Elevated expression of Notch1 is associated with metastasis of human malignancies

International Journal of Surgical Pathology

Volumn 21, Issue 5, 2013, Pages 449-454

  Zhu, He ^a   Zhou, Xinchun ^a   Redfield, Samantha ^a   He, Zhi ^a   Lewin, Jack ^a   Miele, Lucio ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

cancer metastasis; human malignancies; immunohistochemistry (IHC); Notch1; tissue microarray (TMA)

Indexed keywords

NOTCH1 RECEPTOR;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY METASTASIS; LARYNX CANCER; LIVER CELL CARCINOMA; MALE; METASTASIS; PRIORITY JOURNAL; PROSTATE CANCER; STOMACH CANCER;

CANCER METASTASIS; HUMAN MALIGNANCIES; IMMUNOHISTOCHEMISTRY (IHC); NOTCH1; TISSUE MICROARRAY (TMA);

HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM METASTASIS; NEOPLASMS; RECEPTOR, NOTCH1; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84884691422     PISSN: 10668969     EISSN: 19402465     Source Type: Journal    
DOI: 10.1177/1066896913496146     Document Type: Article

References (28)

1. Miele L. Notching signaling. Clin Cancer Res. 2006 ; 12: 1074-1079
2. Miele L, Miao H, Nickoloff BJ. NOTCH signaling as a novel cancer therapeutic target. Curr Cancer Drug Targets. 2006 ; 6: 313-323
3. Shih IeM, Wang TL. Notch signaling, γ-secretase inhibitors, and cancer therapy. Cancer Res. 2007 ; 5: 1879-1882
4. Espinoza I, Miele L. Notch inhibitors for cancer treatment. Pharmacol Ther. 2013 ; 2: 95-110
5. Reedijk M, Odorcic S, Chang L, et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 2005 ; 65: 8530-8537
6. Dickson BC, Mulligan AM, Zhang H, et al. High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol. 2007 ; 20: 685-693
7. Zeng Q, Li S, Chepeha DB, et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell. 2005 ; 1: 13-23
8. Hellström M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007 ; 445: 776-780
9. Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature. 2006 ; 444: 1032-1037
10. Scorey N, Fraser SP, Patel P, Pridgeon C, Dallman MJ, Djamgoz MB. Notch signaling and voltage-gated Na (+) channel activity in human prostate cancer cells: Independent modulation of in vitro motility. Prostate Cancer Prostatic Dis. 2006 ; 9: 399-406
11. Shou J, Ross S, Koeppen H, de Sauvage FJ, Gao W-Q. Dynamics of Notch expression during murine prostate development. Cancer Res. 2001 ; 61: 7291-7297
12. Gipp J, Gu G, Crylen C, Kasper S, Bushman W. Hedgehog pathway activity in the LADY prostate tumor model. Mol Cancer. 2007 ; 6: 19
13. Santagata S, Demichelis F, Riva A, et al. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res. 2004 ; 64: 6854-6857
14. Hafeez BB, Adhami VM, Asim M, et al. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin Cancer Res. 2009 ; 15: 452-459
15. Wang Z, Li Y, Banerjee S, et al. Down-regulation of Notch1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. J Cell Biochem. 2010 ; 109: 726-736
16. Sethi S, Macoska J, Chen W, Sarkar FH. Molecular signature of epithelial-mesenchymal transition (EMT) in human prostate cancer bone metastasis. Am J Transl Res. 2010 ; 3: 90-99
17. Wang XQ, Zhang W, Lui EL, et al. Notch1-Snail1-E-cadherin pathway in metastatic hepatocellular carcinoma. Int J Cancer. 2012 ; 131: E163 - E172
18. Ai Q, Ma X, Huang Q, et al. High-level expression of Notch1 increased the risk of metastasis in T1 stage clear cell renal cell carcinoma. PLoS One. 2012 ; 7: e35022
19. Zavadil J, Cermak L, Soto-Nieves N, Böttinger EP. Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J. 2004 ; 23: 1155-1165
20. Garcia A, Kandel JJ. Notch: a key regulator of tumor angiogenesis and metastasis. Histol Histopathol. 2012 ; 27: 151-156
21. Hu YY, Zheng MH, Zhang R, Liang YM, Han H. Notch signaling pathway and cancer metastasis. Adv Exp Med Biol. 2012 ; 727: 186-198
22. Zhou X, Lawrence TJ, He Z, Pound CR, Mao J, Bigler SA. The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer. Exp Mol Pathol. 2012 ; 92: 105-110
23. Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med. 2002 ; 8: 979-986
24. Rizzo P, Miao H, D'Souza G, et al. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res. 2008 ; 68: 5226-5235
25. Hao L, Rizzo P, Osipo C, et al. Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene. 2010 ; 29: 201-213
26. Pannuti A, Foreman K, Rizzo P, et al. Targeting Notch to target cancer stem cells. Clin Cancer Res. 2010 ; 16: 3141-3152
27. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2002 ; 2: 563-572
28. Fidler IJ. The pathogenesis of cancer metastasis: the "seed and soil" hypothesis revisited. Nat Rev Cancer. 2003 ; 3: 453-458