Minocycline plus N-acetylcysteine synergize to modulate inflammation and prevent cognitive and memory deficits in a rat model of mild traumatic brain injury

Experimental Neurology

Volumn 249, Issue , 2013, Pages 169-177

  Haber, Margalit ^a,b   Abdel Baki, Samah G ^a,b,d   Grin'kina, Natalia M ^a,b   Irizarry, Rachel ^a,b   Ershova, Alina ^a,b   Orsi, Sara ^c   Grill, Raymond J ^c   Dash, Pramod ^c   Bergold, Peter J ^a,b  

^a SUNY Downstate Medical Center   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d Bio Signal Group Inc   (United States)

Author keywords

Animal model; Cognition; Memory; Neuroinflammation; Therapeutics; Traumatic brain injury

Indexed keywords

ACETYLCYSTEINE; CD68 ANTIGEN; MINOCYCLINE;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; AVOIDANCE BEHAVIOR; BRAIN CORTEX; COGNITIVE DEFECT; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CORPUS CALLOSUM; DRUG EFFICACY; DRUG POTENTIATION; HISTOPATHOLOGY; LONG TERM MEMORY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROMODULATION; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHAGOCYTE; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; TRAUMATIC BRAIN INJURY; WHITE MATTER;

ANIMAL MODEL; COGNITION; MEMORY; NEUROINFLAMMATION; THERAPEUTICS; TRAUMATIC BRAIN INJURY;

ACETYLCYSTEINE; ANIMALS; AVOIDANCE LEARNING; BRAIN INJURIES; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; INFLAMMATION; MEMORY DISORDERS; MINOCYCLINE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84884677371     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.09.002     Document Type: Article

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