Low triiodothyronine alters flow-mediated vasodilatation in advanced nondiabetic kidney disease

American Journal of Nephrology

Volumn 33, Issue 1, 2011, Pages 25-32

  Yilmaz, Mahmut Ilker ^a   Sonmez, Alper ^a   Karaman, Murat ^a   Ay, Seyit Ahmet ^a   Saglam, Mutlu ^a   Yaman, Halil ^a   Kilic, Selim ^a   Eyileten, Tayfun ^a   Caglar, Kayser ^a   Oguz, Yusuf ^a   Vural, Abdulgaffar ^a   Yenicesu, Mujdat ^a   Zoccali, Carmine ^b  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b BIANCHI MELACRINO MORELLI HOSPITAL   (Italy)

Author keywords

Chronic kidney disease; Endothelial dysfunction; free; Triiodothyronine

Indexed keywords

HEMOGLOBIN; LIOTHYRONINE; N(G),N(G) DIMETHYLARGININE;

ADULT; ARTICLE; BLOOD FLOW; CHRONIC KIDNEY DISEASE; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; FEMALE; FLOW MEDIATED VASODILATATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; VASODILATATION;

ADULT; DIABETES MELLITUS; FEMALE; HUMANS; HYPOTHYROIDISM; INFLAMMATION; KIDNEY DISEASES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PRESSURE; REGRESSION ANALYSIS; RISK FACTORS; TRIIODOTHYRONINE; VASODILATION;

EID: 78649799030     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000322581     Document Type: Article

References (29)

1. Kaptein EM: Thyroid hormone metabolism and thyroid diseases in chronic renal failure. Endocr Rev 1996; 17: 45-63.
2. Chopra IJ, Chopra U, Smith SR, Reza M, Solomon DH: Reciprocal changes in serum concentrations of 3,3′ ,5-triiodothyronine (T 3 ) in systemic illnesses. J Clin Endocrinol Metab 1975; 41: 1043-1049.
3. Iervasi G, Pingitore A, Landi P, Raciti M, Ripoli A, Scarlattini M, L'Abbate A, Donato L: Low-T 3 syndrome: a strong prognostic predictor of death in patients with heart disease. Circulation 2003; 107: 708-713.
4. Kaptein EM, Weiner JM, Robinson WJ, Wheeler WS, Nicoloff JT: Relationship of altered thyroid hormone indices to survival in nonthyroidal illnesses. Clin Endocrinol (Oxf) 1982; 16: 565-574.
5. Scoscia E, Baglioni S, Eslami A, Iervasi G, Monti S, Todisco T: Low triiodothyronine (T 3 ) state: a predictor of outcome in respiratory failure? Results of a clinical pilot study. Eur J Endocrinol 2004; 151: 557-560.
6. Rink C, Siersleben U, Haerting J, Mende T, Nilius R: Development of the low-T 3 syndrome and prognosis assessment in patients with liver cirrhosis. Gastroenterol J 1991; 51: 138-141.
7. Zoccali C, Tripepi G, Cutrupi S, Pizzini P, Mallamaci F: Low triiodothyronine: a new facet of inflammation in end-stage renal disease. J Am Soc Nephrol 2005; 16: 2789-2795.
8. Zoccali C, Mallamaci F, Tripepi G, Cutrupi S, Pizzini P: Low triiodothyronine and survival in end-stage renal disease. Kidney Int 2006; 70: 523-528.
9. Carrero JJ, Qureshi AR, Axelsson J, Yilmaz MI, Rehnmark S, Witt MR, Bárány P, Heimbürger O, Suliman ME, Alvestrand A, Lindholm B, Stenvinkel P: Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease. J Intern Med 2007; 262: 690-701.
10. Zoccali C, Benedetto F, Mallamaci F, Tripepi G, Cutrupi S, Pizzini P, Malatino LS, Bonanno G, Seminara G: Low triiodothyronine and cardiomyopathy in patients with endstage renal disease. J Hypertens 2006; 24: 2039-2046. (Pubitemid 44376250)
11. Song SH, Kwak IS, Lee DW, Kang YH, Seong EY, Park JS: The prevalence of low triiodothyronine according to the stage of chronic kidney disease in subjects with a normal thyroid- stimulating hormone. Nephrol Dial Transplant 2009; 24: 1534-1538.
12. Napoli R, Guardasole V, Angelini V, Zarra E, Terracciano D, D'Anna C, Matarazzo M, Oliviero U, Macchia V, Saccà L: Acute effects of triiodothyronine on endothelial function in human subjects. J Clin Endocrinol Metab 2007; 92: 250-254.
13. Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, Ghiadoni L, Salvetti A, Ferrannini E, Monzani F: Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab 2003; 88: 3731-3737.
14. Napoli R, Guardasole V, Zarra E, D'Anna C, de Sena A, Lupoli GA, Oliviero U, Matarazzo M, Lupoli G, Saccà L: Impaired endothelialand nonendothelial-mediated vasodilation in patients with acute or chronic hypothyroidism. Clin Endocrinol (Oxf) 2010; 72: 107-111.
15. Yilmaz MI, Saglam M, Caglar K, Cakir E, Sonmez A, Ozgurtas T, Aydin A, Eyileten T, Ozcan O, Acikel C, Tasar M, Genctoy G, Erbil K, Vural A, Zoccali C: The determinants of endothelial dysfunction in CKD: oxidative stress and asymmetric dimethylarginine. Am J Kidney Dis 2006; 47: 42-50.
16. Yilmaz MI, Sonmez A, Saglam M, Gulec M, Kilic S, Eyileten T, Caglar K, Oguz Y, Vural A, Yenicesu M, Zoccali C: Hemoglobin is inversely related to flow-mediated dilatation in chronic kidney disease. Kidney Int 2009; 75: 1316-1321.
17. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D: A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461-470.
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and β -cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
19. Celermajer DS, Sørensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE: Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-1115.
20. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R: Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257-265.
21. Kleinbaum DG, Kupper LL, Muller KE, Nizam A: Applied Regression Analysis and Other Multivariable Methods. Pacific Grove, Duxbury, 1998, pp 388-390.
22. Zoccali C: The endothelium as a target in renal diseases. J Nephrol 2007; 20(suppl 12): S39-S44.
23. Zoccali C: Traditional and emerging cardiovascular and renal risk factors: an epidemiologic perspective. Kidney Int 2006; 70: 26-33.
24. Ravani P, Tripepi G, Malberti F, Testa S, Mallamaci F, Zoccali C: Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach. J Am Soc Nephrol 2005; 16: 2449-2455.
25. Zoccali C, Maio R, Tripepi G, Mallamaci F, Perticone F: Inflammation as a mediator of the link between mild to moderate renal insufficiency and endothelial dysfunction in essential hypertension. J Am Soc Nephrol 2006; 17(4 suppl 2):S64-S68.
26. Caglar K, Yilmaz MI, Saglam M, Cakir E, Kilic S, Sonmez A, Eyileten T, Yenicesu M, Oguz Y, Tasar M, Vural A, Ikizler TA, Stenvinkel P, Lindholm B: Serum fetuin-A concentration and endothelial dysfunction in chronic kidney disease. Nephron Clin Pract 2008; 108:c233-c240. (Pubitemid 351588118)
27. Arikan E, Karadag CH, Guldiken S: Asymmetric dimethylarginine levels in thyroid diseases. J Endocrinol Invest 2007; 30: 186-191.
28. Pingitore A, Galli E, Barison A, Iervasi A, Scarlattini M, Nucci D, L'Abbate A, Mariotti R, Iervasi G: Acute effects of triiodothyronine (T 3 ) replacement therapy in patients with chronic heart failure and low-T 3 syndrome: a randomized, placebo-controlled study. J Clin Endocrinol Metab 2008; 93: 1351-1358.
29. Bocanera LV, Krawiec L, Silberschmidt D, Pignataro O, Juvenal GJ, Pregliasco LB, Pisarev MA: Role of cyclic 3′ 5′ guanosine monophosphate and nitric oxide in the regulation of iodide uptake in calf thyroid cells. J Endocrinol 1997; 155: 451-457.