Preservation of cardiomyocytes from the adult heart

Journal of Molecular and Cellular Cardiology

Volumn 64, Issue , 2013, Pages 108-119

  Abi Gerges, Najah ^a   Pointon, Amy ^a   Pullen, Georgia F ^a   Morton, Michael J ^a   Oldman, Karen L ^a   Armstrong, Duncan ^a   Valentin, Jean Pierre ^a   Pollard, Christopher E ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Adult cardiomyocyte; Long term exposure; Myosin II ATPase; Novel drugs; Preservation

Indexed keywords

BLEBBISTATIN; DASATINIB; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN II ADENOSINE TRIPHOSPHATASE; N BENZYL 4 TOLUENESULFONAMIDE; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; TOLUENESULFONAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ARTICLE; CALCIUM TRANSPORT; CARDIOTOXICITY; CELL DEATH; CELL DIFFERENTIATION; CELL ISOLATION; CELL PRESERVATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; GENE EXPRESSION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; LONG TERM EXPOSURE; PRESERVATION; PRIORITY JOURNAL; TEMPERATURE; VOLTAGE CLAMP;

2,3-BUTANEDIONE MONOXIME; ACTION POTENTIAL DURATION AT 90% REPOLARIZATION; ADULT CARDIOMYOCYTE; APD90; BDM; BTS; C-E CURVE; CALCIUM CHANNEL PRODUCED FROM THE CACNA1C GENE; CARDIAC TROPONIN I; CAV1.2; CONCENTRATION-EFFECT CURVE; CONNEXIN-43; CTNI; CX43; FDACM; FULLY DIFFERENTIATED ADULT CARDIOMYOCYTE; HERG; HIPSC-CMS; HUMAN ETHER-A-GO-GO RELATED GENE (K(V)11.1); HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES; IC(50); LONG-TERM EXPOSURE; MHC; MOLAR CONCENTRATION PRODUCING 50% INHIBITION; MYOSIN HEAVY CHAIN; MYOSIN II ATPASE; N-BENZYL-P-TOLUENE SULPHONAMIDE; NOVEL DRUGS; PRESERVATION; ROOM TEMPERATURE; RT; SARC. SHORT; SARCOMERE SHORTENING; SARCOPLASMIC RETICULUM; SR; TKI; TYROSINE KINASE INHIBITOR;

ACTION POTENTIALS; ANIMALS; CELL DIFFERENTIATION; CELL SURVIVAL; CLUSTER ANALYSIS; DOGS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MYOCYTES, CARDIAC; MYOSIN TYPE II; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SULFONAMIDES; TOLUENE;

EID: 84884953448     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.09.004     Document Type: Article

References (42)

1. Powell T., Twist V.W. A rapid technique for the isolation and purification of adult cardiac muscle cells having respiratory control and a tolerance to calcium. Biochem Biophys Res Commun 1976, 72:327-333.
2. Thum T., Borlak J. Isolation and cultivation of Ca2+ tolerant cardiomyocytes from the adult rat: improvements and applications. Xenobiotica 2000, 30(11):1063-1077.
3. Mitcheson J.S., Hancox J.C., Levi A.J. Cultured adult cardiac myocytes: future implications, culture methods, morphological and electrophysiological properties. Cardiovasc Res 1998, 39(2):280-300.
4. Pollard T., Earnshaw W. Cell biology 2008, W.B. Saunders Co./Elsevier, Philadelphia. 2nd ed.
5. Cooper G.M. Actin, myosin, and cell movement. The Cell: a molecular approach 2000, Sinauer Associates, Inc., Sunderland (MA). 2nd ed.
6. Uchida T., Nagayama M., Taira T., Shimizu K., Sakai M., Gohara K. Optimal temperature range for low-temperature preservation of dissociated neonatal rat cardiomyocytes. Cryobiology 2011, 63(3):279-284.
7. Bussek A., Schmidt M., Bauriedl J., Ravens U., Wettwer E., Lohmann H. Cardiac tissue slices with prolonged survival for in vitro drug safety screening. J Pharmacol Toxicol Methods 2012, 66(2):145-151.
8. Maeda M., Kasahara N., Doi J., Lijima Y., Kikuchi T., Teratani T., et al. A luminance-based heart chip assay for assessing the efficacy of graft preservation solutions in heart transplantation in rats. Heart Asia 2013, 0:7-14.
9. Calaghan S.C., White E., Bedut S., Le Guennec J.Y. Cytochalasin D reduces Ca2+ sensitivity and maximum tension via interactions with myofilaments in skinned rat cardiac myocytes. J Physiol 2000, 529(Pt2):405-411.
10. Takasago T., Goto Y., Kawaguchi O., Hata K., Saeki A., Taylor T.W., et al. 2,3-Butanedione monoxime suppresses excitation-contraction coupling in the canine blood-perfused left ventricles. Jpn J Physiol 1997, 47(2):205-215.
11. Fedorov V.V., Lozinsky I.T., Sosunov E.A., Anyukhovsky E.P., Rosen M.R., Balke C.W., et al. Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts. Heart Rhythm 2007, 4(5):619-626.
12. Dou Y., Arlock P., Arner A. Blebbistatin specifically inhibits actin-myosin interaction in mouse cardiac muscle. Am J Physiol Cell Physiol 2007, 293:C1148-C1153.
13. Farman G.P., tachampa K., Mateja R., Cazorla O., Lacampagne A., de Tombe P.P. Blebbistatin: use as inhibitor of muscle contraction. Pflugers Arch 2008, 455:995-1005.
14. Tian Q., Pahlavan S., Oleinikow K., Jung J., Ruppenthal S., Scholz A., et al. Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement. J Mol Cell Cardiol 2012, 52(1):113-124.
15. Borlak J., Zwaldo C. The myosin ATPase inhibitor 2,3-butanedione monoxime dictates transcriptional activation of ion channels and Ca(2+)-handling problems. Mol Pharmacol 2004, 66(3):708-717.
16. Kabaeva Z., Zhao M., Michele D.E. Blebbistatin extends culture life of adult cardiac myocytes and allows efficient and stable transgene expression. Am J Physiol Heart Circ Physiol 2008, 294(4):H1667-H1674.
17. Johnson D.M., Hussein L., Spatjens R.L., Valebntin J.P., Volders P.G., Abi-Gerges N. Measurement of action potential generation in isolated canine left ventricular midmyocardial myocytes. Curr protoc Pharmacol 2011, 1-23. [10:10.14].
18. Harmer A.R., Abi-Gerges N., Morton M.J., Pullen G.F., Valentin J.P., Pollard C.E. Validation of an in vitro contractility assay using canine ventricular myocytes. Toxicol Appl Pharmacol 2012, 260(2):162-172.
19. Cheung A., Dantzig J.A., Hollingworth S., Baylor S.M., Goldman Y.E., Mitchison T.J., et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol 2002, 4(1):83-88.
20. Fedorov V.V., Lozinsky I.T., Sosunov E.A., Anyukhovsky E.P., Rosen M.R., Balke C.W., et al. Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts. Heart Rhythm 2007, 4(5):619-626.
21. Force T., Kerkelä R. Cardiotoxicity of the new cancer therapeutics-mechanisms of, and approaches to, the problem. Drug Discov Today 2008, 13(17-18):778-784.
22. Stapleton M.T., Fuchsbauer C.M., Allshire A.P. BDM drives protein dephosphorylation and inhibits adenine nucleotide exchange in cardiomyocytes. Am J Physiol 1998, 275(4Pt2):H1260-H1266.
23. Kabaeva Z., Zhao M., Michele D.E. Blebbistatin extends culture life of adult cardiac myocytes and allows efficient and stable transgene expression. Am J Physiol Heart Circ Physiol 2008, 294(4):H1667-H1674.
24. Allingham J.S., Smith R., Rayment I. The structural basis of blebbistatin inhibition and specificity for myosin II. Nat Struct Mol Biol 2005, 12(4):378-379.
25. Higashi H., Takenaka K., Fukuzawa K., Yoshida Y., Sugimachi K. Restoration of ATP contents in the transplanted liver closely relates to graft viability in dogs. Eur Surg Res 1989, 21920:76-82.
26. Sakamoto T., Limouze L., Combs C.A., Straight A.F., Sellers J.R. Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. Biochemistry 2005, 44(2):584-588.
27. Kolega J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem Biophys Res Commun 2004, 320(3):1020-1025.
28. Limouze J., Straight A.F., Mitchison T., Sellers J.R. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil 2004, 25(4-5):337-341.
29. Higuchi H., Takemori S. Butanedione monoxime suppresses contraction and ATPase activity of rabbit skeletal muscle. J Biochem 1989, 105(4):638-643.
30. Johnston I.A., Sidell B.D. Differences in temperature dependence of muscle contractile properties and myofibrillar ATPase activity in a cold-temperate fish. J Exp Biol 1984, 111:179-189.
31. Hardy M.E., Pollard C.E., Small B.G., Bridgland-Taylor M., Woods A.J., Valentin J.P., et al. Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes. J Pharmacol Toxicol Methods 2009, 60(1):94-106.
32. Kaumann A.J. Temporal relationship between long-lasting aftercontractions and action potentials in cat papillary muscles. Science 1968, 161:293-295.
33. Tande P.M., Bjørnstad H., Yang T., Refsum H. Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel Ik blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium. J Cardiovasc Pharmacol 1990, 16(3):401-410.
34. Wettwer E., Scholtysik G., Schaad A., Himmel H., Ravens U. Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters. J Cardiovasc Pharmacol 1991, 17(3):480-487.
35. Force T., Krause D.S., Van Etten R.A. Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Nat Rev Cancer 2007, 7(5):332-344.
36. Will Y., Dykens J.A., Nadanaciva S., Hirakawa B., Jamieson J., Marroquin L.D., et al. Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells. Toxicol Sci 2008, 106(1):153-161.
37. Hasinoff B.B. The cardiotoxicity and Myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity. Toxicol Appl Pharmacol 2010, 249(2):132-139.
38. Cohen J.D., Babiarz J.E., Abrams L.M., Guo L., Kameoka S., Chiao E., et al. Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations. Toxicol Appl Pharmacol 2011, 257:74-83.
39. Boucek M.M., Mashburn C., Dunn S.M., Frizell R., Edwards L., Pietra B., et al. Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med 2008, 359(7):709-714.
40. Nakatani T. Heart transplantation. Circ J 2009, 73(Suppl. A):A55-A60.
41. Thatte H.S., Rousou L., Hussaini B.E., Lu X.G., Treanor P.R., Khuri S.F. Development and evaluation of a novel solution, Somah, for the procurement and preservation of beating and nonbeating donor hearts for transplantation. Circulation 2009, 120:1704-1713.
42. Banyasz T., Lozinskiy I., Payne C.E., Edelmann S., Norton B., Chen B., et al. Transformation of adult rat cardiac myocytes in primary culture. Exp Physiol 2008, 93(3):370-382.