Development and evaluation of a novel DNA vaccine expressing inhibin α (1-32) fragment for improving the fertility in rats and sheep

Animal Reproduction Science

Volumn 109, Issue 1-4, 2008, Pages 251-265

  Han, Li ^a   Mao, D G ^b   Zhang, D K ^b   Liang, A X ^a   Fang, M ^a   Moaeen ud Din, Muhammad ^a   Yang, L G ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

DNA vaccine; Fertility; Inhibin

Indexed keywords

DNA VACCINE; INHIBIN; INHIBIN A; MESSENGER RNA; PRIMER DNA;

ANIMAL; ARTICLE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FERTILITY; GENETICS; HELA CELL; HUMAN; IMMUNOLOGY; LITTER SIZE; NUCLEOTIDE SEQUENCE; OVARY FOLLICLE; PHYSIOLOGY; RAT; SHEEP;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FERTILITY; HELA CELLS; HUMANS; INHIBINS; LITTER SIZE; OVARIAN FOLLICLE; RATS; RNA, MESSENGER; SHEEP; VACCINES, DNA;

ANIMALIA; OVIS ARIES; RATTUS;

EID: 54149086738     PISSN: 03784320     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anireprosci.2007.12.012     Document Type: Article

References (46)

1. Akagi S., Kaneko H., Nakanishi Y., Takedomi T., Watanabe G., and Taya K. Ovarian response and FSH profile in cows following injection of various doses of inhibin antiserum. J. Vet. Med. Sci. 59 (1997) 1129-1135
2. Akagi S., Shi F., Kaneko H., Watanabe G., Tsonis C.G., and Taya K. Ovarian response and hormonal profiles in heifers after immunization and re-immunization against inhibin α-subunit. J. Reprod. Dev. 48 (2002) 599-605
3. Anderson S.T., Bindon B.M., Hillard M.A., and O'Shea T. Increased ovulation rate in Merino ewes immunized against small synthetic peptide fragments of the inhibin alpha-subunit. Reprod. Fert. Dev. 10 (1998) 421-431
4. Araki K., Arai K.Y., Watanabe G., and Taya K. Involvement of inhibin in the regulation of follicle-stimulating hormone secretion in the young adult male Shiba goat. J. Androl. 21 (2000) 558-565
5. Davis H.L., Michel M.L., and Whalen R.G. DNA-based immunization for Hepatitis B induces continuous secretion of antigen and high levels of circulating antibody. Hum. Mol. Genet. 2 (1993) 1847-1851
6. Davis H.L., Weeranta R., Waldschmldt T.J., Tygrett L., Schorr J., and Krieg A.M. CpG DNA is a petent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160 (1998) 870-876
7. De Jong F.H. Inhibin. Physiol. Rev. 68 (1988) 555-607
8. De Kretser D.M., Meinhardt A., Meehan T., Phillips D.J., O'Bryan M.K., and Loveland K.A. The roles of inhibin and related peptides in gonadal function. Mol. Cell. Endocrinol. 161 (2000) 43-46
9. De Kretser D.M., Hedger M.P., Loveland K.L., and Phillips D.J. Inhibin, activins and follistatin in reproduction. Hum. Reprod. Update. 8 (2002) 529-541
10. Delpeyroux F., Chenciner N., Lim A., Malpièce Y., Blondel B., Crainic R., van der Werf S., and Streeck R.E. A poliovirus neutralization epitope expressed on hybrid hepatitis B surface antigen particles. Science 233 (1986) 472-475
11. Ebel G.D., Dupuis II A.P., Nicholas D., Young D., Maffei J., and Kramer L.D. Detection by enzyme-linked immunosorbent assay of antibodies to West Nile virus in birds. Emerg. Infect. Dis. 8 (2002) 979-982
12. Findlay J.K., and Clarke I.J. Regulation of the secretion of FSH in domestic ruminants. J. Reprod. Fertil. Suppl. 34 (1987) 27-37
13. Findlay J.K., Russell D.L., Doughton B., Tsonics C.G., Borchers C., and Forage R.G. Effect of active immunization against the amino-terminal peptide (alpha N) of the alpha 43 kDa subunit of inhibin (alpha 43) on fertility of ewes. Reprod. Fert. Dev. 6 (1994) 265-267
14. Glencross R.G., Bleach E.C., Wood S.C., and Knight P.G. Active immunization of heifers against inhibin: effects on plasma concentrations of gonadotrophins, steroids and ovarian follicular dynamics during prostaglandin synchronized cycles. J. Reprod. Fertil. 100 (1994) 599-605
15. Kaneko H., Nakanishi Y., A kagi S., Taya K., Watanabe G., Sasamoto S., and Hasegawa Y. Immunoneutralization of inhibin and estradiol during the follicular phase of the oestrus cycle in cows. Boil. Reprod. 53 (1995) 931-939
16. Kaneko H., Noguchi J., Kikuchi K., Akaqi S., Shimada A., Taya K., Watanabe G., and Hasegawa Y. Production and endocrine role of inhibin during the early development of bull calves. Biol. Reprod. 65 (2001) 209-215
17. Kishi H., Itoh M., Wada S., Yukinari Y., Tanaka Y., Nagamine N., Jin W., Watanabe G., and Taya K. Inhibin is an important factor in the regulation of FSH secretion in the adult male hamster. Am. J. Physiol. Endocrinol. Metab. 278 (2000) E744-E751
18. Kusina N.T., Meyer R.L., Carlson K.M., and Wheaton J.E. Passive immunization against an inhibin-like peptide increases follicle-stimulating hormone concentrations, ovulation rate, and prolificacy in spring-mated ewes. J. Anim. Sci. 73 (1995) 1433-1439
19. Ling N., Ying S.Y., Ueno N., Esch F., Denoroy L., and Guillemin R. Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid. Porc. Natl. Acad. Sci. U.S.A. 82 (1985) 7217-7221
20. Ling N., Ying S.Y., Ueno N., Shimasaki S., Esch F., Hotta M., and Guillemin R. Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin. Nature 321 (1986) 779-782
21. Mansfield M.A. Rapid immunodetection on polyvinylidene fluoride membrane blots without blocking. Anal. Biochem. 229 (1995) 140-143
22. Mao D.G., Yang L.G., Ye R., and Jiang X.P. Effect of inhibin α (1-32) gene immunization on the follicular development and reproductive hormones in rats. Agric. Sci. China 2 (2003) 337-343
23. Mayo K.E., Cerelli G.M., Spiess J., Rivier J., Rosenfeld M.G., Evans R.M., and Vale W. Inhibin A-Subunit cDNA from porcine ovary and human placenta. Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 5849-5853
24. McCue P.M., Carney N.J., Hughes J.P., Rivier J., Vale W., and Lasley B.L. Ovulation and embryo recovery rates following immunization of mares against an inhibin alpha-subunit fragment. Theriogenology 38 (1992) 823-831
25. Medan M.S., Watanabe G., Sasaki K., Nagura Y., Sakaime H., Fujita M., Sharawy S., and Taya K. Ovarian and hormonal response of female goats to active immunization against inhibin. J. Endocrinol. 177 (2003) 287-294
26. Medan M.S., Wang H., Watanabe G., Suzuki A.K., and Taya K. Immunization against endogenous inhibin increases normal oocyte/embryo production in adult mice. Endocrine 24 (2004) 115-119
27. Medan M.S., Akagi S., Kaneko H., Watanabe G., Tsonis C.G., and Taya K. Effects of re-immunization of heifers against inhibin on hormonal profiles and ovulation rate. Reproduction 128 (2004) 475-482
28. Medan M.S., Watanabe G., Sasaki K., Groome N.P., Sharawy S., and Taya K. Follicular and hormonal dynamics during the estrous cycle in goats. J. Reprod. Dev. 51 (2005) 455-463
29. Medan M.S., Takedom T., Aoyagi Y., Konishi M., Yazawa S., Watanabe G., and Taya K. The effect of active immunization against inhibin on gonadotropin secretions and follicular dynamics during the estrous in cows. J. Reprod. Dev. 52 (2006) 107-113
30. Medan M.S., Arai K.Y., Watanabe G., and Taya k. Inhibin: Regulation of reproductive function and practical use in females. Anim. Sci. J. 78 (2007) 16-27
31. Meyer R.L., Carlson K.M., River J., and Wheaton J.E. Antiserum to an inhibin alpha-chain peptide neutralizes inhibin bioactivity and increases ovulation rate in sheep. J. Anim. Sci. 69 (1991) 747-754
32. Michel M.L., Mancini M., Sobczak E., Favier V., Guetard D., Bahraoui E.M., and Tiollais P. Induction of anti-human immunodeficiency virus (HIV) neutralizing antibodies in rabbits immunized with recombinant HIV-hepatitis B surface antigen particles. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 7975-8061
33. Nambo Y., Kaneko H., Nagata S., Oikawa M., Yoshihara T., Nagamine N., Watanabe G., and Taya K. Effect of passive immunization against inhibin on FSH secretion, folliculogenesis and ovulation rate during the follicular phase of the estrous cycle in mares. Theriogenology 50 (1998) 545-557
34. Padilla G., Knight P.G., and Holtz W. Superovulation and embryo collection in nulliparous Boer goat does immunized against a recombinant ovine α-subunit inhibin. Small. Ruminant. Res. 74 (2007) 159-164
35. Ren X.H., Zhang Y.L., Liu S.C., and Dai J.W. The expression of growth hormone release factor gene carried with PLGA microspheres in muscle tissue and its effect on mouse growth. Sheng. Wu. Gong. Cheng. Xue. Bao. 20 (2004) 615-618 (in Chinese)
36. Sasaki K., Medan M.S., Watanabe G., Sharawy S., and Taya K. Immunization of goats against inhibin increased follicular development and ovulation. J. Reprod. Dev. 52 (2006) 543-550
37. Scanlon A.R., Sunderland S.J., Martin T.L., Goulding D., O'Callaghan D., Williams D.H., Headon D.R., Boland M.P., Ireland J.J., and Roche J.F. Active immunization of herfers against a synthetic fragment of bovine inhibin. J. Reprod. Fertil. 97 (1993) 213-222
38. Schreckenberger C., and Kaufmann A.M. Vaccination strategies for the treatment and prevention of cervical cancer. Curr. Opin. Oncol. 16 (2004) 485-491
39. Shi F., Mochida K., Suzuki O., Matsuda J., Ogura A., Tsonis C.G., Watanabe G., Suzuki A.K., and Taya K. Development of embryos in superovulated guinea pigs following active immunization against the inhibin alpha-subunit. Endocr. J. 47 (2000) 451-459
40. Takedomi T., Kaneko H., Aoyagi Y., Konishi K., Kishi H., Watanabe G., and Taya K. Effects of passive immunization against inhibin on ovulation rate and embryo recovery in holstein herfers. Theriogenology 47 (1997) 1507-1518
41. Tilbrook A.J., de Kretser D.M., and Clarke I.J. A role for inhibin in the regulation of the secretion of follicle stimulating hormone in male domestic animals. Domest. Anim. Endocrinol. 9 (1992) 243-260
42. Valenzuela P., Coit D., Medina-Selby M.A., Kuo C.H., Nest G.V., Burke R.L., Bull P., Urdea M.S., and Graves P.V. Antigen engineering in yeast: synthesis and assembly of hybrid hepatitis B surface antigen-herpes simplex 1 gD particles. Biotechnology 3 (1985) 323-326
43. Vale W., Rivier J., Vaughan J., McClintock R., Corrigan A., Woo W., Karr D., and Spiess J. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 321 (1986) 776-779
44. Vale W., Rivier C., Hsueh A., Campen C., Meunier H., Bicsak T., Vaughan J., Corrigan A., Bardin W., Sawchenko P., et al. Chemical and biological characterization of the inhibin family of protein hormones. Recent. Prog. Horm. Res. 44 (1988) 1-34
45. Yang L.G., Hu S.C., Wei P.H., and Guo A.Z. Enzyme Immunoassay Technology (1998), Nanjing University Press, Nanjing (in Chinese)
46. Ying S.Y. Inhibin, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocr. Rev. 9 (1988) 267-293