Serum levels of soluble TNF-α receptors but not BDNF are associated with apathy symptoms in mild Alzheimer's disease and amnestic mild cognitive impairment;Níveis séricos de receptores solúveis do TNF-α mas não de BDNF estão asociados a sintomas de apat ia na doença de Alzheimer leve e no comprometimento cognitivo leve amnéstico

Dementia e Neuropsychologia

Volumn 7, Issue 3, 2013, Pages 298-303

  Guimarães, Henrique Cerqueira ^a   Caramelli, Paulo ^a   Araujo Fialho, Patricia Paes ^a   de Paula França, Elisa ^a   Dias Afonso, Marcelo Pelizzaro ^a   Teixeira, Antonio Lucio ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Alzheimer's disease; Apathy; BDNF; Dementia; Mild cognitive impairment; sTNFR1; sTNFR2; TNF

Indexed keywords

EID: 84884967600     PISSN: 19805764     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1980-57642013dn70300011     Document Type: Article

References (33)

1. van Reekun R, Stuss DT, Ostrander L. Apathy: why care? J Neuropsychiatry Clin Neursoci 2005; 17:7-19.
2. Guimaraes HC, Levy R, Teixeira AL, Beato RG, Caramelli P. Neurobiology of apathy in Alzheimer's disease. Arq Neuropsiquiatr 2008; 66: 436-443.
3. Robert P, Onyike CU, Leentjens AF, et al. Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders. Eur Psychiatry 2009; 24:98-104.
4. Craig D, Mirakhur A, Hart DJ, McIlroy SP, Passmore AP. A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's disease. Am J Geriatr Psychiatry 2005; 13:460-468.
5. Starkstein SE, Petraca G, Chemerinski E, Kremer J. Syndromic validity of apathy in Alzheimer's disease. Am J Psychiatry 2001; 158:872-877.
6. Starkstein SE, Jorge R, Mizrahi R, et al. A prospective longitudinal study of apathy in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2006; 77:8-11.
7. Robert PH, Berr C, Volteau M, et al. Neuropsychological performance in mild cognitive impairment with and without apathy. Dement Geriatr Cogn Disord 2006; 21:192-197.
8. Geda YE, Roberts RO, Knopman DS, et al. Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: a population-based study. Arch Gen Psychiatr 2008; 65:1193-1198.
9. Robert PH, Berr C, Volteau M, et al. Apathy in patients with mild cognitive impairment and the risk of developing dementia of Alzheimer's disease: a one-year follow-up study. Clin Neurol Neurosurg 2006; 108:733-736.
10. Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci 1991; 3:243-254.
11. Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci 2001; 933:22-34.
12. Palin K, Bluthe RM, McCusker RH, et al. The type 1 TNF receptor and its associated adapter, FAN, are required to TNF-iiinduced sickness behavior. Psychopharmcaology 2009; 201:549-56.
13. Bermejo P, Martín-Aragón S, Benedí J, et al. Differences in peripheral inflammatory markers between mild cognitive impairment and Alzheimer's disease. Immunol Lett 2008; 117:198-202.
14. Amor S, Puentes F, Baker D, van der Valk P. Inflammation in neurodegenerative diseases. Immunology 2010; 129:154-169.
15. Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ 2003; 10:46-65.
16. Diniz BS, Teixeira AL, Talib LL, Mendonça VA, Gattaz WF, Forlenza OV. Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression. World J Biol Psychiatry 2010; 11:550-555.
17. Hubbard RE, O'Mahony MS, Sawa GM, Calver BL, Woodhouse KW. Inflammation and frailty measures in older people. J Cell Mol Med 2009; 13:3103-3109.
18. Coelho FM, Narciso FM, Oliveira DM, et al. sTNFR-1 is an early inflammatory marker in community versus institutionalized elderly women. Inflamm Res 2010; 59:129-134.
19. Caramelli P, Barbosa MT, Sakurai E, et al. The Pietà Study: epidemiological investigation in successful brain aging in Caeté(MG), Brazil. Methods and baseline cohort characteristics. Arq Neuropsiquatr 2011; 69:579-584.
20. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical Diagnosis of Alzheimer's disease: report of the NINCDSADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 1984; 34: 939-944.
21. Reisberg B. Functional assessment staging (FAST). Psychopharmacol Bull 1988; 24:653-659.
22. Roman GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993; 43:250-260.
23. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256:183-194.
24. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM). 4th ed. Washington, DC: American Psychiatric Association, 1994.
25. Starkstein SE, Mayberg HS, Preziosi TJ, Andrezejewski P, Leiguarda R, Robinson RG. Reliability, validity and clinical correlate of apathy in Parkinsons's disease. J Neuropsychiatry Cli Neurosci 1992; 4; 134-139
26. Funkiewiez A, Bertoux M, de Souza LC, Levy R, Dubois B. The SEA (Social Cognition and Emotional Assessment): A clinical neuropsychological tool for early diagnosis of frontal variant frontotemporal lobar degeneration. Neuropsychology 2012; 26:81-90.
27. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessments of psychopathology in dementia. Neurology 1994; 44: 2308-2313.
28. Hall JR, Vo HT, Johnson LA, Winter S, Barber RC, O'Bryant SE. Biomarkers and depressive symptoms in a sample of cognitively intact and Alzheimer's disease elderly males. Neuroscience Med 2011; 2:306-312.
29. Maas DW, van der Mast RC, de Craen AJ. Increased C-reactive protein is not associated with apathy: the Leiden 85-Plus Study. Int J Geriatr Psychiatry 2009; 24:1177-1184.
30. Chaudhry IB, Hallak J, Husain N, et al. Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebocontrolled clinical trial in patients on standard treatment. J Psychopharmacol 2012; 26:1185-93.
31. Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello AC. Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology. J Neuroinflammation 2012; 9:62.
32. Boyle PA, Malloy PF, Salloway S, Cahn-Weiner DA, Cohen R, Cummings JL. Executive dysfunction and apathy predict functional impairment in Alzheimer disease. Am J Geriatr Psychiatry. 2003; 11:214-221.
33. Petersen RC, Aisen P, Boeve BF, et al. Criteria for mild cognitive impairment due to alzheimer's disease in the community. Ann Neurol. 2013 [Epub ahead of print].