Life without TTP: Apparent absence of an important anti-inflammatory protein in birds

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 305, Issue 7, 2013, Pages

  Lai, Wi S ^a   Stumpo, Deborah J ^a   Kennington, Elizabeth A ^a   Burkholder, Adam B ^a   Ward, James M ^a   Fargo, David L ^a   Blackshear, Perry J ^a,b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

AU rich elements; Innate immunity; mRNA turnover; Tristetraprolin; Zinc finger proteins

Indexed keywords

MESSENGER RNA; TRISTETRAPROLIN;

ALLIGATOR; ANIMAL EXPERIMENT; ARTICLE; BIRD; CHICKEN; EMBRYO; FIBROBLAST; GENE EXPRESSION; GENOMICS; KINETICS; LIZARD; MACROPHAGE; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA SEQUENCE;

AU-RICH ELEMENTS; INNATE IMMUNITY; MRNA TURNOVER; TRISTETRAPROLIN; ZINC FINGER PROTEINS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; AVIAN PROTEINS; BASE SEQUENCE; CATTLE; CELL LINE; CHICKENS; DATABASES, GENETIC; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNITY, INNATE; INFLAMMATION; KINETICS; LIPOPOLYSACCHARIDES; MICE; MOLECULAR SEQUENCE DATA; PHYLOGENY; REPTILES; REPTILIAN PROTEINS; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TIME FACTORS; TRANSFECTION; TRISTETRAPROLIN;

EID: 84884969302     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00310.2013     Document Type: Article

References (32)

1. Abramyan J, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hillier LH, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning J, Li Y, Literman R, Mardis ER, McGaugh SE, Minx P, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Shaffer B, Shedlock AM, Spinks PQ, Storey KB, Thane N, Thomson RC, Valenzuela N, Vinar T, Warren DE, Warren WC, Wilson RK, Zimmerman LM, Hernandez O, Amemiya CT. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol 14: R28, 2013.
2. Alfoldi J, Di Palma F, Grabherr M, Williams C, Kong L, Mauceli E, Russell P, Lowe CB, Glor RE, Jaffe JD, Ray DA, Boissinot S, Shedlock AM, Botka C, Castoe TA, Colbourne JK, Fujita MK, Moreno RG, ten Hallers BF, Haussler D, Heger A, Heiman D, Janes DE, Johnson J, de Jong PJ, Koriabine MY, Lara M, Novick PA, Organ CL, Peach SE, Poe S, Pollock DD, de Queiroz K, Sanger T, Searle S, Smith JD, Smith Z, Swofford R, Turner-Maier J, Wade J, Young S, Zadissa A, Edwards SV, Glenn TC, Schneider CJ, Losos JB, Lander ES, Breen M, Ponting CP, Lindblad-Toh K. The genome of the green anole lizard and a comparative analysis with birds and mammals. Nature 477: 587-591, 2011.
3. Beug H, von Kirchbach A, Doderlein G, Conscience JF, Graf T. Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation. Cell 18: 375-390, 1979.
4. Beutler B, Moresco EM. The forward genetic dissection of afferent innate immunity. Curr Top Microbiol Immunol 321: 3-26, 2008.
5. Blackshear PJ, Lai WS, Kennington EA, Brewer G, Wilson GM, Guan X, Zhou P. Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates. J Biol Chem 278: 19947-19955, 2003.
6. Blackshear PJ, Phillips RS, Ghosh S, Ramos SB, Richfield EK, Lai WS. Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. Biol Reprod 73: 297-307, 2005.
7. Brooks SA, Blackshear PJ. Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochim Biophys Acta 1829: 666-679, 2013.
8. Cao H, Tuttle JS, Blackshear PJ. Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein. J Biol Chem 279: 21489-21499, 2004.
9. Carballo E, Blackshear PJ. Roles of tumor necrosis factor-α receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood 98: 2389-2395, 2001.
10. Carballo E, Cao H, Lai WS, Kennington EA, Campbell D, Blackshear PJ. Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway. J Biol Chem 276: 42580-42587, 2001.
11. Carballo E, Gilkeson GS, Blackshear PJ. Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNF-κ overproduction. J Clin Invest 100: 986-995, 1997.
12. Carballo E, Lai WS, Blackshear PJ. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood 95: 1891-1899, 2000.
13. Carballo E, Lai WS, Blackshear PJ. Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin. Science 281: 1001-1005, 1998.
14. Fabian MR, Frank F, Rouya C, Siddiqui N, Lai WS, Karetnikov A, Blackshear PJ, Nagar B, Sonenberg N. Structural basis for the recruitment of the CCR4-NOT complex by tristetraprolin. Nat Struct Mol Biol 20: 735-739, 2013.
15. Frederick ED, Ramos SB, Blackshear PJ. A unique C-terminal repeat domain maintains the cytosolic localization of the placenta-specific tristetraprolin family member ZFP36L3. J Biol Chem 283: 14792-14800, 2008.
16. Horner TJ, Lai WS, Stumpo DJ, Blackshear PJ. Stimulation of pololike kinase 3 mRNA decay by tristetraprolin. Mol Cell Biol 29: 1999-2010, 2009.
17. Kaiser P. Advances in avian immunology-prospects for disease control: a review. Avian Pathol 39: 309-324, 2010.
18. Kaiser P, Poh TY, Rothwell L, Avery S, Balu S, Pathania US, Hughes S, Goodchild M, Morrell S, Watson M, Bumstead N, Kaufman J, Young JR. A genomic analysis of chicken cytokines and chemokines. J Interferon Cytokine Res 25: 467-484, 2005.
19. Kratochvill F, Machacek C, Vogl C, Ebner F, Sedlyarov V, Gruber AR, Hartweger H, Vielnascher R, Karaghiosoff M, Rulicke T, Muller M, Hofacker I, Lang R, Kovarik P. Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation. Mol Syst Biol 7: 560, 2011.
20. Lai WS, Parker JS, Grissom SF, Stumpo DJ, Blackshear PJ. Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts. Mol Cell Biol 26: 9196-9208, 2006.
21. Lai WS, Stumpo DJ, Blackshear PJ. Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. J Biol Chem 265: 16556-16563, 1990.
22. Lai WS, Thompson MJ, Taylor GA, Liu Y, Blackshear PJ. Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. J Biol Chem 270: 25266-25272, 1995.
23. Lyall J, Irvine RM, Sherman A, McKinley TJ, Nunez A, Purdie A, Outtrim L, Brown IH, Rolleston-Smith G, Sang H, Tiley L. Suppression of avian influenza transmission in genetically modified chickens. Science 331: 223-226, 2011.
24. Mozdziak PE, Petitte JN. Status of transgenic chicken models for developmental biology. Dev Dyn 229: 414-421, 2004.
25. Qian X, Ning H, Zhang J, Hoft DF, Stumpo DJ, Blackshear PJ, Liu J. Posttranscriptional regulation of IL-23 expression by IFN-γ through tristetraprolin. J Immunol 186: 6454-6464, 2011.
26. Qiu LQ, Stumpo DJ, Blackshear PJ. Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype. J Immunol 188: 5150-5159, 2012.
27. Smith J, Paton IR, Bruley CK, Windsor D, Burke D, Ponce de Leon FA, Burt DW. Integration of the genetic and physical maps of the chicken macrochromosomes. Anim Genet 31: 20-27, 2000.
28. Smith J, Paton IR, Murray F, Crooijmans RP, Groenen MA, Burt DW. Comparative mapping of human chromosome 19 with the chicken shows conserved synteny and gives an insight into chromosomal evolution. Mamm Genome 13: 310-315, 2002.
29. Stoecklin G, Tenenbaum SA, Mayo T, Chittur SV, George AD, Baroni TE, Blackshear PJ, Anderson P. Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem 283: 11689-11699, 2008.
30. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28: 2731-2739, 2011.
31. Taylor GA, Carballo E, Lee DM, Lai WS, Thompson MJ, Patel DD, Schenkman DI, Gilkeson GS, Broxmeyer HE, Haynes BF, Blackshear PJ. A pathogenetic role for TNF-κ in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 4: 445-454, 1996.
32. Wu Z, Kaiser P. Antigen presenting cells in a non-mammalian model system, the chicken. Immunobiology 216: 1177-1183, 2011.