A molecular mechanism for glaucoma: Endoplasmic reticulum stress and the unfolded protein response

Trends in Molecular Medicine

Volumn 19, Issue 10, 2013, Pages 586-593

  Anholt, Robert R H ^a   Carbone, Mary Anna ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Myocilin; Neurodegenerative disease; Ocular hypertension; Primary open angle glaucoma

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; BINDING IMMUNOGLOBULIN PROTEIN; BINDING PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MATRIX PROTEIN; MEMBRANE PROTEIN; MUTANT PROTEIN; MYOCILIN; OLFACTOMEDIN; PANCREATIC ENDOPLASMIC RETICULUM KINASE LIKE ENDOPLASMIC RETICULUM KINASE; PROTEIN IRE1; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANTERIOR EYE CHAMBER; APOPTOSIS; CONGENITAL GLAUCOMA; DEGENERATIVE DISEASE; DROSOPHILA; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; EYE BLOOD FLOW; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; INTRACELLULAR SIGNALING; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; NONHUMAN; OPEN ANGLE GLAUCOMA; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; REVIEW; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TRABECULAR MESHWORK; TRANSCRIPTION INITIATION; TRANSGENE; UNFOLDED PROTEIN RESPONSE;

MUS;

MYOCILIN; NEURODEGENERATIVE DISEASE; OCULAR HYPERTENSION; PRIMARY OPEN ANGLE GLAUCOMA;

ANIMALS; CYTOSKELETAL PROTEINS; ENDOPLASMIC RETICULUM STRESS; EYE PROTEINS; GLAUCOMA; GLYCOPROTEINS; HUMANS; NEURODEGENERATIVE DISEASES; TRANSLATIONAL MEDICAL RESEARCH; UNFOLDED PROTEIN RESPONSE;

EID: 84884815147     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2013.06.005     Document Type: Review

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