Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC-1 by a neutrophil elastase inhibitor (ONO-5046·Na)

Anticancer Research

Volumn 18, Issue 2 A, 1998, Pages 885-890

  Masayukiinada, ^a   Yamashita, Jun Ichi ^a   Nakano, Shogo ^a   Ogawa, Michio ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

EBC 1; Neutrophil elastase inhibitor; ONO 5046 Na; Pulmonary metastasis; Scid mice

Indexed keywords

LEUKOCYTE ELASTASE; SIVELESTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; LUNG CARCINOMA; LUNG METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; FEMALE; GLYCINE; HUMANS; LEUKOCYTE ELASTASE; LUNG NEOPLASMS; MICE; MICE, SCID; SERINE PROTEINASE INHIBITORS; SULFONAMIDES; TUMOR CELLS, CULTURED;

EID: 15644368483     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Liotta LA and Stetler-Stevenson WG: Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 51: 5054s-5059s, 1991.
2. Matrisian LM: The matrix-degrading metalloproteinases. Bioessays 14: 455-463, 1992.
3. Mignatti P, Robbins E and Rifkin DB: Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade. Cell 47: 487-498, 1986.
4. Nakajima M and Chop AM: Tumor invasion and extracellular matrix degradative enzymes: regulation of activity by organ factors. Semin. Cancer Biol 2: 115-127, 1991.
5. Werb Z, and Gordon S: Elastase secretion by stimulated macrophages: characterization and regulation. J Exp Med 142: 361-377, 1975.
6. Baugh RJ, and Travis J: Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry 15: 836-841, 1976.
7. Janoff A: Elastase in tissue injury. Annu Rev Med 36: 207-216, 1985.
8. Janoff A, and Schere J: Mediators of inflammation in leukocyte lysosomes. IX. Elastolytic activity in granules of human polymorphonuclear leukocytes. J Exp Med 128: 1137-1156, 1968.
9. Mainardi C, Dixit S, and Kang A: Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules. J Biol Chem 255: 5435-5441, 1980.
10. McDonald JA, and Kelley DG: Degradation of fibronectin by human leukocyte elastase: release of biologically active fragments. J Biol Chem 255: 8848-8858, 1980.
11. Yamashita J, Tashiro K, Yoneda S, Kawahara K, and Shirakusa T: Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer. Chest 109: 1328-1334, 1996.
12. Yamashita J, Ogawa M, Abe M, Hayashi N, Kurusu Y, Kawahara K, and Shirakusa T: Tumor neutrophil elastase is closely associated with the direct extension of non-small cell lung cancer into the aorta. Chest 111: 885-890, 1997.
13. Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, and Miyamoto T: ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun 177: 814-820, 1991.
14. Minna JD, Pass H, Glatstein E, and Ihde DC: Lung cancer. In: DeVita, VTJr, Hellman S, Rosenberg SA, editors. Cancer: principles and practice of oncology. Philadelphia: JB Lippincott, 591-705, 1989.
15. Naruke T, Goya T, Tsuchiya R and Suemasu K: Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg 96: 440-447, 1988.
16. Ohta M, Tsuchiya R, Shimoyama M, Sawamura K, Mori T, Miyazawa N, Suemasu K, Watanabe Y, Tomita M, Terashima M: Japan clinical oncology group: Adjuvant chemotherapy for completely resected stage III non-small cell cancer; results of a randomized prospective study. J Thorac Cardiovasc Surg 106: 703-708, 1993.
17. Yamashita J, Ogawa M, Ikei S, Omachi H, Yamashita S, Saishoji T, Nomura K, and Sato H: Production of immunoreactive polymorphonuclear leucocyte elastase in human breast cancer cells: possible role of polymorphonuclear leucocyte elastase in the progression of human breast cancer. Br J Cancer 69: 72-76, 1994.
18. Yamashita J, Ogawa M, and Sakai K: Prognostic significance of three novel biological factors in a clinical trial of adjuvant therapy for node-negative breast cancer. Surgery 117: 601-608, 1995.
19. Yamashita J, Ogawa M, and Shirakusa T: Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer. J Leukoc Biol 57: 375-378, 1995.
20. Mantovani A: Tumor-associated macrophages. Current Opinion in Immunol 2: 689-692, 1990.
21. Opdenakker G, and Van Damme J: Chemotactic factors, passive invasion and metastasis of cancer cells, Immunol Today 13: 463-464, 1992.
22. Opdenakker G, and Van Damme J: Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 4: 251-258, 1992.
23. Sakamoto K, Masuda T, Mita S, Ishiko T, Nakashima Y, Arakawa H, Egami H, Harada S, Matsushima K, and Ogawa M: Interleukin-8 is constitutively and commonly produced by various human carcinoma cell lines. Int J Clin Lab Res 22: 216-219, 1992.
24. Ishiko T, Sakamoto K, Yamashita S, Matsuda Y, Kamohara H, Mita S, and Ogawa M: Carcinoma cells express IL-8 and the IL-8 receptor: their inhibition attenuates the growth of carcinoma cells. Int J Oncol 6: 119-122, 1995.
25. Inada M, Yamashita J, and Ogawa M: Neutrophil elastase inhibitor (ONO-5046 Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice. Res Commun Mol Pathol Pharmacol 97: 229-232, 1997.
26. Kamohara H, Sakamoto K, Mita S, An XY, and Ogawa M: Neutrophil elastase inhibitor (ONO-5046 Na) suppresses the proliferation, motility, and chemoinvasion of a pancreatic carcinoma cell line, Capan-1. Res Commun Mol Pathol Pharmacol, in press.