Alternative 5' Untranslated Regions Are Involved in Expression Regulation of Human Heme Oxygenase-1

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Kramer, Marcel ^a,b   Sponholz, Christoph ^a,b   Slaba, Monique ^a   Wissuwa, Bianka ^a   Claus, Ralf A ^a   Menzel, Uwe ^c   Huse, Klaus ^b   Platzer, Matthias ^b   Bauer, Michael ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; HEMIN; MICROSATELLITE DNA;

5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ARTICLE; CELL STRAIN HEPG2; EXON; GENE AMPLIFICATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; HMOX1 GENE; HUMAN; HUMAN CELL; LUCIFERASE REPORTER ASSAY; MICROSATELLITE MARKER; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUANTITATIVE GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSLATION REGULATION;

5' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; BASE SEQUENCE; EXONS; GENE EXPRESSION REGULATION; GENES, REPORTER; HEME OXYGENASE-1; HEMIN; HEP G2 CELLS; HUMANS; INTRONS; LUCIFERASES; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

EID: 84884869747     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077224     Document Type: Article

References (31)

1. Bauer I, Rensing H, Florax A, Ulrich C, Pistorius G, et al. (2003) Expression pattern and regulation of heme oxygenase-1/heat shock protein 32 in human liver cells. Shock 20: 116-122. doi:10.1097/01.shk.0000075568.93053.fa. PubMed: 12865654.
2. Scott JR, Chin BY, Bilban MH, Otterbein LE, (2007) Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic? Trends Pharmacol Sci 28: 200-205. doi:10.1016/j.tips.2007.03.006. PubMed: 17416426.
3. Bauer M, Huse K, Settmacher U, Claus RA, (2008) The heme oxygenase-carbon monoxide system: regulation and role in stress response and organ failure. Intensive Care Med 34: 640-648. doi:10.1007/s00134-008-1010-2. PubMed: 18286266.
4. Akamatsu Y, Haga M, Tyagi S, Yamashita K, Graça-Souza AV, et al. (2004) Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury. FASEB J 18: 771-772. PubMed: 14977880.
5. Blydt-Hansen TD, Katori M, Lassman C, Ke B, Coito AJ, et al. (2003) Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury. J Am Soc Nephrol 14: 745-754. doi:10.1097/01.ASN.0000050760.87113.25. PubMed: 12595512.
6. Bao W, Song F, Li X, Rong S, Yang W, et al. (2010) Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am J Epidemiol 172: 631-636. doi:10.1093/aje/kwq162. PubMed: 20682519.
7. Buis CI, van der Steege G, Visser DS, Nolte IM, Hepkema BG, et al. (2008) Heme oxygenase-1 genotype of the donor is associated with graft survival after liver transplantation. Am J Transplant 8: 377-385. doi:10.1111/j.1600-6143.2007.02048.x. PubMed: 18093274.
8. Exner M, Minar E, Wagner O, Schillinger M, (2004) The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med 37: 1097-1104. doi:10.1016/j.freeradbiomed.2004.07.008. PubMed: 15451051.
9. Sheu CC, Zhai R, Wang Z, Gong MN, Tejera P, et al. (2009) Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome. Intensive Care Med 35: 1343-1351. doi:10.1007/s00134-009-1504-6. PubMed: 19526221.
10. Sponholz C, Huse K, Kramer M, Giamarellos-Bourboulis EJ, Claus RA, et al. (2012) Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis. Shock 38: 459-465. doi:10.1097/SHK.0b013e31826ae951. PubMed: 23042203.
11. Kutty RK, Kutty G, Rodriguez IR, Chader GJ, Wiggert B, (1994) Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3. Genomics 20: 513-516. doi:10.1006/geno.1994.1213. PubMed: 8034330.
12. Shibahara S, Sato M, Muller RM, Yoshida T, (1989) Structural organization of the human heme oxygenase gene and the function of its promoter. Eur J Biochem 179: 557-563. doi:10.1111/j.1432-1033.1989.tb14583.x. PubMed: 2537723.
13. Tanaka G, Aminuddin F, Akhabir L, He JQ, Shumansky K, et al. (2011) Effect of heme oxygenase-1 polymorphisms on lung function and gene expression. BMC Med Genet 12: 117. doi:10.1186/1471-2350-12-117. PubMed: 21902835.
14. Hirai H, Kubo H, Yamaya M, Nakayama K, Numasaki M, et al. (2003) Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 102: 1619-1621. doi:10.1182/blood-2002-12-3733. PubMed: 12730098.
15. Doberer D, Haschemi A, Andreas M, Zapf TC, Clive B, et al. (2010) Haem arginate infusion stimulates haem oxygenase-1 expression in healthy subjects. Br J Pharmacol 161: 1751-1762. doi:10.1111/j.1476-5381.2010.00990.x. PubMed: 20718734.
16. Ono K, Goto Y, Takagi S, Baba S, Tago N, et al. (2004) A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese. Atherosclerosis 173: 315-319. PubMed: 15064108.
17. Yamada N, Yamaya M, Okinaga S, Nakayama K, Sekizawa K, et al. (2000) Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 66: 187-195. doi:10.1086/302729. PubMed: 10631150.
18. Nagasaki H, Arita M, Nishizawa T, Suwa M, Gotoh O, (2005) Species-specific variation of alternative splicing and transcriptional initiation in six eukaryotes. Gene 364: 53-62. doi:10.1016/j.gene.2005.07.027. PubMed: 16219431.
19. Rosenstiel P, Huse K, Franke A, Hampe J, Reichwald K, et al. (2007) Functional characterization of two novel 5' untranslated exons reveals a complex regulation of NOD2 protein expression. BMC Genomics 8: 472. doi:10.1186/1471-2164-8-472. PubMed: 18096043.
20. Wang G, Guo X, Floros J, (2005) Differences in the translation efficiency and mRNA stability mediated by 5'-UTR splice variants of human SP-A1 and SP-A2 genes. Am J Physiol Lung Cell Mol Physiol 289: L497-L508. doi:10.1152/ajplung.00100.2005. PubMed: 15894557.
21. Kwan T, Benovoy D, Dias C, Gurd S, Provencher C, et al. (2008) Genome-wide analysis of transcript isoform variation in humans. Nat Genet 40: 225-231. doi:10.1038/ng.2007.57. PubMed: 18193047.
22. Kramer M, Huse K, Menzel U, Backhaus O, Rosenstiel P, et al. (2011) Constant splice-isoform ratios in human lymphoblastoid cells support the concept of a splico-stat. Genetics 187: 761-770. doi:10.1534/genetics.110.125096. PubMed: 21220357.
23. Vesely MJ, Exon DJ, Clark JE, Foresti R, Green CJ, et al. (1998) Heme oxygenase-1 induction in skeletal muscle cells: hemin and sodium nitroprusside are regulators in vitro. Am J Physiol 275: C1087-C1094. PubMed: 9755062.
24. ENCODE Project Consortium (2011) A user's guide to the encyclopedia of DNA elements (ENCODE). PLOS Biol 9: e1001046. PubMed: 21526222.
25. Brosius J, (2005) Echoes from the past--are we still in an RNP world? Cytogenet Genome Res 110: 8-24. doi:10.1159/000084934. PubMed: 16093654.
26. Krull M, Petrusma M, Makalowski W, Brosius J, Schmitz J, (2007) Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Genome Res 17: 1139-1145. doi:10.1101/gr.6320607. PubMed: 17623809.
27. Reichard JF, Motz GT, Puga A, (2007) Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. Nucleic Acids Res 35: 7074-7086. doi:10.1093/nar/gkm638. PubMed: 17942419.
28. Euskirchen GM, Rozowsky JS, Wei CL, Lee WH, Zhang ZD, et al. (2007) Mapping of transcription factor binding regions in mammalian cells by ChIP: comparison of array- and sequencing-based technologies. Genome Res 17: 898-909. doi:10.1101/gr.5583007. PubMed: 17568005.
29. Naylor LH, Clark EM, (1990) d(TG)n.d(CA)n sequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription. Nucleic Acids Res 18: 1595-1601.
30. Resch AM, Ogurtsov AY, Rogozin IB, Shabalina SA, Koonin EV, (2009) Evolution of alternative and constitutive regions of mammalian 5'UTRs. BMC Genomics 10: 162. doi:10.1186/1471-2164-10-162. PubMed: 19371439.
31. Hughes TA, (2006) Regulation of gene expression by alternative untranslated regions. Trends Genet 22: 119-122. doi:10.1016/j.tig.2006.01.001. PubMed: 16430990.