N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress

Toxicology and Applied Pharmacology

Volumn 273, Issue 1, 2013, Pages 189-195

  Wang, Gangduo ^a   Wang, Jianling ^a   Ma, Huaxian ^a   Ansari, G A S ^a   Khan, M Firoze ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Autoimmune diseases; Carbonylation; N Acetylcysteine; Oxidative stress; Trichloroethene

Indexed keywords

ACETYLCYSTEINE; ANTIBODY; DOUBLE STRANDED DNA ANTIBODY; DRINKING WATER; HYDROXYNONENAL ANTIBODY; INTERLEUKIN 17; MALONALDEHYDE ANTIBODY; MESSENGER RNA; SM ANTIBODY; TRICHLOROETHYLENE; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; CARBONYLATION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENE EXPRESSION; KIDNEY; LIVER; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; SPLEEN CELL;

AUTOIMMUNE DISEASES; CARBONYLATION; N-ACETYLCYSTEINE; OXIDATIVE STRESS; TRICHLOROETHENE;

ACETYLCYSTEINE; ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; AUTOIMMUNE DISEASES; FEMALE; INTERLEUKIN-17; KIDNEY; LIPID PEROXIDATION; LIVER; MICE; MICE, INBRED MRL LPR; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RNA, MESSENGER; SPLEEN; TRICHLOROETHYLENE;

EID: 84884728651     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.08.020     Document Type: Article

References (49)

1. Amrouche-Mekkioui I., Djerdjouri B. N-acetylcysteine improves redox status, mitochondrial dysfunction, mucin-depleted crypts and epithelial hyperplasia in dextran sulfate sodium-induced oxidative colitis in mice. Eur. J. Pharmacol. 2012, 691:209-217.
2. Andresen L., Jørgensen V.L., Perner A., Hansen A., Eugen-Olsen J., Rask-Madsen J. Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis. Gut 2005, 54:503-509.
3. Atkinson A., Meeks R.G., Roy D. Increased oxidative stress in the liver of mice treated with trichloroethylene. Biochem. Mol. Biol. Int. 1993, 31:297-304.
4. Ben Mansour R., Lassoued S., Elgaied A., Haddouk S., Marzouk S., Bahloul Z., Masmoudi H., Attia H., Aïfa M.S., Fakhfakh F. Enhanced reactivity to malondialdehyde-modified proteins by systemic lupus erythematosus autoantibodies. Scand. J. Rheumatol. 2010, 39:247-253.
5. Benrahmoune M., Therond P., Abedinzadeh Z. The reaction of superoxide radical with N-acetylcysteine. Free Radic. Biol. Med. 2000, 29:775-782.
6. Cai P., König R., Boor P.J., Kondraganti S., Kaphalia B.S., Khan M.F., Ansari G.A.S. Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL+/+ mice. Toxicol. Appl. Pharmacol. 2008, 228:68-75.
7. Channel S.R., Latendresse J.R., Kidney J.K., Grabau J.H., Lane J.W., Steel-Goodwin L., Gothaus M.C. A subchronic exposure to trichloroethylene causes lipid peroxidation and hepatocellular proliferation in male B6C3F1 mouse liver. Toxicol. Sci. 1998, 43:145-154.
8. Chen D.Y., Chen Y.M., Wen M.C., Hsieh T.Y., Hung W.T., Lan J.L. The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis. Lupus 2012, 21:1385-1396.
9. Cojocel C., Beuter W., Müller W., Mayer D. Lipid peroxidation: a possible mechanism of trichloroethylene-induced nephrotoxicity. Toxicology 1989, 55:131-141.
10. Cooper G.S., Makris S.L., Nietert P.J., Jinot J. Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans. Environ. Health Perspect. 2009, 117:696-702.
11. Egner W. The use of laboratory tests in the diagnosis of SLE. J. Clin. Pathol. 2000, 53:424-432.
12. Farhat S.C., Silva C.A., Orione M.A., Campos L.M., Sallum A.M., Braga A.L. Air pollution in autoimmune rheumatic diseases: a review. Autoimmun. Rev. 2011, 11:14-21.
13. Flindt-Hansen H., Isager H. Scleroderma after occupational exposure to trichlorethylene and trichlorethane. Acta Derm. Venereol. 1987, 67:263-264.
14. Frostegard J., Svenungsson E., Wu R., Gunnarsson I., Lundberg I.E., Klareskog L., Horkko S., Witztum J.L. Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations. Arthritis Rheum. 2005, 52:192-200.
15. Gilbert K.M., Przybyla B., Pumford N.R., Han T., Fuscoe J., Schnackenberg L.K., Holland R.D., Doss J.C., Macmillan-Crow L.A., Blossom S.J. Delineating liver events in trichloroethylene-induced autoimmune hepatitis. Chem. Res. Toxicol. 2009, 22:626-632.
16. Griffin J.M., Blossom S.J., Jackson S.K., Gilbert K.M., Pumford N.R. Trichloroethylene accelerates an autoimmune response by Th1 T cell activation in MRL+/+ mice. Immunopharmacology 2000, 46:123-137.
17. Griffin J.M., Gilbert K.M., Lamps L.W., Pumford N.R. CD4(+) T-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+/+ mice. Toxicol. Sci. 2000, 57:345-352.
18. Grune T., Michel P., Sitte N., Eggert W., Albrecht-Nebe H., Esterbauer H., Siems W.G. Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases. Free Radic. Biol. Med. 1997, 23:357-360.
19. Hutter D., Greene J.J. Influence of the cellular redox state on NF-kappaB-regulated gene expression. J. Cell. Physiol. 2000, 183:45-52.
20. Ippolito A., Wallace D.J., Gladman D., Fortin P.R., Urowitz M., Werth V., Costner M., Gordon C., Alarcón G.S., Ramsey-Goldman R., Maddison P., Clarke A., Bernatsky S., Manzi S., Bae S.C., Merrill J.T., Ginzler E., Hanly J.G., Nived O., Sturfelt G., Sanchez-Guerrero J., Bruce I., Aranow C., Isenberg D., Zoma A., Magder L.S., Buyon J., Kalunian K., Dooley M.A., Steinsson K., van Vollenhoven R.F., Stoll T., Weisman M., Petri M. Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity. Lupus 2011, 20:250-255.
21. Januszewski A.S., Alderson N.L., Jenkins A.J., Thorpe S.R., Baynes J.W. Chemical modification of proteins during peroxidation of phospholipids. J. Lipid Res. 2005, 46:1440-1449.
22. Khan M.F., Kaphalia B.S., Prabhakar B.S., Kanz M.F., Ansari G.A. Trichloroethene-induced autoimmune response in female MRL+/+ mice. Toxicol. Appl. Pharmacol. 1995, 134:155-160.
23. Khan M.F., Wu X., Ansari G.A. Anti-malondialdehyde antibodies in MRL+/+ mice treated with trichloroethene and dichloroacetyl chloride: possible role of lipid peroxidation in autoimmunity. Toxicol. Appl. Pharmacol. 2001, 170:88-92.
24. Kilburn K.H., Warshaw R.H. Prevalence of symptoms of systemic lupus erythematosus (SLE) and of fluorescent antinuclear antibodies associated with chronic exposure to trichloroethylene and other chemicals in well water. Environ. Res. 1992, 57:1-9.
25. Kurien B.T., Scofield R.H. Autoimmunity and oxidatively modified autoantigens. Autoimmun. Rev. 2008, 7:567-573.
26. Lai Z.W., Hanczko R., Bonilla E., Caza T.N., Clair B., Bartos A., Miklossy G., Jimah J., Doherty E., Tily H., Francis L., Garcia R., Dawood M., Yu J., Ramos I., Coman I., Faraone S.V., Phillips P.E., Perl A. N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2012, 64:2937-2946.
27. Lushchak V.I., Bagnyukova T.V., Husak V.V., Luzhna L.I., Lushchak O.V., Storey K.B. Hyperoxia results in transient oxidative stress and an adaptive response by antioxidant enzymes in goldfish tissues. Int. J. Biochem. Cell Biol. 2005, 37:1670-1680.
28. Miossec P., Kolls J.K. Targeting IL-17 and TH17 cells in chronic inflammation. Nat. Rev. Drug Discov. 2012, 11:763-776.
29. Morgan P.E., Sturgess A.D., Davies M.J. Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus. Arthritis Rheum. 2005, 52:2069-2079.
30. Nalbandian A., Crispín J.C., Tsokos G.C. Interleukin-17 and systemic lupus erythematosus: current concepts. Clin. Exp. Immunol. 2009, 157:209-215.
31. Niwano S., Niwano H., Sasaki S., Fukaya H., Yuge M., Imaki R., Machida Y., Izumi T. N-acetylcysteine suppresses the progression of ventricular remodeling in acute myocarditis: studies in an experimental autoimmune myocarditis (EAM) model. Circ. J. 2011, 75:662-671.
32. Nur E., Brandjes D.P., Teerlink T., Otten H.M., Oude Elferink R.P., Muskiet F., Evers L.M., ten Cate H., Biemond B.J., Duits A.J., Schnog J.J., CURAMA study group N-acetylcysteine reduces oxidative stress in sickle cell patients. Ann. Hematol. 2012, 91:1097-1105.
33. Oates J.C. The biology of reactive intermediates in systemic lupus erythematosus. Autoimmunity 2010, 43:56-63.
34. Orengo C.A., Todd A.E., Thornton J.M. From protein structure to function. Curr. Opin. Struct. Biol. 1999, 9:374-382.
35. Parks C.G., Cooper G.S. Occupational exposures and risk of systemic lupus erythematosus: a review of the evidence and exposure assessment methods in population- and clinic-based studies. Lupus 2006, 15:728-736.
36. Renke J., Popadiuk S., Korzon M., Bugajczyk B., Wozniak M. Protein carbonyl groups' content as a useful clinical marker of antioxidant barrier impairment in plasma of children with juvenile chronic arthritis. Free Radic. Biol. Med. 2000, 29:101-104.
37. Renke J., Szlagatys A., Hansdorfer-Korzon R., Szumera M., Kamińska B., Knap N., Popadiuk S., Szarszewski A., Woźniak M. Persistence of protein oxidation products and plasma antioxidants in juvenile idiopathic arthritis. A one-year follow-up study. Clin. Exp. Rheumatol. 2007, 25:112-114.
38. Reveille J.D. Predictive value of autoantibodies for activity of systemic lupus erythematosus. Lupus 2004, 13:290-297.
39. Rodeghero R., Cao Y., Olalekan S.A., Iwakua Y., Glant T.T., Finnegan A. Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis. J. Immunol. 2013, 190:5423-5435.
40. Samuni Y., Goldstein S., Dean O.M., Berk M. The chemistry and biological activities of N-acetylcysteine. Biochim. Biophys. Acta 2013, 1830:4117-4129.
41. Suwannaroj S., Lagoo A., Keisler D., McMurray R.W. Antioxidants suppress mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE). Lupus 2001, 10:258-265.
42. Wang G., Cai P., Ansari G.A., Khan M.F. Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response. Toxicology 2007, 229:186-193.
43. Wang G., Ansari G.A., Khan M.F. Involvement of lipid peroxidation-derived aldehyde-protein adducts in autoimmunity mediated by trichloroethene. J. Toxicol. Environ. Health A 2007, 70:1977-1985.
44. Wang G., König R., Ansari G.A.S., Khan M.F. Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4+ T cells. Free Radic. Biol. Med. 2008, 44:1475-1482.
45. Wang G., Wang J., Ma H., Khan M.F. Increased nitration and carbonylation of proteins in MRL+/+ mice exposed to trichloroethene: potential role of protein oxidation in autoimmunity. Toxicol. Appl. Pharmacol. 2009, 237:188-195.
46. Wang G., Pierangeli S.S., Papalardo E., Ansari G.A., Khan M.F. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity. Arthritis Rheum. 2010, 62:2064-2072.
47. Wang G., Wang J., Fan X., Ansari G.A., Khan M.F. Protein adducts of malondialdehyde and 4-hydroxynonenal contribute to trichloroethene-mediated autoimmunity via activating Th17 cells: dose- and time-response studies in female MRL+/+ mice. Toxicology 2012, 292:113-122.
48. Zafarullah M., Li W., Sylvester J., Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell. Mol. Life Sci. 2003, 60:6-20.
49. Zhu Q.X., Shen T., Ding R., Liang Z.Z., Zhang X.J. Cytotoxicity of trichloroethylene and perchloroethylene on normal human epidermal keratinocytes and protective role of vitamin E. Toxicology 2005, 209:55-67.