The impact of low triiodothyronine levels on mortality is mediated by malnutrition and cardiac dysfunction in incident hemodialysis patients

European Journal of Endocrinology

Volumn 169, Issue 4, 2013, Pages 409-419

  Koo, Hyang Mo ^a   Kim, Chan Ho ^a   Doh, Fa Mee ^a   Lee, Mi Jung ^a   Kim, Eun Jin ^a   Han, Jae Hyun ^a   Han, Ji Suk ^a   Oh, Hyung Jung ^a   Han, Seung Hyeok ^a   Yoo, Tae Hyun ^a   Kang, Shin Wook ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALBUMIN; ANGIOTENSIN ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BICARBONATE; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CHOLESTEROL; CLOPIDOGREL; ERYTHROPOIETIN; GLUCOSE; HEMOGLOBIN; LIOTHYRONINE; PHOSPHORUS; RENIN INHIBITOR; THYROTROPIN; TRIACYLGLYCEROL; URIC ACID; VITAMIN D;

ADULT; ALL CAUSE MORTALITY; ARTICLE; BLOOD LEVEL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ESTIMATED GLOMERULUS FILTRATION RATE; FEMALE; GLOMERULUS FILTRATION RATE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE MASS; HEMODIALYSIS PATIENT; HUMAN; HYPERTENSION; INFECTION RELATED MORTALITY; INFLAMMATION; KIDNEY FAILURE; KOREA; LEAN BODY MASS ESTIMATED BY CREATININE KINETICS; LEUKOCYTE COUNT; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; METABOLIC ACIDOSIS; MORTALITY; NORMALIZED PROTEIN CATABOLIC RATE; NUTRITIONAL PARAMETERS; NUTRITIONAL STATUS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SUBJECTIVE GLOBAL ASSESSMENT SCORE; SURVIVAL RATE; THYROID FUNCTION TEST;

ADULT; AGED; ECHOCARDIOGRAPHY; FEMALE; HEART DISEASES; HUMANS; INCIDENCE; INFLAMMATION; KAPLAN-MEIER ESTIMATE; KIDNEY FAILURE, CHRONIC; MALE; MALNUTRITION; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RENAL DIALYSIS; TRIIODOTHYRONINE;

EID: 84884888984     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0540     Document Type: Article

References (36)

1. Iglesias P & Diez JJ. Thyroid dysfunction and kidney disease. European Journal of Endocrinology 2009 160 503-515. (doi:10.1530/EJE-08-0837)
2. den Hollander JG, Wulkan RW, Mantel MJ & Berghout A. Correlation between severity of thyroid dysfunction and renal function. Clinical Endocrinology 2005 62 423-427. (doi:10.1111/j.1365-2265.2005.02236.x)
3. Shin DH, Lee MJ, Kim SJ, Oh HJ, Kim HR, Han JH, Koo HM, Doh FM, Park JT, Han SH et al. Preservation of renal function by thyroid hormone replacement therapy in chronic kidney disease patients with subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2012 97 2732-2740. (doi:10.1210/jc.2012-1663)
4. van Hoek I & Daminet S. Interactions between thyroid and kidney function in pathological conditions of these organ systems: a review. General and Comparative Endocrinology 2009 160 205-215. (doi:10.1016/j.ygcen.2008.12. 008)
5. Song SH, Kwak IS, Lee DW, Kang YH, Seong EY & Park JS. The prevalence of low triiodothyronine according to the stage of chronic kidney disease in subjects with a normal thyroidstimulating hormone. Nephrology, Dialysis, Transplantation 2009 24 1534-1538. (doi:10.1093/ndt/gfn682)
6. Ozen KP, Asci G, Gungor O, Carrero JJ, Kircelli F, Tatar E, Sevinc Ok E, Ozkahya M, Toz H, CiritMet al. Nutritional state alters the association between free triiodothyronine levels and mortality in hemodialysis patients. American Journal of Nephrology 2011 33 305-312. (doi:10.1159/000324883)
7. Chopra IJ. Nonthyroidal illness syndrome or euthyroid sick syndrome? Endocrine Practice 1996 2 45-52. (doi:10.4158/EP.2.1.45)
8. Wiederkehr MR, Kalogiros J & Krapf R. Correction of metabolic acidosis improves thyroid and growth hormone axes in haemodialysis patients. Nephrology, Dialysis, Transplantation 2004 19 1190-1197. (doi:10.1093/ndt/ gfh096) (Pubitemid 38628140)
9. Zoccali C, Tripepi G, Cutrupi S, Pizzini P & Mallamaci F. Low triiodothyronine: a new facet of inflammation in end-stage renal disease. Journal of the American Society of Nephrology 2005 16 2789-2795. (doi:10.1681/ASN.2005040356)
10. Malyszko J, Malyszko JS, Pawlak K & Mysliwiec M. Thyroid function, endothelium, and inflammation in hemodialyzed patients: possible relations? Journal of Renal Nutrition 2007 17 30-37. (doi:10.1053/j.jrn.2006.07.003) (Pubitemid 46014447)
11. Yilmaz MI, Sonmez A, Karaman M, Ay SA, Saglam M, Yaman H, Kilic S, Eyileten T, Caglar K, Oguz Y et al. Low triiodothyronine alters flow-mediated vasodilatation in advanced nondiabetic kidney disease. American Journal of Nephrology 2011 33 25-32. (doi:10.1159/000322581)
12. Zoccali C, Benedetto F, Mallamaci F, Tripepi G, Cutrupi S, Pizzini P, Malatino LS, Bonanno G & Seminara G. Low triiodothyronine and cardiomyopathy in patients with end-stage renal disease. Journal of Hypertension 2006 24 2039-2046. (doi:10.1097/01. hjh.0000244954.62362.8f) (Pubitemid 44270929)
13. Kozdag G, Ural D, Vural A, Agacdiken A, Kahraman G, Sahin T, Ural E & Komsuoglu B. Relation between free triiodothyronine/free thyroxine ratio, echocardiographic parameters and mortality in dilated cardiomyopathy. European Journal of Heart Failure 2005 7 113-118. (doi:10.1016/j.ejheart.2004.04.016) (Pubitemid 40092502)
14. Pingitore A, Landi P, Taddei MC, Ripoli A, L'Abbate A & Iervasi G. Triiodothyronine levels for risk stratification of patients with chronic heart failure. American Journal of Medicine 2005 118 132-136. (doi:10.1016/j.amjmed. 2004.07.052) (Pubitemid 40202859)
15. Scoscia E, Baglioni S, Eslami A, Iervasi G, Monti S & Todisco T. Low triiodothyronine (T3) state: a predictor of outcome in respiratory failure? Results of a clinical pilot study. European Journal of Endocrinology 2004 151 557-560. (doi:10.1530/eje.0.1510557) (Pubitemid 39562509)
16. Malik R & Hodgson H. The relationship between the thyroid gland and the liver. QJM: Monthly Journal of the Association of Physicians 2002 95 559-569. (doi:10.1093/qjmed/95.9.559)
17. Zoccali C, Mallamaci F, Tripepi G, Cutrupi S & Pizzini P. Low triiodothyronine and survival in end-stage renal disease. Kidney International 2006 70 523-528. (doi:10.1038/sj.ki.5001566) (Pubitemid 44144206)
18. Enia G, Panuccio V, Cutrupi S, Pizzini P, Tripepi G, Mallamaci F & Zoccali C. Subclinical hypothyroidism is linked to micro-inflammation and predicts death in continuous ambulatory peritoneal dialysis. Nephrology, Dialysis, Transplantation 2007 22 538-544. (doi:10.1093/ndt/gfl605) (Pubitemid 46189899)
19. Rotondi M, Netti GS, Rosati A, Mazzinghi B, Magri F, Ronconi E, Becherucci F, Pradella F, Salvadori M, Serio M et al. Pretransplant serum FT3 levels in kidney graft recipients are useful for identifying patients with higher risk for graft failure. Clinical Endocrinology 2008 68 220-225. (doi:10.1111/j.1365-2265. 2007.03022.x)
20. Squire CR. Methods for the investigation of thyroid function. Methods in Molecular Biology 2006 324 91-108. (doi:10.1385/1-59259-986-9-91)
21. Kilinc AS, Duzoylum A, Uncugil CF & Yucel D. Falsely increased free triiodothyronine in sera stored in serum separator tubes. Clinical Chemistry 2002 48 2296-2297. (Pubitemid 35397584)
22. Stevenson HP, Archbold GP, Johnston P, Young IS & Sheridan B. Misleading serum free thyroxine results during low molecular weight heparin treatment. Clinical Chemistry 1998 44 1002-1007. (Pubitemid 28213140)
23. Michels WM, Grootendorst DC, Verduijn M, Elliott EG, Dekker FW & Krediet RT. Performance of the Cockcroft-Gault, MDRD, and new CKD-EPI formulas in relation to GFR, age, and body size. Clinical Journal of the American Society of Nephrology 2010 5 1003-1009. (doi:10.2215/CJN.06870909)
24. Steiber AL, Kalantar-Zadeh K, Secker D, McCarthy M, Sehgal A & McCann L. Subjective Global Assessment in chronic kidney disease: a review. Journal of Renal Nutrition 2004 14 191-200. (Pubitemid 39360974)
25. Noori N, Kovesdy CP, Bross R, Lee M, Oreopoulos A, Benner D, Mehrotra R, Kopple JD & Kalantar-Zadeh K. Novel equations to estimate lean body mass in maintenance hemodialysis patients. American Journal of Kidney Diseases 2011 57 130-139. (doi:10.1053/j.ajkd.2010.10.003)
26. Jindal KK & Goldstein MB. Urea kinetic modelling in chronic hemodialysis: benefits, problems, and practical solutions. Seminars in Dialysis1988182-85. (doi:10.1111/j.1525-139X.1988.tb00710.x)
27. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I & Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. American Journal of Cardiology 1986 57 450-458. (doi:10.1016/0002-9149(86) 90771-X) (Pubitemid 16119719)
28. Klein I & Ojamaa K. Thyroid hormone and the cardiovascular system. New England Journal of Medicine 2001 344 501-509. (doi:10.1056/ NEJM200105103441901) (Pubitemid 32164903)
29. Klein I & Danzi S. Thyroid disease and the heart. Circulation 2007 116 1725-1735. (doi:10.1161/CIRCULATIONAHA.106.678326) (Pubitemid 47537847)
30. Tatar E, Kircelli F, Asci G, Carrero JJ, Gungor O, Demirci MS, Ozbek SS, Ceylan N, Ozkahya M, Toz H et al. Associations of triiodothyronine levels with carotid atherosclerosis and arterial stiffness in hemodialysis patients. Clinical Journal of the American Society of Nephrology 2011 6 2240-2246. (doi:10.2215/CJN.02540311)
31. Carrero JJ, Qureshi AR, Axelsson J, Yilmaz MI, Rehnmark S, Witt MR, Barany P, Heimburger O, Suliman ME, Alvestrand A et al. Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease. Journal of Internal Medicine 2007 262 690-701. (doi:10.1111/j.1365-2796.2007.01865.x) (Pubitemid 350135193)
32. Meuwese CL, Dekker FW, Lindholm B, Qureshi AR, Heimburger O, Barany P, Stenvinkel P & Carrero JJ. Baseline levels and trimestral variation of triiodothyronine and thyroxine and their association with mortality in maintenance hemodialysis patients. Clinical Journal of the American Society of Nephrology 2012 7 131-138. (doi:10.2215/CJN.05250511)
33. Jaume JC, Mendel CM, Frost PH, Greenspan FS & Laughton CW. Extremely low doses of heparin release lipase activity into the plasma and can thereby cause artifactual elevations in the serumfree thyroxine concentration as measured by equilibrium dialysis. Thyroid 1996 6 79-83. (doi:10.1089/thy.1996.6. 79) (Pubitemid 26153003)
34. Schiffrin EL, Lipman ML & Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation 2007 116 85-97. (doi:10.1161/ CIRCULATIONAHA.106.678342) (Pubitemid 47016250)
35. Covic A, Mardare NG, Ardeleanu S, Prisada O, Gusbeth-Tatomir P & Goldsmith DJ. Serial echocardiographic changes in patients on hemodialysis: an evaluation of guideline implementation. Journal of Nephrology 2006 19 783-793. (Pubitemid 46415985)
36. Foley RN, Parfrey PS, Kent GM, Harnett JD, Murray DC & Barre PE (Pubitemid 30241725)