High lung-metastatic variant of human osteosarcoma cells, selected by passage of lung metastasis in nude mice, is associated with increased expression of αvβ3 Integrin

Anticancer Research

Volumn 33, Issue 9, 2013, Pages 3623-3628

  Tome, Yasunori ^a,b,c   Kimura, Hiroaki ^a,d   Maehara, Hiroki ^c   Sugimoto, Naotoshi ^d   Bouvet, Michael ^b   Tsuchiya, Hiroyuki ^d   Kanaya, Fuminori ^c   Hoffman, Robert M ^a,b  

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

v 3 integrin; Green fluorescent protein; Lung metastasis; Nude mice; Osteosarcoma; Overexpression; Passage; Red fluorescent protein; Variants

Indexed keywords

GREEN FLUORESCENT PROTEIN; RED FLUORESCENT PROTEIN; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LUNG METASTASIS; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIBIA;

ΑVΒ3 INTEGRIN; GREEN FLUORESCENT PROTEIN; LUNG METASTASIS; NUDE MICE; OSTEOSARCOMA; OVEREXPRESSION; PASSAGE; RED FLUORESCENT PROTEIN; VARIANTS;

ANIMALS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INTEGRIN ALPHAVBETA3; LUNG NEOPLASMS; MICE; MICE, NUDE; OSTEOSARCOMA;

EID: 84884993355     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Huvos AG: Osteogenic sarcoma. In: Bone Tumors: Diagnosis, Treatment and Prognosis. Second edition. Huvos AG (eds.). Philadelphia: WB Saunders; pp. 85-155, 1991.
2. Unni KK: Osteosarcoma. In: Dahlin's Bone Tumors: General Aspects and Data on 11,087 Cases. Fifth edition. Unni KK and Inwards CY (eds.). New York: Lippincott-Raven, pp. 143-183, 1996.
3. Tsuchiya H, Tomita K, Mori Y, Asada N, Morinaga T, Kitano S and Yamamoto N: Caffeine-assisted chemotherapy and minimized tumor excision for nonmetastatic osteosarcoma. Anticancer Res 18: 657-666, 1998.
4. Bacci G, Picci P, Ferrari S, Ruggieri P, Casadei R, Tienghi A, Brach del Prever A, Gherlinzoni F, Mercuri M and Monti C: Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremities. Results in 164 patients preoperatively treated with high doses of methotrexate followed by cisplatin and doxorubicin. Cancer 72: 3227-3238, 1993.
5. Tsuchiya H, Wan SL, Sakayama K, Yamamoto N, Nishida H and Tomita K: Reconstruction using an autograft containing tumour treated by liquid nitrogen. J Bone Joint Surg Br 87: 218-225, 2005.
6. Torbert TJ, Fox EJ, Hosalkar HS, Ogilvie CM and Lackman RD: Endoprostethic reconstructions: Results of long-term follow-up of 139 patients. Clin Orthop Relat Res 438: 51-59, 2005.
7. Meyers PA, Heller G, Healey JH, Huvos A, Applewhite A, Sun M and LaQuaglia M: Osteogenic sarcoma with clinically detectable metastasis at initial presentation. J Clin Oncol 11: 449-453, 1993.
8. Bacci G, Briccoli A, Mercuri M, Ferrari S, Bertoni F, Gasbarrini A, Fabbri N, Cesari M, Forni C and Campanacci M: Osteosarcoma of the extremities with synchronous lung metastases: long-term results in 44 patients treated with neoadjuvant chemotherapy. J Chemother 10: 69-76, 1998.
9. Kimura H, Tsuchiya H, Shirai T, Nishida H, Hayashi K, Takeuchi A, Ohnari I and Tomita K: Caffeine-potentiated chemotherapy for metastatic osteosarcoma. J Orthop Sci 14: 556-565, 2009.
10. Brooks PC, Clark RA and Cheresh DA: Requirement of vascular integrin αvβ3 for angiogenesis. Science 264: 569-571, 1994.
11. Varner JA, Brooks PC and Cheresh DA: The integrin αvβ3: Angiogenesis and apoptosis. Cell Adhes Commun 3: 367-374, 1995.
12. Eliceiri BP and Cheresh DA: The role of av integrins during angiogenesis: Insights into potential mechanisms of action and clinical development. J Clin Investig 103: 1227-1230, 1999.
13. Felding-Habermann B, Fransvea E, O'Toole TE, Manzuk L, Faha B and Hensler M: Involvement of tumor cell integrin αvβ3 in hematogenous metastasis of human melanoma cells. Clin Exp Metastasis 19: 427-436, 2002.
14. Felding-Habermann B, O'Toole TE, Smith JW, Fransvea E, Ruggeri ZM, Ginsberg MH, Hughes PE, Pampori N, Shattil SJ, Saven A and Mueller BM: Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci USA 98: 1853-1858, 2001.
15. McCabe NP, De S, Vasanji A, Brainard J and Byzova TV: Prostate cancer specific integrin αVβ3 modulates bone metastatic growth and tissue remodeling. Oncogene 26: 6238-6243, 2007.
16. Reinmuth N, Liu W, Ahmad SA, Fan F, Stoeltzing O, Parkikh AA, Bucana CD, Gallick GE, Nickols MA, Westlin WF and Ellis LM: αVβ3 Integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice. Cancer Res 63: 2079-2087, 2003.
17. Platten M, Wick W, Wild-Bode C, Aulwurm S, Dichgans J and Weller M: Transforming growth factors β1 (TGF-β1) and TGF-β2 promote glioma cell migration via up-regulation of αvβ3 integrin expression. Biochem Biophys Res Commun 268: 607-611, 2000.
18. Grzesiak JJ, Tran Cao HS, Burton DW, Kaushal S, Vargas F, Clopton P, Snyder CS, Deftos LJ, Hoffman RM and Bouvet M: Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis. Int J Cancer 129: 2905-2915, 2011.
19. Kimura H, Tome Y, Momiyama M, Hayashi K, Tsuchiya H, Bouvet M and Hoffman RM: Imaging the inhibition by anti-β1 integrin antibody of lung seeding of single osteosarcoma cells in live mice. Int J Cancer 131: 2027-2033, 2012.
20. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR and Hoffman RM: Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent protein expression. Cancer Res 64: 4251-4256, 2004.
21. Jiang P, Yamauchi K, Yang M, Tsuji K, Xu M, Maitra A, Bouvet M and Hoffman RM: Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle 5: 1198-1201, 2006.
22. Hoffman RM and Yang M: Subcellular imaging in the live mouse. Nature Protoc 1: 775-782, 2006.
23. Tome Y, Tsuchiya H, Hayashi K, Yamauchi K, Sugimoto N, Kanaya F, Tomita K and Hoffman RM: In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential. J Cell Biochem 108: 362-367, 2009.
24. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M and Hoffman RM: Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variablemagnification whole-mouse imaging system. Cancer Res 66: 4208-4214, 2006.
25. Bruns CJ, Harbison MT, Kuniyasu H, Eue I and Fidler IJ: In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia 1: 50-62, 1999.