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Volumn 26, Issue , 2013, Pages 107-119

Best paper NASS 2013: Link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs

Author keywords

Bioactive peptides; Biological repair; Human intervertebral disc degeneration; Link N; Organ culture; Proteoglycans; Regeneration; Tissue engineering

Indexed keywords

AGGRECAN; AGGRECANASE 1; AGGRECANASE 2; ANABOLIC AGENT; COLLAGENASE 3; INTERLEUKIN 1; LINK N PEPTIDE; PROTEINASE; STROMELYSIN; UNCLASSIFIED DRUG;

EID: 84884676763     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v026a08     Document Type: Article
Times cited : (41)

References (55)
  • 2
    • 77958519737 scopus 로고    scopus 로고
    • Catabolic cytokine expressions in patients with degenerative disc disease
    • Akyol S, Eraslan BS, Etyemez H, Tanriverdi T, Hanci M (2010) Catabolic cytokine expressions in patients with degenerative disc disease. Turk Neurosurg 20: 492-499.
    • (2010) Turk Neurosurg , vol.20 , pp. 492-499
    • Akyol, S.1    Eraslan, B.S.2    Etyemez, H.3    Tanriverdi, T.4    Hanci, M.5
  • 3
    • 0036035627 scopus 로고    scopus 로고
    • A biological approach to treating disc degeneration: Not for today, but maybe for tomorrow
    • Alini M, Roughley PJ, Antoniou J, Stoll T, Aebi M (2002) A biological approach to treating disc degeneration: not for today, but maybe for tomorrow. Eur Spine J 11 Suppl 2: S215-220.
    • (2002) Eur Spine J , vol.11 , Issue.SUPPL. 2
    • Alini, M.1    Roughley, P.J.2    Antoniou, J.3    Stoll, T.4    Aebi, M.5
  • 6
    • 33748577711 scopus 로고    scopus 로고
    • Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc
    • Boyd LM, Carter AJ (2006) Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc. Eur Spine J 15 Suppl 3: S414-421.
    • (2006) Eur Spine J , vol.15 , Issue.SUPPL. 3
    • Boyd, L.M.1    Carter, A.J.2
  • 8
    • 84863439052 scopus 로고    scopus 로고
    • Intervertebral disc regeneration or repair with biomaterials and stem cell therapy--feasible or fiction?
    • Chan SC, Gantenbein-Ritter B (2012a) Intervertebral disc regeneration or repair with biomaterials and stem cell therapy--feasible or fiction? Swiss Med Wkly 142: w13598.
    • (2012) Swiss Med Wkly , vol.142
    • Chan, S.C.1    Gantenbein-Ritter, B.2
  • 9
    • 84856988419 scopus 로고    scopus 로고
    • Preparation of intact bovine tail intervertebral discs for organ culture
    • in press
    • Chan SC, Gantenbein-Ritter B (2012b) Preparation of intact bovine tail intervertebral discs for organ culture. J Vis Exp, in press.
    • (2012) J Vis Exp
    • Chan, S.C.1    Gantenbein-Ritter, B.2
  • 10
    • 0032167851 scopus 로고    scopus 로고
    • A new culture system to study the metabolism of the intervertebral disc in vitro
    • discussion 1828
    • Chiba K, Andersson GB, Masuda K, Momohara S, Williams JM, Thonar EJ (1998) A new culture system to study the metabolism of the intervertebral disc in vitro. Spine 23: 1821-1827; discussion 1828.
    • (1998) Spine , vol.23 , pp. 1821-1827
    • Chiba, K.1    Andersson, G.B.2    Masuda, K.3    Momohara, S.4    Williams, J.M.5    Thonar, E.J.6
  • 11
    • 56549130107 scopus 로고    scopus 로고
    • Distinct intervertebral disc cell populations adopt similar phenotypes in three-dimensional culture
    • Chou AI, Reza AT, Nicoll SB (2008) Distinct intervertebral disc cell populations adopt similar phenotypes in three-dimensional culture. Tissue Eng Part A 14: 2079-2087.
    • (2008) Tissue Eng Part A , vol.14 , pp. 2079-2087
    • Chou, A.I.1    Reza, A.T.2    Nicoll, S.B.3
  • 12
    • 0038001664 scopus 로고    scopus 로고
    • The molecular basis of intervertebral disk degeneration
    • Chung SA, Khan SN, Diwan AD (2003) The molecular basis of intervertebral disk degeneration. Orthop Clin North Am 34: 209-219.
    • (2003) Orthop Clin North Am , vol.34 , pp. 209-219
    • Chung, S.A.1    Khan, S.N.2    Diwan, A.D.3
  • 14
    • 37349041034 scopus 로고    scopus 로고
    • A systematic review of low back pain cost of illness studies in the United States and internationally
    • Dagenais S, Caro J, Haldeman S (2008) A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J 8: 8-20.
    • (2008) Spine J , vol.8 , pp. 8-20
    • Dagenais, S.1    Caro, J.2    Haldeman, S.3
  • 15
    • 0023916652 scopus 로고
    • Characterization of link protein(s) from human intervertebral-disc tissues
    • Donohue PJ, Jahnke MR, Blaha JD, Caterson B (1988) Characterization of link protein(s) from human intervertebral-disc tissues. Biochem J 251: 739-747.
    • (1988) Biochem J , vol.251 , pp. 739-747
    • Donohue, P.J.1    Jahnke, M.R.2    Blaha, J.D.3    Caterson, B.4
  • 16
    • 0030152675 scopus 로고    scopus 로고
    • Back pain in primary care: Predictors of high health-care costs
    • Engel CC, Von Korff M, Katon WJ (1996) Back pain in primary care: predictors of high health-care costs. Pain 65: 197-204.
    • (1996) Pain , vol.65 , pp. 197-204
    • Engel, C.C.1    von Korff, M.2    Katon, W.J.3
  • 17
    • 0036204872 scopus 로고    scopus 로고
    • Current understanding of cellular and molecular events in intervertebral disc degeneration: Implications for therapy
    • Freemont AJ, Watkins A, Le Maitre C, Jeziorska M, Hoyland JA (2002) Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy. J Pathol 196: 374-379.
    • (2002) J Pathol , vol.196 , pp. 374-379
    • Freemont, A.J.1    Watkins, A.2    Le Maitre, C.3    Jeziorska, M.4    Hoyland, J.A.5
  • 18
    • 0025853547 scopus 로고
    • An overview of the incidences and costs of low back pain
    • Frymoyer JW, Cats-Baril WL (1991) An overview of the incidences and costs of low back pain. Orthop Clin North Am 22: 263-271.
    • (1991) Orthop Clin North Am , vol.22 , pp. 263-271
    • Frymoyer, J.W.1    Cats-Baril, W.L.2
  • 19
    • 80053984178 scopus 로고    scopus 로고
    • Development of an organ culture system for long-term survival of the intact human intervertebral disc
    • Gawri R, Mwale F, Ouellet J, Roughley PJ, Steffen T, Antoniou J, Haglund L (2011) Development of an organ culture system for long-term survival of the intact human intervertebral disc. Spine 36: 1835-1842.
    • (2011) Spine , vol.36 , pp. 1835-1842
    • Gawri, R.1    Mwale, F.2    Ouellet, J.3    Roughley, P.J.4    Steffen, T.5    Antoniou, J.6    Haglund, L.7
  • 21
    • 77956419226 scopus 로고    scopus 로고
    • The combined effects of limited nutrition and high-frequency loading on intervertebral discs with endplates
    • Illien-Junger S, Gantenbein-Ritter B, Grad S, Lezuo P, Ferguson SJ, Alini M, Ito K (2010) The combined effects of limited nutrition and high-frequency loading on intervertebral discs with endplates. Spine 35: 1744-1752.
    • (2010) Spine , vol.35 , pp. 1744-1752
    • Illien-Junger, S.1    Gantenbein-Ritter, B.2    Grad, S.3    Lezuo, P.4    Ferguson, S.J.5    Alini, M.6    Ito, K.7
  • 22
    • 34249043839 scopus 로고    scopus 로고
    • Recombinant human osteogenic protein-1 upregulates proteoglycan metabolism of human anulus fibrosus and nucleus pulposus cells
    • discussion 1310
    • Imai Y, Miyamoto K, An HS, Thonar EJ, Andersson GB, Masuda K (2007a) Recombinant human osteogenic protein-1 upregulates proteoglycan metabolism of human anulus fibrosus and nucleus pulposus cells. Spine 32: 1303-1309; discussion 1310.
    • (2007) Spine , vol.32 , pp. 1303-1309
    • Imai, Y.1    Miyamoto, K.2    An, H.S.3    Thonar, E.J.4    Andersson, G.B.5    Masuda, K.6
  • 23
    • 34248347420 scopus 로고    scopus 로고
    • Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC
    • Imai Y, Okuma M, An HS, Nakagawa K, Yamada M, Muehleman C, Thonar E, Masuda K (2007b) Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC. Spine 32: 1197-1205.
    • (2007) Spine , vol.32 , pp. 1197-1205
    • Imai, Y.1    Okuma, M.2    An, H.S.3    Nakagawa, K.4    Yamada, M.5    Muehleman, C.6    Thonar, E.7    Masuda, K.8
  • 24
    • 83255175729 scopus 로고    scopus 로고
    • Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential
    • Jim B, Steffen T, Moir J, Roughley P, Haglund L (2011) Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential. Eur Spine J 20: 1244-1254.
    • (2011) Eur Spine J , vol.20 , pp. 1244-1254
    • Jim, B.1    Steffen, T.2    Moir, J.3    Roughley, P.4    Haglund, L.5
  • 25
    • 57049099115 scopus 로고    scopus 로고
    • Tissue engineering and the intervertebral disc: The challenges
    • Kandel R, Roberts S, Urban JP (2008) Tissue engineering and the intervertebral disc: the challenges. Eur Spine J 17 Suppl 4: 480-491.
    • (2008) Eur Spine J , vol.17 , Issue.SUPPL. 4 , pp. 480-491
    • Kandel, R.1    Roberts, S.2    Urban, J.P.3
  • 26
    • 46749140292 scopus 로고    scopus 로고
    • Dynamic compression effects on intervertebral disc mechanics and biology
    • Korecki CL, MacLean JJ, Iatridis JC (2008) Dynamic compression effects on intervertebral disc mechanics and biology. Spine 33: 1403-1409.
    • (2008) Spine , vol.33 , pp. 1403-1409
    • Korecki, C.L.1    McLean, J.J.2    Iatridis, J.C.3
  • 27
    • 33750578733 scopus 로고    scopus 로고
    • Adjacent level discitis after anterior cervical discectomy and fusion (ACDF): A case report
    • Kulkarni AG, Hee HT (2006) Adjacent level discitis after anterior cervical discectomy and fusion (ACDF): a case report. Eur Spine J 15 Suppl 5: 559-563.
    • (2006) Eur Spine J , vol.15 , Issue.SUPPL. 5 , pp. 559-563
    • Kulkarni, A.G.1    Hee, H.T.2
  • 28
    • 33645525109 scopus 로고    scopus 로고
    • In vitro organ culture of the bovine intervertebral disc: Effects of vertebral endplate and potential for mechanobiology studies
    • Lee CR, Iatridis JC, Poveda L, Alini M (2006) In vitro organ culture of the bovine intervertebral disc: effects of vertebral endplate and potential for mechanobiology studies. Spine 31: 515-522.
    • (2006) Spine , vol.31 , pp. 515-522
    • Lee, C.R.1    Iatridis, J.C.2    Poveda, L.3    Alini, M.4
  • 30
    • 29744447597 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA (2005) The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 7: R732-745.
    • (2005) Arthritis Res Ther , vol.7
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 31
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 32
    • 80053216438 scopus 로고    scopus 로고
    • Adjacent level disk disease-is it really a fusion disease?
    • Lund T, Oxland TR (2011) Adjacent level disk disease-is it really a fusion disease? Orthop Clin North Am 42: 529-541, viii.
    • (2011) Orthop Clin North Am , vol.42
    • Lund, T.1    Oxland, T.R.2
  • 33
    • 0347416865 scopus 로고    scopus 로고
    • Estimates and patterns of direct health care expenditures among individuals with back pain in the United States
    • Luo X, Pietrobon R, Sun SX, Liu GG, Hey L (2004) Estimates and patterns of direct health care expenditures among individuals with back pain in the United States. Spine 29: 79-86.
    • (2004) Spine , vol.29 , pp. 79-86
    • Luo, X.1    Pietrobon, R.2    Sun, S.X.3    Liu, G.G.4    Hey, L.5
  • 35
    • 0026701757 scopus 로고
    • Initial characterization of the metabolism of intervertebral disc cells encapsulated in microspheres
    • Maldonado BA, Oegema TR Jr (1992) Initial characterization of the metabolism of intervertebral disc cells encapsulated in microspheres. J Orthop Res 10: 677-690.
    • (1992) J Orthop Res , vol.10 , pp. 677-690
    • Maldonado, B.A.1    Oegema Jr., T.R.2
  • 36
    • 0026006730 scopus 로고
    • Enhanced sulfated-proteoglycan core protein synthesis by incubation of rabbit chondrocytes with recombinant transforming growth factor-beta 1
    • Malemud CJ, Killeen W, Hering TM, Purchio AF (1991) Enhanced sulfated-proteoglycan core protein synthesis by incubation of rabbit chondrocytes with recombinant transforming growth factor-beta 1. J Cell Physiol 149: 152-159.
    • (1991) J Cell Physiol , vol.149 , pp. 152-159
    • Malemud, C.J.1    Killeen, W.2    Hering, T.M.3    Purchio, A.F.4
  • 37
    • 1542724880 scopus 로고    scopus 로고
    • Hospital, pharmacy, and outpatient costs for osteoarthritis and chronic back pain
    • Mapel DW, Shainline M, Paez K, Gunter M (2004) Hospital, pharmacy, and outpatient costs for osteoarthritis and chronic back pain. J Rheumatol 31: 573-583.
    • (2004) J Rheumatol , vol.31 , pp. 573-583
    • Mapel, D.W.1    Shainline, M.2    Paez, K.3    Gunter, M.4
  • 38
    • 57049130901 scopus 로고    scopus 로고
    • Biological repair of the degenerated intervertebral disc by the injection of growth factors
    • Masuda K (2008) Biological repair of the degenerated intervertebral disc by the injection of growth factors. Eur Spine J 17 Suppl 4: 441-451.
    • (2008) Eur Spine J , vol.17 , Issue.SUPPL. 4 , pp. 441-451
    • Masuda, K.1
  • 39
    • 14844350606 scopus 로고    scopus 로고
    • Growth factors and treatment of intervertebral disc degeneration
    • Masuda K, Oegema TR Jr, An HS (2004) Growth factors and treatment of intervertebral disc degeneration. Spine 29: 2757-2769.
    • (2004) Spine , vol.29 , pp. 2757-2769
    • Masuda, K.1    Oegema Jr., T.R.2    An, H.S.3
  • 40
    • 33645765778 scopus 로고    scopus 로고
    • Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model
    • Masuda K, Imai Y, Okuma M, Muehleman C, Nakagawa K, Akeda K, Thonar E, Andersson G, An HS (2006) Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine 31: 742-754.
    • (2006) Spine , vol.31 , pp. 742-754
    • Masuda, K.1    Imai, Y.2    Okuma, M.3    Muehleman, C.4    Nakagawa, K.5    Akeda, K.6    Thonar, E.7    Andersson, G.8    An, H.S.9
  • 41
    • 0031961969 scopus 로고    scopus 로고
    • An N-terminal peptide from link protein stimulates proteoglycan biosynthesis in human articular cartilage in vitro
    • McKenna LA, Liu H, Sansom PA, Dean MF (1998) An N-terminal peptide from link protein stimulates proteoglycan biosynthesis in human articular cartilage in vitro. Arthritis Rheum 41: 157-162.
    • (1998) Arthritis Rheum , vol.41 , pp. 157-162
    • McKenna, L.A.1    Liu, H.2    Sansom, P.A.3    Dean, M.F.4
  • 42
    • 0022407815 scopus 로고
    • The role of link protein in mediating the interaction between hyaluronic acid and newly secreted proteoglycan subunits from adult human articular cartilage
    • Melching LI, Roughley PJ (1985) The role of link protein in mediating the interaction between hyaluronic acid and newly secreted proteoglycan subunits from adult human articular cartilage. J Biol Chem 260: 16279-16285.
    • (1985) J Biol Chem , vol.260 , pp. 16279-16285
    • Melching, L.I.1    Roughley, P.J.2
  • 43
    • 0037445979 scopus 로고    scopus 로고
    • A synthetic peptide of link protein stimulates the biosynthesis of collagens II, IX and proteoglycan by cells of the intervertebral disc
    • Mwale F, Demers CN, Petit A, Roughley P, Poole AR, Steffen T, Aebi M, Antoniou J (2003) A synthetic peptide of link protein stimulates the biosynthesis of collagens II, IX and proteoglycan by cells of the intervertebral disc. J Cell Biochem 88: 1202-1213.
    • (2003) J Cell Biochem , vol.88 , pp. 1202-1213
    • Mwale, F.1    Demers, C.N.2    Petit, A.3    Roughley, P.4    Poole, A.R.5    Steffen, T.6    Aebi, M.7    Antoniou, J.8
  • 45
    • 79952920498 scopus 로고    scopus 로고
    • Effect of synthetic Link-N peptide on the expression of type I and type II collagens in human intervertebral disc cells
    • Petit A, Yao G, Rowas SA, Gawri R, Epure L, Antoniou J, Mwale F (2011) Effect of synthetic Link-N peptide on the expression of type I and type II collagens in human intervertebral disc cells. Tissue Eng Part A 17: 899-904.
    • (2011) Tissue Eng Part A , vol.17 , pp. 899-904
    • Petit, A.1    Yao, G.2    Rowas, S.A.3    Gawri, R.4    Epure, L.5    Antoniou, J.6    Mwale, F.7
  • 46
    • 14844362345 scopus 로고    scopus 로고
    • Biology of intervertebral disc aging and degeneration: Involvement of the extracellular matrix
    • Roughley PJ (2004) Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix. Spine 29: 2691-2699.
    • (2004) Spine , vol.29 , pp. 2691-2699
    • Roughley, P.J.1
  • 47
    • 26844568977 scopus 로고    scopus 로고
    • The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation
    • Roughley P, Hoemann C, DesRosiers E, Mwale F, Antoniou J, Alini M (2006a) The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation. Biomaterials 27: 388-396.
    • (2006) Biomaterials , vol.27 , pp. 388-396
    • Roughley, P.1    Hoemann, C.2    DesRosiers, E.3    Mwale, F.4    Antoniou, J.5    Alini, M.6
  • 50
    • 0028128443 scopus 로고
    • In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: Age-related differences
    • Van Beuningen HM, Van der Kraan PM, Arntz OJ, Van den Berg WB (1994) In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences. Ann Rheum Dis 53: 593-600.
    • (1994) Ann Rheum Dis , vol.53 , pp. 593-600
    • van Beuningen, H.M.1    Van der Kraan, P.M.2    Arntz, O.J.3    Van den Berg, W.B.4
  • 51
    • 81155132248 scopus 로고    scopus 로고
    • TNF-alpha and IL-1beta promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc
    • Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV (2011) TNF-alpha and IL-1beta promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem 286: 39738-39749.
    • (2011) J Biol Chem , vol.286 , pp. 39738-39749
    • Wang, J.1    Markova, D.2    Anderson, D.G.3    Zheng, Z.4    Shapiro, I.M.5    Risbud, M.V.6
  • 52
    • 84882449101 scopus 로고    scopus 로고
    • ISSLS prize winner: The effect of Link protein peptide (LPP) on human intervertebral disc cells
    • Wang Z, Hutton WC, Yoon ST (2013) ISSLS prize winner: the effect of Link protein peptide (LPP) on human intervertebral disc cells. Spine 38: 1501-1507.
    • (2013) Spine , vol.38 , pp. 1501-1507
    • Wang, Z.1    Hutton, W.C.2    Yoon, S.T.3
  • 54
    • 28244455888 scopus 로고    scopus 로고
    • Molecular therapy of the intervertebral disc
    • Yoon ST (2005) Molecular therapy of the intervertebral disc. Spine J 5: 280S-286S.
    • (2005) Spine J , vol.5
    • Yoon, S.T.1
  • 55
    • 34548620230 scopus 로고    scopus 로고
    • The cell biology of intervertebral disc aging and degeneration
    • Zhao CQ, Wang LM, Jiang LS, Dai LY (2007) The cell biology of intervertebral disc aging and degeneration. Ageing Res Rev 6: 247-261.
    • (2007) Ageing Res Rev , vol.6 , pp. 247-261
    • Zhao, C.Q.1    Wang, L.M.2    Jiang, L.S.3    Dai, L.Y.4


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