Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells

International Journal of Nanomedicine

Volumn 5, Issue 1, 2010, Pages 385-399

  Wu, Xinying ^a   Tan, Yanbin ^a   Mao, Hui ^b   Zhang, Minming ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytoskeleton; Cytotoxicity; Human umbilical vein endothelial cell; In vitro test; Iron oxide nanoparticles

Indexed keywords

CITRIC ACID; DEXTRAN; F ACTIN; FOCAL ADHESION KINASE; IRON OXIDE NANOPARTICLE; MAGNETIC NANOPARTICLE; TUBULIN; UNCLASSIFIED DRUG; VINCULIN; BIOMATERIAL; MAGNETITE NANOPARTICLE;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL FUNCTION; CELL INTERACTION; CELL INVASION; CELL LABELING; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; ENDOCYTOSIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MATERIAL COATING; PARTICLE SIZE; TRANSMISSION ELECTRON MICROSCOPY; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; CELL ADHESION; CELL CULTURE; CELL MOTION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; METABOLISM; NANOMEDICINE; ULTRASTRUCTURE;

CELL ADHESION; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CITRIC ACID; COATED MATERIALS, BIOCOMPATIBLE; CYTOSKELETON; DEXTRANS; ENDOTHELIAL CELLS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; MAGNETITE NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; NANOMEDICINE; NEOVASCULARIZATION, PHYSIOLOGIC; PARTICLE SIZE; UMBILICAL VEINS;

EID: 79952119001     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/ijn.s10458     Document Type: Article

References (48)

1. Islam T, Harisinghani MG. Overview of nanoparticle use in cancer imaging. Cancer Biomark. 2009;5(2):61-67.
2. Xie J, Huang J, Li X, et al. Iron oxide nanoparticle platform for biomedical applications. Curr Med Chem. 2009;16(10):1278-1294.
3. Sajja HK, East MP, Mao H, et al. Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect. Curr Drug Discov Technol. 2009;6(1):43-51.
4. Gupta AK, Naregalkar RR, Vaidya VD, et al. Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomed. 2007;2(1):23-39.
5. Barry SE. Challenges in the development of magnetic particles for therapeutic applications. Int J Hyperthermia. 2008;24(6):451-466.
6. Hadjipanayis CG, Bonder MJ, Balakrishnan S, et al. Metallic iron nanoparticles for MRI contrast enhancement and local hyperthermia. Small. 2008;4(11):1925-1929.
7. Le Renard PE, Buchegger F, Petri-Fink A, et al. Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model. Int J Hyperthermia. 2009;25(3):229-239.
8. Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials. 2005;26(18): 3995-4021.
9. Ito A, Shinkai M, Honda H, et al. Medical application of functionalized magnetic nanoparticles. J Biosci Bioeng. 2005;100(1):1-11.
10. Berry CC, Wells S, Charles S, et al. Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro. Biomaterials. 2003;24(25):4551-4557.
11. Mahmoudi M, Simchi A, Milani AS, et al. Cell toxicity of superparamagnetic iron oxide nanoparticles. J Colloid Interface Sci. 2009;336(2):510-518.
12. Simoni AR, Garcia MP, Azevedo RB, et al. Evaluation of the binding properties of maghemite nanoparticle surface-coated with meso-2-3- dimercaptosuccinic acid to serum albumin. J Nanosci Nanotechnol. 2008;8(11):5813-5817.
13. Jaffer FA, Nahrendorf M, Sosnovik D, et al. Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials. Mol Imaging. 2006;5(2):85-92.
14. Sosnovik DE. Molecular imaging in cardiovascular magnetic resonance imaging: current perspective and future potential. Top Magn Reson Imaging. 2008;19(1):59-68.
15. Pisanic TR 2nd, Blackwell JD, Shubayev VI, et al. Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials. 2007;28(16):2572-2581.
16. de Freitas ER, Soares PR, Santos Rde P, et al. In vitro biological activities of anionic gamma-Fe2O3 nanoparticles on human melanoma cells. J Nanosci Nanotechnol. 2008;8(5):2385-2391.
17. Liu J, Chao B. MRI-based visualization of iron-labeled CD133+ human endothelial progenitor cells. Biol Trace Elem Res. 2008;126(1-3):83-91.
18. Arbab AS, Janic B, Knight RA, et al. Detection of migration of locally implanted AC133+ stem cells by cellular magnetic resonance imaging with histological findings. FASEB J. 2008;22(9):3234-3246.
19. Wilhelm C, Bal L, Smirnov P, et al. Magnetic control of vascular network formation with magnetically labeled endothelial progenitor cells. Biomaterials. 2007;28(26):3797-3806.
20. Pardoe H, Clark PR, St Pierre TG, et al. A magnetic resonance imaging based method for measurement of tissue iron concentration in liver arterially embolized with ferrimagnetic particles designed for magnetic hyperthermia treatment of tumors. Magn Reson Imaging. 2003;21(5): 483-488.
21. Baalousha M. Aggregation and disaggregation of iron oxide nanoparticles: Influence of particle concentration, pH and natural organic matter. Sci Total Environ. 2009;407(6):2093-2101.
22. Budde MD, Frank JA. Magnetic tagging of therapeutic cells for MRI. J Nucl Med. 2009;50(2):171-174.
23. Schellenberger E, Rudloff F, Warmuth C, et al. Protease-specific nanosensors for magnetic resonance imaging. Bioconjug Chem. 2008;19(12):2440-2445.
24. Pieters R, Loonen AH, Huismans DR, et al. In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions. Blood. 1990;76(11):2327-2336.
25. Mahmoudi M, Simchi A, Milani AS, et al. Cell toxicity of superparamagnetic iron oxide nanoparticles. J Colloid Interface Sci. 2009;336(2):510-518.
26. Kiessling F, Huppert J, Zhang C, et al. RGD-labeled USPIO inhibits adhesion and endocytotic activity of alpha v beta3-integrin-expressing glioma cells and only accumulates in the vascular tumor compartment. Radiology. 2009;253(2):462-469.
27. Akhtar N, Dickerson EB, Auerbach R. The sponge/Matrigel angiogenesis assay. Angiogenesis. 2002;5(1-2):75-80.
28. Auerbach R, Lewis R, Shinners B, et al. Angiogenesis assays: a critical overview. Clin Chem. 2003;49(1):32-40.
29. Kehrer JP. The Haber-Weiss reaction and mechanisms of toxicity. Toxicology. 2000;149(1):43-50.
30. Apopa PL, Qian Y, Shao R, et al. Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling. Part Fibre Toxicol. 2009;6:1.
31. Videla LA, Fernández V, Tapia G, et al. Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells. Biometals. 2003;16(1):103-111.
32. Karlsson HL, Gustafsson J, Cronholm P, et al. Size-dependent toxicity of metal oxide particles-a comparison between nano- and micrometer size. Toxicol Lett. 2009;188(2):112-118.
33. Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004;23(16):2891-2906.
34. Berry DL, Baehrecke EH. Autophagy functions in programmed cell death. Autophagy. 2008;4(3):359-360.
35. Bursch W. Multiple cell death programs: Charon's lifts to Hades. FEMS Yeast Res. 2004;5(2):101-110.
36. Qualmann B, Kessels MM, Kelly RB. Molecular links between endocytosis and the actin cytoskeleton. J Cell Biol. 2000;150(5):F111-F116.
37. Kirchhausen T. Imaging endocytic clathrin structures in living cells. Trends Cell Biol. 2009;19(11):596-605.
38. Schaub S, Bohnet S, Laurent VM, et al. Comparative maps of motion and assembly of filamentous actin and myosin II in migrating cells. Mol Biol Cell. 2007;18(10):3723-3732.
39. Miles FL, Pruitt FL, van Golen KL, et al. Stepping out of the flow: capillary extravasation in cancer metastasis. Clin Exp Metastasis. 2008;25(4):305-324.
40. Kirfel G, Rigort A, Borm B, et al. Cell migration: mechanisms of rear detachment and the formation of migration tracks. Eur J Cell Biol. 2004;83(11-12):717-724.
41. Pollard TD, Cooper JA. Actin, a central player in cell shape and movement. Science. 2009;326(5957):1208-1212.
42. Chiarugi P, Giannoni E. Anoikis: a necessary death program for anchorage- dependent cells. Biochem Pharmacol. 2008;76(11):1352-1364.
43. Hauck CR, Hsia DA, Schlaepfer DD. The focal adhesion kinase-a regulator of cell migration and invasion. IUBMB Life. 2002;53(2):115-119.
44. Oliva IB, Coelho RM, Barcellos GG, et al. Effect of RGD-disintegrins on melanoma cell growth and metastasis: involvement of the actin cytoskeleton, FAK and c-Fos. Toxicon. 2007;50(8):1053-1063.
45. Echarri A, Muriel O, Del Pozo MA. Intracellular trafficking of raft/ caveolae domains: insights from integrin signaling. Semin Cell Dev Biol. 2007;18(5):627-637.
46. Lamalice L, Le Boeuf F, Huot J. Endothelial cell migration during angiogenesis. Circ Res. 2007;100:782-794.
47. Nakatsu MN, Sainson RC, Aoto JN, et al. Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc Res. 2003;66(2):102-112.
48. Goodwin AM. In vitro assays of angiogenesis for assessment of angiogenic and anti-angiogenic agents. Microvasc Res. 2007;74(2-3):172-183.