Increased C-reactive protein is not associated with apathy: The Leiden 85-Plus Study

International Journal of Geriatric Psychiatry

Volumn 24, Issue 11, 2009, Pages 1177-1184

  Maas, D W ^a   Van Der Mast, R C ^a   De Craen, A J M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apathy; C reactive protein; Depression; Elderly; General population; Immune activation; Longitudinal design

Indexed keywords

C REACTIVE PROTEIN;

AGED; APATHY; ARTICLE; DEPRESSION; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GERIATRIC DEPRESSION SCALE; HUMAN; INFLAMMATION; MALE; MINI MENTAL STATE EXAMINATION; RETROSPECTIVE STUDY;

AGED, 80 AND OVER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; DEPRESSIVE DISORDER; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNITY, CELLULAR; MALE; MOOD DISORDERS; PROSPECTIVE STUDIES;

EID: 70350741349     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2242     Document Type: Article

References (33)

1. Almeida OP, Norman P, Hankey GJ, Jamrozik K, Flicker L. 2007. The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the Health in Men Study (HIMS). Psychol Med 37: 1775-1786. (Pubitemid 350100438)
2. Beekman AT, Copeland JR, Prince MJ. 1999. Review of community prevalence of depression in later life. Br J Psychiatry 174: 307-311.
3. Beekman AT, Geerlings SW, Deeg DJ, et al. 2002. The natural history of late-life depression: a 6-year prospective study in the community. Arch Gen Psychiatry 59: 605-611. (Pubitemid 34747240)
4. Bootsma-Van der Wiel A, van Exel E, de Craen AJ, et al. 2002. A high response is not essential to prevent selection bias: results from the Leiden 85-plus Study. J Clin Epidemiol 55: 1119-1125.
5. Bremmer MA, Beekman AT, Deeg DJ, et al. 2008. Inflammatory markers in late-life depression: results from a population-based study. J Affect Disord 106: 249-255.
6. Craddock D, Thomas A. 2006. Cytokines and late-life depression. Essent Psychopharmacol 7: 42-52.
7. de Craen AJ, Heeren TJ, Gussekloo J. 2003. Accuracy of the 15-item Geriatric Depression Scale (GDS-15) in a community sample of the oldest old. Int J Geriatr Psychiatry 18: 63-66. (Pubitemid 36131228)
8. Duffy J. 2000. Apathy in neurologic disorders. Curr Psychiatry Rep 2: 434-439.
9. Folstein MF, Folstein SE, McHugh PR. 1975. 'Mini Mental State': a practical method for grading the cognitive state of patients for the clinician. J Psychiatry Res 12: 189-198.
10. Fones CS. 1998. Distinguishing apathy syndromes from vascular depression. Arch Gen Psychiatry 55: 844-845.
11. Gueorguieva R, Krystal JH. 2004. More over ANOVA: progress in analysing repeated-measures data and its reflection in papers published in the archives of general psychiatry. Arch Gen Psychiatry 61: 310-317. (Pubitemid 38295833)
12. Heun R, Kockler M, Papassotiropoulos A. 2000. Distinction of early- and late-onset depression in the elderly by their lifetime symptomatology. Int J Geriatr Psychiatry 15: 1138-1142. (Pubitemid 32093991)
13. Jongenelis K, Pot AM, Eisses AM, et al. 2004. Prevalence and risk indicators of depression in elderly nursing home patients: the AGED study. J Affect Disord 83: 135-142. (Pubitemid 39536187)
14. Kop WJ, Gottdiener JS, Tangen CM. 2002. Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol 89: 419-424.
15. Kuo HK, Yen CJ, Chang CH, et al. 2005. Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis. Lancet Neurol 4: 371-380.
16. Lagaay AM, van der Meij JC, Hijmans W. 1992. Validation of medical history taking as part of a population based survey in subjects aged 85 and over. BMJ 304: 1091-1092.
17. Landes AM, Sperry SD, Strauss ME. 2005. Prevalence of apathy, dysphoria, and depression in relation to dementia severity in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 17: 342-349.
18. Lavretsky H, Ballmaier M, Pham D, Toga A, Kumar A. 2007. Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study. Am J Geriatr Psychiatry 15: 386-394.
19. Levy ML, Cummings JL, Fairbanks LA, et al. 1998. Apathy is not depression. J Neuropsychiatry Clin Neurosci 10: 314-319.
20. Marin RS. 1990. Differential diagnosis and classification of apathy. Am J Psychiatry 147: 22-30.
21. Marin RS. 1991. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci 3: 243-254.
22. Marin RS, Firinciogullari S, Biedrzycki RC. 1993. The sources of convergence between measures of apathy and depression. J Affect Disord 28: 117-124. (Pubitemid 23178099)
23. Pearson TA, Mensah GA, Alexander RW, et al. 2003. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107: 499-511.
24. Penninx BW, Kritchevsky SB, Yaffe K, et al. 2003. Inflammatory markers and depressed mood in older persons: results from the health, aging and body composition study. Biol Psychiatry 54: 566-572. (Pubitemid 37289443)
25. Starkstein SE, Leentjens AFG. 2008. The nosological position of apathy in clinical practice. J Neurol Neurosurg Psychiatry. DOI: 10.1136/jnnp. 2007.136895
26. Stek ML,Van Exel E, Van TilburgW,Westendorp RG, Beekman AT. 2002. The prognosis of depression in old age: outcome six to eight years after clinical treatment. Aging Ment Health 6: 282-285.
27. Tiemeier H, Hofman A, van Tuijl HR, et al. 2003. Inflammatory proteins and depression in the elderly. Epidemiology 14: 103-107.
28. van den Biggelaar AH, Gussekloo J, de Craen AJ, et al. 2007. Inflammation and interleukin-1 signalling network contribute to depressive symptoms but not cognitive decline in old age. Exp Gerontol 42: 693-701. (Pubitemid 46756098)
29. van der Mast RC, Vinkers DJ, Stek ML, et al. 2008. Vascular disease and apathy in old age. The Leiden 85-plus Study. Int J Geriatr Psychiatry 23: 266-271.
30. van Reekum R, Stuss DT, Ostrander L. 2005. Apathy: why care? J Neuropsychiatry Clin Neurosci 17: 7-19.
31. Vinkers DJ, Gussekloo J, Stek ML, Westendorp RG, Van Der Mast RC. 2004. The 15-item Geriatric Depression Scale (GDS-15) detects changes in depressive symptoms after a major negative life event. The Leiden 85-plus study. Int J Geriatr Psychiatry 19: 80-84. (Pubitemid 38180696)
32. Vinkers DJ, Stek ML, van der Mast RC, et al. 2005. Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age. Neurology 65: 107-112. (Pubitemid 40967784)
33. Yesavage JA, Brink TL, Rose TL, et al. 1982-1983. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiat Res 17: 37-49.