Hedgehog pathway activity in the LADY prostate tumor model

Molecular Cancer

Volumn 6, Issue , 2007, Pages

  Gipp, Jerry ^a   Gu, Guangyu ^b   Crylen, Curtis ^a   Kasper, Susan ^b   Bushman, Wade ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 3ALPHA; NESTIN; NOTCH1 RECEPTOR; PROBASIN; PROTEIN NPDC 1; PROTEIN PATCHED; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TUMOR MARKER; UNCLASSIFIED DRUG; ANDROGEN BINDING PROTEIN; CELL SURFACE RECEPTOR; FOXA1 PROTEIN, MOUSE; FOXA2 PROTEIN, MOUSE; GLI PROTEIN, MOUSE; HEPATOCYTE NUCLEAR FACTOR 3BETA; HYBRID PROTEIN; IHH PROTEIN, MOUSE; INTERMEDIATE FILAMENT PROTEIN; KRUPPEL LIKE FACTOR; MESSENGER RNA; NERVE PROTEIN; NOTCH1 PROTEIN, MOUSE; NPDC1 PROTEIN, MOUSE; PATCHED RECEPTORS; RNA; SHH PROTEIN, MOUSE; TUMOR PROTEIN; VIRUS T ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL POPULATION; CONTROLLED STUDY; GENE TARGETING; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PROSTATE TUMOR; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; TUMOR DIFFERENTIATION; TUMOR XENOGRAFT; ADENOCARCINOMA; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; TIME; TRANSGENIC MOUSE;

ERINACEIDAE; MUS MUSCULUS;

ADENOCARCINOMA; ANDROGEN-BINDING PROTEIN; ANIMALS; ANTIGENS, VIRAL, TUMOR; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; HEPATOCYTE NUCLEAR FACTOR 3-BETA; INTERMEDIATE FILAMENT PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICE; MICE, TRANSGENIC; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; STEM CELLS; TIME FACTORS;

EID: 33947274103     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-6-19     Document Type: Article

References (21)

1. Ingham PW McMahon AP Hedgehog signaling in animal development: Paradigms and principles Genes Dev 2001 15 23 3059-3087 10.1101/gad.938601 11731473
2. Berman DM Desai N Wang X Karhadkar SS Reynon M Abate-Shen C Beachy PA Shen MM Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis Dev Biol 2004 267 2 387-398 10.1016/ j.ydbio.2003.11.018 15013801
3. Freestone SH Marker P Grace OC Tomlinson DC Cunha GR Harnden P Thomson AA Sonic hedgehog regulates prostatic growth and epithelial differentiation Dev Biol 2003 264 2 352-362 10.1016/j.ydbio.2003.08.018 14651923
4. Lamm ML Catbagan WS Laciak RJ Barnett DH Hebner CM Gaffield W Walterhouse D Iannaccone P Bushman W Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation Dev Biol 2002 249 2 349-366 10.1006/dbio.2002.0774 12221011
5. Podlasek CA Barnett DH Clemens JQ Bak PM Bushman W Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium Dev Biol 1999 209 1 28-39 10.1006/dbio.1999.9229 10208740
6. Pu Y Huang L Prins GS Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: Lobe-specific suppression by neonatal estrogens reduces ductal growth and branching Dev Biol 2004 273 2 257-275 10.1016/j.ydbio.2004.06.002 15328011
7. Wang BE Shou J Ross S Koeppen H De Sauvage FJ Gao WQ Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells J Biol Chem 2003 278 20 18506-18513 10.1074/jbc.M300968200 12626524
8. Doles J Cook C Shi X Valosky J Lipinski R Bushman W Functional compensation in Hedgehog signaling during mouse prostate development Dev Biol 2006 295 1 13-25 10.1016/j.ydbio.2005.12.002 16707121
9. Gao N Ishii K Mirosevich J Kuwajima S Oppenheimer SR Roberts RL Jiang M Yu X Shappell SB Caprioli RM Stoffel M Hayward SW Matusik RJ Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation Development 2005 132 15 3431-3443 10.1242/dev.01917 15987773
10. Fan L Pepicelli CV Dibble CC Catbagan W Zarycki JL Laciak R Gipp J Shaw A Lamm ML Munoz A Lipinski R Thrasher JB Bushman W Hedgehog signaling promotes prostate xenograft tumor growth Endocrinology 2004 145 8 3961-3970 10.1210/en.2004-0079 15132968
11. Karhadkar SS Bova GS Abdallah N Dhara S Gardner D Maitra A Isaacs JT Berman DM Beachy PA Hedgehog signalling in prostate regeneration, neoplasia and metastasis Nature 2004 431 7009 707-712 10.1038/ nature02962 15361885
12. Sanchez P Hernandez AM Stecca B Kahler AJ DeGueme AM Barrett A Beyna M Datta MW Datta S Ruiz i Altaba A Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling Proc Natl Acad Sci U S A 2004 101 34 12561-12566 514658 15314219 10.1073/ pnas.0404956101
13. Sheng T Li C Zhang X Chi S He N Chen K McCormick F Gatalica Z Xie J Activation of the hedgehog pathway in advanced prostate cancer Mol Cancer 2004 3 1 29 524523 15482598 10.1186/1476-4598-3-29
14. Kasper S Sheppard PC Yan Y Pettigrew N Borowsky AD Prins GS Dodd JG Duckworth ML Matusik RJ Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: A model for prostate cancer Lab Invest 1998 78 3 319-333 9520945
15. Lipinski RJ Cook CH Barnett DH Gipp JJ Peterson RE Bushman W Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development Dev Dyn 2005 233 3 829-836 10.1002/dvdy.20414 15906375
16. Shaw A Papadopoulos J Johnson C Bushman W Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line Prostate 2006 66 13 1347-1358 10.1002/pros.20357 16752376
17. Wang XD Leow CC Zha J Tang Z Modrusan Z Radtke F Aguet M de Sauvage FJ Gao WQ Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation Dev Biol 2006 290 1 66-80 10.1016/ j.ydbio.2005.11.009 16360140
18. Mirosevich J Gao N Gupta A Shappell SB Jove R Matusik RJ Expression and role of Foxa proteins in prostate cancer Prostate 2006 66 10 1013-1028 10.1002/pros.20299 16001449
19. Shaw A Bushman W Hedgehog Signaling in the Prostate The Journal of Urology 2007 177
20. Goto K Salm SN Coetzee S Xiong X Burger PE Shapiro E Lepor H Moscatelli D Wilson EL Proximal prostatic stem cells are programmed to regenerate a proximal-distal ductal axis Stem Cells 2006 24 8 1859-1868 10.1634/ stemcells.2005-0585 16644920
21. Mirosevich J Gao N Matusik RJ Expression of Foxa transcription factors in the developing and adult murine prostate Prostate 2005 62 4 339-352 10.1002/pros.20131 15389796