Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2

Journal of Medicinal Chemistry

Volumn 56, Issue 18, 2013, Pages 7232-7242

  Hendrickx, Ramon ^a   Johansson, Jenny G ^a,b   Lohmann, Christina ^a,c   Jenvert, Rose Marie ^a,d   Blomgren, Anders ^a,e   Börjesson, Lena ^a   Gustavsson, Lena ^a,f  

^a ASTRAZENECA R AND D   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d Dept of EEE   (India)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

^f LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; FENOTEROL; GLYCOPYRRONIUM BROMIDE; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; OXYPHENONIUM BROMIDE; PHENFORMIN; TIOTROPIUM BROMIDE;

ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; DRUG DISPOSITION; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; HYDROGEN BOND; LIPOPHILICITY; PHYSICAL CHEMISTRY; PRINCIPAL COMPONENT ANALYSIS; QUALITY CONTROL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

BIOLOGICAL TRANSPORT; DRUG EVALUATION, PRECLINICAL; HEK293 CELLS; HUMANS; ORGANIC CATION TRANSPORT PROTEINS; ORGANIC CATION TRANSPORTER 1; PHARMACEUTICAL PREPARATIONS; PHYSICOCHEMICAL PROCESSES; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84884992468     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400966v     Document Type: Article

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