Procalcitonin induced cytotoxicity and apoptosis in mesangial cells: Implications for septic renal injury

Inflammation Research

Volumn 62, Issue 10, 2013, Pages 887-894

  Araujo, Magali ^a,b   Doi, Sonia Q ^a   Palant, Carlos E ^c   Nylen, Eric S ^d   Becker, Kenneth L ^d  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Actin; Apoptosis; Inducible nitric oxide synthase; Interleukin 6; Mesangial cells; Procalcitonin

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MESSENGER RNA; PROCALCITONIN; TUMOR NECROSIS FACTOR ALPHA;

ACTIN FILAMENT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LOSS; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RESPONSE; CYTOTOXICITY; GENE EXPRESSION; GENE FUNCTION; IN VITRO STUDY; INFLAMMATION; KIDNEY INJURY; MESANGIUM CELL; MOUSE; NONHUMAN; PATHOGENESIS; SEPSIS; SPINDLE CELL; STELLATE CELL; UPREGULATION;

ACTINS; ACUTE KIDNEY INJURY; ANIMALS; CALCITONIN; CELL DEATH; CELLS, CULTURED; INTERLEUKIN-6; MESANGIAL CELLS; MICE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN PRECURSORS; RNA, MESSENGER; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84884675133     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-013-0646-8     Document Type: Article

References (42)

1. Becker KL, Nylen ES, White JC, Muller B, Snider RH Jr. Clinical review 167: procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab. 2004;89:1512-25.
2. Morgenthaler NG, Struck J, Chancerelle Y, Weglohner W, Agay D, Bohuon C, et al. Production of procalcitonin (PCT) in non-thyroidal tissue after LPS injection. Horm Metab Res. 2003;35:290-5.
3. Muller B, White JC, Nylen ES, Snider RH, Becker KL, Habener JF. Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab. 2001;86:396-404.
4. Zannoni A, Giunti M, Bernardini C, Gentilini F, Zaniboni A, Bacci ML, et al. Procalcitonin gene expression after LPS stimulation in the porcine animal model. Res Vet Sci. 2012;93:921-7.
5. Wagner KE, Martinez JM, Vath SD, Snider RH, Nylen ES, Becker KL, et al. Early immunoneutralization of calcitonin precursors attenuates the adverse physiologic response to sepsis in pigs. Crit Care Med. 2002;30:2313-21.
6. Martinez JM, Wagner KE, Snider RH, Nylen ES, Muller B, Sarani B, et al. Late immunoneutralization of procalcitonin arrests the progression of lethal porcine sepsis. Surg Infect. 2001;2:193-202 Discussion 202-3.
7. Becker KL, Snider R, Nylen ES. Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target. Br J Pharmacol. 2010;159:253-64.
8. Nylen ES, Alarifi AA. Humoral markers of severity and prognosis of critical illness. Best Pract Res Clin Endocrinol Metab. 2001;15:553-73.
9. Nylen ES, Whang KT, Snider RH Jr, Steinwald PM, White JC, Becker KL. Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis. Crit Care Med. 1998;26:1001-6.
10. Badr KF, Brenner BM, Ichikawa I. Effects of leukotriene D4 on glomerular dynamics in the rat. Am J Physiol. 1987;253:F239-43.
11. Iversen BM, Kvam FI, Matre K, Morkrid L, Horvei G, Bagchus W, et al. Effect of mesangiolysis on autoregulation of renal blood flow and glomerular filtration rate in rats. Am J Physiol. 1992;262:F361-6.
12. Schlondorff D. Roles of the mesangium in glomerular function. Kidney Int. 1996;49:1583-5.
13. Stockand JD, Sansom SC. Regulation of filtration rate by glomerular mesangial cells in health and diabetic renal disease. Am J Kidney Dis Off J Natl Kidney Found. 1997;29:971-81.
14. Wang X, Aukland K, Bostad L, Iversen BM. Autoregulation of total and zonal glomerular filtration rate in spontaneously hypertensive rats with mesangiolysis. Kidney Blood Press Res. 1997;20:11-7.
15. Almeida WS, Maciel TT, Di Marco GS, Casarini DE, Campos AH, Schor N. Escherichia coli lipopolysaccharide inhibits renin activity in human mesangial cells. Kidney Int. 2006;69:974-80.
16. Camussi G, Turello E, Tetta C, Bussolino F, Baglioni C. Tumor necrosis factor induces contraction of mesangial cells and alters their cytoskeletons. Kidney Int. 1990;38:795-802.
17. Maquigussa E, Arnoni CP, Cristovam PC, de Oliveira AS, Higa EM, Boim MA. Escherichia coli lipopolysaccharide impairs the calcium signaling pathway in mesangial cells: role of angiotensin II receptors. Exp Biol Med (Maywood). 2010;235:761-7.
18. Murray PT, Wylam ME, Umans JG. Endotoxin impairs agonist-induced calcium mobilization in rat mesangial cells. Am J Respir Crit Care Med. 1997;156:1846-54.
19. Ortiz-Arduan A, Danoff TM, Kalluri R, Gonzalez-Cuadrado S, Karp SL, Elkon K, et al. Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia. Am J Physiol. 1996;271:F1193-201.
20. Sexton PM, Christopoulos G, Christopoulos A, Nylen ES, Snider RH Jr, Becker KL. Procalcitonin has bioactivity at calcitonin receptor family complexes: potential mediator implications in sepsis. Crit Care Med. 2008;36:1637-40.
21. Doi T, Vlassara H, Kirstein M, Yamada Y, Striker GE, Striker LJ. Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor. Proc Natl Acad Sci USA. 1992;89:2873-7.
22. Iehara N, Takeoka H, Tsuji H, Imabayashi T, Foster DN, Strauch AR, et al. Differentiation of smooth muscle phenotypes in mouse mesangial cells. Kidney Int. 1996;49:1330-41.
23. Moriyama T, Fujibayashi M, Fujiwara Y, Kaneko T, Xia C, Imai E, et al. Angiotensin II stimulates interleukin-6 release from cultured mouse mesangial cells. J Am Soc Nephrol JASN. 1995;6:95-101.
24. Takeuchi Y, Yamauchi K, Nakamura J, Shigematsu S, Hashizume K. Angiotensin II regulates migration in mouse cultured mesangial cells: evidence for the presence of receptor subtype-specific regulation. J Endocrinol. 2006;191:361-7.
25. Rehli M, Luger K, Beier W, Falk W. Molecular cloning and expression of mouse procalcitonin. Biochem Biophys Res Commun. 1996;226:420-5.
26. Doi SQ, Jacot TA, Sellitti DF, Hirszel P, Hirata MH, Striker GE, et al. Growth hormone increases inducible nitric oxide synthase expression in mesangial cells. J Am Soc Nephrol JASN. 2000;11:1419-25.
27. Lancaster JR Jr, Hibbs JB Jr. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc Natl Acad Sci USA. 1990;87:1223-7.
28. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990;87:1620-4.
29. de Jong HK, van der Poll T, Wiersinga WJ. The systemic pro-inflammatory response in sepsis. J Innate Immun. 2010;2:422-30.
30. Mathison JC, Wolfson E, Ulevitch RJ. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Investig. 1988;81:1925-37.
31. John E, Pais P, Furtado N, Chin A, Radhakrishnan J, Fornell L, et al. Early effects of lipopolysaccharide on cytokine release, hemodynamic and renal function in newborn piglets. Neonatology. 2008;93:106-12.
32. Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y. Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol JASN. 2009;20:1997-2008.
33. He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y. Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol JASN. 2009;20:765-76.
34. He W, Kang YS, Dai C, Liu Y. Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol JASN. 2011;22:90-103.
35. Surendran K, McCaul SP, Simon TC. A role for Wnt-4 in renal fibrosis. Am J Physiol Ren Physiol. 2002;282:F431-41.
36. Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol JASN. 2005;16:2373-84.
37. von Toerne C, Schmidt C, Adams J, Kiss E, Bedke J, Porubsky S, et al. Wnt pathway regulation in chronic renal allograft damage. Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surg. 2009;9:2223-39.
38. Kriz W, Elger M, Lemley K, Sakai T. Structure of the glomerular mesangium: a biomechanical interpretation. Kidney Int Suppl. 1990;30:S2-9.
39. Riser BL, Varani J, Cortes P, Yee J, Dame M, Sharba AK. Cyclic stretching of mesangial cells up-regulates intercellular adhesion molecule-1 and leukocyte adherence: a possible new mechanism for glomerulosclerosis. Am J Pathol. 2001;158:11-7.
40. Kikeri D, Pennell JP, Hwang KH, Jacob AI, Richman AV, Bourgoignie JJ. Endotoxemic acute renal failure in awake rats. Am J Physiol. 1986;250:F1098-106.
41. Lugon JR, Boim MA, Ramos OL, Ajzen H, Schor N. Renal function and glomerular hemodynamics in male endotoxemic rats. Kidney Int. 1989;36:570-5.
42. Chawla LS, Seneff MG, Nelson DR, Williams M, Levy H, Kimmel PL, et al. Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis. Clin J Am Soc Nephrol CJASN. 2007;2:22-30.