The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination

Biochemical Pharmacology

Volumn 86, Issue 7, 2013, Pages 991-996

  Wang, Li ^a   Pan, Xiaolei ^a   Sweet, Douglas H ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Drug drug interaction; Nephroprotective; Rhei rhizoma; SLC22A6; SLC22A8; Solute carrier

Indexed keywords

ORGANIC ANION TRANSPORTER; RHEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SPECIES DIFFERENCE; URINARY EXCRETION;

DRUG-DRUG INTERACTION; NEPHROPROTECTIVE; RHEI RHIZOMA; SLC22A6; SLC22A8; SOLUTE CARRIER;

ANIMALS; ANTHRAQUINONES; CELL LINE; CHO CELLS; CRICETULUS; DRUG INTERACTIONS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-AMINOHIPPURIC ACID; SPECIES SPECIFICITY;

EID: 84884669333     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.016     Document Type: Article

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