Lack of HXK2 induces localization of active Ras in mitochondria and triggers apoptosis in the yeast saccharomyces cerevisiae

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Amigoni, Loredana ^a,b   Martegani, Enzo ^a,b   Colombo, Sonia ^a,b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b Milano and Rome   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC CELLS; BIOCHEMICAL CHANGES; DNA FRAGMENTATION; MITOCHONDRIAL DYSFUNCTION; PHOSPHATIDYLSERINE; PROGRAMMED CELL DEATHS; WILD-TYPE STRAIN; YEAST SACCHAROMYCES CEREVISIAE;

BIOINFORMATICS; CELL MEMBRANES; MITOCHONDRIA; PROTEINS; YEAST;

CELL DEATH;

ACETIC ACID; GUANOSINE TRIPHOSPHATE; HEXOKINASE; HEXOKINASE 2; PHOSPHATIDYLSERINE; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CASPASE; GLUCOSE; HXK2 PROTEIN, S CEREVISIAE; MCA1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE; CONTROLLED STUDY; DNA FRAGMENTATION; GENE DELETION; HYPERPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MORPHOLOGY; NONHUMAN; PROTEIN DEPLETION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; WILD TYPE; YEAST; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NECROSIS; PROTEIN TRANSPORT; DRUG EFFECT;

ACETIC ACID; APOPTOSIS; CASPASES; GENE DELETION; GLUCOSE; HEXOKINASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NECROSIS; PROTEIN TRANSPORT; RAS PROTEINS; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84884899274     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/678473     Document Type: Article

References (44)

1. Jones S., Vignais M.-L., Broach J. R., The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to Ras. Molecular and Cellular Biology 1991 11 5 2641 2646 2-s2.0-0026315383 (Pubitemid 21895643)
2. Rudoni S., Colombo S., Coccetti P., Martegani E., Role of guanine nucleotides in the regulation of the Ras/cAMP pathway in Saccharomyces cerevisiae. Biochimica et Biophysica Acta 2001 1538 2-3 181 189 2-s2.0-0035938253 10.1016/S0167-4889(01)00067-2 (Pubitemid 32402241)
3. Tanaka K., Nakafuku M., Satoh T., Marshall M. S., Gibbs J. B., Matsumoto K., Kaziro Y., Toh-e A., S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein. Cell 1990 60 5 803 807 2-s2.0-0025232840 10.1016/0092-8674(90)90094-U (Pubitemid 20086893)
4. Zaman S., Lippman S. I., Zhao X., Broach J. R., How Saccharomyces responds to nutrients. Annual Review of Genetics 2008 42 27 81 2-s2.0-58549084410 10.1146/annurev.genet.41.110306.130206
5. Thevelein J. M., De Winde J. H., Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Molecular Microbiology 1999 33 5 904 918 2-s2.0-0032835137 10.1046/j.1365-2958. 1999.01538.x (Pubitemid 29425244)
6. Rolland F., Winderickx J., Thevelein J. M., Glucose-sensing and -signalling mechanisms in yeast. FEMS Yeast Research 2002 2 2 183 201 2-s2.0-0036281361 10.1016/S1567-1356(02)00046-6 (Pubitemid 34628612)
7. Casperson G. F., Walker N., Bourne H. R., Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America 1985 82 15 5060 5063 2-s2.0-0003293918 (Pubitemid 15249943)
8. Smets B., Ghillebert R., De Snijder P., Binda M., Swinnen E., De Virgilio C., Winderickx J., Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae. Current Genetics 2010 56 1 1 32 2-s2.0-73249152807 10.1007/s00294-009-0287-1
9. Broggi S., Martegani E., Colombo S., Live-cell imaging of endogenous Ras-GTP shows predominant Ras activation at the plasma membrane and in the nucleus in Saccharomyces cerevisiae. The International Journal of Biochemistry & Cell Biology 2013 45 2 384 394
10. Leadsham J. E., Miller K., Ayscough K. R., Colombo S., Martegani E., Sudbery P., Gourlay C. W., Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast. Journal of Cell Science 2009 122 5 706 715 2-s2.0-63549149703 10.1242/jcs.042424
11. Hu Y., Lu W., Chen G., Wang P., Chen Z., Zhou Y., Ogasawara M., Trachootham D., Feng L., Pelicano H., Chiao P. J., Keating M. J., Garcia-Manero G., Huang P., K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Research 2012 22 2 399 412 2-s2.0-84856595714 10.1038/cr.2011.145
12. Büttner S., Eisenberg T., Carmona-Gutierrez D., Ruli D., Knauer H., Ruckenstuhl C., Sigrist C., Wissing S., Kollroser M., Fröhlich K.-U., Sigrist S., Madeo F., Endonuclease G regulates budding yeast life and death. Molecular Cell 2007 25 2 233 246 2-s2.0-33846223232 10.1016/j.molcel.2006.12.021 (Pubitemid 46109611)
13. Madeo F., Fröhlich E., Fröhlich K.-U., A yeast mutant showing diagnostic markers of early and late apoptosis. Journal of Cell Biology 1997 139 3 729 734 2-s2.0-0030667206 10.1083/jcb.139.3.729 (Pubitemid 27486568)
14. Madeo F., Herker E., Wissing S., Jungwirth H., Eisenberg T., Fröhlich K.-U., Apoptosis in yeast. Current Opinion in Microbiology 2004 7 6 655 660 2-s2.0-8844239229 10.1016/j.mib.2004.10.012 (Pubitemid 39536293)
15. Madeo F., Herker E., Maldener C., Wissing S., Lächelt S., Herlan M., Fehr M., Lauber K., Sigrist S. J., Wesselborg S., Fröhlich K.-U., A caspase-related protease regulates apoptosis in yeast. Molecular Cell 2002 9 4 911 917 2-s2.0-18344374857 10.1016/S1097-2765(02)00501-4 (Pubitemid 34454900)
16. Guaragnella N., Pereira C., Sousa M. J., Antonacci L., Passarella S., Côrte-Real M., Marra E., Giannattasio S., YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase-like activity. FEBS Letters 2006 580 30 6880 6884 2-s2.0-33845408268 10.1016/j.febslet.2006.11.050 (Pubitemid 44909129)
17. Li W., Sun L., Liang Q., Wang J., Mo W., Zhou B., Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Molecular Biology of the Cell 2006 17 4 1802 1811 2-s2.0-33745377897 10.1091/mbc.E05-04-0333
18. Wissing S., Ludovico P., Herker E., Büttner S., Engelhardt S. M., Decker T., Link A., Proksch A., Rodrigues F., Corte-Real M., Fröhlich K.-U., Manns J., Candé C., Sigrist S. J., Kroemer G., Madeo F., An AIF orthologue regulates apoptosis in yeast. Journal of Cell Biology 2004 166 7 969 974 2-s2.0-4644246439 10.1083/jcb.200404138 (Pubitemid 39304760)
19. Fahrenkrog B., Sauder U., Aebi U., The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis. Journal of Cell Science 2004 117 1 115 126 2-s2.0-0347917233 10.1242/jcs.00848 (Pubitemid 38072126)
20. Qiu J., Yoon J.-H., Shen B., Search for apoptotic nucleases in yeast: role of Tat-D nuclease in apoptotic DNA degradation. The Journal of Biological Chemistry 2005 280 15 15370 15379 2-s2.0-17644401044 10.1074/jbc.M413547200 (Pubitemid 40562894)
21. Orlandi I., Bettiga M., Alberghina L., Vai M., Transcriptional profiling of ubp10 null mutant reveals altered subtelomeric gene expression and insurgence of oxidative stress response. The Journal of Biological Chemistry 2004 279 8 6414 6425 2-s2.0-1342304123 10.1074/jbc.M306464200 (Pubitemid 38248775)
22. Ligr M., Madeo F., Fröhlich E., Hilt W., Fröhlich K.-U., Wolf D. H., Mammalian Bax triggers apoptotic changes in yeast. FEBS Letters 1998 438 1-2 61 65 2-s2.0-0032582568 10.1016/S0014-5793(98)01227-7 (Pubitemid 28517835)
23. Madeo F., Fröhlich E., Ligr M., Grey M., Sigrist S. J., Wolf D. H., Fröhlich K.-U., Oxygen stress: a regulator of apoptosis in yeast. Journal of Cell Biology 1999 145 4 757 767 2-s2.0-0345643515 10.1083/jcb.145.4.757 (Pubitemid 29240853)
24. Du L., Su Y., Sun D., Zhu W., Wang J., Zhuang X., Zhou S., Lu Y., Formic acid induces Yca1p-independent apoptosis-like cell death in the yeast Saccharomyces cerevisiae. FEMS Yeast Research 2008 8 4 531 539 2-s2.0-43549099808 10.1111/j.1567-1364.2008.00375.x (Pubitemid 351678655)
25. Ludovico P., Sousa M. J., Silva M. T., Leão C., Côrte-Real M., Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology 2001 147 9 2409 2415 2-s2.0-0034807841 (Pubitemid 32899237)
26. Ludovico P., Rodrigues F., Almeida A., Silva M. T., Barrientos A., Côrte-Real M., Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Molecular Biology of the Cell 2002 13 8 2598 2606 2-s2.0-0036678040 10.1091/mbc.E01-12-0161
27. Guaragnella N., Antonacci L., Passarella S., Marra E., Giannattasio S., Hydrogen peroxide and superoxide anion production during acetic acid-induced yeast programmed cell death. Folia Microbiologica 2007 52 3 237 240 2-s2.0-34547327874 10.1007/BF02931304 (Pubitemid 47148560)
28. Giannattasio S., Atlante A., Antonacci L., Guaragnella N., Lattanzio P., Passarella S., Marra E., Cytochrome c is released from coupled mitochondria of yeast en route to acetic acid-induced programmed cell death and can work as an electron donor and a ROS scavenger. FEBS Letters 2008 582 10 1519 1525 2-s2.0-42049087857 10.1016/j.febslet.2008.03.048
29. Guaragnella N., Antonacci L., Giannattasio S., Marra E., Passarella S., Catalase T and Cu, Zn-superoxide dismutase in the acetic acid-induced programmed cell death in Saccharomyces cerevisiae. FEBS Letters 2008 582 2 210 214 2-s2.0-38049068839 10.1016/j.febslet.2007.12.007
30. Guaragnella N., Bobba A., Passarella S., Marra E., Giannattasio S., Yeast acetic acid-induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1. FEBS Letters 2010 584 1 224 228 2-s2.0-71549142551 10.1016/j.febslet.2009.11.072
31. Madeo F., Carmona-Gutierrez D., Ring J., Büttner S., Eisenberg T., Kroemer G., Caspase-dependent and caspase-independent cell death pathways in yeast. Biochemical and Biophysical Research Communications 2009 382 2 227 231 2-s2.0-63549130335 10.1016/j.bbrc.2009.02.117
32. Ahuatzi D., Riera A., Peláez R., Herrero P., Moreno F., Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution. The Journal of Biological Chemistry 2007 282 7 4485 4493 2-s2.0-33947493105 10.1074/jbc.M606854200 (Pubitemid 47100982)
33. Moreno F., Ahuatzi D., Riera A., Palomino C. A., Herrero P., Glucose sensing through the Hxk2-dependent signalling pathway. Biochemical Society Transactions 2005 33 1 265 268 2-s2.0-14644435130 10.1042/BST0330265 (Pubitemid 40313817)
34. Thomas B. J., Rothstein R., Elevated recombination rates in transcriptionally active DNA. Cell 1989 56 4 619 630 2-s2.0-0024977417
35. Robinson L. C., Gibbs J. B., Marshall M. S., Sigal I. S., Tatchell K., CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae. Science 1987 235 4793 1218 1221 2-s2.0-0023155907 (Pubitemid 17034010)
36. Rothstein R. J., One-step gene disruption in yeast. Methods in Enzymology 1983 101 202 211 2-s2.0-0020645054 (Pubitemid 13071047)
37. Bettiga M., Calzari L., Orlandi I., Alberghina L., Vai M., Involvement of the yeast metacaspase Yca1 in ubp10 Δ-programmed cell death. FEMS Yeast Research 2004 5 2 141 147 2-s2.0-5444237172 10.1016/j.femsyr.2004.07.005 (Pubitemid 39360917)
38. Casatta N., Porro A., Orlandi I., Brambilla L., Vai M., Lack of Sir2 increases acetate consumption and decreases extracellular pro-aging factors. Biochimica et Biophysica Acta 2013 1833 3 593 601
39. Colombo S., Ronchetti D., Thevelein J. M., Winderickx J., Martegani E., Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae. The Journal of Biological Chemistry 2004 279 45 46715 46722 2-s2.0-6344256284 10.1074/jbc.M405136200 (Pubitemid 39518319)
40. Fabrizio P., Longo V. D., Chronological aging-induced apoptosis in yeast. Biochimica et Biophysica Acta 2008 1783 7 1280 1285 2-s2.0-50949083311 10.1016/j.bbamcr.2008.03.017
41. Khan M. A. S., Chock P. B., Stadtman E. R., Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America 2005 102 48 17326 17331 2-s2.0-28444499695 10.1073/pnas.0508120102 (Pubitemid 41740865)
42. Wolfman J. C., Planchon S. M., Liao J., Wolfman A., Structural and functional consequences of c-N-Ras constitutively associated with intact mitochondria. Biochimica et Biophysica Acta 2006 1763 10 1108 1124 2-s2.0-33749264618 10.1016/j.bbamcr.2006.07.015 (Pubitemid 44479794)
43. Bivona T. G., Quatela S. E., Bodemann B. O., Ahearn I. M., Soskis M. J., Mor A., Miura J., Wiener H. H., Wright L., Saba S. G., Yim D., Fein A., Pérez De Castro I., Li C., Thompson C. B., Cox A. D., Philips M. R., PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Molecular Cell 2006 21 4 481 493 2-s2.0-32444441115 10.1016/j.molcel.2006.01.012 (Pubitemid 43228004)
44. Rebollo A., Pérez-Sala D., Martínez-A C., Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis. Oncogene 1999 18 35 4930 4939 2-s2.0-0008573656 10.1038/sj.onc.1202875 (Pubitemid 29425299)