The mouse Necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome region

European Journal of Human Genetics

Volumn 5, Issue 5, 1997, Pages 324-332

  Watrin, Françoise ^a   Roëckel, Nathalie ^a   Lacroix, Laurence ^a   Mignon, Cécile ^a   Mattei, Marie Geneviève ^a   Disteche, Christine ^b   Muscatelli, Françoise ^a  

^a INSERM   (France)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Asynchronism of replication; DNA methylation; Imprinting; Necdin gene, mouse; Prader Willi syndrome

Indexed keywords

NECDIN; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ANIMAL TISSUE; ARTICLE; DNA METHYLATION; DNA REPLICATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE EXPRESSION; GENE LOCATION; GENE MAPPING; GENOME IMPRINTING; MALE; MOUSE; NERVOUS SYSTEM; NONHUMAN; PRADER WILLI SYNDROME; PRIORITY JOURNAL; SYNTENY; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

ANIMALIA;

EID: 0030776554     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1159/000484784     Document Type: Article

References (49)

1. Maruyama K, Usami M, Aizawa T, Yoshikawa K: A novel brain-specific mRNA endocing nuclear protein (Necdin) expressed in neurally differentiated embryonal carcinoma cells. Biochem Biophys Res Commun 1991;178:291-296.
2. Uetsuki T, Tagaki K, Sugiura H, Yoshikawa K: Structure and expression of the mouse Necdin gene. J Biol Chem 1996;12:918-924.
3. Aizawa T, Maruyama K, Kondo H, Yoshikawa K: Expression of Necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain. Dev Brain Res 1992;68:265-274.
4. Maruyama E: Biochemical characterization of mouse brain necdin. Biochem J 1996;314:895-901.
5. Hayashi Y, Matsuyama K, Tagaki K, Sugiura H, Yoshikawa K: Arrest of cell growth by necdin, a nuclear protein expressed in postmitotic neurons. Biochem Biophys Res Commun 1995;213:317-324.
6. Jay P, Rougeulle C, Massacrier P, et al: Human NECDIN is maternally imprinted and located in the Prader-Willi syndrome chromosomal region. Nat Genet, in press.
7. Nicholls RD, Knoll JHM, Butler MG, Karam S, Lalande M: Genetic imprinting suggested by maternal heterodisomy in non-deletion Prader-Willi syndrome. Nature 1989;342:281-285.
8. Butler MG, Palmer CG: Parental origin of chromosome 15 deletion in Prader-Willi syndrome. Lancet 1983;1:1285-1286.
9. Knoll JHM, Nicholls RD, Magenis RE, Graham JM, Lalande M, Latt SA: Angelman and Prader-Willi syndromes have a common chromosome 15 deletion but differ in parental origin of the deletion. Am J Med Genet 1989;32: 285-290.
10. Sutcliffe JS, Nakao M, Christian S, et al: Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region. Nat Genet 1994;8:52-58.
11. Buiting K, Saitoh S, Gross S, et al: Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15. Nat Genet 1995;9: 395-400.
12. Saitho S, Buiting K, Rogans P, et al: Minimal definition of the imprinting center and fixation of a chromosome 15q11-q13 epigenotype by imprinting mutations. Proc Natl Acad Sci USA 1996;93:7811-7815.
13. Dittrich B, Buiting K, Korn B, et al: Imprinting switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene. Nat Genet 1996;14:163-170.
14. Jong M, Carey A, Stewart C, et al: The ZNF127 gene encodes a novel C3H4 zinc-finger protein and its expression is regulated by genomic imprinting. Am J Hum Genet 1993;53:697.
15. Ozcelik T, Leff S, Robinson W, et al: Small nuclear ribonucleoprotein polypeptide N (SNRPN), an expressed gene in the Prader-Willi syndrome critical region. Nat Genet 1992;2:260.
16. Wevrick R, Kerns J, Francke U: Identification of a novel paternally expressed gene in the Prader-Willi syndrome region. Hum Mol Genet 1994;3:1877-1882.
17. Suiting K, Dittrich B, Endele S, Horstemke B: Identification of novel exons 3' to the human SNRPN gene. Genomics 1997;40:132-137.
18. Lalande M: Parental imprinting and human disease. Annu Rev Genet 1997;30:173-195.
19. Searle AG, Beechy CV: Genome imprinting phenomena on mouse chromosome 7. Genet Res 1990;56:237-244.
20. Beechy CV, Cattanach BM: Genetic and physical imprinting map of the mouse. Mouse Genome 1997;95:100-105.
21. Cattanach BC, Barr JA, Beechey CV, Martin J, Noebels J, Jones J: A candidate model for Angelman syndrome in the mouse. Mamm Genome 1997;8:472-478.
22. Cattanach BM, Barr JA, Evans EP, et al: A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression. Nat Genet 1992;2:270-274.
23. Ausubel F, Brent R, Kingston R, et al: Current Protocols in Molecular Biology. New York, Wiley Interscience, 1987.
24. Laird PW, Zijderveld A, Linders K, Rudnicki A, Jaenish R, Berns A: Simplified mammalian DNA isolation procedure. Nucleic Acids Res 1991;19:4293-4295.
25. Chomcynszki P, Sacchi N: Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorofbrm extraction. Anal Biochem 1987;162:156-159.
26. Pinkel D, Straume T, Gray JW: Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization. Proc Natl Acad Sci USA 1986;83:2934-2938.
27. Matsuda Y, Harada YN, Natsuume-Sakai S, Lee K, Shiomi T, Chapman VM: Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding. Cytogenet Cell Genet 1992;61:282-285.
28. Lemieux N, Dutrillaux B, Viegas-Péquignot E: A simple method for simultaneous R- or G-banding and fluorescence in situ hybridization of small single-copy genes. Cytogenet Cell Genet 1992;59:311-312.
29. Selig S, Okumura K, Ward DC, Cedar H: Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J 1992; 11:1217-1225.
30. Chaillet JR, Knoll JHM, Horsthemke B, Lalande M: The syntenic relationship between the critical deletion region for the Prader-Willi/ Angelman syndromes and proximal mouse chromosome 7. Genomics 1991;11:773-776.
31. Nicholls RD, Gottleib W, Avidano K, Williams CA, Driscoll D: Mouse chromosome mapping of clones from the PWS/AS genetic region. Mouse Genome 1991;89:254.
32. Nicholls RD, Gottleib W, Russel LB, Davda M, Horsthemke B, Rinchick EM: Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse. Proc Natl Acad Sci USA 1993;90:2050-2054.
33. Hansen RS, Canfield TK, Gartler SM: Reverse replication timing for the XIST gene in human fibroblasts. Hum Mol Genet 1995;4:813-820.
34. Kitsberg D, Selig S, Brandeis M, et al: Allele specific replication timing of imprinted gene regions. Nature 1993;364:459-463.
35. Chess A, Simon I, Cedar H, Axel R: Allelic inactivation regulates olfactory receptor gene expression. Cell 1994;78:823-834.
36. De Chiara TM, Robertson EJ, Efstratiadis A: Parental imprinting of the mouse insulin-like growth factor II (Igf2) gene. Cell 1991;64:849-859.
37. Giddings SJ, King CD, Harman KW, Flood JF, Camaghi LR: Allele-specific inactivation of insulin 1 and 2, in the mouse yolk sac indicates imprinting. Nat Genet 1994;6:310-313.
38. Villar AJ, Pederson RA: Parental imprinting of the Mas protooncogene in mouse. Nat Genet 1994;8:373-379.
39. Li E, Bestor TH, Jaenisch R: Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992;69:915-926.
40. Razin A, Cedar H: DNA methylation and genomic imprinting. Cell 1994;77:473-476.
41. Jaenisch R: DNA methylation and imprinting: Why bother? Trends Genet 1997;13:323-329.
42. Horsthemke B, Dittrich B, Buiting K: Parent-of-Origin-Specific DNA Methylation and Imprinting Mutations on Human Chromosome 15. Cambridge, Cambridge University Press, 1995, pp 295-308.
43. Barlow DP: Methylation and imprinting: From host defense to gene regulation? Science 1993; 260:309-310.
44. Hansen RS, Canfield TK, Lamb MM, Gartler SM, Laird CD: Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell 1993;73:1403-1409.
45. Knoll JHG, Cheng SD, Lalande M: Allele specificity of DNA replication timing in the Angelman/Prader-Willi syndrome imprinted chromosomal region. Nat Genet 1994;6:41-46.
46. Gunaratne PH, Nakao M, Ledbetter DH, Sutcliffe JS, Chinault AC: Tissue-specific and allele-specific replication timing control in the imprinted human Prader-Willy syndrome region. Genes Dev 1995;9:808-820.
47. Kawame H, Gartler S, Hansen S: Allele-specific replication timing in imprinted domains: Absence of asynchrony at several loci. Hum Mol Genet 1995;4:2287-2293.
48. White LM, Rogan PK, Nicholls RD, Wu BL, Korf B, Knoll JHM: Allele-specific replication of 15q11-q13 loci: A diagnostic test for detection of uniparental disomy. Am J Hum Genet 1996;59:423-430.
49. Bickmore WA, Carothers AD: Factors affecting the timing and imprinting of replication on a mammalian chromosome. J Cell Sci 1995;108: 2801-2809.