Targeting chromatin readers

Clinical Pharmacology and Therapeutics

Volumn 93, Issue 4, 2013, Pages 312-314

  James, L I ^a   Frye, S V ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE; PIPERIDINE DERIVATIVE; PROTEIN P53; PYRROLIDINE DERIVATIVE; RETINOBLASTOMA BINDING PROTEIN 2; SYNAPSIN I; UNC 669; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CELL ACTIVITY; CELL CYCLE ARREST; CELL DIFFERENTIATION; CHEMICAL MODIFICATION; CHROMATIN; DRUG DESIGN; GENE EXPRESSION; GENE INACTIVATION; HEMATOLOGIC MALIGNANCY; HUMAN GENOME; HYDROGEN BOND; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PROCESSING; REGULATORY MECHANISM; RNA INTERFERENCE; TARGET CELL; TUMOR XENOGRAFT;

CHROMATIN; EPIGENESIS, GENETIC; HUMANS; MOLECULAR TARGETED THERAPY; PROTEIN INTERACTION DOMAINS AND MOTIFS;

EID: 84875434484     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2013.6     Document Type: Article

References (5)

1. Dawson, M.A., Kouzarides, T. & Huntly, B.J. Targeting epigenetic readers in cancer. N. Engl. J. Med. 367, 647-657 (2012).
2. Herold, J.M. et al. Small-molecule ligands of methyl-lysine binding proteins. J. Med. Chem. 54, 2504-2511 (2011).
3. Wang, G.G. et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature 459, 847-851 (2009).
4. Wagner, E.K., Nath, N., Flemming, R., Feltenberger, J.B. & Denu, J.M. Identification and characterization of small molecule inhibitors of a plant homeodomain finger. Biochemistry 51, 8293-8306 (2012).
5. James, L.I. et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. (2013); e-pub ahead of print 6 January 2013.