Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 591-600

  Mohamed, M S ^a   Youns, M M ^a   Ahmed, N M ^a  

^a Helwan   (Egypt)

Author keywords

6 Aryl 5 cyano thiouracils; Antibacterial; Antifungal; Antioxidant activity; Radical scavenging; Synthesis

Indexed keywords

2 METHYL 5 THIOXO 7 (3,4,5 TRIMETHOXY PHENYL) 5,6 DIHYDRO [1,2,4] TRIAZOLO [1,5 C] PYRIMIDINE 8 CARBONITRILE; 3 METHYL 5 THIOXO 7 (3,4,5 TRIMETHOXY PHENYL) 5, 6 DIHYDRO [1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; 4 [2 (4 FLUOROBENZYLIDENE) HYDRAZINO] 6 (4 BROMO PHENYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRAMIDINE 5 CARBONITRILE; 4 [2 (4 FLUOROBENZYLIDENE) HYDRAZINO] 6 (4 FLUORO PHENYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRAMIDINE 5 CARBONITRILE; 4 [2 BENZYLIDENE HYDRAZINO] 6 (3,4,5 TRIMETHOXY PHENYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRAMIDINE 5 CARBONITRILE; 4 [2 BENZYLIDENE HYDRAZINO] 6 (4 BROMO PHENYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBONITRILE; 4 [2 BENZYLIDENE HYDRAZINO] 6 (4 FLUORO PHENYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBONITRILE; 4 HYDRAZINO 2 THIOXO 6 (3,4,5 TRIMETHOXY PHENYL) 1,2 DIHYDROPYRIMIDINE 5 CARBON; 5 THIOXO 7 (3,4,5 TRIMETHOXY PHENYL) 5,6 DIHYDRO[1,2,4] [1,5 C] PYRIMIDINE 8 CARBONITRILE; 6 (4 BROMO PHENYL) 4 HYDRAZINO 2 THIOXO 1,2 DIHYDROPYRIMIDINE 5 CARBONITRILE; 6 (4 FLUORO PHENYL) 4 HYDRAZINO 2 THIOXO 1,2 DIHYDROPYRIMIDINE 5 CARBONITRILE; 7 (4 BROMO PHENYL 2 METHYL 5 THIOXO 5,6 DIHYDRO[1,2,4] TRIAZOLO [1,5 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 BROMO PHENYL) 3 OXO 5 THIOXO 2,3,5,6 TETRAHYDRO [1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 BROMO PHENYL) 3,5 DITHIOXO 2,3,5,6 TETRAHYDRO [1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 BROMO PHENYL) 5 THIOXO 5,6 DIHYDRO[1,2,4] TRIAZOLO [1,5 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 BROMO PHENYL) 5 THIOXO 5,6 DIHYDRO[1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 BROMO PHENYL) ARYL 3 METHYL 5 THIOXO 5, 6 DIHYDRO [1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 FLUORO PHENYL 2 METHYL 5 THIOXO 5,6 DIHYDRO[1,2,4] TRIAZOLO [1,5 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 FLUORO PHENYL) 3 OXO 5 THIOXO 2,3,5,6 TETRAHYDRO [1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 FLUORO PHENYL) 3,5 DITHIOXO 2,3,5,6 TETRAHYDRO [1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 FLUORO PHENYL) 5 THIOXO 5,6 DIHYDRO[1,2,4] TRIAZOLO [1,5 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 FLUORO PHENYL) 5 THIOXO 5,6 DIHYDRO[1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; 7 (4 FLUORO PHENYL) ARYL 3 METHYL 5 THIOXO 5, 6 DIHYDRO [1,2,4] TRIAZOLO [4,3 C] PYRIMIDINE 8 CARBONITRILE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIOXIDANT; FLUCONAZOLE; PENICILLIN G; THIOURACIL DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; BACILLUS CEREUS; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; INFRARED RADIATION; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS;

6-ARYL-5-CYANO THIOURACILS; ANTIBACTERIAL; ANTIFUNGAL; ANTIOXIDANT ACTIVITY; RADICAL SCAVENGING; SYNTHESIS;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTIOXIDANTS; BACTERIA; BIPHENYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; FUNGI; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PICRATES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOURACIL;

EID: 84884698050     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.032     Document Type: Article

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