Phenylpyrazolo[1,5-a]quinazolin-5(4 H)-one: A suitable scaffold for the development of noncamptothecin topoisomerase i (Top1) inhibitors

Journal of Medicinal Chemistry

Volumn 56, Issue 18, 2013, Pages 7458-7462

  Taliani, Sabrina ^a   Pugliesi, Isabella ^a   Barresi, Elisabetta ^a   Salerno, Silvia ^a   Marchand, Christophe ^c   Agama, Keli ^c   Simorini, Francesca ^a   La Motta, Concettina ^a   Marini, Anna Maria ^a   Di Leva, Francesco Saverio ^d   Marinelli, Luciana ^f   Cosconati, Sandro ^e   Novellino, Ettore ^f   Pommier, Yves ^c   Di Santo, Roberto ^b   Da Settimo, Federico ^a  

^a UNIVERSITY OF PISA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^e SECOND UNIVERSITY OF NAPLES   (Italy)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE INHIBITOR; QUINAZOLINE DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; DNA CLEAVAGE; DRUG DEVELOPMENT; PRECURSOR;

DNA TOPOISOMERASES, TYPE I; DRUG DISCOVERY; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; PYRROLES; QUINAZOLINES; TOPOISOMERASE I INHIBITORS;

EID: 84884999162     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400932c     Document Type: Article

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