메뉴 건너뛰기




Volumn 10, Issue 9, 2013, Pages 4261-4273

Epigenetic findings in autism: New perspectives for therapy

Author keywords

Autism; Environmental factors; Gene expression

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; DNA; MESSENGER RNA; NEUROMODULIN; POLYBROMINATED DIPHENYL ETHER; PROTEIN BCL 2;

EID: 84884677843     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph10094261     Document Type: Review
Times cited : (54)

References (85)
  • 1
    • 84870469320 scopus 로고    scopus 로고
    • American Psychiatric Association, 4th ed.; American Psychiatric Association: Washington, DC, USA
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Text Revision, 4th ed.; American Psychiatric Association: Washington, DC, USA, 2000.
    • (2000) Diagnostic and Statistical Manual of Mental Disorders, Text Revision
  • 2
    • 84875676583 scopus 로고    scopus 로고
    • A brief history of autism, the autism/vaccine hypothesis and areview of the genetic basis of autism spectrum disorders
    • Spec No: 58-65
    • Blake, J.; Hoyme, H.E.; Crotwell, P.L. A brief history of autism, the autism/vaccine hypothesis and areview of the genetic basis of autism spectrum disorders. S D Med. 2013, Spec No: 58-65.
    • (2013) S D Med
    • Blake, J.1    Hoyme, H.E.2    Crotwell, P.L.3
  • 3
    • 84878527894 scopus 로고    scopus 로고
    • Possible use of Trichuris suis ova in autism spectrum disorders therapy
    • Siniscalco, D.; Antonucci, N. Possible use of Trichuris suis ova in autism spectrum disorders therapy. Med. Hypotheses 2013, 81, 1-4.
    • (2013) Med. Hypotheses , vol.81 , pp. 1-4
    • Siniscalco, D.1    Antonucci, N.2
  • 4
    • 79952448691 scopus 로고
    • Autism Spectrum Disorders
    • Pagon, R.A., Adam, M.P., Bird, T.D., Dolan, C.R., Fong, C.T., Stephens, K., Eds.; University of Washington: Seattle, WA, USA,-2013
    • Miles, J.H.; McCathren, R.B.; Stichter, J.; Shinawi, M. Autism Spectrum Disorders. In GeneReviews™ (Internet); Pagon, R.A., Adam, M.P., Bird, T.D., Dolan, C.R., Fong, C.T., Stephens, K., Eds.; University of Washington: Seattle, WA, USA, 1993-2013.
    • (1993) GeneReviews™ (Internet)
    • Miles, J.H.1    McCathren, R.B.2    Stichter, J.3    Shinawi, M.4
  • 5
    • 77952501114 scopus 로고    scopus 로고
    • Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder
    • Bradstreet, J.J.; Smith, S.; Baral, M.; Rossignol, D.A. Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. Altern. Med. Rev. 2010, 15, 15-32.
    • (2010) Altern. Med. Rev , vol.15 , pp. 15-32
    • Bradstreet, J.J.1    Smith, S.2    Baral, M.3    Rossignol, D.A.4
  • 7
    • 77957228730 scopus 로고    scopus 로고
    • The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels
    • doi:10.1155/2009/532640
    • Adams, J.B.; Baral, M.; Geis, E.; Mitchell, J.; Ingram, J.; Hensley, A.; Zappia, I.; Newmark, S.; Gehn, E.; Rubin, R.A.; et al. The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels. J. Toxicol. 2009, 2009, doi:10.1155/2009/532640.
    • (2009) J. Toxicol , vol.2009
    • Adams, J.B.1    Baral, M.2    Geis, E.3    Mitchell, J.4    Ingram, J.5    Hensley, A.6    Zappia, I.7    Newmark, S.8    Gehn, E.9    Rubin, R.A.10
  • 8
    • 84879809574 scopus 로고    scopus 로고
    • What is new in adolescent psychiatry? Literature review and clinical implications
    • Kaplan, G. What is new in adolescent psychiatry? Literature review and clinical implications. Adolesc. Med. State Art. Rev. 2013, 24, 29-42.
    • (2013) Adolesc. Med. State Art. Rev , vol.24 , pp. 29-42
    • Kaplan, G.1
  • 9
    • 84880231234 scopus 로고    scopus 로고
    • Epigenomic strategies at the interface of genetic and environmental risk factors for autism
    • doi:10.1038/jhg.2013.49
    • Lasalle, J.M. Epigenomic strategies at the interface of genetic and environmental risk factors for autism. J. Hum. Genet. 2013, 58, 396-401, doi:10.1038/jhg.2013.49.
    • (2013) J. Hum. Genet , vol.58 , pp. 396-401
    • Lasalle, J.M.1
  • 10
    • 84875740830 scopus 로고    scopus 로고
    • Environmental influences and emerging mechanisms in the etiology of autism
    • Bushnell, P.J. Environmental influences and emerging mechanisms in the etiology of autism. Neurotoxicol. Teratol. 2013, 36, 1-2.
    • (2013) Neurotoxicol. Teratol , vol.36 , pp. 1-2
    • Bushnell, P.J.1
  • 12
    • 77949368541 scopus 로고    scopus 로고
    • Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
    • Herbert, M.R. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr. Opin. Neurol. 2010, 23, 103-110.
    • (2010) Curr. Opin. Neurol , vol.23 , pp. 103-110
    • Herbert, M.R.1
  • 13
    • 84858119840 scopus 로고    scopus 로고
    • Autism spectrum disorders: Is mesenchymal stem cell personalized therapy the future?
    • doi:10.1155/2012/480289
    • Siniscalco, D.; Sapone, A.; Cirillo, A.; Giordano, C.; Maione, S.; Antonucci, N. Autism spectrum disorders: Is mesenchymal stem cell personalized therapy the future? J. Biomed. Biotechnol. 2012, 2012, doi:10.1155/2012/480289.
    • (2012) J. Biomed. Biotechnol , vol.2012
    • Siniscalco, D.1    Sapone, A.2    Cirillo, A.3    Giordano, C.4    Maione, S.5    Antonucci, N.6
  • 16
  • 17
    • 0002947085 scopus 로고
    • The epigenotype
    • Waddington, C.H. The epigenotype. Endeavor.1942, 1, 18-20.
    • (1942) Endeavor. , vol.1 , pp. 18-20
    • Waddington, C.H.1
  • 19
    • 84871231837 scopus 로고    scopus 로고
    • The expanding genomic landscape of autism: Discovering the "forest" beyond the "trees"
    • Hu, V.W. The expanding genomic landscape of autism: Discovering the "forest" beyond the "trees". Future Neurol. 2013, 8, 29-42.
    • (2013) Future Neurol , vol.8 , pp. 29-42
    • Hu, V.W.1
  • 21
    • 33646557031 scopus 로고    scopus 로고
    • Epigenetics: Unfinished symphony
    • Qiu, J. Epigenetics: Unfinished symphony. Nature 2006, 441, 143-145.
    • (2006) Nature , vol.441 , pp. 143-145
    • Qiu, J.1
  • 22
    • 84865447919 scopus 로고    scopus 로고
    • The epigenetic lorax: Gene-environment interactions in human health
    • Latham, K.E.; Sapienza, C.; Engel, N. The epigenetic lorax: Gene-environment interactions in human health. Epigenomics 2012, 4, 383-402.
    • (2012) Epigenomics , vol.4 , pp. 383-402
    • Latham, K.E.1    Sapienza, C.2    Engel, N.3
  • 24
    • 84874134580 scopus 로고    scopus 로고
    • DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor
    • doi:10.1371/ journal.pone.0056869
    • Mamrut, S.; Harony, H.; Sood, R.; Shahar-Gold, H.; Gainer, H.; Shi, Y.J.; Barki-Harrington, L.; Wagner, S. DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor. PLoS One 2013, 8, e56869, doi:10.1371/ journal.pone.0056869.
    • (2013) PLoS One , vol.8
    • Mamrut, S.1    Harony, H.2    Sood, R.3    Shahar-Gold, H.4    Gainer, H.5    Shi, Y.J.6    Barki-Harrington, L.7    Wagner, S.8
  • 25
    • 79952438178 scopus 로고    scopus 로고
    • The contribution of oxytocin and vasopressin to mammalian social behavior: Potential role in autism spectrum disorder
    • Harony, H.; Wagner, S. The contribution of oxytocin and vasopressin to mammalian social behavior: Potential role in autism spectrum disorder. Neurosignals 2010, 18, 82-97.
    • (2010) Neurosignals , vol.18 , pp. 82-97
    • Harony, H.1    Wagner, S.2
  • 26
    • 84933674198 scopus 로고    scopus 로고
    • DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli
    • doi:10.3389/fnhum.2012.00280
    • Jack, A.; Connelly, J.J.; Morris, J.P. DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli. Front. Hum. Neurosci. 2012, 6, 280, doi:10.3389/fnhum.2012.00280.
    • (2012) Front. Hum. Neurosci , vol.6 , pp. 280
    • Jack, A.1    Connelly, J.J.2    Morris, J.P.3
  • 28
    • 84872401292 scopus 로고    scopus 로고
    • SHANK3 as an autism spectrum disorder-associated gene
    • Uchino, S.; Waga, C. SHANK3 as an autism spectrum disorder-associated gene. Brain Dev. 2013, 35, 106-110.
    • (2013) Brain Dev , vol.35 , pp. 106-110
    • Uchino, S.1    Waga, C.2
  • 31
    • 84877336575 scopus 로고    scopus 로고
    • Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling
    • Földy, C.; Malenka, R.C.; Südhof, T.C. Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron 2013,78, 498-509.
    • (2013) Neuron , vol.78 , pp. 498-509
    • Földy, C.1    Malenka, R.C.2    Südhof, T.C.3
  • 34
    • 77955803943 scopus 로고    scopus 로고
    • Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain
    • Nguyen, A.; Rauch, T.A.; Pfeifer, G.P.; Hu, V.W. Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J. 2010, 24, 3036-3051.
    • (2010) FASEB J , vol.24 , pp. 3036-3051
    • Nguyen, A.1    Rauch, T.A.2    Pfeifer, G.P.3    Hu, V.W.4
  • 35
    • 84870990121 scopus 로고    scopus 로고
    • The secrets of the Bcl-2 family
    • García-Sáez, A.J. The secrets of the Bcl-2 family. Cell. Death Differ. 2012, 19, 1733-1740.
    • (2012) Cell. Death Differ , vol.19 , pp. 1733-1740
    • García-Sáez, A.J.1
  • 37
    • 84871713273 scopus 로고    scopus 로고
    • Is retinoic acid-related orphan receptor-alpha (RORA) a target for gene-environment interactions contributing to autism?
    • Hu, VW. Is retinoic acid-related orphan receptor-alpha (RORA) a target for gene-environment interactions contributing to autism? Neurotoxicology 2012, 33, 1434-1435.
    • (2012) Neurotoxicology , vol.33 , pp. 1434-1435
    • Hu, V.W.1
  • 38
    • 79951876357 scopus 로고    scopus 로고
    • Sex hormones in autism: Androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism
    • doi:10.1371/journal.pone.0017116
    • Sarachana, T.; Xu, M.; Wu, R.C.; Hu, V.W. Sex hormones in autism: Androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism. PLoS One 2011, 6, e17116, doi:10.1371/journal.pone.0017116.
    • (2011) PLoS One , vol.6
    • Sarachana, T.1    Xu, M.2    Wu, R.C.3    Hu, V.W.4
  • 39
    • 77957364779 scopus 로고    scopus 로고
    • Epigenetics, copy number variation, and other molecular mechanisms underlying neurodevelopmental disabilities: New insights and diagnostic approaches
    • Gropman, A.L.; Batshaw, M.L. Epigenetics, copy number variation, and other molecular mechanisms underlying neurodevelopmental disabilities: New insights and diagnostic approaches. J. Dev. Behav. Pediatr. 2010, 31, 582-591.
    • (2010) J. Dev. Behav. Pediatr , vol.31 , pp. 582-591
    • Gropman, A.L.1    Batshaw, M.L.2
  • 40
    • 38449096091 scopus 로고    scopus 로고
    • Epigenetics and Neural developmental disorders: Washington DC, September 18 and 19, 2006
    • Zhao, X.; Pak, C.; Smrt, R.D.; Jin, P. Epigenetics and Neural developmental disorders: Washington DC, September 18 and 19, 2006. Epigenetics 2007, 2, 126-134.
    • (2007) Epigenetics , vol.2 , pp. 126-134
    • Zhao, X.1    Pak, C.2    Smrt, R.D.3    Jin, P.4
  • 41
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger, S.L. The complex language of chromatin regulation during transcription. Nature 2007, 447, 407-412.
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 42
    • 58149316420 scopus 로고    scopus 로고
    • Epigenetic regulation in human brain-focus on histone lysine methylation
    • Akbarian, S.; Huang, H.S. Epigenetic regulation in human brain-focus on histone lysine methylation. Biol. Psychiatry 2009, 65, 198-203.
    • (2009) Biol. Psychiatry , vol.65 , pp. 198-203
    • Akbarian, S.1    Huang, H.S.2
  • 43
    • 9944228800 scopus 로고    scopus 로고
    • Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development
    • Biron, V.L.; McManus, K.J.; Hu, N.; Hendzel, M.J.; Underhill, D.A. Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development. Dev. Biol. 2004, 276, 337-351.
    • (2004) Dev. Biol , vol.276 , pp. 337-351
    • Biron, V.L.1    McManus, K.J.2    Hu, N.3    Hendzel, M.J.4    Underhill, D.A.5
  • 45
    • 38849159213 scopus 로고    scopus 로고
    • A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD)
    • Adegbola, A.; Gao, H.; Sommer, S.; Browning, M. A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD). Am. J. Med. Genet. Part A 2008, 146A, 505-511.
    • (2008) Am. J. Med. Genet. Part A , vol.146 A , pp. 505-511
    • Adegbola, A.1    Gao, H.2    Sommer, S.3    Browning, M.4
  • 46
    • 84891672572 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles
    • Wang, H.; Duclot, F.; Liu, Y.; Wang, Z.; Kabbaj, M. Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles. Nat. Neurosci. 2013, 16, 919-924.
    • (2013) Nat. Neurosci , vol.16 , pp. 919-924
    • Wang, H.1    Duclot, F.2    Liu, Y.3    Wang, Z.4    Kabbaj, M.5
  • 47
    • 84859508516 scopus 로고    scopus 로고
    • Epigenetics in autism and other neurodevelopmental diseases
    • Miyake, K.; Hirasawa, T.; Koide, T.; Kubota, T. Epigenetics in autism and other neurodevelopmental diseases. Adv. Exp. Med. Biol. 2012, 724, 91-98.
    • (2012) Adv. Exp. Med. Biol , vol.724 , pp. 91-98
    • Miyake, K.1    Hirasawa, T.2    Koide, T.3    Kubota, T.4
  • 48
  • 52
    • 47549119657 scopus 로고    scopus 로고
    • Central vasopressin and oxytocin release: Regulation of complex social behaviours
    • Veenema, A.H.; Neumann, I.D. Central vasopressin and oxytocin release: Regulation of complex social behaviours. Prog. Brain Res. 2008, 170, 261-276.
    • (2008) Prog. Brain Res , vol.170 , pp. 261-276
    • Veenema, A.H.1    Neumann, I.D.2
  • 53
    • 84880325577 scopus 로고    scopus 로고
    • Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders
    • doi:10.1016/j.bbr.2012.08.011
    • Lukas, M.; Neumann, I.D. Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders. Behav. Brain Res. 2012, doi:10.1016/j.bbr.2012.08.011.
    • (2012) Behav. Brain Res
    • Lukas, M.1    Neumann, I.D.2
  • 54
    • 79960936405 scopus 로고    scopus 로고
    • Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice
    • Murakami, G.; Hunter, R.G.; Fontaine, C.; Ribeiro, A.; Pfaff, D. Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice. Eur. J. Neurosci. 2011, 34, 469-477.
    • (2011) Eur. J. Neurosci , vol.34 , pp. 469-477
    • Murakami, G.1    Hunter, R.G.2    Fontaine, C.3    Ribeiro, A.4    Pfaff, D.5
  • 55
    • 84878872432 scopus 로고    scopus 로고
    • Epigenetic regulation of the oxytocin receptor gene: Implications for behavioral neuroscience
    • doi:10.3389/ fnins.2013.00083
    • Kumsta, R.; Hummel, E.; Chen, F.S.; Heinrichs, M. Epigenetic regulation of the oxytocin receptor gene: Implications for behavioral neuroscience. Front. Neurosci. 2013, 7, 83, doi:10.3389/ fnins.2013.00083.
    • (2013) Front. Neurosci , vol.7 , pp. 83
    • Kumsta, R.1    Hummel, E.2    Chen, F.S.3    Heinrichs, M.4
  • 56
    • 84879471590 scopus 로고    scopus 로고
    • Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: A case-control study in a Japanese population and functional analysis
    • doi:10.1186/2040-2392-4-22
    • Ma, W.J.; Hashii, M.; Munesue, T.; Hayashi, K.; Yagi, K.; Yamagishi, M.; Higashida, H.; Yokoyama, S. Non-synonymous single-nucleotide variations of the human oxytocin receptor gene and autism spectrum disorders: A case-control study in a Japanese population and functional analysis. Mol. Autism. 2013, 4, 22, doi:10.1186/2040-2392-4-22.
    • (2013) Mol. Autism , vol.4 , pp. 22
    • Ma, W.J.1    Hashii, M.2    Munesue, T.3    Hayashi, K.4    Yagi, K.5    Yamagishi, M.6    Higashida, H.7    Yokoyama, S.8
  • 57
    • 37849008239 scopus 로고    scopus 로고
    • Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesis
    • Viberg, H.; Mundy, W.; Eriksson, P. Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesis. Neurotoxicology 2008, 29, 152-159.
    • (2008) Neurotoxicology , vol.29 , pp. 152-159
    • Viberg, H.1    Mundy, W.2    Eriksson, P.3
  • 58
    • 77954392043 scopus 로고    scopus 로고
    • Exposure to environmental toxins in mothers of children with autism spectrum disorder
    • Kim, S.M.; Han, D.H.; Lyoo, H.S.; Min, K.J.; Kim, K.H.; Renshaw, P. Exposure to environmental toxins in mothers of children with autism spectrum disorder. Psychiatry Investig. 2010, 7, 122-127.
    • (2010) Psychiatry Investig , vol.7 , pp. 122-127
    • Kim, S.M.1    Han, D.H.2    Lyoo, H.S.3    Min, K.J.4    Kim, K.H.5    Renshaw, P.6
  • 63
    • 78049488635 scopus 로고    scopus 로고
    • Changes in prefrontal axons may disrupt the network in autism
    • Zikopoulos, B.; Barbas, H. Changes in prefrontal axons may disrupt the network in autism. J. Neurosci. 2010, 30, 14595-14609.
    • (2010) J. Neurosci , vol.30 , pp. 14595-14609
    • Zikopoulos, B.1    Barbas, H.2
  • 64
    • 84874014649 scopus 로고    scopus 로고
    • Flowers for Algernon: Steroid dysgenesis, epigenetics and brain disorders
    • Sanders, B.K. Flowers for Algernon: Steroid dysgenesis, epigenetics and brain disorders. Pharmacol. Rep. 2012, 64, 1285-1290.
    • (2012) Pharmacol. Rep , vol.64 , pp. 1285-1290
    • Sanders, B.K.1
  • 66
    • 80052194675 scopus 로고    scopus 로고
    • Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism
    • Grant, W.B.; Soles, C.M. Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism. Derm. Endocrinol. 2009, 1, 223-228.
    • (2009) Derm. Endocrinol. , vol.1 , pp. 223-228
    • Grant, W.B.1    Soles, C.M.2
  • 67
    • 84857002191 scopus 로고    scopus 로고
    • Vitamin d and susceptibility of chronic lung diseases: Role of epigenetics
    • doi:10.3389/fphar.2011.00050
    • Sundar, I.K.; Rahman, I. Vitamin d and susceptibility of chronic lung diseases: Role of epigenetics. Front. Pharmacol. 2011, 2, 50, doi:10.3389/fphar.2011.00050.
    • (2011) Front. Pharmacol , vol.2 , pp. 50
    • Sundar, I.K.1    Rahman, I.2
  • 69
    • 84865125057 scopus 로고    scopus 로고
    • Role of a redox-based methylation switch in mRNA life cycle (pre-and post-transcriptional maturation) and protein turnover: Implications in neurological disorders
    • doi:10.3389/fnins.2012.00092
    • Trivedi, M.S.; Deth, R.C. Role of a redox-based methylation switch in mRNA life cycle (pre-and post-transcriptional maturation) and protein turnover: Implications in neurological disorders. Front. Neurosci. 2012, 6, 92, doi:10.3389/fnins.2012.00092.
    • (2012) Front. Neurosci , vol.6 , pp. 92
    • Trivedi, M.S.1    Deth, R.C.2
  • 70
    • 84883793430 scopus 로고    scopus 로고
    • Therapeutic role of hematopoietic stem cells in autism spectrum disorder-related inflammation
    • doi:10.3389/ fimmu.2013.00140
    • Siniscalco, D.; Bradstreet, J.J.; Antonucci, N. Therapeutic role of hematopoietic stem cells in autism spectrum disorder-related inflammation. Front. Immunol. 2013, 4, 140, doi:10.3389/ fimmu.2013.00140.
    • (2013) Front. Immunol , vol.4 , pp. 140
    • Siniscalco, D.1    Bradstreet, J.J.2    Antonucci, N.3
  • 71
    • 37849037738 scopus 로고    scopus 로고
    • How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis
    • Deth, R.; Muratore, C.; Benzecry, J.; Power-Charnitsky, V.A.; Waly, M. How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology 2008, 29, 190-201.
    • (2008) Neurotoxicology , vol.29 , pp. 190-201
    • Deth, R.1    Muratore, C.2    Benzecry, J.3    Power-Charnitsky, V.A.4    Waly, M.5
  • 72
    • 84878406298 scopus 로고    scopus 로고
    • Epigenetic mechanisms of gene expression regulation in neurological diseases
    • (Wars)
    • Gos, M. Epigenetic mechanisms of gene expression regulation in neurological diseases. Acta Neurobiol. Exp. (Wars) 2013, 73, 19-37.
    • (2013) Acta Neurobiol. Exp. , vol.73 , pp. 19-37
    • Gos, M.1
  • 75
    • 80051718820 scopus 로고    scopus 로고
    • Fragile X syndrome: An update on developing treatment modalities
    • Healy, A.; Rush, R.; Ocain, T. Fragile X syndrome: An update on developing treatment modalities. ACS Chem. Neurosci. 2011, 2, 402-410.
    • (2011) ACS Chem. Neurosci , vol.2 , pp. 402-410
    • Healy, A.1    Rush, R.2    Ocain, T.3
  • 76
    • 84856147847 scopus 로고    scopus 로고
    • Epigenetics in nucleotide repeat expansion disorders
    • He, F.; Todd, P.K. Epigenetics in nucleotide repeat expansion disorders. Semin. Neurol. 2011, 31, 470-483.
    • (2011) Semin. Neurol , vol.31 , pp. 470-483
    • He, F.1    Todd, P.K.2
  • 77
    • 0036782129 scopus 로고    scopus 로고
    • Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome
    • Coffee, B.; Zhang, F.; Ceman, S.; Warren, S.T.; Reines, D. Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome. Am. J. Hum. Genet. 2002, 71, 923-932.
    • (2002) Am. J. Hum. Genet , vol.71 , pp. 923-932
    • Coffee, B.1    Zhang, F.2    Ceman, S.3    Warren, S.T.4    Reines, D.5
  • 78
    • 34147154800 scopus 로고    scopus 로고
    • Characterization of an autism-associated segmental maternal heterodisomy of the chromosome 15q11-13 region
    • Kwasnicka-Crawford, D.A.; Roberts, W.; Scherer, S.W. Characterization of an autism-associated segmental maternal heterodisomy of the chromosome 15q11-13 region. J. Autism Dev. Disord. 2007, 37, 694-702.
    • (2007) J. Autism Dev. Disord. , vol.37 , pp. 694-702
    • Kwasnicka-Crawford, D.A.1    Roberts, W.2    Scherer, S.W.3
  • 79
    • 33749007122 scopus 로고    scopus 로고
    • Epigenetics of autism spectrum disorders
    • doi: 10.1093/hmg/ddl213
    • Schanen, N.C. Epigenetics of autism spectrum disorders. Hum. Mol. Genet. 2006, 15, R138-R150, doi: 10.1093/hmg/ddl213.
    • (2006) Hum. Mol. Genet , vol.15
    • Schanen, N.C.1
  • 80
    • 62149112931 scopus 로고    scopus 로고
    • Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number
    • Hogart, A.; Leung, K.N.; Wang, N.J.; Wu, D.J.; Driscoll, J.; Vallero, R.O.; Schanen, N.C.; LaSalle, J.M. Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number. J. Med. Genet. 2009, 46, 86-93.
    • (2009) J. Med. Genet , vol.46 , pp. 86-93
    • Hogart, A.1    Leung, K.N.2    Wang, N.J.3    Wu, D.J.4    Driscoll, J.5    Vallero, R.O.6    Schanen, N.C.7    LaSalle, J.M.8
  • 81
    • 34247170891 scopus 로고    scopus 로고
    • 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders
    • Hogart, A.; Nagarajan, R.P.; Patzel, K.A.; Yasui, D.H.; Lasalle, J.M. 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum. Mol. Genet. 2007, 16, 691-703.
    • (2007) Hum. Mol. Genet , vol.16 , pp. 691-703
    • Hogart, A.1    Nagarajan, R.P.2    Patzel, K.A.3    Yasui, D.H.4    Lasalle, J.M.5
  • 82
    • 65249157050 scopus 로고    scopus 로고
    • Epigenetics, DNA methylation, and chromatin modifying drugs
    • Szyf, M. Epigenetics, DNA methylation, and chromatin modifying drugs. Annu. Rev. Pharmacol. Toxicol. 2009, 49, 243-263.
    • (2009) Annu. Rev. Pharmacol. Toxicol , vol.49 , pp. 243-263
    • Szyf, M.1
  • 83
    • 84875217416 scopus 로고    scopus 로고
    • An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
    • Millan, M.J. An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy. Neuropharmacology 2013, 68, 2-82.
    • (2013) Neuropharmacology , vol.68 , pp. 2-82
    • Millan, M.J.1
  • 85
    • 84883788666 scopus 로고    scopus 로고
    • Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease?
    • doi: 10.1016/j.pharmthera.2013.05.010
    • Harrison, I.F.; Dexter, D.T. Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease? Pharmacol. Ther. 2013, doi: 10.1016/j.pharmthera.2013.05.010.
    • (2013) Pharmacol. Ther
    • Harrison, I.F.1    Dexter, D.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.