Stochastic Loss of Silencing of the Imprinted Ndn/NDN Allele, in a Mouse Model and Humans with Prader-Willi Syndrome, Has Functional Consequences

PLoS Genetics

Volumn 9, Issue 9, 2013, Pages

  Rieusset, Anne ^a   Schaller, Fabienne ^a   Unmehopa, Unga ^b   Matarazzo, Valery ^a   Watrin, Françoise ^a   Linke, Matthias ^c   Georges, Beatrice ^d   Bischof, Jocelyn ^e   Dijkstra, Femke ^b   Bloemsma, Monique ^b   Corby, Severine ^a   Michel, François J ^a   Wevrick, Rachel ^e   Zechner, Ulrich ^c   Swaab, Dick ^b   Dudley, Keith ^a   Bezin, Laurent ^d   Muscatelli, Françoise ^a  

^a Turing Center for Living Systems CENTURI Aix Marseille University   (France)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^d UNIVERSITÉ LYON 1   (France)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NECDIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APNEA; ARTICLE; AUTOPSY; CASE REPORT; CELL LOSS; CONTROLLED STUDY; DISEASE SEVERITY; EPIGENETICS; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; GENETIC HETEROGENEITY; GENOME IMPRINTING; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INHERITANCE; LETHALITY; MOUSE; NDN GENE; NON GENETIC HETEROGENEITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRADER WILLI SYNDROME; PROMOTER REGION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SEROTONINERGIC NERVE CELL; WILD TYPE;

ALLELES; ANIMALS; APNEA; BRAIN; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENOMIC IMPRINTING; HETEROZYGOTE; HUMANS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PRADER-WILLI SYNDROME; PROMOTER REGIONS, GENETIC;

EID: 84884695639     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003752     Document Type: Article

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