Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: Crosstalk between NFκB and MAPK regulates endothelial cell survival

Molecular and Cellular Biochemistry

Volumn 382, Issue 1-2, 2013, Pages 153-162

  Kao, Derrick D ^a   Oldebeken, Scott R ^a   Rai, Anjali ^a   Lubos, Edith ^b   Leopold, Jane A ^a   Loscalzo, Joseph ^a   Handy, Diane E ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY HEART CENTER HAMBURG   (Germany)

Author keywords

Cellular proliferation; DNA synthesis; Dual specificity phosphatase; Endothelial cells; MAP kinase signaling; NF B

Indexed keywords

ACTIN; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADENOVIRUS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADENOVIRIDAE;

CELL PROLIFERATION; CELL SURVIVAL; DUAL-SPECIFICITY PHOSPHATASES; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROVESSELS; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; NF-KAPPA B; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84884673317     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1730-7     Document Type: Article

References (38)

1. Turjanski AG, Vaque JP, Gutkind JS (2007) MAP kinases and the control of nuclear events. Oncogene 26(22):3240-3253
2. Owens DM, Keyse SM (2007) Differential regulation of MAP kinase signalling by dual specificity protein phosphatases. Oncogene 26(22):3203-3213
3. Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22(4):954-965
4. Roux PP, Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68(2):320-344
5. Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81(2):807-869
6. Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288(5467):870-874
7. Kriehuber E, Bauer W, Charbonnier AS, Winter D, Amatschek S, Tamandl D, Schweifer N, Stingl G, Maurer D (2005) Balance between NF-kappaB and JNK/AP-1 activity controls dendritic cell life and death. Blood 106(1):175-183
8. Chen YR, Wang X, Templeton D, Davis RJ, Tan TH (1996) The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem 271(50):31929-31936
9. Molnar A, Theodoras AM, Zon LI, Kyriakis JM (1997) Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK. J Biol Chem 272(20):13229-13235
10. Lubos E, Kelly NJ, Oldebeken SR, Leopold JA, Zhang YY, Loscalzo J, Handy DE (2011) Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. J Biol Chem 286(41):35407-35417
11. Brondello JM, Brunet A, Pouyssegur J, McKenzie FR (1997) The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade. J Biol Chem 272(2):1368-1376
12. Sieben NL, Oosting J, Flanagan AM, Prat J, Roemen GM, Kolkman-Uljee SM, van Eijk R, Cornelisse CJ, Fleuren GJ, van Engeland M (2005) Differential gene expression in ovarian tumors reveals Dusp 4 and Serpina 5 as key regulators for benign behavior of serous borderline tumors. J Clin Oncol 23(29):7257-7264
13. Teng CH, Huang WN, Meng TC (2007) Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress. J Biol Chem 282(39):28395-28407
14. Waha A, Felsberg J, Hartmann W, von dem Knesebeck A, Mikeska T, Joos S, Wolter M, Koch A, Yan PS, Endl E, Wiestler OD, Reifenberger G, Pietsch T, Waha A (2010) Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells. Cancer Res 70(4):1689-1699
15. Chitale D, Gong Y, Taylor BS, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Seshan VE, Zakowski MF, Rusch V, Pao W, Gerald W, Ladanyi M (2009) An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. Oncogene 28(31):2773-2783
16. Lawan A, Al-Harthi S, Cadalbert L, McCluskey AG, Shweash M, Grassia G, Grant A, Boyd M, Currie S, Plevin R (2011) Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival. J Biol Chem 286(15):12933-12943
17. Furusu A, Nakayama K, Xu Q, Konta T, Kitamura M (2007) MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha. J Cell Physiol 210(3):703-710
18. Shen WH, Wang J, Wu J, Zhurkin VB, Yin Y (2006) Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis. Cancer Res 66(12):6033-6039
19. Ramesh S, Wildey GM, Howe PH (2009) Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise and fall of Bim. Cell Cycle 8(1):11-17
20. Peng DJ, Zhou JY, Wu GS (2010) Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK. Cell Cycle 9(23):4650-4655
21. Madonna R, De Caterina R (2012) Relevance of new drug discovery to reduce NF-kappaB activation in cardiovascular disease. Vascul Pharmacol 57(1):41-47
22. Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M (2012) NF-kappaB as a potential therapeutic target in microbial diseases. Mol BioSyst 8(4):1108-1120
23. Baker RG, Hayden MS, Ghosh S (2011) NF-kappaB, inflammation, and metabolic disease. Cell Metab 13(1):11-22
24. Al-Mutairi M, Al-Harthi S, Cadalbert L, Plevin R (2010) Over-expression of mitogen-activated protein kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells. Br J Pharmacol 161(4):782-798
25. Tresini M, Lorenzini A, Torres C, Cristofalo VJ (2007) Modulation of replicative senescence of diploid human cells by nuclear ERK signaling. J Biol Chem 282(6):4136-4151
26. Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (1997) Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). Genomics 42(3):524-527
27. Emmert-Buck MR, Vocke CD, Pozzatti RO, Duray PH, Jennings SB, Florence CD, Zhuang Z, Bostwick DG, Liotta LA, Linehan WM (1995) Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia. Cancer Res 55(14):2959-2962
28. Balko JM, Cook RS, Vaught DB, Kuba MG, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, Salter J, Dowsett M, Stemke-Hale K, Gonzalez-Angulo AM, Mills GB, Pinto JA, Gomez HL, Arteaga CL (2012) Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Nat Med 18:1052-1059
29. Cuadrado A, Nebreda AR (2010) Mechanisms and functions of p38 MAPK signalling. Biochem J 429(3):403-417
30. Li SP, Junttila MR, Han J, Kahari VM, Westermarck J (2003) p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2. Cancer Res 63(13):3473-3477
31. Lee J, Hong F, Kwon S, Kim SS, Kim DO, Kang HS, Lee SJ, Ha J, Kim SS (2002) Activation of p38 MAPK induces cell cycle arrest via inhibition of Raf/ERK pathway during muscle differentiation. Biochem Biophys Res Commun 298(5):765-771
32. Shen HM, Pervaiz S (2006) TNF receptor superfamily-induced cell death: redox-dependent execution. FASEB J 20(10):1589-1598
33. Tong X, Yin L, Washington R, Rosenberg DW, Giardina C (2004) The p50-p50 NF-kappaB complex as a stimulus-specific repressor of gene activation. Mol Cell Biochem 265(1-2):171-183
34. Acharyya S, Sharma SM, Cheng AS, Ladner KJ, He W, Kline W, Wang H, Ostrowski MC, Huang TH, Guttridge DC (2010) TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One 5(8):e12479
35. Liu Y, Mayo MW, Nagji AS, Smith PW, Ramsey CS, Li D, Jones DR (2011) Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1. Oncogene 31(9):1143-1154
36. Taganov KD, Boldin MP, Chang KJ, Baltimore D (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103(33):12481-12486
37. Thompson RC, Herscovitch M, Zhao I, Ford TJ, Gilmore TD (2011) NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway. J Biol Chem 286(3):1675-1682
38. Zhou R, Hu G, Liu J, Gong AY, Drescher KM, Chen XM (2009) NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. PLoS Pathog 5(12):e100068