Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin

Nature Medicine

Volumn 18, Issue 11, 2012, Pages 1658-1664

  Muramatsu, Rieko ^a,b   Takahashi, Chisato ^a,b   Miyake, Shuzo ^a,b   Fujimura, Harutoshi ^c   Mochizuki, Hideki ^a,b   Yamashita, Toshihide ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TONEYAMA NATIONAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ILOPROST; PROSTACYCLIN; PROSTAGLANDIN RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AXON REMODELING; BLOOD VESSEL; CAPILLARY ENDOTHELIUM; CELL REGENERATION; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; CONVALESCENCE; ENDOTHELIUM CELL; MOTOR PERFORMANCE; MOUSE; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOTHELIAL CELLS; EPOPROSTENOL; HUMANS; ILOPROST; INFLAMMATION; MICE; MOTOR NEURONS; MULTIPLE SCLEROSIS; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE REGENERATION; PYRAMIDAL TRACTS; RECEPTORS, PROSTAGLANDIN; SIGNAL TRANSDUCTION;

EID: 84869175300     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2943     Document Type: Article

References (32)

1. Lucas, S.M., Rothwell, N.J. & Gibson, R.M. The role of inflammation in CNS injury and disease. Br. J. Pharmacol. 147, S232-S240 (2006 (Pubitemid 43077281)
2. Harel, N.Y. & Strittmatter, S.M. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat. Rev. Neurosci. 7, 603-616 (2006 (Pubitemid 44106743)
3. Hauser, S.L. & Oksenberg, J.R. The neurobiology of multiple sclerosis: Genes, inflammation, and neurodegeneration. Neuron 52, 61-76 (2006 (Pubitemid 44466355)
4. Trapp, B.D. & Nave, K.A. Multiple sclerosis: An immune or neurodegenerative disorder? Annu. Rev. Neurosci. 31, 247-269 (2008
5. Nikić, I. et al. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat. Med. 17, 495-499 (2011
6. DeLuca, G.C., Ebers, G.C. & Esiri, M.M. Axonal loss in multiple sclerosis: A pathological survey of the corticospinal and sensory tracts. Brain 127, 1009-1018 (2004 (Pubitemid 38623038)
7. Black, J.A., Liu, S., Hains, B.C., Saab, C.Y. & Waxman, S.G. Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE. Brain 129, 3196-3208 (2006 (Pubitemid 44871436)
8. Kerschensteiner, M. et al. Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosis. J. Exp. Med. 200, 1027-1038 (2004 (Pubitemid 39431127)
9. Jackson, J.R., Seed, M.P., Kircher, C.H., Willoughby, D.A. & Winkler, J.D. The codependence of angiogenesis and chronic inflammation. FASEB J. 11, 457-465 (1997 (Pubitemid 27259987)
10. Fokman, J. & Brem, H. Angiogenesis and inflammation. in Inflammation: Basic Principles and Clinical Correlates. 2nd edn., 821-839 (Raven Press, New York, 1992
11. Kirk, S., Frank, J.A. & Karlik, S. Angiogenesis in multiple sclerosis: Is it good, bad or an epiphenomenon? J. Neurol. Sci. 217, 125-130 (2004 (Pubitemid 38056544)
12. Costa, C., Incio, J. & Soares, R. Angiogenesis and chronic inflammation: Cause or consequence? Angiogenesis 10, 149-166 (2007 (Pubitemid 47305203)
13. Carmeliet, P. Blood vessels and nerves: Common signals, pathways and diseases. Nat. Rev. Genet. 4, 710-720 (2003 (Pubitemid 37046138)
14. Vane, J.R. & Botting, R.M. Pharmacodynamic profile of prostacyclin. Am. J. Cardiol. 75, 3A-10A (1995
15. Buddeberg, B.S. et al. Behavioral testing strategies in a localized animal model of multiple sclerosis. J. Neuroimmunol. 153, 158-170 (2004 (Pubitemid 38950938)
16. Bareyre, F.M. et al. The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat. Neurosci. 7, 269-277 (2004 (Pubitemid 38280451)
17. Courtine, G. et al. Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Nat. Med. 14, 69-74 (2008
18. Menétrey, D., de Pommery, J. & Roudier, F. Propriospinal fibers reaching the lumber enlargement in the rat. Neurosci. Lett. 58, 257-261 (1985 (Pubitemid 15017201)
19. Tessier-Lavigne, M. & Goodman, C.S. The molecular biology of axon guidance. Science 274, 1123-1133 (1996 (Pubitemid 26389268)
20. Kirk, S.L. & Karlik, S.J. VEGF and vascular changes in chronic neuroinflammation. J. Autoimmun. 21, 353-363 (2003 (Pubitemid 37420080)
21. Holley, J.E., Newcombe, J., Whatmore, J.L. & Gutowski, N.J. Increased blood vessel density and endothelial cell proliferation in multiple sclerosis cerebral white matter. Neurosci. Lett. 470, 65-70 (2010
22. Uesugi, N., Muramatsu, R. & Yamashita, T. Endothelin promotes neurite elongation by a mechanism dependent on c-Jun N-terminal kinase. Biochem. Biophys. Res. Commun. 383, 509-512 (2009
23. Snider, W.D., Zhou, F.Q., Zhong, J. & Markus, A. Signaling the pathway to regeneration. Neuron 35, 13-16 (2002 (Pubitemid 34804317)
24. Hannila, S.S. & Filbin, M.T. The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. Exp. Neurol. 209, 321-332 (2008 (Pubitemid 351174133)
25. Jung, S., Donhauser, T., Toyka, K.V. & Hartung, H.P. Propentofylline and iloprost suppress the production of TNF-α by macrophages but fail to ameliorate experimental autoimmune encephalomyelitis in Lewis rats. J. Autoimmun. 10, 519-529 (1997 (Pubitemid 28053540)
26. Makita, T., Sucov, H.M., Gariepy, C.E., Yanagisawa, M. & Ginty, D.D. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature 452, 759-763 (2008 (Pubitemid 351521084)
27. Dray, C., Rougon, G. & Debarbieux, F. Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord. Proc. Natl. Acad. Sci. USA 106, 9459-9464 (2009
28. Tammela, T. et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454, 656-660 (2008
29. Vavrek, R., Girgis, J., Tetzlaff, W., Hiebert, G.W. & Fouad, K. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal injured rats. Brain 129, 1534-1545 (2006 (Pubitemid 43999385)
30. Liu, K. et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat. Neurosci. 13, 1075-1081 (2010
31. Ueno, M., Hayano, Y., Nakagawa, H. & Yamashita, T. Intraspinal rewiring of the corticospinal tract requires target-derived neurotrophic factor and compensates lost function after brain injury. Brain 135, 1253-1267 (2012
32. Hino, T. et al. In vivo delivery of small interfering RNA targeting brain capillary endothelial cells. Biochem. Biophys. Res. Commun. 340, 263-267 (2006 (Pubitemid 41827675)