Nutritional state alters the association between free triiodothyronine levels and mortality in hemodialysis patients

American Journal of Nephrology

Volumn 33, Issue 4, 2011, Pages 305-312

  Ozen, Kezban Pinar ^a   Asci, Gulay ^b   Gungor, Ozkan ^b   Carrero, Juan Jesus ^c   Kircelli, Fatih ^b   Tatar, Erhan ^b   Sevinc Ok, Ebru ^b   Ozkahya, Mehmet ^b   Toz, Huseyin ^b   Cirit, Mustafa ^a   Basci, Ali ^b   Ok, Ercan ^b  

^a ATATURK TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b EGE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Free triiodothyronine; Hemodialysis; Low T3 syndrome; Survival

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; LIOTHYRONINE; THYROTROPIN;

ADULT; ARTICLE; BLOOD SAMPLING; DISEASE ASSOCIATION; ENZYME IMMUNOASSAY; FEMALE; FOLLOW UP; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; LOW T3 SYNDROME; MAJOR CLINICAL STUDY; MALE; MORTALITY; NUTRITIONAL STATUS; PRIORITY JOURNAL; THYROID DISEASE; THYROTROPIN BLOOD LEVEL;

AGED; COHORT STUDIES; COMORBIDITY; EUTHYROID SICK SYNDROMES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; NUTRITIONAL STATUS; PROPORTIONAL HAZARDS MODELS; RENAL DIALYSIS; RISK FACTORS; THYROTROPIN; TRIIODOTHYRONINE;

EID: 79952320636     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000324883     Document Type: Article

References (28)

1. Iglesias P, Díez JJ: Thyroid dysfunction and kidney disease. Eur J Endocrinol 2009; 160: 503-515.
2. Amato AA, Santos GM, Neves Fde A: Thyroid hormone action in chronic kidney disease. Curr Opin Endocrinol Diabetes Obes 2008; 15: 459-465.
3. Lo JC, Chertow GM, Go AS, Hsu CY: Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease. Kidney Int 2005; 67: 1047-1052.
4. Chonchol M, Lippi G, Salvagno G, Zoppini G, Muggeo M, Targher G: Prevalence of subclinical hypothyroidism in patients with chronic kidney disease. Clin J Am Soc Nephrol 2008; 3: 1296-1300.
5. Song SH, Kwak IS, Lee DW, Kang YH, Seong EY, Park JS: The prevalence of low triiodothyronine according to the stage of chronic kidney disease in subjects with a normal thyroid- stimulating hormone. Nephrol Dial Transplant 2009; 24: 1534-1538.
6. Iervasi G, Pingitore A, Landi P, Raciti M, Ripoli A, Scarlattini M, L'Abbate A, Donato L: Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease. Circulation 2003; 107: 708-713.
7. Iervasi G, Molinaro S, Landi P, Taddei MC, Galli E, Mariani F, L'Abbate A, Pingitore A: Association between increased mortality and mild thyroid dysfunction in cardiac patients. Arch Intern Med 2007; 167: 1526-1532.
8. Zoccali C, Tripepi G, Cutrupi S, Pizzini P, Mallamaci F: Low triiodothyronine: a new facet of inflammation in end-stage renal disease. J Am Soc Nephrol 2005; 16: 2789-2795.
9. Zoccali C, Mallamaci F, Tripepi G, Cutrupi S, Pizzini P: Low triiodothyronine and survival in end-stage renal disease. Kidney Int 2006; 70: 523-528.
10. Enia G, Panuccio V, Cutrupi S, Pizzini P, Tripepi G, Mallamaci F, Zoccali C: Subclinical hypothyroidism is linked to micro-inflammation and predicts death in continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant 2007; 22: 538-544.
11. Zoccali C, Benedetto F, Mallamaci F, Tripepi G, Cutrupi S, Pizzini P, Malatino LS, Bonanno G, Seminara G: Low triiodothyronine and cardiomyopathy in patients with endstage renal disease. J Hypertens 2006; 24:2039-2046.
12. Kang EW, Nam JY, Yoo TH, Shin SK, Kang SW, Han DS, Han SH: Clinical implications of subclinical hypothyroidism in continuous ambulatory peritoneal dialysis patients. Am J Nephrol 2008; 28: 908-913.
13. Fernández-Reyes MJ, Diez JJ, Collado A, Iglesias P, Bajo MA, Estrada P, Del Peso G, Heras M, Molina A, Selgas R: Are low concentrations of serum triiodothyronine a good marker for long-term mortality in hemodialysis patients? Clin Nephrol 2010; 73: 238-240.
14. Carrero JJ, Qureshi AR, Axelsson J, Yilmaz MI, Rehnmark S, Witt MR, Bárány P, Heimbürger O, Suliman ME, Alvestrand A, Lindholm B, Stenvinkel P: Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease. J Intern Med 2007; 262: 690-702.
15. De Groot LJ: Dangerous dogmas in medicine: the nonthyroidal illness syndrome. J Clin Endocrinol Metab 1999; 84: 151-164.
16. Song SH, Kwak IS, Lee DW, Kang YH, Seong EY, Park JS: The prevalence of low triiodothyronine according to the stage of chronic kidney disease in subjects with a normal thyroid- stimulating hormone. Nephrol Dial Transplant 2009; 24: 1534-1538.
17. Díez JJ, Iglesias P, Selgas R: Pituitary dysfunctions in uremic patients undergoing peritoneal dialysis: a cross sectional descriptive study. Adv Perit Dial 1995; 11: 218-224.
18. Wiederkehr MR, Kalogiros J, Krapf R: Correction of metabolic acidosis improves thyroid and growth hormone axes in haemodialysis patients. Nephrol Dial Transplant 2004; 19: 1190-1197.
19. Trivieri MG, Oudit GY, Sah R, Kerfant BG, Sun H, Gramolini AO, Pan Y, Wickenden AD, Croteau W, Morreale de Escobar G, Pekhletski R, St. Germain D, Maclennan DH, Backx PH: Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proc Natl Acad Sci USA 2006; 103: 6043-6048.
20. Bussemaker E, Popp R, Fisslthaler B, Larson CM, Fleming I, Busse R, Brandes RP: Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery. Cardiovasc Res 2003; 59: 181-188.
21. Vanhorebeek I, Langouche L, Van den Berghe G: Endocrine aspects of acute and prolonged critical illness. Nat Clin Pract Endocrinol Metab 2006; 2: 20-31.
22. Torpy DJ, Tsigos C, Lotsikas AJ, Defensor R, Chrousos GP, Papanicolaou DA: Acute and delayed effects of a single-dose injection of interleukin-6 on thyroid function in healthy humans. Metabolism 1998; 47: 1289-1293.
23. Boelen A, Kwakkel J, Wiersinga WM, Fliers E: Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake. J Endocrinol 2006; 191: 707-714.
24. de Mutsert R, Grootendorst DC, Axelsson J, Boeschoten EW, Krediet RT, Dekker FW, NECOSAD Study Group: Excess mortality due to interaction between protein-energy wasting, inflammation and cardiovascular disease in chronic dialysis patients. Nephrol Dial Transplant 2008; 23: 2957-2964.
25. Pecoits-Filho R, Lindholm B, Stenvinkel P: The malnutrition, inflammation, and atherosclerosis (MIA) syndrome - the heart of the matter. Nephrol Dial Transplant 2002; 17(suppl 11):28-31.
26. Carrero JJ, Stenvinkel P: Persistent inflammationas a catalyst for other risk factors in chronic kidney disease: a hypothesis proposal. Clin J Am Soc Nephrol 2009; 4(suppl 1):49-55.
27. Axelsson J, Qureshi AR, Divino-Filho JC, Bárány P, Heimbürger O, Lindholm B, Stenvinkel P: Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease? Eur J Clin Nutr 2006; 60: 718-726.
28. Chopra IJ: Simultaneous measurement of free thyroxine and free 3,5,3́ - triiodothyronine in undiluted serum by direct equilibrium dialysis/radioimmunoassay: evidence that free triiodothyronine and free thyroxine are normal in many patients with the low triiodothyronine syndrome. Thyroid 1998; 8: 249-257.