Peroxisome Protein Transportation Affects Metabolism of Branched-Chain Fatty Acids That Critically Impact Growth and Development of C. elegans

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Wang, Rencheng ^a   Kniazeva, Marina ^a   Han, Min ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; MICROORGANISM PROTEIN; MONOMETHYL BRANCHED CHAIN FATTY ACID; PEROXISOME PROTEIN; PROTEIN ELO6; PROTEIN PRX5; TYPE 1 PEROXISOMAL TARGETING SIGNAL PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DEGRADATION KINETICS; ELO 5 GENE; FATTY ACID ANALYSIS; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENE; GENETIC SCREENING; GROWTH REGULATION; LARVAL STAGE; LOSS OF FUNCTION MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPIC VARIATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN TRANSPORT; PRX5 GENE;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHROMATOGRAPHY, GAS; CLONING, MOLECULAR; DNA PRIMERS; FATTY ACIDS; GENETIC TESTING; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; PEROXISOMES; PROTEIN TRANSPORT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA INTERFERENCE; SUPPRESSION, GENETIC;

EID: 84884684685     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076270     Document Type: Article

References (35)

1. Spector AA, Yorek MA, (1985) Membrane lipid composition and cellular function. J Lipid Res 26: 1015-1035. PubMed: 3906008.
2. Yeagle PL, (1989) Lipid regulation of cell membrane structure and function. FASEB J 3: 1833-1842. PubMed: 2469614.
3. Wymann MP, Schneiter R, (2008) Lipid signalling in disease. Nat Rev Mol Cell Biol 9: 162-176. doi:10.1038/nrg2324. PubMed: 18216772.
4. Pitson SM, (2011) Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem Sci 36: 97-107. doi:10.1016/j.tibs.2010.08.001. PubMed: 20870412.
5. Jordan SD, Könner AC, Brüning JC, (2010) Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci 67: 3255-3273. doi:10.1007/s00018-010-0414-7. PubMed: 20549539.
6. Vrablik TL, Watts JL, (2012) Emerging roles for specific fatty acids in developmental processes. Genes Dev 26: 631-637. doi:10.1101/gad.190777.112. PubMed: 22474257.
7. Webster CM, Deline ML, Watts JL, (2013) Stress response pathways protect germ cells from omega-6 polyunsaturated fatty acid-mediated toxicity in Caenorhabditis elegans. Dev Biol 373: 14-25. doi:10.1016/j.ydbio.2012.10.002. PubMed: 23064027.
8. Vrablik TL, Watts JL, (2013) Polyunsaturated fatty acid derived signaling in reproduction and development: insights from Caenorhabditis elegans and Drosophila melanogaster. Mol Reprod Dev 80: 244-259. doi:10.1002/mrd.22167. PubMed: 23440886.
9. Heird WC, Lapillonne A, (2005) The role of essential fatty acids in development. Annu Rev Nutr 25: 549-571. doi:10.1146/annurev.nutr.24.012003.132254. PubMed: 16011478.
10. Riediger ND, Othman RA, Suh M, Moghadasian MH, (2009) A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc 109: 668-679. doi:10.1016/j.jada.2008.12.022. PubMed: 19328262.
11. Kniazeva M, Crawford QT, Seiber M, Wang CY, Han M, (2004) Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. PLOS Biol 2: E257. doi:10.1371/journal.pbio.0020257. PubMed: 15340492.
12. Jones LN, Rivett DE, (1997) The role of 18-methyleicosanoic acid in the structure and formation of mammalian hair fibres. Micron 28: 469-485. doi:10.1016/S0968-4328(97)00039-5. PubMed: 9519472.
13. Hradec J, Dufek P, (1994) Determination of cholesteryl 14-methylhexadecanoate in blood serum by reversed-phase high-performance liquid chromatography. J Chromatogr B Appl Biomed 660: 386-389. PubMed: 7866530.
14. Kniazeva M, Euler T, Han M, (2008) A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans. Genes Dev 22: 2102-2110. doi:10.1101/gad.1692008. PubMed: 18676815.
15. Kniazeva M, Shen H, Euler T, Wang C, Han M, (2012) Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Genes Dev 26: 554-566. doi:10.1101/gad.187054.112. PubMed: 22426533.
16. Zhu H, Shen H, Sewell AK, Kniazeva M, Han M, (2013) A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. eLife. 2: e00429.
17. Thieringer H, Moellers B, Dodt G, Kunau WH, Driscoll M, (2003) Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. J Cell Sci 116: 1797-1804. doi:10.1242/jcs.00380. PubMed: 12665560.
18. Purdue PE, Lazarow PB, (2001) Peroxisome biogenesis. Annu Rev Cell Dev Biol 17: 701-752. doi:10.1146/annurev.cellbio.17.1.701. PubMed: 11687502.
19. Moser HW, (1999) Genotype-phenotype correlations in disorders of peroxisome biogenesis. Mol Genet Metab 68: 316-327. doi:10.1006/mgme.1999.2926. PubMed: 10527683.
20. Seamen E, Blanchette JM, Han M, (2009) P-type ATPase TAT-2 negatively regulates monomethyl branched-chain fatty acid mediated function in post-embryonic growth and development in C. elegans. PLOS Genet 5: e1000589.
21. Davis MW, Hammarlund M, Harrach T, Hullett P, Olsen S, et al. (2005) Rapid single nucleotide polymorphism mapping in C. elegans. BMC Genomics 6: 118. doi:10.1186/1471-2164-6-118. PubMed: 16156901.
22. Hillier LW, Marth GT, Quinlan AR, Dooling D, Fewell G, et al. (2008) Whole-genome sequencing and variant discovery in C. elegans. Nat Methods 5: 183-188. doi:10.1038/nmeth.1179. PubMed: 18204455.
23. Bigelow H, Doitsidou M, Sarin S, Hobert O, (2009) MAQGene: software to facilitate C. elegans mutant genome sequence analysis. Nat Methods 6: 549. doi:10.1038/nmeth.f.260. PubMed: 19620971.
24. Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231-237. doi:10.1038/nature01278. PubMed: 12529635.
25. Zipperlen P, Fraser AG, Kamath RS, Martinez-Campos M, Ahringer J, (2001) Roles for 147 embryonic lethal genes on C. elegans chromosome I identified by RNA interference and video microscopy. EMBO J 20: 3984-3992. doi:10.1093/emboj/20.15.3984. PubMed: 11483502.
26. Rebbapragada I, Lykke-Andersen J, (2009) Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol 21: 394-402. doi:10.1016/j.ceb.2009.02.007. PubMed: 19359157.
27. Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, et al. (2006) Peroxisome biogenesis disorders. Biochim Biophys Acta 1763: 1733-1748. doi:10.1016/j.bbamcr.2006.09.010. PubMed: 17055079.
28. Brock TJ, Browse J, Watts JL, (2006) Genetic regulation of unsaturated fatty acid composition in C. elegans. PLOS Genet 2: e108. doi:10.1371/journal.pgen.0020108. PubMed: 16839188.
29. Watts JL, Browse J, (2002) Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans. Proc Natl Acad Sci U S A 99: 5854-5859. doi:10.1073/pnas.092064799. PubMed: 11972048.
30. Zhang Y, Zou X, Ding Y, Wang H, Wu X, et al. (2013) Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. BMC Genomics 14: 164. doi:10.1186/1471-2164-14-164. PubMed: 23496871.
31. Poirier Y, Antonenkov VD, Glumoff T, Hiltunen JK, (2006) Peroxisomal beta-oxidation--a metabolic pathway with multiple functions. Biochim Biophys Acta 1763: 1413-1426. doi:10.1016/j.bbamcr.2006.08.034. PubMed: 17028011.
32. Zhang SO, Box AC, Xu N, Le Men J, Yu J, et al. (2010) Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans. Proc Natl Acad Sci U S A 107: 4640-4645. doi:10.1073/pnas.0912308107. PubMed: 20176933.
33. Zhu H, Shen H, Sewell AK, Kniazeva M, Han M, (2013) A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in C. elegans. eLife. In press.
34. Joo HJ, Yim YH, Jeong PY, Jin YX, Lee JE, et al. (2009) Caenorhabditis elegans utilizes dauer pheromone biosynthesis to dispose of toxic peroxisomal fatty acids for cellular homoeostasis. Biochem J 422: 61-71. doi:10.1042/BJ20090513. PubMed: 19496754.
35. Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, et al. (2009) Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A 106: 1875-1879. doi:10.1073/pnas.0810338106. PubMed: 19174521.