Dexmedetomidine;Dexmedetomidin

Anaesthesist

Volumn 62, Issue 8, 2013, Pages 661-674

  Gerresheim, G ^a   Schwemmer, U ^a  

^a Chirurgische Klinik   (Germany)

Author keywords

Delirium; Hypnotics and sedatives; Intensive care; Receptors, adrenergic, alpha 2; Sleep

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DEXMEDETOMIDINE; MIDAZOLAM; PROPOFOL;

ANESTHESIA; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DELIRIUM; DISEASE DURATION; DRUG EFFECT; EXTUBATION; HEALTH CARE COST; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; PREVALENCE; SEDATION;

ADRENERGIC ALPHA-AGONISTS; ADULT; ANALGESICS, NON-NARCOTIC; BARIATRIC SURGERY; CHILD; CONSCIOUS SEDATION; COST-BENEFIT ANALYSIS; DELIRIUM; DEXMEDETOMIDINE; DRUG INTERACTIONS; ELECTROENCEPHALOGRAPHY; HUMANS; HYPNOTICS AND SEDATIVES; INTENSIVE CARE; INTUBATION, INTRATRACHEAL; MAGNETIC RESONANCE IMAGING; NONINVASIVE VENTILATION;

EID: 84884700691     PISSN: 00032417     EISSN: 1432055X     Source Type: Journal    
DOI: 10.1007/s00101-013-2206-6     Document Type: Article

References (22)

1. Martin J, Franck M, Sigel S, et al. (2007) Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey. Crit Care 11:R124
2. Shehabi Y, Botha JA, Ernest DA, et al. (2010) Clinical application, the use of dexmedetomidine in intensive care sedation. Crit Care Shock 13:40-50
3. Brede M, Philipp M, Knau A, et al. (2004) α2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models. Biol Cell 96:343-348
4. Riker R, Shehabi Y, Bokesch P (2009) Dexmedetomidine vs midazolam for sedation of critically ill patients. JAMA 301:489-499
5. Pandaharipande P, Pun B, Herr D (2007) Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients. JAMA 298:2644-2653
6. Kress JP, Pohlman AS, O'Connor AF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342:1471-1477
7. Strom T, Martinussen T, Toft P (2010) A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 375:475-480
8. AWMF, S3-Leitlinie "Analgesie, Sedierung und Delirmanagement in der Intensivmedizin", Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, 2009
9. Jakob S, Ruokonen E, Grounds R (2012) Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation. JAMA 307:1151-1160
10. Schmitt TK, Pajonk FG (2008) Postoperatives Delir beim Intensivpatienten. Anaesthesist 57:403-431
11. Ely W, Shintani A, Truman B (2004) Delirium as predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291:1753-1762
12. Pisani MA, Kong SYJ, Kasl SV, et al. (2009) Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 180:1092-1097
13. Pisani MA, Murphy TE, Araujo KL, et al. (2009) Benzodiazepine and opioid use and the duration of ICU delirium in an older population. Crit Care Med 37:177-183
14. Huupponen E, Maksimow A, Lapinlampi P (2008) Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesth Scand 52:289-294
15. Adler J, Malone D (2012) Early mobilisation in the intensive care unit: a systemic review. Cardiopulm Phys Ther J 23:5-13
16. Devlin JW, Nava S, Fong JJ (2007) Survey of sedation practices during noninvasive positive-pressure ventilation to treat acute respiratory failure. Crit Care Med 35:2298-2302
17. Bergese SD, Bender SP, McSweeney TD (2010) A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation. J Clin Anest 22:35-40
18. Korogulu A, Teksan H, Sagir O (2006) A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Anesth Analg 103:63-67
19. Su F, Hammer GB (2011) Dexmedetomidine: pediatric pharmacology, clinical use and safety. Expert Opin Drug Saf 10:55-66
20. Carollo DS, Nossaman BD, Ramadhyani U (2008) Dexmedetomidine: a review of clinical applications. Curr Opin Anaesthesiol 21:457-461
21. Dasta JF, Kane-Gill SL, Pencina M, et al. (2010) A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit. Crit Care Med 38:497-503
22. Meagher DJ, O'Hanlon D, Mahony D, et al. (2000) Relationship between symptoms and motoric subtype of delirium. J Neuropsychiatry Clin Neurosci 12:51-56