Bortezomib overcomes MGMT-related resistance of glioblastoma cell lines to temozolomide in a schedule-dependent manner

Investigational New Drugs

Volumn 31, Issue 5, 2013, Pages 1169-1181

  Vlachostergios, Panagiotis J ^a   Hatzidaki, Eleana ^a   Befani, Christina D ^a   Liakos, Panagiotis ^a   Papandreou, Christos N ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

AKT; Bortezomib; Glioblastoma; HIF 1 ; MAPK; MGMT; NF B; p53; STAT3; Temozolomide

Indexed keywords

BORTEZOMIB; HYPOXIA INDUCIBLE FACTOR 1ALPHA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN P53; STAT3 PROTEIN; TEMOZOLOMIDE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CELL NUCLEUS; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MONOTHERAPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; BORONIC ACIDS; CELL LINE, TUMOR; DACARBAZINE; DRUG RESISTANCE, NEOPLASM; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZINES; STAT3 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84884813627     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-013-9968-1     Document Type: Article

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