Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats

European Journal of Pharmacology

Volumn 641, Issue 2-3, 2010, Pages 220-225

  Yoshikawa, Sumiko ^a   Tsushima, Kenji ^a   Koizumi, Tomonobu ^a   Kubo, Keishi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Hydrochloric acid; Neutrophil; Neutrophil elastase; Protease inhibitor

Indexed keywords

ALBUMIN; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; GABEXATE MESILATE; HYDROCHLORIC ACID; SIVELESTAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CHEMOPROPHYLAXIS; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; LUNG FLUID; LUNG HEMORRHAGE; LUNG INJURY; LUNG LAVAGE; MALE; MONOTHERAPY; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; RAT; TRACHEOSTOMY;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GABEXATE; GLYCINE; HYDROCHLORIC ACID; LEUKOCYTE COUNT; LUNG INJURY; MALE; NEUTROPHILS; PROTEASE INHIBITORS; PROTEINASE INHIBITORY PROTEINS, SECRETORY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SULFONAMIDES;

EID: 77954087026     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.039     Document Type: Article

References (27)

1. Aosasa S., Ono S., Mochizuki H., Tsujimoto H., Ueno C., Matsumoto A. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock 2001, 15:101-105.
2. Bédard M., McClure C.D., Schiller N.L., Francoeur C., Cantin A., Denis M. Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis. Am. J. Respir. Cell Mol. Biol. 1993, 9:455-462.
3. Chen H.M., Shyr M.H., Chen M.F. Gabexate mesilate improves pancreatic microcirculation and reduces lung edema in a rat model of acute pancreatitis. J. Formos. Med. Assoc. 1997, 96:704-709.
4. Davidson B.A., Knight P.R., Helinski J.D., Nader N.D., Shanley T.P., Johnson K.J. The role of tumor necrosis factor-alpha in the pathogenesis of aspiration pneumonitis in rats. Anesthesiology 1999, 91:486-499.
5. Folkesson H.G., Matthay M.A., Hébert C.A., Broaddus V.C. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J. Clin. Invest. 1995, 96:107-116.
6. Hagio T., Matsumoto S., Nakao S., Abiru T., Ohno H., Kawabata K. Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters. Eur. J. Pharmacol. 2004, 488:173-180.
7. Hagiwara S., Iwasaka H., Hidaka S., Hasegawa A., Noguchi T. Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB. Inflamm. Res. 2009, 58:198-203.
8. Harada N., Okajima K., Kushimoto S. Gabexate mesilate, a synthetic protease inhibitor, reduces ischemia/reperfusion injury of rat liver by inhibiting leukocyte activation. Crit. Care Med. 1999, 27:1958-1964.
9. Hidaka S., Iwasaka H., Hagiwara S., Noguchi T. Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury. J. Surg. Res. 2009, Jun 25.
10. Iba T., Kidokoro A., Fukunaga M., Takuhiro K., Yoshikawa S., Sugimotoa K. Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters. Shock 2006, 26:95-98.
11. Jian M.Y., Koizumi T., Tsushima K., Fujimoto K., Kubo K. Effects of granulocyte colony-stimulating factor (G-CSF) and neutrophil elastase inhibitor (ONO-5046) on acid-induced lung injury in rats. Inflammation 2004, 28:327-336.
12. Jian M.Y., Koizumi T., Tsushima K., Fujimoto K., Kubo K. Activated protein C attenuates acid-aspiration lung injury in rats. Pulm. Pharmacol. Ther. 2005, 18:291-296.
13. Kennedy T.P., Johnson K.J., Kunkel R.G., Ward P.A., Knight P.R., Finch J.S. Acute acid aspiration lung injury in the rat: biphasic pathogenesis. Anesth. Analg. 1989, 69:87-92.
14. Kiefmann R., Heckel K., Schenkat S., Dörger M., Wesierska-Gadek J., Goetz A.E. Platelet-endothelial cell interaction in pulmonary micro-circulation: the role of PARS. Thromb. Haemost. 2004, 91:761-770.
15. Murakami K., Okajima K., Uchiba M., Okabe H., Takatsuki K. Gabexate mesilate, a synthetic protease inhibitor, attenuates endotoxin-induced pulmonary vascular injury by inhibiting tumor necrosis factor production by monocytes. Crit. Care Med. 1996, 24:1047-1053.
16. Nakatani K., Takeshita S., Tsujimoto H., Kawamura Y., Sekine I. Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury. J. Leukoc. Biol. 2001, 69:241-247.
17. Niehaus G.D., Kimura R., Traber L.D., Herndon D.N., Flynn J.T., Traber D.L. Administration of a synthetic antiprotease reduces smoke-induced lung injury. J. Appl. Physiol. 1990, 69:694-699.
18. Ohno H., Kambayashi J., Chang S.W., Kosaki G. FOY: [ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulofibrinolytic system in comparison with heparin or aprotinin. Thromb. Res. 1981, 24:445-452.
19. Rainger G.E., Rowley A.F., Nash G.B. Adhesion-dependent release of elastase from human neutrophils in a novel, flow-based model: specificity of different chemotactic agents. Blood 1998, 92:4819-4827.
20. Rubenfeld G.D., Caldwell E., Peabody E., Weaver J., Martin D.P., Neff M., Stern E.J., Hudson L.D. Incidence and outcomes of acute lung injury. N Engl J. Med. 2005, 353:1685-1693.
21. Sakamaki F., Ishizaka A., Urano T., Sayama K., Nakamura H., Terashima T., Waki Y., Tasaka S., Hasegawa N., Sato K., Nakagawa N., Obata T., Kanazawa M. Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury. Am. J. Respir. Crit. Care Med. 1996, 153:391-397.
22. Taenaka N., Shimada Y., Hirata T., Nishijima M.K., Takezawa J., Yoshiya I., Kambayashi J. Gabexate mesilate (FOY) therapy of disseminated intravascular coagulation due to sepsis. Crit. Care Med. 1983, 11:735-738.
23. Yamaguchi Y., Akizuki E., Ichiguchi O., Matsumura F., Goto M., Miyanari N., Mori K., Yamada S., Ogawa M. Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver. Gastroenterology 1997, 112:551-560.
24. Yamamoto H., Koizumi T., Kaneki T., Kubo K. Lecithinized superoxide dismutase and neutrophil elastase inhibitor attenuated hyperoxia-induced lung injury in rat. Eur. J. Pharmacol. 2000, 409:179-183.
25. Yuksel M., Okajima K., Uchiba M., Okabe H. Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes. J. Pharmacol. Exp. Ther. 2003, 305:298-305.
26. Uchiba M., Okajima K., Kaun C., Binder B.R., Wojta J. Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro. Crit. Care Med. 2003, 31:1147-1153.
27. Walsh D.E., Greene C.M., Carroll T.P., Taggart C.C., Gallagher P.M., O'Neill S.J., McElvaney N.G. Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium. J. Biol. Chem. 2001, 276:35494-35499.