Non-metallic nanomaterials in cancer theranostics: A review of silica- and carbon-based drug delivery systems

Science and Technology of Advanced Materials

Volumn 14, Issue 4, 2013, Pages

  Chen, Yu Cheng ^a   Huang, Xin Chun ^a   Luo, Yun Ling ^a   Chang, Yung Chen ^a   Hsieh, You Zung ^a   Hsu, Hsin Yun ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

carbon based nanomaterials; drug delivery systems; mesoporous silica nanoparticles; theranostics

Indexed keywords

CARBON-BASED; CHEMICAL FUNCTIONALIZATION; CLINICAL EVALUATION; DRUG DELIVERY SYSTEM; MESOPOROUS SILICA NANOPARTICLES; NON-METALLIC SUBSTANCES; THERANOSTICS; THERAPEUTIC EFFICACY;

CARBON; DISEASES; DRUG DELIVERY; PATIENT TREATMENT;

NANOSTRUCTURED MATERIALS;

EID: 84884892021     PISSN: 14686996     EISSN: None     Source Type: Journal    
DOI: 10.1088/1468-6996/14/4/044407     Document Type: Article

References (174)

1. Dean M, Fojo T and Bates S 2005 Tumour stem cells and drug resistance Nature Rev. Cancer 5 275-84 (Pubitemid 40488633)
2. Paciotti G F, Kingston D G I and Tamarkin L 2006 Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor-targeted drug delivery vectors Drug Dev. Res. 67 47-54 (Pubitemid 43765048)
3. Slowing I I, Trewyn B G, Giri S and Lin V S Y 2007 Mesoporous silica nanoparticles for drug delivery and biosensing applications Adv. Funct. Mater. 17 1225-36 (Pubitemid 46847636)
4. Nasonkla N, Bey E, Ren J, Ai H, Khemtong C, Guthi J S, Chin S F, Sherry A D, Boothman D A and Gao J 2006 Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems Nano Lett. 6 2427-30 (Pubitemid 46076928)
5. Soppimath K S, Tan D C and Yang Y Y 2005 pH-triggered thermally responsive polymer core-shell nanoparticles for drug delivery Adv. Mater. 17 318-23 (Pubitemid 40320152)
6. Dromi S, Frenkel V, Luk A, Traughber B, Angstadt M, Bur M, Poff J, Xie J, Libutti S K, Li K C and Wood B J 2007 Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect Clin. Cancer Res. 13 2722-7 (Pubitemid 46788041)
7. Yang H and Kao W J 2007 Synthesis and characterization of nanoscale dendritic RGD clusters for potential applications in tissue engineering and drug delivery Int. J. Nanomed. 1 89-99 (Pubitemid 46901785)
8. Ariga K, Ji Q, McShane M J, Lvov Y M, Vinu A and Hill J P 2011 Inorganic nanoarchitectonics for biological applications Chem. Mater. 24 728-37
9. Uboldi C, Giudetti G, Broggi F, Gilliland D, Ponti J and Rossi F 2012 Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts Mutat. Res. 745 11-20
10. Xiao Q G, Tao X, Zou H K and Chen J F 2008 Comparative study of solid silica nanoparticles and hollow silica nanoparticles for the immobilization of lysozyme Chem. Eng. J. 137 38-44 (Pubitemid 351226635)
11. Stöber W, Fink A and Bohn E 1968 Controlled growth of monodisperse silica spheres in the micron size range J. Colloid Interface Sci. 26 62-9
12. Grün M, Lauer I and Unger K K 1997 The synthesis of micrometer-and submicrometer-size spheres of ordered mesoporous oxide MCM-41 Adv. Mater. 9 254-7 (Pubitemid 127527615)
13. Beck J S et al 1992 A new family of mesoporous molecular-sieves prepared with liquid-crystal templats J. Am. Chem. Soc. 114 10834-43
14. Kresge C T, Leonowicz M E, Roth W J, Vartuli J C and Beck J S 1992 Ordered mesoporous molecular-sieves synthesized by a liquid-crystal template mechanism Nature 359 710-2 (Pubitemid 23589384)
15. Huo Q, Margolese D I and Stucky G D 1996 Surfactant control of phases in the synthesis of mesoporous silica-based materials Chem. Mater. 8 1147-60 (Pubitemid 126467425)
16. Vartuli J, Schmitt K, Kresge C, Roth W, Leonowicz M, McCullen S, Hellring S, Beck J and Schlenker J 1994 Effect of surfactant/silica molar ratios on the formation of mesoporous molecular sieves: inorganic mimicry of surfactant liquid-crystal phases and mechanistic implications Chem. Mater. 6 2317-26
17. Cai Q, Luo Z-S, Pang W-Q, Fan Y-W, Chen X-H and Cui F-Z 2001 Dilute solution routes to various controllable morphologies of MCM-41 silica with a basic medium Chem. Mater. 13 258-63 (Pubitemid 32199327)
18. Suzuki K, Ikari K and Imai H 2004 Synthesis of silica nanoparticles having a well-ordered mesostructure using a double surfactant system J. Am. Chem. Soc. 126 462-3 (Pubitemid 38084616)
19. Slowing I I, Vivero-Escoto J L, Trewyn B G and Lin V S Y 2010 Mesoporous silica nanoparticles: structural design and applications J. Mater. Chem. 20 7924-37
20. Ambrogio M W, Thomas C R, Zhao Y-L, Zink J I and Stoddart J F 2011 Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine Acc. Chem. Res. 44 903-13
21. Ariga K, Vinu A, Yamauchi Y, Ji Q and Hill J P 2012 Nanoarchitectonics for mesoporous materials Bull. Chem. Soc. Japan 85 1-32
22. Li Z, Barnes J C, Bosoy A, Stoddart J F and Zink J I 2012 Mesoporous silica nanoparticles in biomedical applications Chem. Soc. Rev. 41 2590-605
23. Tarn D, Ashley C E, Xue M, Carnes E C, Zink J I and Brinker C J 2013 Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility Acc. Chem. Res. 46 792-801
24. Wu K C W, Jiang X and Yamauchi Y 2011 New trend on mesoporous films: precise controls of one-dimensional (1D) mesochannels toward innovative applications J. Mater. Chem. 21 8934-9
25. Wu K C W and Yamauchi Y 2012 Controlling physical features of mesoporous silica nanoparticles (MSNs) for emerging applications J. Mater. Chem. 22 1251-6
26. Ferris D P, Zhao Y-L, Khashab N M, Khatib H A, Stoddart J F and Zink J I 2009 Light-operated mechanized nanoparticles J. Am. Chem. Soc. 131 1686-8
27. Wang Y, Li B, Zhang L, Song H and Zhang L 2012 Targeted delivery system based on magnetic mesoporous silica nanocomposites with light-controlled release character ACS App. Mater. Interfaces 5 11-5
28. Yuan Q, Zhang Y, Chen T, Lu D, Zhao Z, Zhang X, Li Z, Yan C-H and Tan W 2012 Photon-manipulated drug release from a mesoporous nanocontainer controlled by azobenzene-modified nucleic acid ACS Nano 6 6337-44
29. Park C, Lee K and Kim C 2009 Photoresponsive cyclodextrin-covered nanocontainers and their sol-gel transition induced by molecular recognition Angew. Chem. Int. Edn. Engl. 48 1275-8
30. Mal N K, Fujiwara M and Tanaka Y 2003 Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica Nature 421 350-3 (Pubitemid 36157928)
31. Knezevic N Z, Trewyn B G and Lin V S Y 2011 Functionalized mesoporous silica nanoparticle-based visible light responsive controlled release delivery system Chem. Commun. 47 2817-9
32. Vivero-Escoto J L, Slowing I I, Wu C-W and Lin V S Y 2009 Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere J. Am. Chem. Soc. 131 3462-3
33. Lin Q, Huang Q, Li C, Bao C, Liu Z, Li F and Zhu L 2010 Anticancer drug release from a mesoporous silica based nanophotocage regulated by either a one- or two-photon process J. Am. Chem. Soc. 132 10645-7
34. Schwarz A, Ständer S, Berneburg M, Böhm M, Kulms D, van Steeg H, Grosse-Heitmeyer K, Krutmann J and Schwarz T 2001 Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair Nature Cell Biol. 4 26-31 (Pubitemid 34071977)
35. Juzenas P, Juzeniene A, Kaalhus O, Iani V and Moan J 2002 Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo Photochem. Photobiol. Sci. 1 745-8 (Pubitemid 37069793)
36. Liu H, Chen D, Li L, Liu T, Tan L, Wu X and Tang F 2011 Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity Angew. Chem. 123 921-5
37. Fang W, Yang J, Gong J and Zheng N 2012 Photo-and pH-triggered release of anticancer drugs from mesoporous silica-coated Pd@ Ag nanoparticles Adv. Funct. Mater. 22 842-8
38. 2 with a smart polymer shell responsive to heat/near-infrared light for chemo-photothermal therapy J. Mater. Chem. 22 16095-103
39. 2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation Nature Med. 3 177-82 (Pubitemid 27064702)
40. Silva A S, Yunes J A, Gillies R J and Gatenby R A 2009 The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion Cancer Res. 69 2677-84
41. Maxfield F R and McGraw T E 2004 Endocytic recycling Nature Rev. Mol. Cell Biol. 5 121-32 (Pubitemid 38160255)
42. Zhao Y-L, Li Z, Kabehie S, Botros Y Y, Stoddart J F and Zink J I 2010 pH-operated nanopistons on the surfaces of mesoporous silica nanoparticles J. Am. Chem. Soc. 132 13016-25
43. Meng H, Xue M, Xia T, Zhao Y-L, Tamanoi F, Stoddart J F, Zink J I and Nel A E 2010 Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves J. Am. Chem. Soc. 132 12690-7
44. Lin C-H, Cheng S-H, Liao W-N, Wei P-R, Sung P-J, Weng C-F and Lee C-H 2012 Mesoporous silica nanoparticles for the improved anticancer efficacy of cis-platin Int. J. Pharm. 429 138-47
45. Lee C H, Cheng S H, Huang I, Souris J S, Yang C S, Mou C Y and Lo L W 2010 Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics Angew. Chem. 122 8390-5
46. Liu R, Zhang Y, Zhao X, Agarwal A, Mueller L J and Feng P 2010 pH-responsive nanogated ensemble based on gold-capped mesoporous silica through an acid-labile acetal linker J. Am. Chem. Soc. 132 1500-1
47. 4 nanoparticles-capped mesoporous silica Biomaterials 32 1932-42
48. Aznar E, Marcos M D, Martiánez-Maánñez R N, Sancenón F, Soto J, Amoroás P and Guillem C 2009 pH-and photo-switched release of guest molecules from mesoporous silica supports J. Am. Chem. Soc. 131 6833-43
49. Gao C, Zheng H, Xing L, Shu M and Che S 2010 Designable coordination bonding in mesopores as a pH-responsive release system Chem. Mater. 22 5437-44
50. Popat A, Liu J, Lu G Q M and Qiao S Z 2012 A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles J. Mater. Chem. 22 11173-8
51. Chen F and Zhu Y 2012 Chitosan enclosed mesoporous silica nanoparticles as drug nano-carriers: sensitive response to the narrow pH range Micropor. Mesopor. Mater. 150 83-9
52. Tang H, Guo J, Sun Y, Chang B, Ren Q and Yang W 2011 Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery Int. J. Pharm. 421 388-96
53. Muhammad F, Guo M, Qi W, Sun F, Wang A, Guo Y and Zhu G 2011 pH-Triggered controlled drug release from mesoporous silica nanoparticles via intracelluar dissolution of ZnO nanolids J. Am. Chem. Soc. 133 8778-81
54. Schafer F Q and Buettner G R 2001 Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radi. Biol. Med. 30 1191-212 (Pubitemid 32463931)
55. Wu G, Fang Y-Z, Yang S, Lupton J R and Turner N D 2004 Glutathione metabolism and its implications for health J. Nutr. 134 489-92 (Pubitemid 38298485)
56. Arunachalam B, Phan U T, Geuze H J and Cresswell P 2000 Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT) Proc. Nat. Acad. Sci. 97 745-50 (Pubitemid 30070380)
57. Trachootham D, Alexandre J and Huang P 2009 Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nature reviews. Drug Disc. 8 579-91
58. Luo Z, Cai K, Hu Y, Zhao L, Liu P, Duan L and Yang W 2011 Mesoporous silica nanoparticles end-capped with collagen: redox-responsive nanoreservoirs for targeted drug delivery Angew. Chem. Int. Edn. 50 640-3
59. Cui Y, Dong H, Cai X, Wang D and Li Y 2012 Mesoporous silica nanoparticles capped with disulfide-linked peg gatekeepers for glutathione-mediated controlled release ACS Appl. Mater. Interfaces 4 3177-83
60. Kim H, Kim S, Park C, Lee H, Park H J and Kim C 2010 Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers Adv. Mater. 22 4280-3
61. Zhang Q, Liu F, Nguyen K T, Ma X, Wang X, Xing B and Zhao Y 2012 Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery Adv. Funct. Mater. 22 5144-56
62. Sauer A M, Schlossbauer A, Ruthardt N, Cauda V, Bein T and Braäuchle C 2010 Role of endosomal escape for disulfide-based drug delivery from colloidal mesoporous silica evaluated by live-cell imaging Nano Lett. 10 3684-91
63. Zong S, Wang Z, Chen H, Yang J and Cui Y 2013 Surface enhanced Raman scattering traceable and glutathione responsive nanocarrier for the intracellular drug delivery Anal. Chem. 85 2223-30
64. Zhu C-L, Song X-Y, Zhou W-H, Yang H-H, Wen Y-H and Wang X-R 2009 An efficient cell-targeting and intracellular controlled-release drug delivery system based on MSN-PEM-aptamer conjugates J. Mater. Chem. 19 7765-70
65. Wan X, Wang D and Liu S 2010 Fluorescent pH-sensing organic/inorganic hybrid mesoporous silica nanoparticles with tunable redox-responsive release capability Langmuir 26 15574-9
66. Davis J J, Huang W-Y and Davies G-L 2012 Location-tuned relaxivity in Gd-doped mesoporous silica nanoparticles J. Mater. Chem. 22 22848-50
67. Carniato F, Tei L, Cossi M, Marchese L and Botta M 2010 A chemical strategy for the relaxivity enhancement of GdIII chelates anchored on mesoporous silica nanoparticles Chemistry-A Eur. J. 16 10727-34
68. Lin W-I, Lin C-Y, Lin Y-S, Wu S-H, Huang Y-R, Hung Y, Chang C and Mou C-Y 2013 High payload Gd (iii) encapsulated in hollow silica nanospheres for high resolution magnetic resonance imaging J. Mater. Chem. B 1 639-45
69. Liu J, Bu W, Zhang S, Chen F, Xing H, Pan L, Zhou L, Peng W and Shi J 2012 Controlled synthesis of uniform and monodisperse upconversion core/mesoporous silica shell nanocomposites for bimodal imaging Chemistry-A Eur. J. 18 2335-41
70. Guillet-Nicolas R, Bridot J L, Seo Y, Fortin M A and Kleitz F 2011 Enhanced relaxometric properties of MRI 'Positive' contrast agents confined in three-dimensional cubic mesoporous silica nanoparticles Adv. Funct. Mater. 21 4653-62
71. Kim T, Momin E, Choi J, Yuan K, Zaidi H, Kim J, Park M, Lee N, McMahon M T and Quinones-Hinojosa A 2011 Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T 1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells J. Am. Chem. Soc. 133 2955-61
72. Chen Y, Yin Q, Ji X, Zhang S, Chen H, Zheng Y, Sun Y, Qu H, Wang Z and Li Y 2012 Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells Biomaterials 33 7126-37
73. 4 -capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging J. Mater. Chem. 21 2535-43
74. Lee J E, Lee N, Kim H, Kim J, Choi S H, Kim J H, Kim T, Song I C, Park S P and Moon W K 2009 Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery J. Am. Chem. Soc. 132 552-7
75. Chen Y, Chen H, Zeng D, Tian Y, Chen F, Feng J and Shi J 2010 Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery ACS Nano 4 6001-13
76. Thomas C R, Ferris D P, Lee J-H, Choi E, Cho M H, Kim E S, Stoddart J F, Shin J-S, Cheon J and Zink J I 2010 Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles J. Am. Chem. Soc. 132 10623-5
77. Baeza A, Guisasola E, Ruiz-Hernaández E and Vallet-Regiá M a 2012 Magnetically triggered multidrug release by hybrid mesoporous silica nanoparticles Chem. Mater. 24 517-24
78. Bringas E, Köysüren Ö, Quach D V, Mahmoudi M, Aznar E, Roehling J D, Marcos M D, Martínez-Máñez R and Stroeve P 2012 Triggered release in lipid bilayer-capped mesoporous silica nanoparticles containing SPION using an alternating magnetic field Chem. Commun. 48 5647-9
79. Schrand A, Hens S A C and Shenderova O 2009 Nanodiamond particles: properties and perspectives for bioapplications Crit. Rev. Solid State Mater. Sci. 34 18-74
80. Cao L, Wang X, Meziani M J, Lu F, Wang H, Luo P G, Lin Y, Harruff B A, Veca M, Murray D, Xie S Y and Sun Y P 2007 Carbon dots for multiphoton bioimaging J. Am. Chem. Soc. 129 11318-19 (Pubitemid 47555535)
81. Yang K, Zhang S, Zhang G, Sun X, Lee S T and Liu Z 2010 Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy Nano Lett. 10 3318-23
82. Kim J W, Galanzha E I, Shashkov E V, Moon H M and Zharov V P 2009 Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents Nature Nanotechnol. 4 688-94
83. Mroz P, Tegos G P, Gali H, Wharton T, Sarna T and Hamblin M R 2007 Photodynamic therapy with fullerenes Photochem. Photobiol. Sci. 6 1139-49 (Pubitemid 350064036)
84. Huang H, Pierstorff E, Osawa E and Ho D 2008 Protein-mediated assembly of nanodiamond hydrogels into a biocompatible and biofunctional multilayer nanofilm ACS Nano 2 203-12 (Pubitemid 351585936)
85. Liu X, Tao H, Yang K, Zhang S, Lee S T and Liu Z 2011 Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors Biomaterials 32 144-51
86. Jia N, Lian Q, Shen H, Wang C, Li X and Yang Z 2007 Intracellular delivery of quantum dots tagged antisense oligodeoxynucleotides by functionalized multiwalled carbon nanotubes Nano Lett. 7 2976-80 (Pubitemid 350132915)
87. Lam R, Chen M, Pierstorff E, Huang H, Osawa E and Ho D 2008 Nanodiamond-embedded microfilm devices for localized chemotherapeutic elution ACS Nano 2 2095-102
88. Kim T W, Chung P W, Slowing I I, Tsunoda M, Yeung E S and Lin V S 2008 Structurally ordered mesoporous carbon nanoparticles as transmembrane delivery vehicle in human cancer cells Nano Lett. 8 3724-27
89. Bhirde A A, Patel V, Gavard J, Zhang G, Sousa A A, M A., Leapman R D, Weigert R, Gutkind J S and Rusling J F 2009 Targeted killing of cancer cells in Vivo and in Vitro with EGF ACS Nano 3 307-16
90. Kroto H W, Heath J R, O'Briem S C, Curl R F and Smalley R E 1985 C-60: Buckminsterfullerene Nature 318 162-63
91. Iijima S 1991 HELICAL Microtubules of graphitic carbon Nature 354 56-8 (Pubitemid 21896780)
92. Baughman R H, Zakhidov A A and de Heer W A 2002 Carbon nanotubes - the route toward applications Science 297 787-92 (Pubitemid 34845917)
93. Geim A K and Novoselov K S 2007 the rise of graphene Nature Mater. 6 183-91 (Pubitemid 46353764)
94. Zhang Y, Nayak T R, Hong H and Cai W 2012 Graphene: a versatile nanoplatform for biomedical applications Nanoscale 4 3833-42
95. Yang K, Feng L, Shi X and Liu Z 2013 Nano-graphene in biomedicine: theranostic applications Chem. Soc. Rev. 42 530-47
96. Xu X, Ray R, Gu Y, Ploehn H J, Gearheart L, Raker K and Scrivens W A 2004 Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments J. Am. Chem. Soc. 126 12736-7 (Pubitemid 39372278)
97. Liu H, Ye T and Mao C 2007 Fluorescent carbon nanoparticles derived from candle soot Angew. Chem. Int. Edn Engl. 46 6473-5 (Pubitemid 47340175)
98. Ray S C, Saha A, Jana N R and Sarkar R 2009 Fluorescent carbon nanoparticles: synthesis, characterization, and bioimaging application J. Phys. Chem. C 113 18546-51
99. Kam N W S, Liu Z A and Dai H J 2006 Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway Angew. Chem. Int. Edn. Engl. 45 577-81 (Pubitemid 43121447)
100. Katz E and Willner I 2004 Biomolecule-functionalized carbon nanotubes: applications in nanobioelectronics ChemPhysChem 5 1084-104
101. Friebel M and Meinke M 2005 Determination of the complex refractive index of highly concentrated hemoglobin solutions using transmittance and reflectance measurements J. Biomed. opt. 10 064019 (Pubitemid 44255972)
102. Shi D, Guo Y, Dong Z, Lian J, Wang W, Liu G, Wang L and Ewing R C 2007 Quantum-dot-activated luminescent carbon nanotubes via a nano scale surface functionalization for in vivo imaging Adv. Mater. 19 4033-7 (Pubitemid 350190459)
103. Welsher K, Liu Z, Daraciang D and Dai H 2008 Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules Nano Lett. 8 586-90 (Pubitemid 351346022)
104. de la Zerda A, Liu Z, Bodapati S, Teed R, Vaithilingam S, Khuri-Yakub B T, Chen X, Dai H and Gambhir S S 2010 Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice Nano Lett. 10 2168-72
105. Guo Y et al 2008 In vivo imaging and drug storage by quantum-dot- conjugated carbon nanotubes Adv. Funct. Mater. 18 2489-97
106. Hartman K B, Laus S, Bolskar R D, Muthupollai R, Helm L, Toth E, Mebrach A E and Wilson L J 2008 Gadonanotubes as ultrasensitive pH-smart probes for magnetic resonance imaging Nano Lett. 8 415-19 (Pubitemid 351345992)
107. Heister E, Neves V, Tîlmaciu C, Lipert K, Beltrán V S, Coley H M, Silva S R P and McFadden J 2009 Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy Carbon 47 2152-60
108. Chen J, Chen S, Zhao X, Kuznetsova L V, Wong S S and Ojima L 2008 Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery J. Am. Chem. Soc. 130 16778-85
109. Dhar S, Liu Z, Thomale J, Dai H and Lippard S J 2008 Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device J. Am. Chem. Soc. 130 11467-76
110. Liu Z, Sun X, Ratchford N N and Dai H 2007 Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery ACS Nano 1 50-6
111. Li R, Wu R, Zhao L, Wu M, Yang L and Zou H 2010 P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells ACS Nano 4 1399-408
112. Ghosh S, Dutta S, Gnomes E, Carroll D, Jr R D, Olson J, Guthold M and Gmeiner W H 2009 Increased heating efficiency and selective thermal ablation of malignant tissue with dna-encased multiwalled carbon nanotubes ACS Nano 3 2667-73
113. Moon H K, Lee S H and Choi H C 2009 In vivo near-infrared mediated tumor destruction by photothermal effect of carbon nanotubes ACS Nano 3 3707-13
114. Chakravarty P, Marches R, Zimmerman N S, Swafford A D, Bajaj P, Musselman I H, Pantano P, Draper R K and Vitetta E S 2008 Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes Proc. Natl Acad. Sci. USA 105 8697-702 (Pubitemid 351987743)
115. Carlson L J and Krauss T D 2008 Photophysics of individual single-walled carbon nanotubes Acc. Chem. Res. 41 235-43
116. Robinson J T, Welsher K, Tabakman S M, Sherlock S P, Wang H, Luong R and Dai H 2010 High performance in vivo near-IR (> 1 mum) imaging and photothermal cancer therapy with carbon nanotubes Nano Research 3 779-93
117. Zhou F, Xing D, Ou Z, Wu B, Resasco D E and Chen W R 2009 Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes J. Biomed. Opt. 14 021009
118. Klingeler R, Hampel S and Buchner B 2008 Carbon nanotube based biomedical agents for heating, temperature sensoring and drug delivery Int. J. Hyperth. 24 496-505
119. Hatakeyama H, Akita H, Kogure K, Oishi M, Nagasaki Y, Kihira Y, Ueno M, Kobayashi H, Kikuchi H and Harashima H 2007 Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid Gene Ther. 14 68-77 (Pubitemid 44942867)
120. Morille M, Passirani C, Vonarbourg A, Clavreul A and Benoit J P 2008 Progress in developing cationic vectors for non-viral systemic gene therapy against cancer Biomaterials 29 3477-96
121. Waehler R, Russell S J and Curiel D T 2007 Engineering targeted viral vectors for gene therapy Nature Rev. Genetics 8 573-87 (Pubitemid 47077278)
122. Ferrer-Miralles N, Vazquez E and Villaverde A 2008 Membrane-active peptides for non-viral gene therapy: making the safest easier Trends Biotechnol. 26 267-75
123. Dass C R and Choong P F 2006 Selective gene delivery for cancer therapy using cationic liposomes: in vivo proof of applicability J. Control. Release 113 155-63 (Pubitemid 43928149)
124. Herrero M A, Toma F M, Al-jamal K T, Kosrarelos K, Bianco A, Ros T D, Bano F, Casalis L, Scoles G and Prato M 2009 Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery J. Am. Chem. Soc. 131 9843-48
125. 4 nanoparticles hybrid for controlled targeted drug carriers J. Mater. Chem. 19 2710
126. Lu C H, Zhu C L, Li J, Liu J J, Chen X and Yang H H 2010 Using graphene to protect DNA from cleavage during cellular delivery Chem. Commun. (Camb.) 46 3116-8
127. Markovic Z M, Harhaji-Trajkovic L M, Todorovic-Markovic B M, Kepic D P, Arsikin K M, Jovanovic S P, Pantovic A C, Dramicanin M D and Trajkovic V S 2011 In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes Biomaterials 32 1121-9
128. Robinson J T, Tabakman S M, Liang Y, Wang H, Casalongue H S, Vinh D and Dai H 2011 Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy J. Am. Chem. Soc. 133 6825-31
129. Yang X, Wang Y, Huang X, Ma Y, Huang Y, Yang R, Duan H and Chen Y 2011 Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity J. Mater. Chem. 21 3448
130. Bottini M, Balasubramanian C, Dawson M I, Bergamaschi A, Bellucci S and Mustelin T 2006 Isolation and characterization of fluorescent nanoparticles from pristine and oxidized electric arc-produced single-walled carbon nanotubes J. Phys. Chem. B 110 831-6 (Pubitemid 43164704)
131. Fang Y, Guo S, Li D, Zhu C, Ren W, Dong S and Wang E 2012 Easy synthesis and imaging applications of cross-linked green fluorescent hollow carbon nanoparticles ACS Nano 6 400-9
132. Sun Y P et al 2006 Quantum-sized carbon dots for bright and colorful photoluminescence J. Am. Chem. Soc. 128 7756-7 (Pubitemid 43945716)
133. Huang H, Pierstorff E, Osawa E and Ho D 2007 Active nanodiamond hydrogels for chemotherapeutic delivery Nano Lett. 7 3305-14 (Pubitemid 350216021)
134. Chen M, Pierstorff E D, Lam R, Li S Y, Huang H, Osawa E and Ho D 2009 Nanodiamond-mediated delivery of water-insoluble therapeutics ACS Nano 3 2016-22
135. Zhang X Q, Chen M, Lam R, Xu X, Osawa E and Ho D 2009 Polymer-functionalized nanodiamond platforms as vehicles for gene delivery ACS Nano 3 2609-16
136. Zhao Q-L, Zhang Z-L, Huang B-H, Peng J, Zhang M and Pang D-W 2008 Facile preparation of low cytotoxicity fluorescent carbon nanocrystals by electrooxidation of graphite Chem. Commun. (Camb.) 5116-8
137. Zhang S, He Q, Li R, Wang Q, Hu Z, Liu X and Chang X 2011 Study on the fluorescence carbon nanoparticles Mater. Lett. 65 2371-3
138. Lu W, Qin X, Liu S, Chang G, Zhang Y, Luo Y, Asiri A M, Al-Youbi A O and Sun X 2012 Economical, green synthesis of fluorescent carbon nanoparticles and their use as probes for sensitive and selective detection of mercury(II) ions Anal. Chem. 84 5351-7
139. Mroz P, Pawlak A, Satti M, Lee H, Wharton T, Gali H, Sarna T and Hamblin M R 2007 Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism Free Rad. Biol. Med. 43 711-9 (Pubitemid 47102125)
140. Shanbhag P P, Jog S V, Chogale M M and Gaikwad S S 2013 Theranostics for cancer therapy Curr. Drug. Deliv. 10 357-62
141. Povoski S P, Hatzaras I S, Mojzisik C M and Martin E W Jr. 2011 Oncologic theranostics: recognition of this concept in antigen-directed cancer therapy for colorectal cancer with anti-TAG-72 monoclonal antibodies Expert Rev. Mol. Diagn. 11 667-70
142. Omidi Y 2011 Smart multifunctional theranostics: simultaneous diagnosis and therapy of cancer Bioimpacts 1 145-7
143. Chen W, Xu N, Xu L, Wang L, Li Z, Ma W, Zhu Y, Xu C and Kotov N A 2010 Multifunctional magnetoplasmonic nanoparticle assemblies for cancer therapy and diagnostics (theranostics) Macromol. Rapid Commun. 31 228-36
144. Bangham A D, Standish M M and Watkins J C 1965 Diffusion of univalent ions across the lamellae of swollen phospholipids J. Mol. Biol. 13 238-52
145. Torchilin V 2009 Multifunctional and stimuli-sensitive pharmaceutical nanocarriers Eur. J. Pharm. Biopharm. 71 431-44
146. Langer R and Folkman J 1976 Polymers for the sustained release of proteins and other macromolecules Nature 263 797-800
147. Harries M, Ellis P and Harper P 2005 Nanoparticle albumin-bound paclitaxel for metastatic breast cancer J. Clin. Oncol. 23 7768-71 (Pubitemid 46657369)
148. Khoee S and Rahmatolahzadeh R 2012 Synthesis and characterization of pH-responsive and folated nanoparticles based on self-assembled brush-like PLGA/PEG/AEMA copolymer with targeted cancer therapy properties: a comprehensive kinetic study Eur. J. Med. Chem. 50 416-27
149. Astete C E and Sabliov C M 2006 Synthesis and characterization of PLGA nanoparticles J. Biomater. Sci. Polym. Ed. 17 247-89 (Pubitemid 47279194)
150. Klibanov A L, Maruyama K, Torchilin V P and Huang L 1990 Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes FEBS Lett. 268 235-7 (Pubitemid 20233874)
151. Papahadjopoulos D et al 1991 Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy Proc. Natl Acad. Sci. USA 88 11460-4 (Pubitemid 21916061)
152. Liu Z, Robinson J T, Sun X and Dai H 2008 PEGylated nanographene oxide for delivery of water-insoluble cancer drugs J. Am. Chem. Soc. 130 10876-77
153. Buning H 2013 Gene therapy enters the pharma market: the short story of a long journey EMBO Mol. Med. 5 1-3
154. Wen Y, Pan S, Luo X, Zhang X, Zhang W and Feng M 2009 A biodegradable low molecular weight polyethylenimine derivative as low toxicity and efficient gene vector Bioconjug. Chem. 20 322-32
155. Cavazzana-Calvo M et al 2000 Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease Science 288 669-72 (Pubitemid 30241569)
156. Thomas C E, Ehrhardt A and Kay M A 2003 Progress and problems with the use of viral vectors for gene therapy Nature Rev. Genetics 4 346-58 (Pubitemid 36538359)
157. Farokhzad O C and Langer R 2006 Nanomedicine: developing smarter therapeutic and diagnostic modalities Adv. Drug. Deliv. Rev. 58 1456-9 (Pubitemid 44820502)
158. Anderson D G, Peng W, Akinc A, Hossain N, Kohn A, Padera R, Langer R and Sawicki J A 2004 A polymer library approach to suicide gene therapy for cancer Proc. Natl Acad. Sci. USA 101 16028-33 (Pubitemid 39507921)
159. Maurer-Jones M A and Haynes C L 2012 Toward correlation in in vivo and in vitro nanotoxicology studies J. Law Med. Ethics 40 795-801
160. Maurer-Jones M A, Bantz K C, Love S A, Marquis B J and Haynes C L 2009 Toxicity of therapeutic nanoparticles Nanomedicine 4 219-41
161. Slowing, II, Wu C W, Vivero-Escoto J L and Lin V S 2009 Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells Small 5 57-62
162. Lin Y S and Haynes C L 2009 Synthesis and characterization of biocompatible and size-tunable multifunctional porous silica nanoparticles Chem. Mater. 21 3979-86
163. Ji S R, Liu C, Zhang B, Yang F, Xu J, Long J, Jin C, Fu D L, Ni Q X and Yu X J 2010 Carbon nanotubes in cancer diagnosis and therapy Biochim. Biophys. Acta. 1806 29-35
164. Han S-o, Mahato R I and Kim S W 2001 Water-soluble lipopolymer for gene delivery Bioconjug. Chem. 12 337-45 (Pubitemid 32464179)
165. De la Zerda A et al 2008 Carbon nanotubes as photoacoustic molecular imaging agents in living mie Nature Nanotechnol. 3 557-62
166. Zavaleta C, Zerda A D L, Liu S, Keren S, Cheng Z, Schipper M, Chen X, Dai H and Gambhir S S 2008 Noninvasive raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes Nano Lett. 8 2800-05
167. Shi X, Wang S H, Shen M, Antwerp M E, Chen X, Li C, Petersen E J, Huang Q, Weber W J Jr and Baker J R Jr 2009 Multifunctional dendrimer-modified multiwalled carbon nanotubes synthesis, characterization and in vitro cancer cell targeting and imaging Biomacromolecules 10 1744-50
168. Wu W, Li R, Bian X, Zhu Z, Ding D, Li X, Jia Z, Jiang X and Hu Y 2009 Covalently combining carbon nanotubes with anticancer agent preparation and antitumor activity ACS Nano 3 2740-50
169. Zhang X, Meng L, Lu Q, Fei Z and Dyson P J 2009 Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes Biomaterials 30 6041-7
170. Liu Z, Fan A C, Rakhra K, Sherlock S, Goodwin A, Chen X, Yang Q, Felsher D W and Dai H 2009 Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy Angew. Chem. Int. Edn. Engl. 48 7668-72
171. Feazell R P, Ratchford N N, Dai H and Lippard S J 2007 Soluble single-walled carbon nanotubes as longboat delivery systems for platinum (IV) anticancer drug design J. Am. Chem. Soc. 129 8438-39 (Pubitemid 47066504)
172. Ali-Boucetta H, Al-Jamal K T, McCarthy D, Prato M, Bianco A and Kostarelos K 2008 Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics Chem. Commun. (Camb.) 459-61
173. Kim J W, Shashkov E V, Galanzha E I, Kotagiri N and Zharov V P 2007 Photothermal antimicrobial nanotherapy and nanodiagnostics with self-assembling carbon nanotube clusters Lasers Surg. Med. 39 622-34 (Pubitemid 47505214)
174. Gannon C J et al 2007 Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field Cancer 110 2654-65 (Pubitemid 350250334)