Suppressing iron oxide nanoparticle toxicity by vascular targeted antioxidant polymer nanoparticles

Biomaterials

Volumn 34, Issue 37, 2013, Pages 9615-9622

  Cochran, David B ^a   Wattamwar, Paritosh P ^a   Wydra, Robert ^a   Hilt, J Zach ^a   Anderson, Kimberly W ^a   Eitel, Richard E ^a   Dziubla, Thomas D ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Adhesion molecule; Antioxidant; Endothelial cell; Nanoparticle; Oxidation

Indexed keywords

ADHESION MOLECULES; CLINICAL APPLICATION; IRON OXIDE NANOPARTICLE; PLATELET ENDOTHELIAL CELL ADHESION MOLECULES; POLYMER NANOPARTICLES; POLYMERIC ANTIOXIDANTS; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES; VASCULAR ENDOTHELIAL CELLS;

ANTIOXIDANTS; ENZYMATIC HYDROLYSIS; ESTERIFICATION; ESTERS; IRON OXIDES; METAL NANOPARTICLES; NANOPARTICLES; OXIDATION; POLYMERS; TOXICITY;

ENDOTHELIAL CELLS;

ANTIOXIDANT; CD31 ANTIGEN; NANOPARTICLE; OXIDIZING AGENT; POLY(TROLOX ESTER); POLYMER; REACTIVE OXYGEN METABOLITE; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TROLOX C; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; DRUG BINDING; DRUG CYTOTOXICITY; DRUG RELEASE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYDROLYSIS; INTERNALIZATION; NANOTOXICOLOGY; OXIDATIVE STRESS; PRIORITY JOURNAL; SYSTEMATIC REVIEW;

ADHESION MOLECULE; ANTIOXIDANT; ENDOTHELIAL CELL; NANOPARTICLE; OXIDATION;

ANTIGENS, CD31; ANTIOXIDANTS; CHROMANS; FERRIC COMPOUNDS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NANOPARTICLES; OXIDATIVE STRESS; POLYMERS; REACTIVE OXYGEN SPECIES;

EID: 84884813148     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.08.025     Document Type: Article

References (48)

1. Frimpong R.A., Hilt J.Z. Magnetic nanoparticles in biomedicine: synthesis, functionalization and applications. Nanomedicine 2010, 5(9):1401-1414.
2. Pouliquen D., Perroud H., Calza F., Jallet P., Le Jeune J.J. Investigation of the magnetic properties of iron oxide nanoparticles used as contrast agent for MRI. Magn Reson Med 1992, 24(1):75-84.
3. Lu M., Suh K., Lee H., Cohen M., Rieves D., Pazdur R. FDA review of ferumoxytol (Feraheme) for the treatment of iron deficiency anemia in adults with chronic kidney disease. Am J Hematol 2010, 85:315-319.
4. Hilger I., Hiergeist R., Hergt R., Winnefeld K., Schubert H., Kaiser W.A. Thermal ablation of tumors using magnetic nanoparticles: an invivo feasibility study. Invest Radiol 2002, 37(10):580-586.
5. Gupta A.K., Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005, 26(18):3995-4021.
6. Chertok B., Moffat B.A., David A.E., Yu F., Bergemann C., Ross B.D., et al. Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 2008, 29(4):487-496.
7. Zhu M.T., Wang Y., Feng W.Y., Wang B., Wang M., Ouyang H., et al. Oxidative stress and apoptosis induced by iron oxide nanoparticles in cultured human umbilical endothelial cells. JNanosci Nanotechnol 2010, 10(12):8584-8590.
8. Buyukhatipoglu K., Clyne A.M. Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation. JBiomed Mater Res A 2011, 96(1):186-195.
9. Stroh A., Zimmer C., Gutzeit C., Jakstadt M., Marschinke F., Jung T., et al. Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages. Free Radic Biol Med 2004, 36(8):976-984.
10. Wu X., Tan Y., Mao H., Zhang M. Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells. Int J Nanomedicine 2010, 5:385.
11. Sasaki M., Joh T. Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents. JClin Biochem Nutr 2007, 40(1):1-12.
12. Halliwell B., Gutteridge J.M., Cross C.E. Free radicals, antioxidants, and human disease: where are we now?. JLab Clin Med 1992, 119(6):598-620.
13. Kalra J., Chaudhary A.K., Prasad K. Increased production of oxygen free radicals in cigarette smokers. Int J Exp Pathol 1991, 72(1):1-7.
14. Comporti M. Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest 1985, 53(6):599-623.
15. Macdonald J., Galley H.F., Webster N.R. Oxidative stress and gene expression in sepsis. Br J Anaesth 2003, 90(2):221-232.
16. Rinaldi S., Landucci F., De Gaudio A.R. Antioxidant therapy in critically septic patients. Curr Drug Targets 2009, 10(9):872-880.
17. Dunlap W.C., Yamamoto Y. Small-molecule antioxidants in marine organisms: antioxidant activity of mycosporine-glycine. Comp Biochem Physiol B Biochem Mol Biol 1995, 112(1):105-114.
18. Seo J.Y., Kim H., Seo J.T., Kim K.H. Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants. Pharmacology 2002, 64(2):63-70.
19. Frei B. Molecular and biological mechanisms of antioxidant action. FASEB J 1999, 13(9):963-964.
20. Shek P.N., Suntres Z.E., Brooks J.I. Liposomes in pulmonary applications: physicochemical considerations, pulmonary distribution and antioxidant delivery. JDrug Target 1994, 2(5):431-442.
21. Kosaraju S.L., D'Ath L., Lawrence A. Preparation and characterisation of chitosan microspheres for antioxidant delivery. Carbohydr Polym 2006, 64(2):163-167.
22. Thorek D.L.J., Chen A.K., Czupryna J., Tsourkas A. Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann Biomed Eng 2006, 34(1):23-38.
23. Zhang C., Jugold M., Woenne E.C., Lammers T., Morgenstern B., Mueller M.M., et al. Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner. Cancer Res 2007, 67(4):1555-1562.
24. Spencer J.P.E. Metabolism of tea flavonoids in the gastrointestinal tract. JNutr 2003, 133(10):3255S-3261S.
25. Wattamwar P.P., Mo Y., Wan R., Palli R., Zhang Q., Dziubla T.D. Antioxidant activity of degradable polymer poly(trolox ester) to suppress oxidative stress injury in the cells. Adv Funct Mater 2010, 20(1):147-154.
26. Newman P.J. The biology of PECAM-1. JClin Invest 1997, 99(1):3-8.
27. Albelda S.M., Muller W.A., Buck C.A., Newman P.J. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. JCell Biol 1991, 114(5):1059-1068.
28. Bogen S., Pak J., Garifallou M., Deng X., Muller W.A. Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation invivo. JExp Med 1994, 179(3):1059-1064.
29. Dziubla T.D., Shuvaev V.V., Hong N.K., Hawkins B.J., Madesh M., Takano H., et al. Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies. Biomaterials 2008, 29(2):215-227.
30. Muro S., Dziubla T., Qiu W., Leferovich J., Cui X., Berk E., et al. Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to intercellular adhesion molecule 1. JPharmacol Exp Ther 2006, 317(3):1161-1169.
31. Dziubla T.D., Karim A., Muzykantov V.R. Polymer nanocarriers protecting active enzyme cargo against proteolysis. JControl Release 2005, 102(2):427-439.
32. Muro S., Garnacho C., Champion J.A., Leferovich J., Gajewski C., Schuchman E.H., et al. Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Mol Ther 2008, 16(8):1450-1458.
33. Anderson M.E., Siahaan T.J. Mechanism of binding and internalization of ICAM-1-derived cyclic peptides by LFA-1 on the surface of T cells: a potential method for targeted drug delivery. Pharm Res 2003, 20(10):1523-1532.
34. Christofidou-Solomidou M., Scherpereel A., Wiewrodt R., Ng K., Sweitzer T., Arguiri E., et al. PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress. Am J Physiol Lung Cell Mol Physiol 2003, 285(2):L283-L292.
35. Frimpong R.A., Dou J., Pechan M., Hilt J.Z. Enhancing remote controlled heating characteristics in hydrophilic magnetite nanoparticles via facile co-precipitation. JMagn Magn Mater 2010, 322(3):326-331.
36. Muro S., Wiewrodt R., Thomas A., Koniaris L., Albelda S.M., Muzykantov V.R., et al. Anovel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1. JCell Sci 2003, 116(8):1599-1609.
37. Garnacho C., Albelda S.M., Muzykantov V.R., Muro S. Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes. JControl Release 2008, 130(3):226-233.
38. Qiao R., Yang C., Gao M. Superparamagnetic iron oxide nanoparticles: from preparations to invivo MRI applications. JMater Chem 2009, 19(35):6274-6293.
39. Taupitz M., Wagner S., Schnorr J., Kravec I., Pilgrimm H., Bergmann-Fritsch H., et al. Phase I clinical evaluation of citrate-coated monocrystalline very small superparamagnetic iron oxide particles as a new contrast medium for magnetic resonance imaging. Invest Radiol 2004, 39(7):394-405.
40. Griffiths S.M., Singh N., Jenkins G.J.S., Williams P.M., Orbaek A.W., Barron A.R., et al. Dextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes. Anal Chem 2011, 83(10):3778.
41. Wattamwar P.P., Hardas S.S., Butterfield D.A., Anderson K.W., Dziubla T.D. Tuning of the pro-oxidant and antioxidant activity of trolox through the controlled release from biodegradable poly(trolox ester) polymers. JBiomed Mater Res A 2011, 99(2):184-191.
42. Ding B.S., Dziubla T., Shuvaev V.V., Muro S., Muzykantov V.R. Advanced drug delivery systems that target the vascular endothelium. Mol Interv 2006, 6(2):98.
43. Xia T., Kovochich M., Liong M., Mädler L., Gilbert B., Shi H., et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2008, 2(10):2121-2134.
44. Madamanchi N.R., Vendrov A., Runge M.S. Oxidative stress and vascular disease. Arteriosclerosis, Thromb Vasc Biol 2005, 25(1):29-38.
45. Bannerman D.D., Goldblum S.E. Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis. Am J Physiol Lung Cell Mol Physiol 2003, 284(6):L899-L914.
46. Jansen T., Hortmann M., Oelze M., Opitz B., Steven S., Schell R., et al. Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin. JMol Cell Cardiol 2010, 49(2):186-195.
47. Sun B., Zou X., Chen Y., Zhang P., Shi G. Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC. Int J Biol Sci 2008, 4(5):270.
48. Hanini A., Schmitt A., Kacem K., Chau F., Ammar S., Gavard J. Evaluation of iron oxide nanoparticle biocompatibility. Int J Nanomedicine 2011, 6:787.