Characterization of the Mechanism of Inhibin α-Subunit Gene in Mouse Anterior Pituitary Cells by RNA Interference

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Han, Li ^a   Wu, Canjie ^a   Riaz, Hasan ^a   Bai, Liya ^a   Chen, Jianguo ^a   Zhen, Yanhong ^a   Guo, Aizhen ^a   Yang, Liguo ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; ACTIVIN BETA; CASPASE 3; FOLLITROPIN; GONADORELIN RECEPTOR; INHIBIN ALPHA SUBUNIT PROTEIN; INHIBIN B; LUTEINIZING HORMONE; MESSENGER RNA; MYELOPID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; CASPASE 3 GENE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; ENZYME REGULATION; FEMALE; GENE; GENE SILENCING; HYPOPHYSIS CELL; INHA GENE; MOUSE; NONHUMAN; P53 GENE; PROTEIN EXPRESSION; RNA INTERFERENCE; RNA TRANSCRIPTION; RNA TRANSLATION; SIGNAL PROCESSING; TRANSCRIPTION REGULATION; UPREGULATION;

ACTIVINS; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL PROLIFERATION; FEMALE; FOLLICLE STIMULATING HORMONE; GENE EXPRESSION REGULATION; INHIBINS; LUTEINIZING HORMONE; MICE; PITUITARY GLAND, ANTERIOR; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, LHRH; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REPRODUCTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84884850933     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074596     Document Type: Article

References (38)

1. Welt C, Sidis Y, Keutmann H, Schneyer A, (2002) Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. ExpBiol Med 227: 724-52.
2. Forage RG, Ring JM, Brown RW, McInerney BV, Cobon GS, et al. (1986) Cloning and sequence analysis of cDNA species coding for the two subunits of inhibin from bovine follicular fluid. Proc Natl Acad Sci U S A 83: 3091-5.
3. Woodruff TK, Meunier H, Jones PB, Hsueh AJ, Mayo KE, (1987) Rat inhibin: molecular cloning of alpha- and beta-subunit complementary deoxyribonucleic acids and expression in the ovary. Mol Endocrinol 1: 561-8.
4. Han L, Mao DG, Zhang DK, Liang AX, Fang M, et al. (2008) Development and evaluation of a novel DNA vaccine expressing inhibin alpha (1-32) fragment for improving the fertility in rats and sheep. Anim Reprod Sci 109: 251-65.
5. Wang SL, Han L, Ahmad S, Cao SX, Xue LQ, et al. (2012) Effect of a DNA vaccine harboring two copies of inhibin α (1-32) fragments on immune response, hormone concentrations and reproductive performance in rats. Theriogenology 78: 393-401.
6. Demura R, Suzuki T, Yajima R, Tajima S, Kubo O, et al. (1996) Inhibin alpha, beta A and beta B subunit messenger ribonucleic acid levels in cultured rat pituitary: studies by a quantitative RT-PCR. Endocr J 43: 403-10.
7. De Kretser DM, Hedger MP, Loveland KL, Phillips DJ, (2002) Inhibins, activins and follistatin in reproduction. Hum Reprod Update 8: 529-41.
8. Pierson TM, Wang Y, DeMayo FJ, Matzuk MM, Tsai SY, et al. (2000) Regulable expression of inhibin A in wild-type and inhibin alpha null mice". Mol Endocrinol 14: 1075-85.
9. Wang QF, Farnworth PG, Findlay JK, Burger HG, (1989) Inhibitory effect of pure 31-kilodalton bovine inhibin on gonadotropin-releasing hormone (GnRH)-induced up-regulation of GnRH binding sites in cultured rat anterior pituitary cells. Endocrinology 124: 363-368.
10. Chapman SC, Woodruff TK, (2003) Betaglycan localization in the female rat pituitary: implications for the regulation of follicle-stimulating hormone by inhibin. Endocrinology 144: 5640-9.
11. Kumar TR, Agno J, Janovick JA, Conn PM, Matzuk MM, (2003) Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice. Mol Cell Endocrinol 212: 19-27.
12. Makanji Y, Walton KL, Wilce MC, Chan KL, Robertson DM, et al. (2008) Suppression of inhibin A biological activity by alterations in the binding site for betaglycan. J Biol Chem 283: 16743-51.
13. Hammond SM, Boettcher S, Caudy AA, Kobayashi R, Hannon GJ, (2001) Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293: 1146-50.
14. Cai K, Hua G, Ahmad S, Liang A, Han L, et al. (2011) Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice. PLoS One 6: e25585.
15. Zatz M, Reisine TD, (1985) Lithium induces corticotropin secretion and desensitization in cultured anterior pituitary cells. Proc Natl Acad Sci U S A 82: 1286-90.
16. Ding Y, Chan CY, Lawrence CE, (2004) Sfold web server for statistical folding and rational design of nucleic acids. Nucleic Acids Research 32: W135-W141.
17. Elbashir SM, Lendeckel W, Tuschl T, (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15: 188-200.
18. Matz MV, Fradkov AF, Labas YA, Savitsky AP, Zaraisky AG, et al. (1999) Fluorescent proteins from nonbioluminescent Anthozoa species. Nat Biotechnol 17: 969-73.
19. Vitale AM, Gonzalez OM, Parborell F, Irusta G, Campo S, et al. (2002) Inhibin a increases apoptosis in early ovarian antral follicles of diethylstilbestrol-treated rats. Biol Reprod 67: 1989-95.
20. Chen F, Jiang X, Chen X, Liu G, Ding J, (2007) Effects of downregulation of inhibin alpha gene expression on apoptosis and proliferation of goose granulosa cells. J Genet Genomics 34: 1106-13.
21. Denkova R, Bourneva V, Staneva-Dobrovski L, Zvetkova E, Baleva K, et al. (2004) In vitro effects of inhibin on apoptosis and apoptosis related proteins in human ovarian granulosa cells. EndocrRegul 38: 51-5.
22. Klocke BJ, Latham CB, D'Sa C, Roth KA, (2002) p53 deficiency fails to prevent increased programmed cell death in the Bcl-X(L)-deficient nervous system. Cell Death Differ 9: 1063-8.
23. Shen G, Xu C, Chen C, Hebbar V, Kong AN, (2006) p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. Cancer Chemother Pharmacol 57: 317-27.
24. Braden TD, Farnworth PG, Burger HG, Conn PM, (1990) Regulation of the synthetic rate of gonadotropin-releasing hormone receptors in rat pituitary cell cultures by inhibin. Endocrinology 127: 2387-2392.
25. Gray P, Bilezikjian LM, Harrison C, Wiater E, Vale W (2004) Activins and inhibins: physiologic roles, signaling mechanisms and regulation. In Hormones and the Brain, pp 1-28.
26. Wiater E, Harrison CA, Lewis KA, Gray PC, Vale WW, (2006) Identification of distinct inhibin and TGFb binding sites on betaglycan: functional separation of betaglycan co-receptor actions. J Biol Chem 281: 17011-17022.
27. Childs GV, Unabia G, Rougeau D, (1994) Cells that express luteinizing hormone (LH) and follicle stimulating hormone (FSH) beta(β) subunit mRNAs during the estrous cycle: the major contributors contain LH, FSH and/or growth hormone. Endocrinology 134: 990-998.
28. Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, et al. (2008) Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology 149: 5811-21.
29. Sari IP, Rao A, Smith JT, Tilbrook AJ, Clarke IJ, (2009) Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology 150: 5549-56.
30. Ciccone NA, Dunn IC, Boswell T, Tsutsui K, Ubuka T, et al. (2004) Gonadotrophin inhibitory hormone depresses gonadotrophin alpha and follicle-stimulating hormone beta subunit expression in the pituitary of the domestic chicken. J Neuroendocrinol 16: 999-1006.
31. Ellsworth BS, Burns AT, Escudero KW, Duval DL, Nelson SE, et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol Cell Endocrinol 206: 93-111.
32. Burger LL, Haisenleder DJ, Aylor KW, Dalkin AC, Prendergast KA, et al. (2004) Regulation of luteinizing hormone-beta and follicle-stimulating hormone (FSH)-beta gene transcription by androgens: testosterone directly stimulates FSH-beta transcription independent from its role on follistatin gene expression. Endocrinology 145: 71-8.
33. Thackray VG, Mellon PL, Coss D, (2010) Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol 314: 192-203.
34. Woodruff TK, Mather JP, (1995) Inhibin, activin and the female reproductive axis. Annu Rev Physiol 57: 219-44.
35. Kotsuji F, Winters SJ, Attardi B, Keeping HS, Oshima H, et al. (1988) Effects of gonadal steroids on gonadotropin secretion in males: studies with perifused rat pituitary cells. Endocrinology 123: 2683-9.
36. Childs GV, Miller BT, Miller WL, (1997) Differential effects of inhibin on gonadotropin stores and gonadotropin-releasing hormone binding to pituitary cells from cycling female rats. Endocrinology 138: 1577-84.
37. Kananen K, Markkula M, el-Hefnawy T, Zhang FP, Paukku T, et al. (1996) The mouse inhibin alpha-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice. Mol Cell Endocrinol 119: 135-46.
38. Woodruff TK, Krummen LA, Lyon RJ, Stocks DL, Mather JP, (1993) Recombinant human inhibin A and recombinant human activin A regulate pituitary and ovarian function in the adult female rat. Endocrinology 132: 2332-41.