Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs

Biochemical Pharmacology

Volumn 86, Issue 7, 2013, Pages 950-959

  Kim, Byung Hak ^a   Won, Cheolhee ^a   Lee, Yun Han ^b   Choi, Jung Sook ^c   Noh, Kum Hee ^a   Han, Songhee ^a   Lee, Haeri ^a   Lee, Chang Seok ^a   Lee, Dong Sup ^a   Ye, Sang Kyu ^a   Kim, Myoung Hwan ^a,d  

^a Seoul National University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c GyeongDo Provincial College   (South Korea)

^d Seoul National University Bundang Hospital   (South Korea)

Author keywords

Apoptosis; Cancer; Small molecule inhibitor; Sophoraflavanone G; STATs

Indexed keywords

FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; SOPHORAFLAVANONE G; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STAT5B PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING;

APOPTOSIS; CANCER; SMALL-MOLECULE INHIBITOR; SOPHORAFLAVANONE G; STATS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOKINES; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVANONES; HUMANS; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TYROSINE;

EID: 84884673792     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.009     Document Type: Article

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