Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase

Bioorganic Chemistry

Volumn 34, Issue 1, 2006, Pages 26-38

  Ding, Yili ^a   Girardet, Jean Luc ^a   Smith, Kenneth L ^a   Larson, Gary ^a   Prigaro, Brett ^a   Wu, Jim Z ^a   Yao, Nanhua ^a  

^a Valeant Pharmaceuticals International   (United States)

Author keywords

5 Cyano 6 aryl 2 thiouracil derivatives; HCV; Inhibitors; NS5B

Indexed keywords

5 CYANO 6 ARYL 2 THIOURACIL; RNA POLYMERASE; THIOURACIL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMPLEX FORMATION; HEPATITIS C VIRUS; PRIORITY JOURNAL; SYNTHESIS;

ANTIVIRAL AGENTS; ENZYME INHIBITORS; HEPACIVIRUS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; PYRIDINES; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 31744448134     PISSN: 00452068     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bioorg.2005.10.001     Document Type: Article

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