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Volumn 45, Issue 3, 2010, Pages 1158-1166
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Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors
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Author keywords
Antitumor; CDK2; Docking; Pharmacophore; Pyrimidines
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Indexed keywords
1PU501;
2 (2 CHLORO 4 NITROPHENYLAMINO) 6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (3 NITROPHENYL) 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
2 (2 CHLORO 4 NITROPHENYLAMINO) 6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (4 METHYLPHENYL) 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
2 (5 BENZYLIDENE 4 OXO 2 THIOXOTHIAZOLIDIN 3 YLAMINO) 6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (3 NITROPHENYL) 1,6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
2 (BENZYLAMINO) 6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (3 NITROPHENYL) 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
2 (BENZYLAMINO) 6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (4 METHYLPHENYL) 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
2 (BENZYLSULFONYL) 4 (2,4 DIHYDROXYPHENYL) 6 METHYL N (3 NITROPHENYL)PYRIMIDINE 5 CARBOXAMIDE;
2 (BENZYLSULFONYL) 4 (2,4 DIHYDROXYPHENYL) 6 METHYL N (4 METHYLPHENYL)PYRIMIDINE 5 CARBOXAMIDE;
2 (BENZYLTHIO) 6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (3 NITROPHENYL) 6 DIHYDRO PYRIMIDINE 5 CARBOXAMIDE;
2 (BENZYLTHIO) 6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (4 METHYLPHENYL) 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
2PU501;
4 (2,4 DIHYDROXYPHENYL) 2 [5 (FURAN 2 YLMETHYLENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YLAMINO] 6 METHYL N (3 NITROPHENYL) 1,4 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 2 [2 (FURAN 2 YLMETHYLENE)HYDRAZINYL] 4 METHYL N (3 NITROPHENYL) 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 2 [4 (FURAN 2 YLMETHYLENE) 3 METHYL 5 OXO 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 METHYL N (3 NITROPHENYL) 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 2 [4 [N (4,6 DIMETHYLPYRIMIDIN 2 YL)SULFAMOYL]PHENYLAMINO] 4 METHYL N (3 NITROPHENYL)LEVO 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 2 HYDRAZINYL 4 METHYL N (3 NITROPHENYL)LEVO 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 2 MERCAPTO 4 METHYL N (3 NITROPHENYL) 1,6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 2 MERCAPTO 4 METHYL N (4 METHYLPHENYL) 1,6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 4 METHYL 2 [3 METHYL 5 OXO 4 (THIOPHEN 2 YLMETHYLENE) 4,5 DIHYDRO 1H PYRAZOL 1 YL] N (3 NITROPHENYL) 1,6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 4 METHYL 2 [4 [N (5 METHYLISOXAZOL 3 YL)SULFAMOYL]PHENYLAMINO] N (3 NITROPHENYL) 1,2,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (3 NITROPHENYL) 2 [2 (THIOPHEN 2 YLMETHYLENE)HYDRAZINYL] 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (3 NITROPHENYL) 2 [4 (N PYRIMIDIN 2 YL SULFAMOYL)PHENYLAMINO] 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 (2,4 DIHYDROXYPHENYL) 4 METHYL N (3 NITROPHENYL) 2 [4 OXO 5 (THIOPHEN 2 YLMETHYLENE) 2 THIOXOTHIAZOLIDIN 3 YLAMINO] 6 DIHYDROPYRIMIDINE 5 CARBOXAMIDE;
6 O CYCLOHEXYLMETHYLGUANINE;
CYCLIN DEPENDENT KINASE 2 INHIBITOR;
I 17400;
N 201298;
OLOMOUCINE;
PURVALANOL A;
PURVALANOL B;
PYRIMIDINE DERIVATIVE;
ROSCOVITINE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CANCER CELL;
CANCER CELL CULTURE;
CELL PROLIFERATION;
COLON CANCER;
COMPETITIVE INHIBITION;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG POTENCY;
DRUG SCREENING;
DRUG SYNTHESIS;
FEMALE;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
MOLECULAR DOCKING;
MOLECULAR INTERACTION;
PHARMACOPHORE;
UTERINE CERVIX CANCER;
ANTINEOPLASTIC AGENTS;
CATALYTIC DOMAIN;
CELL LINE, TUMOR;
CYCLIN-DEPENDENT KINASE 2;
DRUG DESIGN;
HUMANS;
HYDROGEN BONDING;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
PYRIMIDINES;
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EID: 75849162809
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2009.12.026 Document Type: Article |
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Times cited : (101)
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References (22)
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