Characterization of a low-level unknown isomeric degradation product using an integrated online-offline top-down tandem mass spectrometry platform

Analytical Chemistry

Volumn 85, Issue 19, 2013, Pages 8964-8967

  Yu, Xiang ^a,b   Warme, Christopher ^a   Lee, Dinah ^a   Zhang, Jing ^a   Zhong, Wendy ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION PRODUCTS; ELECTRON CAPTURE DISSOCIATION; FRACTION COLLECTION; LIMIT OF DETECTION; OFFLINE; STABILITY STUDY; TANDEM MASS SPECTROMETRY; TOPDOWN;

AMINO ACIDS; DEGRADATION; EXPERIMENTS;

MASS SPECTROMETRY;

ISOASPARTIC ACID;

ARTICLE; METHODOLOGY; ONLINE SYSTEM; TANDEM MASS SPECTROMETRY;

ISOASPARTIC ACID; ONLINE SYSTEMS; TANDEM MASS SPECTROMETRY;

EID: 84884997180     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac401911n     Document Type: Article

References (17)

1. Strohl, W. R.; Knight, D. M. Curr. Opin. Biotechnol. 2009, 20, 668-672
2. Manning, M. C.; Chou, D. K.; Murphy, B. M.; Payne, R. W.; Katayama, D. S. Pharm. Res. 2010, 27, 544-575
3. Ding, X. K.; Saxena, N. K.; Lin, S. B.; Gupta, N.; Anania, F. A. Hepatology 2006, 43, 173-181
4. Wakankar, A. A.; Borchardt, R. T. J. Pharm. Sci. 2006, 95, 2321-2336
5. Wakankar, A. A.; Borchardt, R. T.; Eigenbrot, C.; Shia, S.; Wang, Y. J.; Shire, S. J.; Liu, J. L. Biochemistry 2007, 46, 1534-1544
6. Capasso, S.; Kirby, A. J.; Salvadori, S.; Sica, F.; Zagari, A. J. Chem. Soc., Perkin Trans. 2 1995, 437-442
7. Wakankar, A. A.; Borchardt, R. T. J. Pharm. Sci. 2006, 95, 2321-2336
8. Dick, L. W.; Qiu, D. F.; Cheng, K. C. J. Chromatogr. B 2009, 877, 3841-3849
9. Ni, W. Q.; Dai, S. J.; Karger, B. L.; Zhou, Z. H. S. Anal. Chem. 2010, 82, 7485-7491
10. Liu, M.; Cheetham, J.; Cauchon, N.; Ostovic, J.; Ni, W. Q.; Ren, D.; Zhou, Z. S. Anal. Chem. 2012, 84, 1056-1062
11. Li, X. J.; Cournoyer, J. J.; Lin, C.; O'Connor, P. B. J. Am. Soc. Mass Spectrom. 2008, 19, 855-864
12. Cournoyer, J. J.; Pittman, J. L.; Ivleva, V. B.; Fallows, E.; Waskell, L.; Costello, C. E.; O'Connor, P. B. Protein Sci. 2005, 14, 452-463
13. Li, X. J.; Yu, X.; Costello, C. E.; Lin, C.; O'Connor, P. B. Anal. Chem. 2012, 84, 6150-6157
14. Zhong, W. D.; Yang, J.; Yang, X. Rapid Commun. Mass Spectrom. 2011, 25, 3650-3655
15. Kelleher, N. L.; Wenger, C. D.; Boyne, M. T.; Ferguson, J. T.; Robinson, D. E. Anal. Chem. 2008, 80, 8055-8063
16. Tipton, J. D.; Tran, J. C.; Catherman, A. D.; Ahlf, D. R.; Durbin, K. R.; Lee, J. E.; Kellie, J. F.; Kelleher, N. L.; Hendrickson, C. L.; Marshall, A. G. Anal. Chem. 2012, 84, 2111-2117
17. Mazur, M. T.; Seipert, R. S.; Mahon, D.; Zhou, Q. W.; Liu, T. AAPS J. 2012, 14, 530-541