Altered cytokine and BDNF levels in autism spectrum disorder

Neurotoxicity Research

Volumn 24, Issue 4, 2013, Pages 491-501

  Ricci, S ^a   Businaro, R ^a   Ippoliti, F ^a   Lo Vasco, V R ^a   Massoni, F ^a   Onofri, E ^a   Troili, G M ^a   Pontecorvi, V ^a   Morelli, M ^a   Rapp Ricciardi, M ^b,c   Archer, T ^b,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c LINNAEUS UNIVERSITY   (Sweden)

Author keywords

Autism; Cytokines; Handicap; Immune system; Immunoexcitotoxicity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGE; ARTICLE; AUTISM; BLOOD SAMPLING; BRAIN DERIVED NEUROTROPHIC FACTOR BLOOD LEVEL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE BLOOD LEVEL; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXCITOTOXICITY; FEMALE; GENDER; HUMAN; IMMUNOTOXICITY; ITALY; MALE; NERVOUS SYSTEM INFLAMMATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD;

ADOLESCENT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; CYTOKINES; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-12; INTERLEUKIN-6; MALE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84885426598     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-013-9393-4     Document Type: Article

References (57)

1. Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, Gehn E, Loresto M, Mitchell J, Atwood S, Barnhouse S, Lee W (2011) Nutritional and metabolic status of children with autism vs neurotypical children, and the association with autism severity. Nutr Metab 8:34
2. Al-Ayadhi LY (2012) Relationship between sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders. Neurochem Res 37:394-400
3. Al-Ayadhi LY, Mostafa GA (2012) Elevated serum levels of interleukin-17A in children with autism. J Neuroinflamm 9:158
4. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders DSM-IV-TR, 4th edn. American Psychiatric Association, Washington, DC
5. Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC (2012) Perinatal stress, brain inflammation and risk of autism: review and proposal. BMC Pediatr 12:89. doi: 10.1186/1471-2431-12-89
6. Archer T, Fredriksson A, Schütz E, Kostrzewa RM (2011) Influence of physical exercise on neuroimmunological functioning and health: aging and stress. Neurotox Res 20:69-83
7. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J (2011) Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 25:40-45
8. Besedovsky H, del Rey A, Sorkin E, Dinarello CA (1986) Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233:652-654
9. Blaylock RL (2008) A possible central mechanism in autism spectrum disorders, part 1. Altern Ther Health Med 14:46-53
10. Blaylock RL (2009) A possible central mechanism in autism spectrum disorders, part 2: immunoexcitotoxicity. Altern Ther Health Med 15:60-67
11. Blaylock RL, Maroon J (2011) Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy: a unifying hypothesis. Surg Neurol Int 2:107
12. Blaylock RL, Maroon J (2012) Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. Surg Neurol Int 3:19
13. Boulanger LM (2009) Immune proteins in brain development and synaptic plasticity. Neuron 64:93-109
14. Bovolenta R, Zucchini S, Paradiso B, Rodi D, Merigo F, Navarro MG, Osculati F, Berto E, Marconi P, Marzola A, Fabene PF, Simonato M (2010) Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures. J Neuroinflamm 7:81-87
15. Brynskikh A, Warren T, Zhu J, Kipnis J (2008) Adaptive immunity affects learning behavior in mice. Brain Behav Immun 22:861-869
16. Buehler MR (2011) A proposed mechanism for autism: an aberrant neuroimmune response manifested as a psychiatric disorder. Med hypothes 76:863-870
17. Cacabelos R, Franco-Maside A, Alvarez XA (1991) Interleukin-1 in Alzheimer's disease and multi-infarct dementia: neuropsychological correlations. Methods Find Exp Clin Pharmacol 13:703-708
18. Courchesne E, Mouton PR, Calhoun ME, Semendeferi K, Ahrens-Barbeau C, Hallet MJ, Barnes CC, Pierce K (2011) Neuron number and size in prefrontal cortex of children with autism. JAMA 306:2001-2010
19. Essa MM, Braidy N, Vijayan KR, Subash S, Guillemin GJ (2013) Excitotoxicity in the pathogenesis of autism. Neurotox Res 23(4):393-400
20. Eurispes (2006) 18 Rapporto Italia, vol 8. Eurispes, p 245
21. Fredriksson A, Stigsdotter IM, Hurtig A, Ewalds-Kvist B, Archer T (2011) Running wheel activity restores MPTP-induced functional deficits. J Neural Tranms 18:407-420
22. Garay PA, McAllister AK (2010) Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders. Front Synaptic Neurosci 2:136
23. Garcia KL, Yu G, Nicolini C, Michalski B, Garzon DJ, Chiu VS, Tongiorgi E, Szatmari P, Fahnestock M (2012) Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism. J Neuropathol Exp Neurol 71:289-297
24. Goines P, Van de Water J (2010) The immune system's role in the biology of autism. Curr Opin Neurol 23:111-117
25. Green HF, Treacy E, Keohane AK, Sullivan AM, O'Keeffe GW, Nolan YM (2012) A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells. Mol Cell Neurosci 49:311-321
26. Hurley LL, Tizabi Y (2013) Neuroinflammation, neurodegeneration, and depression. Neurotox Res 23(2):131-144. doi: 10.1007/s12640-012-9348-1
27. Johnson NL, Giarelli E, Lewis C, Rice CE (2013) Genomics and autism spectrum disorder. J Nurs Scholarsh 45(1):69-78. doi: 10.1111/j.1547-5069.2012. 01483.x
28. Jyonouchi H, Sun S, Le H (2001) Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol 120:170-179
29. Jyonouchi H, Sun S, Itokazu N (2002) Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology 46:76-84
30. Kalkbrenner AE, Daniels JL, Chen JC, Poole C, Emch M, Morrissey J (2010) Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8. Epidemiology 21:631-641
31. Lainhart JE, Lange N (2011) Increased neuron number and head size in autism. JAMA 306:2031-2032
32. Leonard B, Maes M (2012) Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Bio Behav Rev 36:764-785
33. Li X, Chauhan A, Sheikh AM, Patil S, Chauhan V, Li XM, Ji L, Brown T, Malik M (2009) Elevated immune response in the brain of autistic patients. J Neuroimmunol 207:111-116
34. Lintas C, Sacco R, Persico AM (2012) Genome-wide expression studies in autism spectrum disorder, Rett syndrome, and Down syndrome. Neurobiol Dis 45:57-68
35. McAllister AK, van de Water J (2009) Breaking boundaries in neural-immune interactions. Neuron 64:9-12
36. Molloy CA, Morrow AL, Meinzen-Derr J, Schleifer K, Dienger K, Manning-Courtney P, Altaye M, Wills-Karp M (2006) Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol 172:198-205
37. Mostafa GA, Al-Ayadhi LY (2011a) The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism. J Neuroinflamm 8:180
38. Mostafa GA, Al-Ayadhi LY (2011b) A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children. J Neuroinflamm 8:71
39. Mostafa GA, Al-Ayadhi LY (2012) The relationship between the increased frequency of serum antineuronal antibodies and the severity of autism in children. Eur J Paediatr Neurol 16(5):464-468
40. Mostafa GA, Shehab AA, Al-Ayadhi LY (2013) The link between some alleles on human leukocyte antigen system and autism in children. J Neuroimmunol 255(1-2):70-74. doi: 10.1016/j.jneuroim.2012.10.002
41. Müller N, Schwarz MJ (2007) The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry 12:988-1000
42. Murray PS, Holmes PV (2011) An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus. Int J Pept. doi: 10.1155/2011/654085
43. Onore C, Careaga M, Ashwood P (2012) The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun 26:383-392
44. Pardo CA, Vargas DL, Zimmerman AW (2005) Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry 17:485-495
45. Petitto JM, Huang Z, Meola D, Ha GK, Dauer D (2012) Interleukin-2 and the septohippocampal system: intrinsic actions and autoimmune processes relevant to neuropsychiatric disorders. Methods Mol Biol 829:433-443
46. Pucak ML, Carroll KA, Kerr DA, Kaplin AI (2007) Neuropsychiatric manifestations of depression in multiple sclerosis: neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression. Dialogues Clin Neurosci 9:125-139
47. Ramos PS, Sajuthi S, Langefeld CD, Walker SJ (2012) Immune function genes CD99L2, JARID2 and TPO show association with autism spectrum disorder. Mol Autism 3:4
48. Ray B, Long JM, Sokol DK, Lahiri DK (2011) Increased secreted amyloid precursor protein-α (sAPPα) in severe autism: proposal of a specific, anabolic pathway and putative biomarker. PLoS One 6:e20405
49. Ricci S, Fuso A, Ippoliti F, Businaro R (2012) Stress-induced cytokines and neuronal dysfunction in Alzheimer's disease. J Alzheimers Dis 28:11-24
50. Rook GA, Lowry CA, Raison CL (2011) Lymphocytes in neuroprotection, cognition and emotion: is intolerance really the answer? Brain Behav Immun 25:591-601
51. Sacco R, Curatolo P, Manzi B, Militerni R, Bravaccio C, Frolli A, Lenti C, Saccani M, Elia M, Reichelt KL, Pascucci T, Puglisi-Allegra S, Persico AM (2010) Principal pathogenetic components and biological endophenotypes in autism spectrum disorders. Autism Res 3:237-252
52. Sokol DK, Chen D, Farlow MR, Dunn DW, Maloney B, Zimmer JA, Lahiri DK (2006) High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. J Child Neurol 21:444-449
53. Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA (2005) Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 57:67-81
54. Vezzani A, Friedman A (2011) Brain inflammation as a biomarker in epilepsy. Biomark Med 5:607-614
55. Weinstein AA, Deuster PA, Francis JL, Bonsall RW, Tracy RP, Kop WJ (2010) Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression. Biol Psychol 84:228-234
56. Ziats MN, Rennert OM (2011) Expression profiling of autism candidate genes during human brain development implicates central immune signaling pathways. PLoS One 6:e24691
57. Zunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM (2011) Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuropsychopharmacol Biol Psychiatry 35:722-729