SOX9 Is highly expressed in nonampullary duodenal adenoma and adenocarcinoma in humans

Gut and Liver

Volumn 7, Issue 5, 2013, Pages 513-518

  Sakamoto, Hirotsugu ^a   Mutoh, Hiroyuki ^a   Miura, Yoshimasa ^a   Sashikawa, Miho ^a   Yamamoto, Hironori ^a   Sugano, Kentaro ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Duodenal adenocarcinoma; Duodenal adenoma; SOX9

Indexed keywords

TRANSCRIPTION FACTOR SOX9;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DUODENUM ADENOCARCINOMA; DUODENUM ADENOMATOSIS; DUODENUM CARCINOMA; ENDOSCOPIC SURGERY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROTEIN EXPRESSION;

EID: 84884807940     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2013.7.5.513     Document Type: Article

References (24)

1. Jepsen JM, Persson M, Jakobsen NO, et al. Prospective study of prevalence and endoscopic and histopathologic characteristics of duodenal polyps in patients submitted to upper endoscopy. Scand J Gastroenterol 1994;29:483-487. (Pubitemid 24176432)
2. Dabaja BS, Suki D, Pro B, Bonnen M, Ajani J. Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients. Cancer 2004;101:518-526. (Pubitemid 38970602)
3. Kalogerinis PT, Poulos JE, Morfesis A, et al. Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective. BMC Gastroenterol 2010;10:109.
4. Oka S, Tanaka S, Nagata S, et al. Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma. J Clin Gastroenterol 2003;37:381-386. (Pubitemid 37296166)
5. Alexander S, Bourke MJ, Williams SJ, Bailey A, Co J. EMR of large, sessile, sporadic nonampullary duodenal adenomas: technical aspects and long-term outcome (with videos). Gastrointest Endosc 2009;69:66-73.
6. Honda T, Yamamoto H, Osawa H, et al. Endoscopic submucosal dissection for superficial duodenal neoplasms. Dig Endosc 2009;21:270-274.
7. Abbass R, Rigaux J, Al-Kawas FH. Nonampullary duodenal polyps: characteristics and endoscopic management. Gastrointest Endosc 2010;71:754-759.
8. Okada K, Fujisaki J, Kasuga A, et al. Sporadic nonampullary duodenal adenoma in the natural history of duodenal cancer: a study of follow-up surveillance. Am J Gastroenterol 2011;106:357-364.
9. Blache P, van de Wetering M, Duluc I, et al. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol 2004;166:37-47. (Pubitemid 38931915)
10. Jay P, Berta P, Blache P. Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells. Cancer Res 2005;65:2193-2198. (Pubitemid 40490127)
11. Furuyama K, Kawaguchi Y, Akiyama H, et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet 2011;43:34-41.
12. Bastide P, Darido C, Pannequin J, et al. Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. J Cell Biol 2007;178:635-648. (Pubitemid 47267275)
13. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-850. (Pubitemid 40558990)
14. Lu B, Xu J, Lai M, Zhang H, Chen J. A transcriptome anatomy of human colorectal cancers. BMC Cancer 2006;6:40.
15. Lu B, Fang Y, Xu J, et al. Analysis of SOX9 expression in colorectal cancer. Am J Clin Pathol 2008;130:897-904.
16. Sashikawa Kimura M, Mutoh H, Sugano K. SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans. J Gastroenterol 2011;46:1292-1299.
17. Mutoh H, Hakamata Y, Sato K, et al. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun 2002;294:470-479. (Pubitemid 34694118)
18. Sakamoto H, Mutoh H, Ido K, et al. Intestinal metaplasia in gallbladder correlates with high amylase levels in bile in patients with a morphologically normal pancreaticobiliary duct. Hum Pathol 2009;40:1762-1767.
19. Shih IM, Wang TL, Traverso G, et al. Top-down morphogenesis of colorectal tumors. Proc Natl Acad Sci U S A 2001;98:2640-2645. (Pubitemid 32209535)
20. Preston SL, Wong WM, Chan AO, et al. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res 2003;63:3819-3825. (Pubitemid 36793072)
21. Jiang SS, Fang WT, Hou YH, et al. Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin Cancer Res 2010;16:4363-4373.
22. Chakravarty G, Moroz K, Makridakis NM, et al. Prognostic significance of cytoplasmic SOX9 in invasive ductal carcinoma and metastatic breast cancer. Exp Biol Med (Maywood) 2011;236:145-155.
23. Ling S, Chang X, Schultz L, et al. An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer. Cancer Res 2011;71:3812-3821.
24. Mazur PK, Riener MO, Jochum W, et al. Expression and clinicopathological significance of notch signaling and cell-fate genes in biliary tract cancer. Am J Gastroenterol 2012;107:126-135.