Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression

Gene Expression Patterns

Volumn 3, Issue 6, 2003, Pages 761-765

  Andrieu, David ^a   Watrin, Françcoise ^a   Niinobe, Michio ^b   Yoshikawa, Kazuaki ^b   Muscatelli, Françoise ^a   Fernandez, Pierre Alain ^a  

^a AIX MARSEILLE UNIVERSITÉ   (France)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Brain development; Gene; In situ hybridization; Mouse; Necdin; p75NTR; Prader Willi; Protein expression pattern; Protein immunostaining

Indexed keywords

CELL MARKER; GENE PRODUCT; MELANOMA ANTIGEN; NECDIN; NEUROTROPHIN RECEPTOR; PROTEIN P75; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRANCHIAL ARCH; CELL CYCLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORRELATION ANALYSIS; DEVELOPMENTAL STAGE; DIENCEPHALON; GENE EXPRESSION; GENE INTERACTION; GENE LOCATION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; INTRACELLULAR MEMBRANE; LIMB DEVELOPMENT; MITOSIS; MOUSE; MULTIGENE FAMILY; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PATHOGENESIS; PERIPHERAL NERVOUS SYSTEM; PONS; PRADER WILLI SYNDROME; PROTEIN DOMAIN; PROTEIN EXPRESSION; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOMITE; THALAMUS;

ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; NERVE TISSUE PROTEINS; NERVOUS SYSTEM; NEURONS; NUCLEAR PROTEINS; PRADER-WILLI SYNDROME; RECEPTOR, NERVE GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR; RNA, MESSENGER;

EID: 0344876548     PISSN: 1567133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-133X(03)00138-8     Document Type: Article

References (11)

1. Aizawa T. Maruyama K. Kondo H. Yoshikawa K. Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain Dev. Brain Res. 68 1992 265-274
2. Berg-von der Emde K. Dees W.L. Hiney J.K. Hill D.F. Dissen G.A. Costa M.E. Moholt-Siebert M. Ojeda S.R. Neurotrophins and the neuroendocrine brain: different neurotrophins sustain anatomically and functionally segregated subsets of hypothalamic dopaminergic neurons J. Neurosci. 15 1995 4223-4237
3. Greferath U. Bennie A. Kourakis A. Bartlett P.F. Murphy M. Barrett G.L. Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice Eur. J. Neurosci. 12 2000 885-893
4. Kendall S.E. Goldhawk D.E. Kubu C. Barker P.A. Verdi J.M. Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis Mech. Dev. 117 2002 187-200
5. Mastick G.S. Andrews G.L. Pax6 regulates the identity of embryonic diencephalic neurons Mol. Cell. Neurosci. 17 2001 190-207
6. McQuillen P.S. DeFreitas M.F. Zada G. Shatz C.J. A novel role for p75NTR in subplate growth cone complexity and visual thalamocortical innervation J. Neurosci. 22 2002 3580-3593
7. Muscatelli F. Abrous D.N. Massacrier A. Boccaccio I. Moal M.L. Cau P. Cremer H. Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome Hum. Mol. Genet. 9 2000 3101-3110
8. Niinobe M. Koyama K. Yoshikawa K. Cellular and subcellular localization of necdin in fetal and adult mouse brain Dev. Neurosci. 22 2000 310-319
9. Salehi A.H. Roux P.P. Kubu C.J. Zeindleer C. Bhakar A. Tannis L.L. Verdi J.M. Barker P.A. NRAGE, a novel MAGE protein, interacts with the p75NTR neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis Neuron 27 2000 279-288
10. Tcherpakov M. Bronfman F.C. Conticello S.G. Vaskovsky A. Levy Z. Niinobe M. Yoshikawa K. Arenas E. Fainzilber M. The p75 neurotrophin receptor interacts with multiple MAGE proteins J. Biol. Chem. 277 2002 49101-49104
11. Yoshikawa K. Cell cycle regulators in neural stem cells and post-mitotic neurons Neurosci. Res. 37 2000 1-14