메뉴 건너뛰기




Volumn 96, Issue 6, 2013, Pages 509-518

Ex vivo lung perfusion: A comprehensive review of the development and exploration of future trends

Author keywords

Donor optimization; Ex vivo lung perfusion; Lung transplantation; Perfusion

Indexed keywords

ADENOVIRUS VECTOR; ANTIBIOTIC AGENT; ARTIFICIAL LUNG SURFACTANT; CLARITHROMYCIN; CYTOKINE; GLUCOSE; HEPARIN; INTERLEUKIN 10; LACTATE DEHYDROGENASE; LACTIC ACID; METHYLPREDNISOLONE; NITRIC OXIDE; PRESERVATION SOLUTION; PROSTACYCLIN; STEROID;

EID: 84884813310     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318295eeb7     Document Type: Review
Times cited : (38)

References (97)
  • 1
    • 84892573458 scopus 로고    scopus 로고
    • NHSBT as at 7 September 2012 Available at Accessed September 17 2012
    • NHSBT (2012). Organ Donation and TransplantationVActivity Figures for the UK as at 7 September 2012. Available at http://www.organdonation.nhs.uk:8001/ ukt/statistics/downloads/weekly-stats.pdf. Accessed September 17, 2012.
    • (2012) Organ Donation and TransplantationVActivity Figures for the UK
  • 2
    • 80052668248 scopus 로고    scopus 로고
    • Donation after cardiac death lung transplantation outcomes
    • Wigfield CH, Love RB. Donation after cardiac death lung transplantation outcomes. Curr Opin Organ Transplant 2011; 16: 462.
    • (2011) Curr Opin Organ Transplant , vol.16 , pp. 462
    • Wigfield, C.H.1    Love, R.B.2
  • 3
    • 79954620911 scopus 로고    scopus 로고
    • Novel approaches to expanding the lung donor pool: Donation after cardiac death and ex-vivo conditioning
    • Cypel M, Yeung J, Keshavjee S. Novel approaches to expanding the lung donor pool: donation after cardiac death and ex-vivo conditioning. Clin Chest Med 2011; 32: 233.
    • (2011) Clin Chest Med , vol.32 , pp. 233
    • Cypel, M.1    Yeung, J.2    Keshavjee, S.3
  • 4
    • 0001551786 scopus 로고
    • The culture of whole organs
    • Carrel A, Lindbergh C. The culture of whole organs. Science 1935; 81: 621.
    • (1935) Science , vol.81 , pp. 621
    • Carrel, A.1    Lindbergh, C.2
  • 5
    • 0035901275 scopus 로고    scopus 로고
    • Transplantation of lungs from a non-heart-beating donor
    • Steen S, et al. Transplantation of lungs from a non-heart-beating donor. Lancet 2001; 357: 825.
    • (2001) Lancet , vol.357 , pp. 825
    • Steen, S.1
  • 6
    • 34249036433 scopus 로고    scopus 로고
    • First human transplantation of a nonacceptable donor lung after reconditioning ex vivo
    • Steen S, Ingemansson R, Ericksson L. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg 2007; 83: 2194.
    • (2007) Ann Thorac Surg , vol.83 , pp. 2194
    • Steen, S.1    Ingemansson, R.2    Ericksson, L.3
  • 7
    • 57149102713 scopus 로고    scopus 로고
    • Technique for prolonged normothermic ex vivo lung perfusion
    • Cypel M, et al. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008; 27: 1319.
    • (2008) J Heart Lung Transplant , vol.27 , pp. 1319
    • Cypel, M.1
  • 8
    • 75649121111 scopus 로고    scopus 로고
    • Proceedings of the conference on swine in biomedical research
    • Critser JK, et al. Proceedings of the conference on swine in biomedical research. ILAR J 2009; 50: 89.
    • (2009) ILAR J , vol.50 , pp. 89
    • Critser, J.K.1
  • 9
    • 0037999920 scopus 로고    scopus 로고
    • Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo
    • Steen S, et al. Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo. Ann Thorac Surg 2003; 76: 244.
    • (2003) Ann Thorac Surg , vol.76 , pp. 244
    • Steen, S.1
  • 10
    • 84886752525 scopus 로고    scopus 로고
    • Injury of donor lungs from donation after cardiac death in various settings; Investigation by RT-PCR and pathology
    • Yamada T, et al. Injury of donor lungs from donation after cardiac death in various settings; investigation by RT-PCR and pathology. J Heart Lung Transplant 2010; 29: 1053.
    • (2010) J Heart Lung Transplant , vol.29 , pp. 1053
    • Yamada, T.1
  • 11
    • 84866053941 scopus 로고    scopus 로고
    • Protective effect of pre-recovery surfactant inhalation on lungs donated after cardiac death in a canine lung transplantation model
    • Ohsumi A, et al. Protective effect of pre-recovery surfactant inhalation on lungs donated after cardiac death in a canine lung transplantation model. J Heart Lung Transplant 2012; 31: 1136.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 1136
    • Ohsumi, A.1
  • 12
    • 0019495880 scopus 로고
    • Role of albumin in prevention of edema in perfused rabbit lungs
    • Chang R, Wright K, Effros R. Role of albumin in prevention of edema in perfused rabbit lungs. J Appl Physiol 1981; 50: 1065.
    • (1981) J Appl Physiol , vol.50 , pp. 1065
    • Chang, R.1    Wright, K.2    Effros, R.3
  • 13
    • 84886746523 scopus 로고    scopus 로고
    • Evaluating a novel albumin free lung perfusion solution in a swine lung transplant model
    • AvsarM, et al. Evaluating a novel albumin free lung perfusion solution in a swine lung transplant model. J Heart Lung Transplant 2012; 31: 1053.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 1053
    • Avsar, M.1
  • 14
    • 79959397846 scopus 로고    scopus 로고
    • Comparison of extracellular-type-Kyoto solution and Perfadex as a preservation solution in a pig ex vivo lung perfusion model: Impact of potassium level
    • Okamoto T, et al. Comparison of extracellular-type-Kyoto solution and Perfadex as a preservation solution in a pig ex vivo lung perfusion model: impact of potassium level. Transplant Proc 2011; 43: 1525.
    • (2011) Transplant Proc , vol.43 , pp. 1525
    • Okamoto, T.1
  • 15
    • 0028831948 scopus 로고
    • Effect of blood and albumin on pulmonary hypertension and edema in perfused rabbit lungs
    • Kraft S, et al. Effect of blood and albumin on pulmonary hypertension and edema in perfused rabbit lungs. J Appl Physiol 1995; 78: 499.
    • (1995) J Appl Physiol , vol.78 , pp. 499
    • Kraft, S.1
  • 16
    • 0013869160 scopus 로고
    • Vasoconstriction in isolated blood-perfused rabbit lungs and its inhibition by cresols
    • Hauge A, Lunde P, Waaler B. Vasoconstriction in isolated blood-perfused rabbit lungs and its inhibition by cresols. Acta Physiol Scand 1966; 66: 226.
    • (1966) Acta Physiol Scand , vol.66 , pp. 226
    • Hauge, A.1    Lunde, P.2    Waaler, B.3
  • 17
    • 0026735930 scopus 로고
    • Spontaneous injury in isolated sheep lungs: Role of resident polymorphonuclear leukocytes
    • Pearse D, Sylvester J. Spontaneous injury in isolated sheep lungs: role of resident polymorphonuclear leukocytes. J Appl Physiol 1992; 72: 2475.
    • (1992) J Appl Physiol , vol.72 , pp. 2475
    • Pearse, D.1    Sylvester, J.2
  • 18
    • 84857065107 scopus 로고    scopus 로고
    • Histologic and functional evaluation of lungs reconditioned by ex vivo lung perfusion
    • Medeiros I.L, et al. Histologic and functional evaluation of lungs reconditioned by ex vivo lung perfusion. J Heart Lung Transplant 2012; 31: 305.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 305
    • Medeiros, I.L.1
  • 19
    • 84884818885 scopus 로고    scopus 로고
    • UK Clinical Research Network Portfolio Database. DEVELOPUK: A Study of Donor Ex-Vivo Lung Perfusion in United Kingdom Lung Transplantation. ISRCTN 44922411, 2012 Available at Accessed October 4
    • UK Clinical Research Network: Portfolio Database. DEVELOPUK: A Study of Donor Ex-Vivo Lung Perfusion in United Kingdom Lung Transplantation. ISRCTN 44922411, 2012. Available at http://england.ukcrn. org.uk/StudyDetail.aspx? StudyID=11451. Accessed October 4, 2012.
    • (2012)
  • 20
    • 50249106860 scopus 로고    scopus 로고
    • Impact of topical cooling solution and prediction of pulmonary graft viability from non-heart-beating donors
    • Inci I, et al. Impact of topical cooling solution and prediction of pulmonary graft viability from non-heart-beating donors. J Heart Lung Transplant 2008; 27: 1016.
    • (2008) J Heart Lung Transplant , vol.27 , pp. 1016
    • Inci, I.1
  • 21
    • 84886751884 scopus 로고    scopus 로고
    • Hypothermic ex vivo perfusion prevents ischemia reperfusion injury in rat lungs from non-heart-beating donors
    • Nakajima D, et al. Hypothermic ex vivo perfusion prevents ischemia reperfusion injury in rat lungs from non-heart-beating donors. J Heart Lung Transplant 2011; 30: S142.
    • (2011) J Heart Lung Transplant , vol.30
    • Nakajima, D.1
  • 22
    • 84886746480 scopus 로고    scopus 로고
    • Comparison between lungs preserved for 6 and 12 hours using celsior or perfadex in an ex-vivo perfusion rat lung model
    • Menezes A, et al. Comparison between lungs preserved for 6 and 12 hours using celsior or perfadex in an ex-vivo perfusion rat lung model. Heart Surg Forum 2011; 14: S57.
    • (2011) Heart Surg Forum , vol.14
    • Menezes, A.1
  • 23
    • 79951788689 scopus 로고    scopus 로고
    • Comparison between Perfadex and locally manufactured low-potassiumdextran solution for pulmonary preservation in an ex vivo isolated lung perfusion model
    • Soares PR, et al. Comparison between Perfadex and locally manufactured low-potassiumdextran solution for pulmonary preservation in an ex vivo isolated lung perfusion model. Transplant Proc 2011; 43: 84.
    • (2011) Transplant Proc , vol.43 , pp. 84
    • Soares, P.R.1
  • 24
    • 0018449942 scopus 로고
    • Effect of perfusate glucose concentration on rat lung glycolysis
    • Kerr J, et al. Effect of perfusate glucose concentration on rat lung glycolysis. Am J Physiol 1979; 236: E229.
    • (1979) Am J Physiol , vol.236
    • Kerr, J.1
  • 25
    • 33745066151 scopus 로고    scopus 로고
    • Normothermic ex vivo lung perfusion of nonheart- beating donor lungs in pigs: From pretransplant function analysis towards a 6-h machine preservation
    • Erasmus ME, et al. Normothermic ex vivo lung perfusion of nonheart- beating donor lungs in pigs: from pretransplant function analysis towards a 6-h machine preservation. Transpl Int 2006; 19: 589.
    • (2006) Transpl Int , vol.19 , pp. 589
    • Erasmus, M.E.1
  • 26
    • 84856426095 scopus 로고    scopus 로고
    • Reconditioning of lungs donated after circulatory death with normothermic ex vivo lung perfusion
    • Nakajima D, et al. Reconditioning of lungs donated after circulatory death with normothermic ex vivo lung perfusion. J Heart Lung Transplant 2012; 31: 187.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 187
    • Nakajima, D.1
  • 27
    • 84886752322 scopus 로고    scopus 로고
    • Closed or open circuit during ex-vivo lung perfusion for reconditioning of damaged donor-lungsVwhich shall we use?
    • Wipp S, et al. Closed or open circuit during ex-vivo lung perfusion for reconditioning of damaged donor-lungsVwhich shall we use? J Heart Lung Transplant 2010; 29: S79.
    • (2010) J Heart Lung Transplant , vol.29
    • Wipp, S.1
  • 28
    • 84859512801 scopus 로고    scopus 로고
    • Beta-adrenergic agonist infusion during extracorporeal lung perfusion: Effects on glucose concentration in the perfusion fluid and on lung function
    • Valenza F, et al. Beta-adrenergic agonist infusion during extracorporeal lung perfusion: effects on glucose concentration in the perfusion fluid and on lung function. J Heart Lung Transplant 2012; 31: 524.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 524
    • Valenza, F.1
  • 29
    • 0030021213 scopus 로고    scopus 로고
    • Influence of pulmonary arterial pressure during flushing on lung preservation
    • Sasaki M, et al. Influence of pulmonary arterial pressure during flushing on lung preservation. Transplantation 1996; 61: 22.
    • (1996) Transplantation , vol.61 , pp. 22
    • Sasaki, M.1
  • 30
    • 0026777909 scopus 로고
    • High lung volume increases stress failure in pulmonary capillaries
    • Fu Z, Costello M, Tsukimoto K. High lung volume increases stress failure in pulmonary capillaries. J Appl Physiol 1992; 73: 123.
    • (1992) J Appl Physiol , vol.73 , pp. 123
    • Fu, Z.1    Costello, M.2    Tsukimoto, K.3
  • 31
    • 33947720089 scopus 로고    scopus 로고
    • A model explaining genotypic and ontogenetic variation of leaf photosynthetic rate in rice (Oryza sativa) based on leaf nitrogen content and stomatal conductance
    • Ohsumi A, et al. A model explaining genotypic and ontogenetic variation of leaf photosynthetic rate in rice (Oryza sativa) based on leaf nitrogen content and stomatal conductance. Ann Bot 2007; 99: 265.
    • (2007) Ann Bot , vol.99 , pp. 265
    • Ohsumi, A.1
  • 32
    • 79957586760 scopus 로고    scopus 로고
    • The consumption of glucose during ex vivo lung perfusion correlates with lung edema
    • Valenza F, et al. The consumption of glucose during ex vivo lung perfusion correlates with lung edema. Transplant Proc 2011; 43: 993.
    • (2011) Transplant Proc , vol.43 , pp. 993
    • Valenza, F.1
  • 33
    • 33750502031 scopus 로고    scopus 로고
    • Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice
    • Otani N, et al. Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice. J ClinNeurosci 2006; 13: 934.
    • (2006) J ClinNeurosci , vol.13 , pp. 934
    • Otani, N.1
  • 34
    • 84886746066 scopus 로고    scopus 로고
    • Lactate production during acellular normothermic ex vivo pig and human lung perfusion
    • Koike T, et al. Lactate production during acellular normothermic ex vivo pig and human lung perfusion. J Heart Lung Transplant 2010; 29: S96.
    • (2010) J Heart Lung Transplant , vol.29
    • Koike, T.1
  • 35
    • 80155194268 scopus 로고    scopus 로고
    • Adenosine A2A agonist improves lung function during ex vivo lung perfusion
    • Emaminia A, et al. Adenosine A2A agonist improves lung function during ex vivo lung perfusion. Ann Thorac Surg 2011; 92: 1840.
    • (2011) Ann Thorac Surg , vol.1840 , pp. 92
    • Emaminia, A.1
  • 36
    • 80051549917 scopus 로고    scopus 로고
    • Preemptive therapy with steroids but not macrolides improves gas exchange in caustic-injured donor lungs
    • Meers CM, et al. Preemptive therapy with steroids but not macrolides improves gas exchange in caustic-injured donor lungs. J Surg Res 2011; 170: e141.
    • (2011) J Surg Res , vol.170
    • Meers, C.M.1
  • 37
    • 80155214237 scopus 로고    scopus 로고
    • An experimental rat model of ex vivo lung perfusion for the assessment of lungs after prostacyclin administration: Inhaled versus parenteral routes
    • Cardoso PF, et al. An experimental rat model of ex vivo lung perfusion for the assessment of lungs after prostacyclin administration: inhaled versus parenteral routes. J Bras Pneumol 2011; 37: 589.
    • (2011) J Bras Pneumol , vol.37 , pp. 589
    • Cardoso, P.F.1
  • 38
    • 33748683742 scopus 로고    scopus 로고
    • Potential of an injectable polymer to prevent hyperacute rejection of ex vivo perfused porcine lungs
    • Wiebe K, et al. Potential of an injectable polymer to prevent hyperacute rejection of ex vivo perfused porcine lungs. Transplantation 2006; 82: 681.
    • (2006) Transplantation , vol.82 , pp. 681
    • Wiebe, K.1
  • 39
    • 0028863235 scopus 로고
    • Inhaled nitric oxide does not alter endotoxininduced nitric oxide synthase activity during rat lung perfusion
    • Kurrek MM, et al. Inhaled nitric oxide does not alter endotoxininduced nitric oxide synthase activity during rat lung perfusion. J Appl Physiol 1995; 79: 1088.
    • (1995) J Appl Physiol , vol.79 , pp. 1088
    • Kurrek, M.M.1
  • 40
    • 0342288069 scopus 로고    scopus 로고
    • Inhalation of nitric oxide after lung transplantation
    • Lindberg L, et al. Inhalation of nitric oxide after lung transplantation. Ann Thorac Surg 1996; 61: 956.
    • (1996) Ann Thorac Surg , vol.61 , pp. 956
    • Lindberg, L.1
  • 41
    • 72449188654 scopus 로고    scopus 로고
    • Nitric oxide ventilation of rat lungs from non-heart-beating donors improves posttransplant function
    • Dong BM, Abano JB, Egan TM. Nitric oxide ventilation of rat lungs from non-heart-beating donors improves posttransplant function. Am J Transplant 2009; 9: 2707.
    • (2009) Am J Transplant , vol.9 , pp. 2707
    • Dong, B.M.1    Abano, J.B.2    Egan, T.M.3
  • 42
    • 84862798497 scopus 로고    scopus 로고
    • Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig
    • Yeung JC, et al. Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig. Mol Ther 2012; 20: 1204.
    • (2012) Mol Ther , vol.20 , pp. 1204
    • Yeung, J.C.1
  • 43
    • 77952001279 scopus 로고    scopus 로고
    • Functional repair of human donor lungs by IL-10 gene therapy
    • Cypel M, et al. Functional repair of human donor lungs by IL-10 gene therapy. Sci Translat Med 2009; 1: 4ra9.
    • (2009) Sci Translat Med , vol.1
    • Cypel, M.1
  • 44
    • 0033029463 scopus 로고    scopus 로고
    • Release of neutrophil elastase and its role in tissue injury in acute inflammation: Effect of the elastase inhibitor, FR134043
    • Fujie K, Shinguh Y, Inamura N. Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043. Eur J Pharmacol 1999; 374: 117.
    • (1999) Eur J Pharmacol , vol.374 , pp. 117
    • Fujie, K.1    Shinguh, Y.2    Inamura, N.3
  • 45
    • 77954087026 scopus 로고    scopus 로고
    • Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats
    • Yoshikawa S, Tsushima K, Koizumi T. Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats. Eur J Pharmacol 2010; 641: 220.
    • (2010) Eur J Pharmacol , vol.641 , pp. 220
    • Yoshikawa, S.1    Tsushima, K.2    Koizumi, T.3
  • 46
    • 84886750357 scopus 로고    scopus 로고
    • Neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion
    • Harada M, et al. Neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion. J Heart Lung Transplant 2012; 31: S221.
    • (2012) J Heart Lung Transplant , vol.31
    • Harada, M.1
  • 47
    • 84886748769 scopus 로고    scopus 로고
    • Ex vivo perfusion worsened lung injuries induced by gastric acid aspiration in rigs
    • Khalifé-Hocquemiller T, et al. Ex vivo perfusion worsened lung injuries induced by gastric acid aspiration in rigs. J Heart Lung Transplant 2011; 30: S135.
    • (2011) J Heart Lung Transplant , vol.30
    • Khalifé-Hocquemiller, T.1
  • 48
    • 84886753021 scopus 로고    scopus 로고
    • Ex-vivo repair of donor pig-lungs damaged by aspiration
    • Wipper S, et al. Ex-vivo repair of donor pig-lungs damaged by aspiration. J Heart Lung Transplant 2009; 28: S237.
    • (2009) J Heart Lung Transplant , vol.28
    • Wipper, S.1
  • 49
    • 80051548251 scopus 로고    scopus 로고
    • A model of ex vivo perfusion of porcine donor lungs injured by gastric aspiration: A step towards pretransplant reconditioning
    • Meers CM, et al. A model of ex vivo perfusion of porcine donor lungs injured by gastric aspiration: a step towards pretransplant reconditioning. J Surg Res 2011; 170: e159.
    • (2011) J Surg Res , vol.170
    • Meers, C.M.1
  • 50
    • 29144533368 scopus 로고    scopus 로고
    • Does Perfadex affect outcomes in clinical lung transplantation?
    • Nath D, et al. Does Perfadex affect outcomes in clinical lung transplantation? J Heart Lung Transplant 2005; 24: 2243.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 2243
    • Nath, D.1
  • 51
    • 79952489926 scopus 로고    scopus 로고
    • A porcine model to study ex vivo reconditioning of injured donor lungs
    • Meers CM, et al. A porcine model to study ex vivo reconditioning of injured donor lungs. J Surg Res 2011; 166: e175.
    • (2011) J Surg Res , vol.166
    • Meers, C.M.1
  • 52
    • 84886750076 scopus 로고    scopus 로고
    • Prevention of hyper-acute pulmonary xenograft dysfunction using GalT-KO swine in an ex-vivo lung perfusion model
    • Sahara H, et al. Prevention of hyper-acute pulmonary xenograft dysfunction using GalT-KO swine in an ex-vivo lung perfusion model. Xenotransplantation 2011; 18: 299.
    • (2011) Xenotransplantation , vol.18 , pp. 299
    • Sahara, H.1
  • 53
    • 79955029439 scopus 로고    scopus 로고
    • Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection
    • Nguyen BN, et al. Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection. Xenotransplantation 2011; 18: 94.
    • (2011) Xenotransplantation , vol.18 , pp. 94
    • Nguyen, B.N.1
  • 54
    • 84886747668 scopus 로고    scopus 로고
    • 5 years experience with lung donation after cardiac death
    • Cypel M, et al. 5 years experience with lung donation after cardiac death. J Heart Lung Transplant 2012; 31: 1053.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 1053
    • Cypel, M.1
  • 55
    • 84964935802 scopus 로고    scopus 로고
    • Differential gene regulation between brain and cardiac death donor lungs during ex vivo lung perfusion
    • Zamel R, et al. Differential gene regulation between brain and cardiac death donor lungs during ex vivo lung perfusion. J Heart Lung Transplant 2012; 31: S146.
    • (2012) J Heart Lung Transplant , vol.31
    • Zamel, R.1
  • 56
    • 79954611346 scopus 로고    scopus 로고
    • Ex vivo lung perfusion in clinical lung transplantation Vthe "HELP" trial
    • CypelM, et al. Ex vivo lung perfusion in clinical lung transplantationVthe "HELP" trial. J Heart Lung Transplant 2010; 29: S88.
    • (2010) J Heart Lung Transplant , vol.29
    • Cypel, M.1
  • 57
    • 84886751302 scopus 로고    scopus 로고
    • Ex-vivo perfusion and transplantation of initially rejected donor lungs
    • Wallinder A, et al. Ex-vivo perfusion and transplantation of initially rejected donor lungs. J Heart Lung Transplant 2012; 31: S98.
    • (2012) J Heart Lung Transplant , vol.31
    • Wallinder, A.1
  • 58
    • 84886751011 scopus 로고    scopus 로고
    • The effect of ex-vivo perfusion on the inflammatory profile of the donor lung
    • Karamanou DM, et al. The effect of ex-vivo perfusion on the inflammatory profile of the donor lung. J Heart Lung Transplant 2010; 29: S165.
    • (2010) J Heart Lung Transplant , vol.29
    • Karamanou, D.M.1
  • 59
    • 77952256598 scopus 로고    scopus 로고
    • Thoracic organs: Current preservation technology and future prospects; Part 1: Lung
    • Van Raemdonck D. Thoracic organs: current preservation technology and future prospects; part 1: lung. Curr Opin Organ Transplant 2010; 15: 150.
    • (2010) Curr Opin Organ Transplant , vol.15 , pp. 150
    • Van Raemdonck, D.1
  • 60
    • 70349218771 scopus 로고    scopus 로고
    • Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation
    • Cypel M, et al. Normothermic ex vivo perfusion prevents lung injury compared to extended cold preservation for transplantation. Am J Transplant 2009; 9: 2262.
    • (2009) Am J Transplant , vol.9 , pp. 2262
    • Cypel, M.1
  • 61
    • 33645342744 scopus 로고    scopus 로고
    • Ex vivo evaluation of human lungs for transplant suitability
    • Egan TM, et al. Ex vivo evaluation of human lungs for transplant suitability. Ann Thorac Surg 2006; 81: 1205.
    • (2006) Ann Thorac Surg , vol.81 , pp. 1205
    • Egan, T.M.1
  • 62
    • 0035482539 scopus 로고    scopus 로고
    • Influence of preservation solution on early graft failure in clinical lung transplantation
    • Thabut G, et al. Influence of preservation solution on early graft failure in clinical lung transplantation. Am J Respir Crit Care Med 2001; 164: 1204.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1204
    • Thabut, G.1
  • 63
    • 11844301554 scopus 로고    scopus 로고
    • Switch from Euro-Collins to Perfadex for pulmonary graft preservation resulted in superior outcome in transplant recipients
    • Rega F, et al. Switch from Euro-Collins to Perfadex for pulmonary graft preservation resulted in superior outcome in transplant recipients. J Heart Lung Transplant 2003; 22: S111.
    • (2003) J Heart Lung Transplant , vol.22
    • Rega, F.1
  • 64
    • 33750084399 scopus 로고    scopus 로고
    • Early outcomes comparing perfadex. Euro-Collins, and Papworth solutions in lung transplantation
    • Oto T, et al. Early outcomes comparing Perfadex, Euro-Collins, and Papworth solutions in lung transplantation. Ann Thorac Surg 2006; 82: 1842.
    • (2006) Ann Thorac Surg , vol.82 , pp. 1842
    • Oto, T.1
  • 65
    • 0035075551 scopus 로고    scopus 로고
    • Low-potassium dextran preservation solution improves lung function after human lung transplantation
    • Fischer S, et al. Low-potassium dextran preservation solution improves lung function after human lung transplantation. J Thorac Cardiovasc Surg 2001; 121: 594.
    • (2001) J Thorac Cardiovasc Surg , vol.121 , pp. 594
    • Fischer, S.1
  • 66
    • 0042482646 scopus 로고    scopus 로고
    • Lung procurement by low-potassium dextran and the effect on preservation injury. Munich Lung Transplant Group
    • Muller C, et al. Lung procurement by low-potassium dextran and the effect on preservation injury. Munich Lung Transplant Group. Transplantation 1999; 68: 1139.
    • (1999) Transplantation , vol.68 , pp. 1139
    • Muller, C.1
  • 68
    • 79954566390 scopus 로고    scopus 로고
    • Normothermic ex vivo lung perfusion in clinical lung transplantation
    • Cypel M, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 2011; 364: 1431.
    • (2011) N Engl J Med , vol.364 , pp. 1431
    • Cypel, M.1
  • 69
    • 77952310674 scopus 로고    scopus 로고
    • Suppression of inflammatory cytokines during ex vivo lung perfusion with an adsorbent membrane
    • Kakishita T, et al. Suppression of inflammatory cytokines during ex vivo lung perfusion with an adsorbent membrane. Ann Thorac Surg 2010; 89: 1773.
    • (2010) Ann Thorac Surg , vol.89 , pp. 1773
    • Kakishita, T.1
  • 70
    • 84886750040 scopus 로고    scopus 로고
    • Ex-vivo lung perfusion reduces graft immunogenicity via the removal of passenger monocytesVa porcine model
    • Fildes JE, et al. Ex-vivo lung perfusion reduces graft immunogenicity via the removal of passenger monocytesVa porcine model. Transpl Int 2011; 24: 0934.
    • (2011) Transpl Int , vol.24 , pp. 0934
    • Fildes, J.E.1
  • 71
    • 67349168408 scopus 로고    scopus 로고
    • Detection of a quantitative trait locus controlling carbon isotope discrimination and its contribution to stomatal conductance in japonica rice
    • Takai T, et al. Detection of a quantitative trait locus controlling carbon isotope discrimination and its contribution to stomatal conductance in japonica rice. Theor Appl Genet 2009; 118: 1401.
    • (2009) Theor Appl Genet , vol.118 , pp. 1401
    • Takai, T.1
  • 72
    • 74549138295 scopus 로고    scopus 로고
    • Long-term survival after video-assisted thoracic surgery lobectomy for primary lung cancer
    • Yamamoto K, et al. Long-term survival after video-assisted thoracic surgery lobectomy for primary lung cancer. Ann Thorac Surg 2010; 89: 353.
    • (2010) Ann Thorac Surg , vol.89 , pp. 353
    • Yamamoto, K.1
  • 73
    • 84886750040 scopus 로고    scopus 로고
    • Ex-vivo lung perfusion reduces graft immunogenicity via the removal of passenger monocytes-a porcine model
    • Fildes JE, et al. Ex-vivo lung perfusion reduces graft immunogenicity via the removal of passenger monocytes-a porcine model. Transpl Int 2011; 24: 225.
    • (2011) Transpl Int , vol.24 , pp. 225
    • Fildes, J.E.1
  • 74
    • 84886752154 scopus 로고    scopus 로고
    • Ex-vivo lung perfusion removes donor derived nonclassical monocytes that rapidly differentiate into inflammatory dendritic cells?
    • Fildes JE, et al. Ex-vivo lung perfusion removes donor derived nonclassical monocytes that rapidly differentiate into inflammatory dendritic cells? Transpl Int 2011; 24: 72.
    • (2011) Transpl Int , vol.24 , pp. 72
    • Fildes, J.E.1
  • 75
    • 79960945974 scopus 로고    scopus 로고
    • Cytokine expression profile in human lungs undergoing normothermic ex-vivo lung perfusion
    • Sadaria MR, et al. Cytokine expression profile in human lungs undergoing normothermic ex-vivo lung perfusion. Ann Thorac Surg 2011; 92: 478.
    • (2011) Ann Thorac Surg , vol.92 , pp. 478
    • Sadaria, M.R.1
  • 76
    • 0003033571 scopus 로고
    • Utilization of blood sugar and formation of lactic acid by the lungs
    • Evans CL, Hsu FY, Kosaka T. Utilization of blood sugar and formation of lactic acid by the lungs. J Physiol 1934; 82: 41.
    • (1934) J Physiol , vol.82 , pp. 41
    • Evans, C.L.1    Hsu, F.Y.2    Kosaka, T.3
  • 78
    • 80655148986 scopus 로고    scopus 로고
    • Kinetics of lactate metabolism during acellular normothermic ex vivo lung perfusion
    • Koike T, et al. Kinetics of lactate metabolism during acellular normothermic ex vivo lung perfusion. J Heart Lung Transplant 2011; 30: 1312.
    • (2011) J Heart Lung Transplant , vol.30 , pp. 1312
    • Koike, T.1
  • 79
    • 84886751810 scopus 로고    scopus 로고
    • Ex vivo lungenperfusion VDer probelauf vor der transplantation
    • Slama A, et al. Ex vivo LungenperfusionVDer Probelauf vor der Transplantation. Eur Surg 2011; 43: 1682.
    • (2011) Eur Surg , vol.43 , pp. 1682
    • Slama, A.1
  • 80
    • 77949430803 scopus 로고    scopus 로고
    • Ex vivo lung perfusion: Early report of brazilian experience
    • Pego-Fernandes PM, et al. Ex vivo lung perfusion: early report of Brazilian experience. Transplant Proc 2010; 42: 440.
    • (2010) Transplant Proc , vol.42 , pp. 440
    • Pego-Fernandes, P.M.1
  • 81
    • 79952255852 scopus 로고    scopus 로고
    • Ex vivo lung evaluation and reconditioning
    • Pego-Fernandes PM, et al. Ex vivo lung evaluation and reconditioning. Rev Bras Cirurg Cardiovasc 2010; 25: 441.
    • (2010) Rev Bras Cirurg Cardiovasc , vol.25 , pp. 441
    • Pego-Fernandes, P.M.1
  • 82
    • 84863186385 scopus 로고    scopus 로고
    • Clinical ex vivo lung perfusionVpushing the limits
    • Aigner C, et al. Clinical ex vivo lung perfusionVpushing the limits. Am J Transplant 2012; 12: 1839.
    • (2012) Am J Transplant , vol.1839 , pp. 12
    • Aigner, C.1
  • 83
    • 84857038090 scopus 로고    scopus 로고
    • Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning
    • Zych B, et al. Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning. J Heart Lung Transplant 2012; 31: 274.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 274
    • Zych, B.1
  • 84
    • 84886746346 scopus 로고    scopus 로고
    • Physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform
    • George TJ, et al. Physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform. J Heart Lung Transplant 2012, 31: S105.
    • (2012) J Heart Lung Transplant , vol.31
    • George, T.J.1
  • 85
    • 84886752720 scopus 로고    scopus 로고
    • Time-course microarray analysis of rejected human donor lungs during 12 hours of acellular normothermic ex vivo lung perfusion
    • Yeung JC, et al. Time-course microarray analysis of rejected human donor lungs during 12 hours of acellular normothermic ex vivo lung perfusion. J Heart Lung Transplant 2012; 31: S106.
    • (2012) J Heart Lung Transplant , vol.31
    • Yeung, J.C.1
  • 86
    • 84886752206 scopus 로고    scopus 로고
    • One year survival and functional status of patients from the Human Ex vivo Lung Perfusion (HELP) trial
    • Cypel M, et al. One year survival and functional status of patients from the Human Ex vivo Lung Perfusion (HELP) trial. J Heart Lung Transplant 2011; 30: S8.
    • (2011) J Heart Lung Transplant , vol.30
    • Cypel, M.1
  • 87
    • 85027942682 scopus 로고    scopus 로고
    • Experience with the first 50 ex vivo lung perfusions in clinical transplantation
    • Cypel M, et al. Experience with the first 50 ex vivo lung perfusions in clinical transplantation. J Thorac Cardiovasc Surg 2012; 144: 1200.
    • (2012) J Thorac Cardiovasc Surg , vol.144 , pp. 1200
    • Cypel, M.1
  • 88
    • 84886746952 scopus 로고    scopus 로고
    • Improved clinical outcome of patients transplanted with reconditioned donor lungs via evlp compared to standard lung transplantation
    • Fildes JE, et al. Improved clinical outcome of patients transplanted with reconditioned donor lungs via evlp compared to standard lung transplantation. Transpl Int 2011; 24: 77.
    • (2011) Transpl Int , vol.24 , pp. 77
    • Fildes, J.E.1
  • 89
    • 0032527932 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) inhibits interleukin- 1 induced acute lung leak
    • Stringer K, et al. Tissue plasminogen activator (tPA) inhibits interleukin- 1 induced acute lung leak. Free Radic Biol Med 1998; 25: 184.
    • (1998) Free Radic Biol Med , vol.25 , pp. 184
    • Stringer, K.1
  • 90
    • 84863523680 scopus 로고    scopus 로고
    • Donor lungs with pulmonary embolism evaluated with ex vivo lung perfusion
    • Brown CR, et al. Donor lungs with pulmonary embolism evaluated with ex vivo lung perfusion. ASAIO J 2012; 58: 432.
    • (2012) ASAIO J , vol.58 , pp. 432
    • Brown, C.R.1
  • 91
    • 31644450990 scopus 로고    scopus 로고
    • Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
    • Lange C, Togel F, Ittrich H. Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats. Kidney Int 2005; 68: 1613.
    • (2005) Kidney Int , vol.68 , pp. 1613
    • Lange, C.1    Togel, F.2    Ittrich, H.3
  • 92
    • 79955706042 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model
    • Kanazawa H, Fujimoto Y, Teratani T. Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model. PLoS One 2011; 6: e19195.
    • (2011) PLoS One , vol.6
    • Kanazawa, H.1    Fujimoto, Y.2    Teratani, T.3
  • 93
    • 70349392958 scopus 로고    scopus 로고
    • Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    • Lee J, et al. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Oric Batk Acad Sci YSA 2009; 106: 16357.
    • (2009) Oric Batk Acad Sci YSA , vol.106 , pp. 16357
    • Lee, J.1
  • 94
    • 77955422758 scopus 로고    scopus 로고
    • Regeneration and orthotopic transplantation of a bioartificial lung
    • Ott HC, Clippinger B, Conrad C. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med 2010; 16: 927.
    • (2010) Nat Med , vol.16 , pp. 927
    • Ott, H.C.1    Clippinger, B.2    Conrad, C.3
  • 95
    • 80052786772 scopus 로고    scopus 로고
    • Enhanced in vivo function of bioartificial lungs in rats
    • Song J, Kim S, Liu Z. Enhanced in vivo function of bioartificial lungs in rats. Ann Thorac Surg 2011; 92: 998.
    • (2011) Ann Thorac Surg , vol.92 , pp. 998
    • Song, J.1    Kim, S.2    Liu, Z.3
  • 96
    • 84858314261 scopus 로고    scopus 로고
    • The effect of ex-vivo perfusion on the microbiological profile of the donor lung
    • Karamanou DM, et al. The effect of ex-vivo perfusion on the microbiological profile of the donor lung. J Heart Lung Transplant 2010; 29: S94.
    • (2010) J Heart Lung Transplant , vol.29
    • Karamanou, D.M.1
  • 97
    • 84886748142 scopus 로고    scopus 로고
    • Novel nebulized arginase inhibitor increases human lung compliance during normothermic ex vivo lung perfusion
    • George TJ, et al. Novel nebulized arginase inhibitor increases human lung compliance during normothermic ex vivo lung perfusion. J Heart Lung Transplant 2012; 31: S106.
    • (2012) J Heart Lung Transplant , vol.31
    • George, T.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.