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Volumn 73, Issue 15, 2013, Pages 1699-1709

Testosterone boosts for treatment of castration resistant prostate cancer: An experimental implementation of intermittent androgen deprivation

Author keywords

androgen receptor; castration resistant prostate cancer (CRPC); intermittent androgen deprivation (IAD); resistance mechanisms; therapy resistance

Indexed keywords

ANDROGEN RECEPTOR; BROXURIDINE; TESTOSTERONE;

EID: 84884905467     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.22711     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 33847638137 scopus 로고    scopus 로고
    • Estimates of the cancer incidence and mortality in Europe in 2006
    • Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P,. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007; 18 (3): 581-592.
    • (2007) Ann Oncol , vol.18 , Issue.3 , pp. 581-592
    • Ferlay, J.1    Autier, P.2    Boniol, M.3    Heanue, M.4    Colombet, M.5    Boyle, P.6
  • 3
    • 77952554163 scopus 로고    scopus 로고
    • Partners in crime: Deregulation of AR activity and androgen synthesis in prostate cancer
    • Knudsen KE, Penning TM,. Partners in crime: Deregulation of AR activity and androgen synthesis in prostate cancer. Trends Endocrinol Metab 2010; 21 (5): 315-324.
    • (2010) Trends Endocrinol Metab , vol.21 , Issue.5 , pp. 315-324
    • Knudsen, K.E.1    Penning, T.M.2
  • 4
    • 84857034381 scopus 로고    scopus 로고
    • Prostate cancer in 2011: Redefining the therapeutic landscape for CRPC
    • Pezaro C, Attard G,. Prostate cancer in 2011: Redefining the therapeutic landscape for CRPC. Nat Rev Urol 2012; 9 (2): 63-64.
    • (2012) Nat Rev Urol , vol.9 , Issue.2 , pp. 63-64
    • Pezaro, C.1    Attard, G.2
  • 5
    • 79951825699 scopus 로고    scopus 로고
    • Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity
    • Sadar MD,. Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activity. Cancer Res 2011; 71 (4): 1208-1213.
    • (2011) Cancer Res , vol.71 , Issue.4 , pp. 1208-1213
    • Sadar, M.D.1
  • 6
    • 84864017026 scopus 로고    scopus 로고
    • Androgen receptor (AR) aberrations in castration-resistant prostate cancer
    • Waltering KK, Urbanucci A, Visakorpi T,. Androgen receptor (AR) aberrations in castration-resistant prostate cancer. Mol Cell Endocrinol 2012; 360 (1-2): 38-43.
    • (2012) Mol Cell Endocrinol , vol.360 , Issue.12 , pp. 38-43
    • Waltering, K.K.1    Urbanucci, A.2    Visakorpi, T.3
  • 7
    • 84868571745 scopus 로고    scopus 로고
    • Does primary androgen-deprivation therapy delay the receipt of secondary cancer therapy for localized prostate cancer
    • Lu-Yao GL, Albertsen PC, Li H, Moore DF, Shih W, Lin Y, DiPaola RS, Yao SL,. Does primary androgen-deprivation therapy delay the receipt of secondary cancer therapy for localized prostate cancer ? Eur Urol 2012; 62 (6): 966-972.
    • (2012) Eur Urol , vol.62 , Issue.6 , pp. 966-972
    • Lu-Yao, G.L.1    Albertsen, P.C.2    Li, H.3    Moore, D.F.4    Shih, W.5    Lin, Y.6    Dipaola, R.S.7    Yao, S.L.8
  • 9
    • 84870403088 scopus 로고    scopus 로고
    • Urological cancer. The benefits of intermittent androgen-deprivation therapy
    • Mitin T, Efstathiou JA, Shipley WU,. Urological cancer. The benefits of intermittent androgen-deprivation therapy. Nat Rev Clin Oncol 2012; 9 (12): 672-673.
    • (2012) Nat Rev Clin Oncol , vol.9 , Issue.12 , pp. 672-673
    • Mitin, T.1    Efstathiou, J.A.2    Shipley, W.U.3
  • 10
    • 84870507809 scopus 로고    scopus 로고
    • Advanced prostate cancer treated with intermittent or continuous androgen deprivation in the randomised finnprostate study VII: Quality of life and adverse effects
    • Salonen AJ, Taari K, Ala-Opas M, Viitanen J, Lundstedt S, Tammela TL,. Advanced prostate cancer treated with intermittent or continuous androgen deprivation in the randomised finnprostate study VII: Quality of life and adverse effects. Eur Urol 2013; 63 (1): 111-120.
    • (2013) Eur Urol , vol.63 , Issue.1 , pp. 111-120
    • Salonen, A.J.1    Taari, K.2    Ala-Opas, M.3    Viitanen, J.4    Lundstedt, S.5    Tammela, T.L.6
  • 11
    • 70449523110 scopus 로고    scopus 로고
    • Potential benefits of intermittent androgen suppression therapy in the treatment of prostate cancer: A systematic review of the literature
    • Abrahamsson PA,. Potential benefits of intermittent androgen suppression therapy in the treatment of prostate cancer: A systematic review of the literature. Eur Urol 2010; 57 (1): 49-59.
    • (2010) Eur Urol , vol.57 , Issue.1 , pp. 49-59
    • Abrahamsson, P.A.1
  • 12
    • 78149441214 scopus 로고    scopus 로고
    • Intermittent versus continuous androgen suppression therapy: Do we have consensus yet
    • Buchan NC, Goldenberg SL,. Intermittent versus continuous androgen suppression therapy: Do we have consensus yet ? Curr Oncol 2010; 17 (Suppl 2): S45-S48.
    • (2010) Curr Oncol , vol.17 , Issue.SUPPL. 2
    • Buchan, N.C.1    Goldenberg, S.L.2
  • 14
    • 34047233908 scopus 로고    scopus 로고
    • Stabilizing androgen receptor in mitosis inhibits prostate cancer proliferation
    • Vander Griend DJ, Litvinov IV, Isaacs JT,. Stabilizing androgen receptor in mitosis inhibits prostate cancer proliferation. Cell Cycle 2007; 6 (6): 647-651.
    • (2007) Cell Cycle , vol.6 , Issue.6 , pp. 647-651
    • Vander Griend, D.J.1    Litvinov, I.V.2    Isaacs, J.T.3
  • 15
    • 77957001324 scopus 로고    scopus 로고
    • Bipolar androgen therapy: The rationale for rapid cycling of supraphysiologic androgen/ablation in men with castration resistant prostate cancer
    • Denmeade SR, Isaacs JT,. Bipolar androgen therapy: The rationale for rapid cycling of supraphysiologic androgen/ablation in men with castration resistant prostate cancer. Prostate 2010; 70 (14): 1600-1607.
    • (2010) Prostate , vol.70 , Issue.14 , pp. 1600-1607
    • Denmeade, S.R.1    Isaacs, J.T.2
  • 16
    • 84865498990 scopus 로고    scopus 로고
    • Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer
    • Isaacs JT, D'Antonio JM, Chen S, Antony L, Dalrymple SP, Ndikuyeze GH, Luo J, Denmeade SR,. Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer. Prostate 2012; 72 (14): 1491-1505.
    • (2012) Prostate , vol.72 , Issue.14 , pp. 1491-1505
    • Isaacs, J.T.1    D'Antonio, J.M.2    Chen, S.3    Antony, L.4    Dalrymple, S.P.5    Ndikuyeze, G.H.6    Luo, J.7    Denmeade, S.R.8
  • 17
    • 33847384225 scopus 로고    scopus 로고
    • Locally advanced prostate cancer-biochemical results from a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific antigen recurrence after radiotherapy
    • Bruchovsky N, Klotz L, Crook J, Goldenberg SL,. Locally advanced prostate cancer-biochemical results from a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific antigen recurrence after radiotherapy. Cancer 2007; 109 (5): 858-867.
    • (2007) Cancer , vol.109 , Issue.5 , pp. 858-867
    • Bruchovsky, N.1    Klotz, L.2    Crook, J.3    Goldenberg, S.L.4
  • 18
    • 84870571940 scopus 로고    scopus 로고
    • Intermittent androgen deprivation therapy in prostate cancer: Is everything so clear
    • Mottet N,. Intermittent androgen deprivation therapy in prostate cancer: Is everything so clear ? Eur Urol 2013; 63 (1): 121-122.
    • (2013) Eur Urol , vol.63 , Issue.1 , pp. 121-122
    • Mottet, N.1
  • 19
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25 (4): 402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 20
    • 35848961688 scopus 로고    scopus 로고
    • The relevance of estrogen receptor-beta expression to the antiproliferative effects observed with histone deacetylase inhibitors and phytoestrogens in prostate cancer treatment
    • Stettner M, Kaulfuss S, Burfeind P, Schweyer S, Strauss A, Ringert RH, Thelen P,. The relevance of estrogen receptor-beta expression to the antiproliferative effects observed with histone deacetylase inhibitors and phytoestrogens in prostate cancer treatment. Mol Cancer Ther 2007; 6 (10): 2626-2633.
    • (2007) Mol Cancer Ther , vol.6 , Issue.10 , pp. 2626-2633
    • Stettner, M.1    Kaulfuss, S.2    Burfeind, P.3    Schweyer, S.4    Strauss, A.5    Ringert, R.H.6    Thelen, P.7
  • 21
    • 70350244512 scopus 로고    scopus 로고
    • Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
    • Waltering KK, Helenius MA, Sahu B, Manni V, Linja MJ, Janne OA, Visakorpi T,. Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens. Cancer Res 2009; 69 (20): 8141-8149.
    • (2009) Cancer Res , vol.69 , Issue.20 , pp. 8141-8149
    • Waltering, K.K.1    Helenius, M.A.2    Sahu, B.3    Manni, V.4    Linja, M.J.5    Janne, O.A.6    Visakorpi, T.7
  • 23
    • 70350464492 scopus 로고    scopus 로고
    • Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone
    • Sedelaar JP, Isaacs JT,. Tissue culture media supplemented with 10% fetal calf serum contains a castrate level of testosterone. Prostate 2009; 69 (16): 1724-1729.
    • (2009) Prostate , vol.69 , Issue.16 , pp. 1724-1729
    • Sedelaar, J.P.1    Isaacs, J.T.2
  • 25
    • 67349240143 scopus 로고    scopus 로고
    • A randomized phase 1 study of testosterone replacement for patients with low-risk castration-resistant prostate cancer
    • Szmulewitz R, Mohile S, Posadas E, Kunnavakkam R, Karrison T, Manchen E, Stadler WM,. A randomized phase 1 study of testosterone replacement for patients with low-risk castration-resistant prostate cancer. Eur Urol 2009; 56 (1): 97-103.
    • (2009) Eur Urol , vol.56 , Issue.1 , pp. 97-103
    • Szmulewitz, R.1    Mohile, S.2    Posadas, E.3    Kunnavakkam, R.4    Karrison, T.5    Manchen, E.6    Stadler, W.M.7
  • 26
    • 0345631293 scopus 로고
    • Discussion of Dr. Huggins' paper: Control of cancers of man by endocrinological methods
    • Pearson OH,. Discussion of Dr. Huggins' paper: Control of cancers of man by endocrinological methods. Cancer Res 1957; 17 (5): 473-479.
    • (1957) Cancer Res , vol.17 , Issue.5 , pp. 473-479
    • Pearson, O.H.1
  • 27
    • 0014154355 scopus 로고
    • Response of men with advanced prostatic carcinoma to exogenous administration of testosterone
    • Prout GR Jr, Brewer WR,. Response of men with advanced prostatic carcinoma to exogenous administration of testosterone. Cancer 1967; 20 (11): 1871-1878.
    • (1967) Cancer , vol.20 , Issue.11 , pp. 1871-1878
    • Prout Jr., G.R.1    Brewer, W.R.2
  • 28
    • 68049131467 scopus 로고    scopus 로고
    • Reactivation of androgen receptor-regulated TMPRSS2: ERG gene expression in castration resistant prostate cancer
    • Cai C, Wang H, Xu Y, Chen S, Balk SP,. Reactivation of androgen receptor-regulated TMPRSS2: ERG gene expression in castration resistant prostate cancer. Cancer Res 2009; 69 (15): 6027-6032.
    • (2009) Cancer Res , vol.69 , Issue.15 , pp. 6027-6032
    • Cai, C.1    Wang, H.2    Xu, Y.3    Chen, S.4    Balk, S.P.5
  • 29
    • 78049280194 scopus 로고    scopus 로고
    • Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    • Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, Sawyers CL,. Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci USA 2010; 107 (39): 16759-16765.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.39 , pp. 16759-16765
    • Watson, P.A.1    Chen, Y.F.2    Balbas, M.D.3    Wongvipat, J.4    Socci, N.D.5    Viale, A.6    Kim, K.7    Sawyers, C.L.8
  • 31
    • 77954422728 scopus 로고    scopus 로고
    • The transcriptomics of de novo androgen biosynthesis in prostate cancer cells following androgen reduction
    • Cheng J, Wu Y, Mohler JL, Ip C,. The transcriptomics of de novo androgen biosynthesis in prostate cancer cells following androgen reduction. Cancer Biol Ther 2010; 9 (12): 1033-1042.
    • (2010) Cancer Biol Ther , vol.9 , Issue.12 , pp. 1033-1042
    • Cheng, J.1    Wu, Y.2    Mohler, J.L.3    Ip, C.4
  • 32
    • 39149084101 scopus 로고    scopus 로고
    • Endogenous sex hormones and prostate cancer: A collaborative analysis of 18 prospective studies
    • Roddam AW, Allen NE, Appleby P, Key TJ,. Endogenous sex hormones and prostate cancer: A collaborative analysis of 18 prospective studies. J Natl Cancer Inst 2008; 100 (3): 170-183.
    • (2008) J Natl Cancer Inst , vol.100 , Issue.3 , pp. 170-183
    • Roddam, A.W.1    Allen, N.E.2    Appleby, P.3    Key, T.J.4
  • 33
    • 0034598559 scopus 로고    scopus 로고
    • Involvement of p27Kip1 in G1 arrest by high dose 5 alpha- dihydrotestosterone in LNCaP human prostate cancer cells
    • Tsihlias J, Zhang W, Bhattacharya N, Flanagan M, Klotz L, Slingerland J,. Involvement of p27Kip1 in G1 arrest by high dose 5 alpha-dihydrotestosterone in LNCaP human prostate cancer cells. Oncogene 2000; 19 (5): 670-679.
    • (2000) Oncogene , vol.19 , Issue.5 , pp. 670-679
    • Tsihlias, J.1    Zhang, W.2    Bhattacharya, N.3    Flanagan, M.4    Klotz, L.5    Slingerland, J.6
  • 34
    • 84455161127 scopus 로고    scopus 로고
    • Androgens repress expression of the F-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells
    • Jiang J, Pan Y, Regan KM, Wu C, Zhang X, Tindall DJ, Huang H,. Androgens repress expression of the F-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells. Prostate 2012; 72 (2): 225-232.
    • (2012) Prostate , vol.72 , Issue.2 , pp. 225-232
    • Jiang, J.1    Pan, Y.2    Regan, K.M.3    Wu, C.4    Zhang, X.5    Tindall, D.J.6    Huang, H.7
  • 35
    • 16844385404 scopus 로고    scopus 로고
    • Androgen causes growth suppression and reversion of androgen-independent prostate cancer xenografts to an androgen-stimulated phenotype in athymic mice
    • Chuu CP, Hiipakka RA, Fukuchi J, Kokontis JM, Liao S,. Androgen causes growth suppression and reversion of androgen-independent prostate cancer xenografts to an androgen-stimulated phenotype in athymic mice. Cancer Res 2005; 65 (6): 2082-2084.
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2082-2084
    • Chuu, C.P.1    Hiipakka, R.A.2    Fukuchi, J.3    Kokontis, J.M.4    Liao, S.5
  • 37
    • 0028220323 scopus 로고
    • Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation
    • Kokontis J, Takakura K, Hay N, Liao S,. Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation. Cancer Res 1994; 54 (6): 1566-1573.
    • (1994) Cancer Res , vol.54 , Issue.6 , pp. 1566-1573
    • Kokontis, J.1    Takakura, K.2    Hay, N.3    Liao, S.4
  • 38
    • 0027135973 scopus 로고
    • Effect of culture conditions on androgen sensitivity of the human prostatic cancer cell line LNCaP
    • Langeler EG, van Uffelen CJ, Blankenstein MA, van Steenbrugge GJ, Mulder E,. Effect of culture conditions on androgen sensitivity of the human prostatic cancer cell line LNCaP. Prostate 1993; 23 (3): 213-223.
    • (1993) Prostate , vol.23 , Issue.3 , pp. 213-223
    • Langeler, E.G.1    Van Uffelen, C.J.2    Blankenstein, M.A.3    Van Steenbrugge, G.J.4    Mulder, E.5
  • 39
    • 0024402439 scopus 로고
    • Negative controls of cell proliferation: Human prostate cancer cells and androgens
    • Sonnenschein C, Olea N, Pasanen ME, Soto AM,. Negative controls of cell proliferation: Human prostate cancer cells and androgens. Cancer Res 1989; 49 (13): 3474-3481.
    • (1989) Cancer Res , vol.49 , Issue.13 , pp. 3474-3481
    • Sonnenschein, C.1    Olea, N.2    Pasanen, M.E.3    Soto, A.M.4
  • 40
    • 0029859580 scopus 로고    scopus 로고
    • Human prostate tumor growth in athymic mice: Inhibition by androgens and stimulation by finasteride
    • Umekita Y, Hiipakka RA, Kokontis JM, Liao S,. Human prostate tumor growth in athymic mice: Inhibition by androgens and stimulation by finasteride. Proc Natl Acad Sci USA 1996; 93 (21): 11802-11807.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.21 , pp. 11802-11807
    • Umekita, Y.1    Hiipakka, R.A.2    Kokontis, J.M.3    Liao, S.4
  • 41
    • 0025823337 scopus 로고
    • Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP
    • Wolf DA, Schulz P, Fittler F,. Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP. Br J cancer 1991; 64 (1): 47-53.
    • (1991) Br J Cancer , vol.64 , Issue.1 , pp. 47-53
    • Wolf, D.A.1    Schulz, P.2    Fittler, F.3
  • 42
    • 0034456723 scopus 로고    scopus 로고
    • Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase
    • Shen R, Sumitomo M, Dai J, Harris A, Kaminetzky D, Gao M, Burnstein KL, Nanus DM,. Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase. Endocrinology 2000; 141 (5): 1699-1704.
    • (2000) Endocrinology , vol.141 , Issue.5 , pp. 1699-1704
    • Shen, R.1    Sumitomo, M.2    Dai, J.3    Harris, A.4    Kaminetzky, D.5    Gao, M.6    Burnstein, K.L.7    Nanus, D.M.8
  • 43
    • 0027407539 scopus 로고
    • Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA
    • Yuan S, Trachtenberg J, Mills GB, Brown TJ, Xu F, Keating A,. Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA. Cancer Res 1993; 53 (6): 1304-1311.
    • (1993) Cancer Res , vol.53 , Issue.6 , pp. 1304-1311
    • Yuan, S.1    Trachtenberg, J.2    Mills, G.B.3    Brown, T.J.4    Xu, F.5    Keating, A.6
  • 44
    • 18744369944 scopus 로고    scopus 로고
    • Testosterone as a predictor of pathological stage in clinically localized prostate cancer
    • Isom-Batz G, Bianco FJ Jr, Kattan MW, Mulhall JP, Lilja H, Eastham JA,. Testosterone as a predictor of pathological stage in clinically localized prostate cancer. J Urol 2005; 173 (6): 1935-1937.
    • (2005) J Urol , vol.173 , Issue.6 , pp. 1935-1937
    • Isom-Batz, G.1    Bianco Jr., F.J.2    Kattan, M.W.3    Mulhall, J.P.4    Lilja, H.5    Eastham, J.A.6
  • 45
    • 57649176913 scopus 로고    scopus 로고
    • Shifting the paradigm of testosterone and prostate cancer: The saturation model and the limits of androgen-dependent growth
    • Morgentaler A, Traish AM,. Shifting the paradigm of testosterone and prostate cancer: The saturation model and the limits of androgen-dependent growth. Eur Urol 2009; 55 (2): 310-320.
    • (2009) Eur Urol , vol.55 , Issue.2 , pp. 310-320
    • Morgentaler, A.1    Traish, A.M.2
  • 46
    • 41749098807 scopus 로고    scopus 로고
    • The ratio of serum testosterone-to-prostate specific antigen predicts prostate cancer in hypogonadal men
    • Rhoden EL, Riedner CE, Morgentaler A,. The ratio of serum testosterone-to-prostate specific antigen predicts prostate cancer in hypogonadal men. J Urol 2008; 179 (5): 1741-1744.
    • (2008) J Urol , vol.179 , Issue.5 , pp. 1741-1744
    • Rhoden, E.L.1    Riedner, C.E.2    Morgentaler, A.3
  • 47
    • 27744467589 scopus 로고    scopus 로고
    • Low serum testosterone levels are associated with positive surgical margins in radical retropubic prostatectomy: Hypogonadism represents bad prognosis in prostate cancer
    • Teloken C, Da Ros CT, Caraver F, Weber FA, Cavalheiro AP, Graziottin TM,. Low serum testosterone levels are associated with positive surgical margins in radical retropubic prostatectomy: Hypogonadism represents bad prognosis in prostate cancer. J Urol 2005; 174 (6): 2178-2180.
    • (2005) J Urol , vol.174 , Issue.6 , pp. 2178-2180
    • Teloken, C.1    Da Ros, C.T.2    Caraver, F.3    Weber, F.A.4    Cavalheiro, A.P.5    Graziottin, T.M.6
  • 48
    • 84867077468 scopus 로고    scopus 로고
    • Goodbye androgen hypothesis hello saturation model
    • Morgentaler A,. Goodbye androgen hypothesis hello saturation model. Eur Urol 2012; 62 (5): 765-767.
    • (2012) Eur Urol , vol.62 , Issue.5 , pp. 765-767
    • Morgentaler, A.1
  • 49
    • 84867052045 scopus 로고    scopus 로고
    • Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the reduction by dutasteride of prostate cancer events trial
    • Muller RL, Gerber L, Moreira DM, Andriole G, Castro-Santamaria R, Freedland SJ,. Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the reduction by dutasteride of prostate cancer events trial. Eur Urol 2012; 62 (5): 757-764.
    • (2012) Eur Urol , vol.62 , Issue.5 , pp. 757-764
    • Muller, R.L.1    Gerber, L.2    Moreira, D.M.3    Andriole, G.4    Castro-Santamaria, R.5    Freedland, S.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.