiple sclerosis. Immunopharmacol Immunotoxicol 2010; 32: 543-554
29. Marusic S, Leach MW, Pelker JW, Azoitei ML, Uozumi N, Cui J et al. Cytosolic phospholipase A2a-deficient mice are resistant to experimental autoimmune encephalomyelitis. J Exp Med 2005; 202: 841-851
30. Ayoub SS, Wood EG, Hassan SU, Bolton C. Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). Inflamm Res 2011; 60: 919-928
31. Kihara Y, Matsushita T, Kita Y, Uematsu U, Akira S, Kira J et al. Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. Proc Natl Acad Sci USA 2009; 106: 21807-21812
32. Lin X, Ramamurthy SK, Le Breton GC. Thromboxane A2 receptor-mediated cell proliferation, survival and gene expression in oligodendrocyte. J Neurochem 2005; 90: 257-268
33. Sun X, Liu Y, Liu B, Xiao Z, Zhang L. Rolipram promotes remyelination possibly via MEKERK signal pathway in cuprizone-induced demyelination mouse. Exp Neuro 2012; 237: 304-311
34. Pearse DD, Pereira FC, Marcillo AE, Bates ML, Berrocal YA, Filbin MT et al. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med 2004; 10: 610-616
35. Raible DW, McMorris FA. Cyclic AMP regulates the rate of differentiation of oligodendrocytes without changing the lineage commitment of their progenitors. Dev Biol 1989; 133: 437-446
36. Sato-Bigbee C, DeVries GH. Treatment of oligodendrocytes with antisense deoxyoligonucleotide directed against CREB mRNA: Effect on the cyclic AMP-dependent induction of myelin basic protein expression. J Neurosci Res 1996; 46: 98-107
37. Raible DW, McMorris FA. Oligodendrocyte differentiation and progenitor cell proliferation are independently regulated by cyclic AMP. J Neurosci Res 1993; 34: 287-294
38. McMorris FA, Furlanetto RW, Mozell RL, Carson MJ, Raible DW. Regulation of oligodendrocyte development by insulin-like growth factors and cyclic nucleotides. Ann N Y Acad Sci 1990; 605: 101-109
39. Murata T, Ushikubi F, Matsuoka T, Hirata M, Yamasaki A, Sugimoto Y et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 1997; 388: 678-682
40. Iadecola C, Nedergaard M. Glial regulation of the cerebral microvasculature. Nat Neurosci 2007; 10: 1369-1376
41. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K et al. Cell-cell signaling in the neurovascular unit. Neurochem Res 2007; 32: 2032-2045
42. Guo S, Lo EH. Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system disease. Stroke 2009; 40: S4-S7
43. Arai K, Lo EH. An oligovascular niche: Cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci 2009; 29: 4351-4355
44. Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma 2006; 23: 635-659