The neutrophil elastase inhibitor sivelestat suppresses accelerated gastrointestinal tumor growth via peritonitis after cecal ligation and puncture

Anticancer Research

Volumn 33, Issue 9, 2013, Pages 3653-3660

  Kumagai, Koshi ^a   Saikawa, Yoshiro ^a   Takeuchi, Hiroya ^a   Suda, Koichi ^a   Fukuda, Kazumasa ^a   Nakamura, Rieko ^a   Takahashi, Tsunehiro ^a   Kawakubo, Hirofumi ^a   Wada, Norihito ^a   Miyasho, Taku ^b   Kitagawa, Yuko ^a  

^a KEIO UNIVERSITY   (Japan)

^b RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

Cecal ligation and puncture; Compensatory anti inflammatory response syndrome; CT26 murine colon cancer; Neutrophil elastase inhibitor; Sivelestat

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; SIVELESTAT; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; COLON CARCINOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIGESTIVE SYSTEM CANCER; FEMALE; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; TUMOR GROWTH;

CECAL LIGATION AND PUNCTURE; COMPENSATORY ANTI-INFLAMMATORY RESPONSE SYNDROME; CT26 MURINE COLON CANCER; NEUTROPHIL ELASTASE INHIBITOR; SIVELESTAT;

ANIMALS; CECUM; CELL DIVISION; CELL LINE; GASTROINTESTINAL NEOPLASMS; GLYCINE; LEUKOCYTE ELASTASE; LIGATION; MICE; MICE, INBRED C57BL; PERITONITIS; SERINE PROTEINASE INHIBITORS; SULFONAMIDES;

EID: 84885003494     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Docherty JG, McGregor JR, Akyol AM, Murray GD and Galloway DJ: Comparison of manually constructed and stapled anastomoses in colorectal surgery. West of Scotland and Highland Anastomosis Study Group. Ann Surg 221: 176-184, 1995.
2. Fujita S, Teramoto T, Watanabe M, Kodaira S and Kitajima M: Anastomotic leakage after colorectal cancer surgery: A risk factor for recurrence and poor prognosis. Jpn J Clin Oncol 23: 299-302, 1993.
3. Sierzega M, Kolodziejczyk P and Kulig J: Impact of anastomotic leakage on long-term survival after total gastrectomy for carcinoma of the stomach. Br J Surg 97: 1035-1042, 2010.
4. Fucini C, Bandettini L, D'Elia M, Filipponi F and Herd-Smith A: Are postoperative fever and/or septic complications prognostic factors in colorectal cancer resected for cure? Dis Colon Rectum 28: 94-95, 1985.
5. Varty PP, Linehan IP and Boulos PB: Intra-abdominal sepsis and survival after surgery for colorectal cancer. Br J Surg 81: 915-918, 1994.
6. Baker CC, Chaudry IH, Gaines HO and Baue AE: Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 94: 331-335, 1983.
7. Wichterman KA, Baue AE and Chaudry IH: Sepsis and septic shock-a review of laboratory models and a proposal. J Surg Res 29: 189-201, 1980.
8. Otero-Anton E, Gonzalez-Quintela A, Lopez-Soto A, Lopez-Ben S, Llovo J and Perez LF: Cecal ligation and puncture as a model of sepsis in the rat: Influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels. Eur Surg Res 33: 77-79, 2001.
9. Yoshikawa T, Takeuchi H, Suda K, Miyasho T, Yamada S, Okamoto M, Kawamura Y, Maruyama I, Kitajima M and Kitagawa Y: High-dose immunoglobulin preparations improve survival in a CLP-induced rat model of sepsis. Langenbecks Arch Surg 397: 457-465, 2012.
10. Suda K, Takeuchi H, Hagiwara T, Miyasho T, Okamoto M, Kawasako K, Yamada S, Suganuma K, Wada N, Saikawa Y, Fukunaga K, Funakoshi Y, Hashimoto S, Yokota H, Maruyama I, Ishizaka A and Kitagawa Y: Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis. Shock 33: 526-531, 2010.
11. Suda K, Kitagawa Y, Ozawa S, Saikawa Y, Ueda M, Ebina M, Yamada S, Hashimoto S, Fukata S, Abraham E, Maruyama I, Kitajima M and Ishizaka A: Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis. World J Surg 30: 1755-1762, 2006.
12. Wada Y, Yoshida K, Hihara J, Konishi K, Tanabe K, Ukon K, Taomoto J, Suzuki T and Mizuiri H: Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha. Cancer Sci 97: 1037-1043, 2006.
13. Doi K, Horiuchi T, Uchinami M, Tabo T, Kimura N, Yokomachi J, Yoshida M and Tanaka K: Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats. Eur J Surg 168: 507-510, 2002.
14. Kamohara H, Sakamoto K, Mita S, An XY and Ogawa M: Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1. Res Commun Mol Pathol Pharmacol 98: 103-108, 1997.
15. Kerr JR, Cunniffe VS, Kelleher P, Coats AJ and Mattey DL: Circulating cytokines and chemokines in acute symptomatic parvovirus B19 infection: Negative association between levels of pro-inflammatory cytokines and development of B19-associated arthritis. J Med Virol 74: 147-155, 2004.
16. Murthy BL, Thomson CS, Dodwell D, Shenoy H, Mikeljevic JS, Forman D and Horgan K: Postoperative wound complications and systemic recurrence in breast cancer. Br J Cancer 97: 1211-1217, 2007.
17. Yan T, Yin W, Zhou L, Jiang Y, Shen Z, Shao Z and Lu J: Postoperative fever: The potential relationship with prognosis in node-negative breast cancer patients. PLoS One 5: e15903, 2010.
18. Coward J, Kulbe H, Chakravarty P, Leader D, Vassileva V, Leinster DA, Thompson R, Schioppa T, Nemeth J, Vermeulen J, Singh N, Avril N, Cummings J, Rexhepaj E, Jirstrom K, Gallagher WM, Brennan DJ, McNeish IA and Balkwill FR: Interleukin-6 as a therapeutic target in human ovarian cancer. Clin Cancer Res 17: 6083-6096, 2011.
19. Akamoto S, Okano K, Sano T, Yachida S, Izuishi K, Usuki H, Wakabayashi H and Suzuki Y: Neutrophil elastase inhibitor (sivelestat) preserves antitumor immunity and reduces the inflammatory mediators associated with major surgery. Surg Today 37: 359-365, 2007.
20. Inada M, Yamashita J, Nakano S and Ogawa M: Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046.Na). Anticancer Res 18: 885-890, 1998.
21. Inada M, Yamashita J and Ogawa M: Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice. Res Commun Mol Pathol Pharmacol 97: 229-232, 1997.
22. Matsumura F, Yamaguchi Y and Ogawa M: Adhesion molecule expression in vascular endothelial cells incubated with cancer cell line supernatant are inhibited by neutrophil elastase inhibitor (ONO-5046.Na). Res Commun Mol Pathol Pharmacol 98: 109-112, 1997.
23. Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK and Shapiro SD: Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med 16: 219-223, 2010.
24. Oberholzer A, Oberholzer C and Moldawer LL: Sepsis syndromes: Understanding the role of innate and acquired immunity. Shock 16: 83-96, 2001.
25. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL and Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29: 530-538, 2003.
26. Keel M and Trentz O: Pathophysiology of polytrauma. Injury 36: 691-709, 2005.
27. Bone RC, Grodzin CJ and Balk RA: Sepsis: A new hypothesis for pathogenesis of the disease process. Chest 112: 235-243, 1997.
28. Hu HM, Urba WJ and Fox BA: Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T-cell response from a type 2 to a type 1 cytokine profile. J Immunol 161: 3033-3041, 1998.
29. Kobayashi M, Kobayashi H, Pollard RB and Suzuki F: A pathogenic role of Th2 cells and their cytokine products on the pulmonary metastasis of murine B16 melanoma. J Immunol 160: 5869-5873, 1998.
30. Tsung K, Meko JB, Peplinski GR, Tsung YL and Norton JA: IL-12 induces T-helper 1-directed antitumor response. J Immunol 158: 3359-3365, 1997.
31. Weiner GJ, Liu HM, Wooldridge JE, Dahle CE and Krieg AM: Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA 94: 10833-10837, 1997.
32. Zitvogel L, Mayordomo JI, Tjandrawan T, DeLeo AB, Clarke MR, Lotze MT and Storkus WJ: Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T-cells, B7 co-stimulation, and T-helper cell 1-associated cytokines. J Exp Med 183: 87-97, 1996.
33. Kamohara H, Sakamoto K, Mita S, An XY and Ogawa M: Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1. Res Commun Mol Pathol Pharmacol 98: 103-108, 1997.